AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaGeographicals
MisoprostolAbortifacient Agents, NonsteroidalOxytocicsAdministration, IntravaginalAdministration, SublingualAbortifacient Agents, SteroidalAbortion, InducedVacuum CurettagePostpartum HemorrhageAbortion, IncompleteCervical RipeningMifepristoneAbortifacient AgentsPregnancy Trimester, FirstDilatation and CurettageUterine HemorrhageLabor, InducedPregnancyDilatationHysteroscopyAlprostadilLabor Stage, ThirdAnti-Ulcer AgentsOxytocinAdministration, OralAdministration, BuccalCervix UteriAnti-Inflammatory Agents, Non-SteroidalProstaglandins E, SyntheticDiclofenacEndometritisAbortion, MissedMedicine, Tibetan TraditionalPregnancy Trimester, SecondMauritaniaClostridium sordelliiErgonovineHome ChildbirthMenstruation-Inducing Agents
CervixMifepristoneDinoprostoneIntravaginal MisoprostolDilationLacerationTranscervical Foley catheterHysteroscopyLabor inductionProstaglandinCytotecPlasma concentrations of misoprostolGestationComplicationsAdministration of misoprostolVersusInduction of labVaginallyPregnancyProstaglandinsDilatation comparedPlaceboOxytocin InductionDoseDosesAbortionsActive ingredientPreoperativeTabletsDiarrheaObstetrics and gynecoDilatorTablet was placedConclusionMedicationsSignificantlyNSAIDsHyperstimulationSurgicalReduces2016UlcersMiscarriageGastricNonsteroidalExtracellularL'administration
Cervix14
  • The aim of this study was to compare the efficacy of vaginal misoprostol with Foley balloon catheter for cervical ripening in women with singleton pregnancies and an unfavorable cervix. (jogcr.com)
  • Eighty pregnant women with unfavorable cervix were randomly divided in two groups of Foley catheter or misoprostol modes. (jogcr.com)
  • Misoprostol then dilates the cervix and induces muscle contractions which clear the uterus. (wikipedia.org)
  • Misoprostol can also be used to dilate the cervix in preparation for a surgical abortion, particularly in the second trimester (either alone or in combination with laminaria stents). (wikipedia.org)
  • Second, in preparation for labor and delivery, the cervix softens and becomes more distensible, a process called cervical ripening. (medscape.com)
  • Cervical ripening refers to the softening of the cervix that typically begins prior to the onset of labor contractions and is necessary for cervical dilation and the passage of the fetus. (medscape.com)
  • Intravaginal misoprostol is associated with a shorter induction to delivery interval as compared to Foley's catheter and it increases the rate of vaginal delivery in cases of unripe cervix at term. (hindawi.com)
  • The most common methods of labour induction when the status of cervix is unfavourable involve intravaginal use of misoprostol, transcervical insertion of Foley's catheter, and insertion of prostaglandin gel whereas with a ripe cervix oxytocin may be administered intravenously. (hindawi.com)
  • Mifepristone and misoprostol tablets soften the cervix, making it easier to dilate (open). (bpas.org)
  • Transabdominal cervical cerclage (TAC) is a surgery performed to prevent pregnancy loss in patients with the most challenging cases of incompetent cervix (cervical insufficiency) . (uchicagomedicine.org)
  • Cervical ripening - the softening of the cervix that begins prior to the onset of the labor contractions. (med247online.com)
  • Gemeprost pessaries soften and dilate the cervix to facilitate trans-cervical operative procedures. (biologydiscussion.com)
  • As medical providers began to understand the effect misoprostol had on the cervix and uterus, they began to use it "off label" to induce labor, medically manage miscarriages and for medical abortion. (suzyknew.com)
  • Exclusion criteria were any contraindication for misoprostol, untreated genital infection, previous history of surgery to the cervix, or abnormal pregnancy. (bollettinoginendo.it)
Mifepristone12
Dinoprostone9
  • Ces différences mécaniques peuvent affecter les résultats chez les femmes traitées au dinoprostone, une formule identique au PGE2 endogène, comparé au misoprostol, un PGE1 analogue. (afar.info)
  • Résultats : Bien que le dinoprostone et le misoprostol soient tous deux efficaces pour la maturation du col et le déclenchement du travail, ils se différencient par leurs profils cliniques et pharmacologiques. (afar.info)
  • Matonhodze Baron B, Hofmeyr GJ, Levin J. Labour induction at term - a randomised trial comparing Foley catheter plus titrated oral misoprostol solution, titrated oral misoprostol solution alone, and dinoprostone. (jogcr.com)
  • To compare the effectiveness of vaginal misoprostol and dinoprostone for cervical ripening before diagnostic hysteroscopy in nulliparous women. (bollettinoginendo.it)
  • Randomly assignment to receive 400 mg of misoprostol (n = 30) or 10 mg of dinoprostone (n ¼ 30) vaginally before diagnostic hysteroscopy, with a control group (n = 30) not receiving any cervical priming agent. (bollettinoginendo.it)
  • In the placebo group, 23 patients required cervical dilatation compared with 17 in the misoprostol group and 9 in the dinoprostone group. (bollettinoginendo.it)
  • The mean (± standard deviation) cervical widths for the placebo, misoprostol, and dinoprostone groups were 4.23 ± 0.43 mm, 5.43 ± 0.5 mm, and 5.83 ± 0.64 mm, respectively. (bollettinoginendo.it)
  • Conclusion(s): Vaginally administered dinoprostone before diagnostic hysteroscopy is more effective than misoprostol for inducing cervical priming. (bollettinoginendo.it)
  • E2: dinoprostone, misoprostol, sulprostone) are capable of inducing rhythmic uterine contractions and cervical relaxation at any time. (manualofmedicine.com)
Intravaginal Misoprostol7
  • Comparison of 25 µg sublingual and 50 µg intravaginal misoprostol for cervical ripening and labor: a randomized controlled equivalence trial. (qxmd.com)
  • This study aimed to compare the efficacy of 25-µg sublingual misoprostol with 50-µg intravaginal misoprostol for cervical ripening prior to labor induction in primiparous women. (qxmd.com)
  • The women were randomly assigned to receive 25-µg sublingual misoprostol with vaginal placebo (n = 63) or 50-µg intravaginal misoprostol with sublingual placebo (n = 63). (qxmd.com)
  • Sublingual administration of 25-µg of misoprostol appears to be as effective as 50 µg intravaginal misoprostol for cervical ripening and labor induction. (qxmd.com)
  • To compare the efficacy and safety of intravaginal misoprostol with transcervical Foley catheter for labour induction. (hindawi.com)
  • ABSTRACT To assess the effectiveness of intravaginal misoprostol for second trimester uterine evacuation, we studied 70 women with singleton pregnancies complicated by fetal malformation or dead fetuses. (who.int)
  • ACOG does have recommendations for reducing dilation pain during a hysteroscopy , including providing intravaginal misoprostol and estrogen . (medscape.com)
Dilation6
  • These chemical and physical changes are required for cervical dilation, labor, and delivery of a fetus. (medscape.com)
  • Cervical dilation results from these processes plus uterine contractions. (medscape.com)
  • If you're not able to take misoprostol, you may be wondering if a dilation and curettage (D&C) is a better option. (athenspregnancy.com)
  • It has never been studied during cervical dilator placement prior to dilation and evacuation. (societyfp.org)
  • This is a single-blinded, randomized controlled trial to evaluate TENS as a method of pain relief during cervical dilator placement prior to dilation and evacuation. (societyfp.org)
  • Threatened abortion is vaginal bleeding without cervical dilation before 20 weeks in a confirmed viable intrauterine pregnancy. (msdmanuals.com)
Laceration3
  • The time to reach complete dilatation (Hegar 3 to 10 mm), size of the first Hegar used to apply force, bleeding volume, and cervical laceration were compared between the groups using the IBM SPSS Statistics for Windows, Version 21.0 (Armonk, NY: IBM Corp). (jogcr.com)
  • Gesta- safe methods of terminating second trimes- tional age was 15-23 weeks (2nd trimester ter pregnancy other than surgery, which pregnancy is defined as the period of preg- can result in serious complications such as nancy from the beginning of the 15th cervical laceration, uterine perforation and through the 28th completed week of gesta- bowel injury. (who.int)
  • This cervical dilatation is the source of the principal complications of abortions including cervical laceration, uterine perforation with a risk of wounding adjoining organs, haemorrhage and, finally, the long term risks of cervical incompetence, late miscarriage and preterm delivery.On the other hand, when cervical dilatation is not adequate at the moment of aspiration, it can also cause other short-term complications: ongoing pregnancy and infection that can affect fertility. (fiapac.org)
Transcervical Foley catheter2
  • Cervical ripening in Foley catheter group was done with transcervical Foley catheter 18, and in misoprostol group with 25 μg single dose vaginal misoprostol (The maximum allowed dose for patients was 6 doses. (jogcr.com)
  • The rate of vaginal delivery was 76.7% versus 56.8% in misoprostol and transcervical Foley catheter group, respectively. (hindawi.com)
Hysteroscopy6
  • Therefore, routine use of misoprostol before every hysteroscopy is not suggested and it should be used for selected cases by consideration of patients' medical history and clinical characteristics (7). (jogcr.com)
  • Considering the effect of EPO on cervical dilatation before hysteroscopy procedure, studies comparing vaginal soft gels of EPO with placebo have confirmed the efficacy of vaginal EPO for cervical ripening and have suggested it as an appropriate cervical priming agent to be used prior to gynecologic procedures (15, 16). (jogcr.com)
  • In the first trial, one thousand micrograms of self-administered vaginal misoprostol taken 12 hours before day-care operative hysteroscopy showed a significant cervical ripening effect, compared with placebo. (fiapac.org)
  • In the second trial, one thousand micrograms of self-administered vaginal misoprostol taken 12 hours before day-care operative hysteroscopy results in significant cervical ripening in postmenopausal women, compared with placebo, after 14 days pre-treatment with vaginal estradiol tablets. (fiapac.org)
  • Self-administered vaginal misoprostol at home the evening before operative hysteroscopy is safe and highly acceptable. (fiapac.org)
  • Hysteroscopy should not be performed in the setting of cervical or endometrial cancer. (medscape.com)
Labor induction8
  • Misoprostol combined with cervical single or double balloon catheters versus misoprostol alone for labor induction of singleton pregnancies: a meta-analysis of randomized trials. (jogcr.com)
  • A randomized clinical trial comparing vaginal misoprostol versus cervical Foley plus oral misoprostol for cervical ripening and labor induction. (jogcr.com)
  • A randomized controlled trial comparing vaginal misoprostol versus Foley catheter plus oxytocin for labor induction. (jogcr.com)
  • medical citation needed] Misoprostol is commonly used for labor induction. (wikipedia.org)
  • It was not approved for use in the United States, and the US FDA still considers cervical ripening and labor induction to be outside of the approved uses for misoprostol. (wikipedia.org)
  • Sublingual misoprostol, used for labor induction, produces earlier and higher peak plasma concentrations of misoprostol than vaginal or rectal misoprostol. (qxmd.com)
  • Misoprostol and oxytocin are the most commonly used agents for cervical ripening and labor induction. (fistofawesome.com)
  • STUDY DESIGN: Six hundred women at 287+/-1 days of gestation with definitely unfavorable cervical scores were randomized to labor induction (N=300) or spontaneous follow-up (N=300) with twice-weekly nonstress testing and amniotic fluid measurement and once-weekly biophysical scoring. (afar.info)
Prostaglandin6
  • Misoprostol is a synthetic prostaglandin medication used to prevent and treat stomach and duodenal ulcers, induce labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. (wikipedia.org)
  • Misoprostol is a synthetic prostaglan- women had a 5-MHz transducer sono- din, structurally related to prostaglandin graphic examination. (who.int)
  • Misoprostol oral tablets contain either 100 mcg or 200 mcg of misoprostol, a synthetic prostaglandin E1 analog. (nih.gov)
  • What sets Cytotec apart is its 200mcg dose of Misoprostol, a powerful synthetic prostaglandin that has been proven to effectively induce labor or terminate an early pregnancy. (topdollsites.com)
  • It contains the active ingredient misoprostol, which is a synthetic prostaglandin E1 analogue. (topdollsites.com)
  • Cytotec 200 mcg or Misoprostol is a synthetic prostaglandin that reduces the risk of stomach ulcers in patients getting treated with NSAIDs. (med247online.com)
Cytotec16
Plasma concentrations of misoprostol1
  • Maximum plasma concentrations of misoprostol acid are diminished when the dose is taken with food and total availability of misoprostol acid is reduced by use of concomitant antacid. (nih.gov)
Gestation3
  • citation needed] Misoprostol alone is less effective (typically 88% up to eight-weeks gestation). (wikipedia.org)
  • Misoprostol alone may be more effective in earlier gestation. (wikipedia.org)
  • Induction of labor with three different techniques at 41 weeks of gestation or spontaneous follow-up until 42 weeks in women with definitely unfavorable cervical scores. (afar.info)
Complications6
  • Although the efficacy of misoprostol has been confirmed and it is considered as one of the most commonly used methods for cervical ripening/dilatation (5), life-threatening complications have been reported for it, such as dose-dependent myometrial contractility, which may cause uterine tachysystole, hyper systole, or hyper tonus uterine, and uterine hyperstimulation syndrome during labor (6). (jogcr.com)
  • Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. (wikipedia.org)
  • Misoprostol Tablets should not be used for reducing the risk of NSAID-induced ulcers in women of childbearing potential unless the patient is at high risk of complications from gastric ulcers associated with use of the NSAID, or is at high risk of developing gastric ulceration. (nih.gov)
  • Cervical preparation has shown benefits in terms of cervical dilatation and reduction of intraoperative bleeding as well as a reduction in the incidence of complications. (fiapac.org)
  • secondary outcomes: cervical width before surgery, duration of dilatation time, ease of dilatation, complications during surgical procedure, and side effects of the drugs. (bollettinoginendo.it)
  • WHAT IS KNOWN ALREADY Misoprostol reduces complications and morbidity when used for cervical priming prior to surgical dilatation and vacuum aspiration in first trimester pregnancy. (bollettinoginendo.it)
Administration of misoprostol5
  • However, there remains some controversy concerning the dosage, the mode, and interval of administration of misoprostol. (hindawi.com)
  • Administration of misoprostol is an effective clinical method to terminate second trimester, complicated pregnancy. (who.int)
  • STUDY QUESTION Can sublingual administration of misoprostol 1 h prior to vacuum aspiration be more effective than vaginal administration and as effective as either route three 3 h prior to surgery? (bollettinoginendo.it)
  • Despite the widespread use and extensive studies, the optimal route of administration of misoprostol before surgical abortion remains to be defined. (bollettinoginendo.it)
  • The pharmacokinetic properties of misoprostol indicate that sublingual compared with vaginal administration of misoprostol may result in a more rapid cervical priming effect. (bollettinoginendo.it)
Versus5
  • The mean time of ripening and the active phase in vaginal misoprostol group was significantly shorter than in Foley catheter group (2.32 versus 5.11 hours respectively, P-value = 0.0001). (jogcr.com)
  • After intervention, Bishop score in vaginal misoprostol group was significantly more than Foley catheter group (8.70 versus 6.68 respectively, P-value = 0.0001). (jogcr.com)
  • Kandil M, Emarh M, Sayyed T, Masood A. Foley catheter versus intra-vaginal misoprostol for induction of labor in post-term gestations. (jogcr.com)
  • A randomized comparison of oral misoprostol versus Foley catheter and oxytocin for induction of labor at term. (jogcr.com)
  • To compare the effect of sublingual versus vaginal misoprostol on preoperative cervical priming in first trimester abortion. (marysfamilymedicine.org)
Induction of lab4
  • Alfirevic Z, Weeks A. Oral misoprostol for induction of labour. (jogcr.com)
  • In the case of women who have previously undergone a caesarean section and thereby run an increased risk for uterine rupture in connection with vaginal delivery, induction of labour with misoprostol may further enhance this risk and is not recommended. (hindawi.com)
  • The aim of this study is the comparison of vaginal misoprostol and transcervical Foley's catheter for induction of labour. (hindawi.com)
  • This guideline presents evidence and recommendations for cervical ripening and induction of labour. (bvsalud.org)
Vaginally4
  • Misoprostol (PGE 2 ) is given by mouth or vaginally to induce medical abortion. (biologydiscussion.com)
  • The women were admitted on the morning of the procedure and misoprostol was administered either vaginally or sublingually by doctors other than surgeons Gestational 7.76 ± 1.37 assessing the treatment outcome. (marysfamilymedicine.org)
  • SUMMARY ANSWER Sublingually administered misoprostol is superior to vaginally administered misoprostol when given 1 h pre operatively, and it is as effective as after a three 3 h priming interval with either route of administration. (bollettinoginendo.it)
  • STUDY DESIGN, SIZE, DURATION Women were randomized to four treatment groups and received 400 mcg misoprostol sublingually, or vaginally, 1 or 3 h prior to surgery. (bollettinoginendo.it)
Pregnancy4
  • Misoprostol and Pregnancy. (jogcr.com)
  • It is not inherently unsafe if medically supervised, but 1% of women will have heavy bleeding requiring medical attention, some women may have ectopic pregnancy, and the 12% of pregnancies that continue after misoprostol failure are more likely to have birth defects and are usually followed up with a more effective method of abortion. (wikipedia.org)
  • It changes little during the menstrual cycle and pregnancy until the onset of cervical ripening. (medscape.com)
  • Misoprostol is taken 24-48 hours later, which causes the uterus to cramp, bleed, and expel the pregnancy. (athenspregnancy.com)
Prostaglandins1
  • Several methods are used for induction of cervical ripening/dilatation, including mechanical methods, like the use of expanding balloon and Foley catheters (3), as well as medical treatment, which mainly include prostaglandins (PGs), like misoprostol, an analogue of PGE 1 . (jogcr.com)
Dilatation compared1
  • Subjects in the sublingual group achieved significantly higher mean cervical dilatation compared to vaginal group (8.34 ± 0.62 mm vs 7.60 ± 0.67 mm, p = 0.0001). (marysfamilymedicine.org)
Placebo4
Oxytocin Induction1
  • The treatments used in the induction group were (1) vaginal administration of 50 microg misoprostol (n=100), (2) oxytocin induction (n=100), and (3) transcervical insertion of a Foley balloon (n=100). (afar.info)
Dose4
  • Le misoprostol a démontré qu'il provoquait un effet dose dépendant sur la contractilité du myomètre, ce qui peut affecter les taux d'hypercinésie utérine en pratique clinique. (afar.info)
  • The mean dose of misoprostol applied was significantly lower in the sublingual group (P = 0.001). (qxmd.com)
  • There is high variability of plasma levels of misoprostol acid between and within studies but mean values after single doses show a linear relationship with dose over the range of 200 to 400 mcg. (nih.gov)
  • Cytotec's 200mcg dose of Misoprostol has a success rate of over 90%, making it one of the most reliable options available. (topdollsites.com)
Doses3
  • Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy. (wikipedia.org)
  • In Group I, 25 μ g of misoprostol tablet was placed intravaginally, 4 hourly up to maximum 6 doses. (hindawi.com)
  • Smaller doses are used for "cervical ripening" to induce labor or prepare for uterine surgical procedures. (suzyknew.com)
Abortions4
Active ingredient1
  • It contains Misoprostol as its active ingredient, which works by protecting the lining of the stomach and reducing the production of stomach acid. (topdollsites.com)
Preoperative2
Tablets3
  • has received both oral and written warnings of the hazards of Misoprostol Tablets, the risk of possible contraception failure, and the danger to other women of childbearing potential should the drug be taken by mistake. (nih.gov)
  • will begin Misoprostol Tablets only on the second or third day of the next normal menstrual period. (nih.gov)
  • Misoprostol tablets are either placed in your vagina or under your tongue in clinic before the procedure. (bpas.org)
Diarrhea1
  • Magnesium-containing antacids may potentiate misoprostol-induced diarrhea. (medscape.com)
Obstetrics and gyneco2
  • Uses of misoprostol in obstetrics and gynecology. (jogcr.com)
  • For more information about misoprostol and its various obgyn usages, see a review on the journal Obstetrics and Gynecology and the Gynuity website . (suzyknew.com)
Dilator1
Tablet was placed1
Conclusion3
  • Conclusion : Les différences de mécanismes d'action entre le misoprostol et le PGE2 peuvent contribuer à leurs effets variables sur le col et le myomètre, ce qui devrait être considéré afin d'optimiser les résultats. (afar.info)
  • Conclusion: The superiority of EPO capsules to misoprostol for cervical ripening before gynecologic procedures in women of reproductive age without history of normal NVD and menopause women suggests it as an appropriate alternative to misoprostol. (jogcr.com)
  • Conclusion: This study aims to provide additional information on the procedures of cervical preparation particularly for Western countries where these medical practices are poorly documented. (fiapac.org)
Medications2
  • Study objectives: The main objective is to describe the different surgical abortion procedures especially the methods used for cervical preparation prior to surgical abortion including mechanical dilatation, therapeutic regimen, prescribed medications and conditions of administration. (fiapac.org)
  • If you are allergic to Misoprostol or any other medications. (med247online.com)
Significantly2
  • The hospitalization time in Foley catheter group was significantly more than vaginal misoprostol group (P-value = 0.0001). (jogcr.com)
  • citation needed] However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol, but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. (wikipedia.org)
NSAIDs1
  • Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g., with diclofenac in Arthrotec). (wikipedia.org)
Hyperstimulation1
Surgical2
  • Cervical preparation is given before surgical abortion at all gestations. (bpas.org)
  • However, clinical practices on surgical abortion and particularly on cervical preparation are not well known and not sufficiently documented. (fiapac.org)
Reduces1
  • When administered prior to myomectomy in women with uterine fibroids, misoprostol reduces operative blood loss and requirement of blood transfusion. (wikipedia.org)
20161
  • The most recent clinical bulletin on the topic, published in 2016, states routine misoprostol is not recommended for IUD placement, although it may be considered with difficult insertions for management of pain. (medscape.com)
Ulcers3
  • Misoprostol is used for the prevention of NSAID-induced gastric ulcers. (wikipedia.org)
  • Misoprostol helps in the prevention and treatment of ulcers by increasing the production of mucus and bicarbonate in the stomach. (topdollsites.com)
  • By reducing stomach acid levels, Misoprostol helps to alleviate the symptoms associated with ulcers and prevents further damage. (topdollsites.com)
Miscarriage1
  • Misoprostol was developed in the 1980's as a stomach ulcer drug and was not prescribed for pregnant women because it could cause miscarriage. (suzyknew.com)
Gastric1
  • Misoprostol also functions by inhibiting the production of gastric acid. (topdollsites.com)
Nonsteroidal1
  • Drug interaction studies between misoprostol and several nonsteroidal anti-inflammatory drugs showed no effect on the kinetics of ibuprofen or diclofenac, and a 20% decrease in aspirin AUC, not thought to be clinically significant. (nih.gov)
Extracellular1
  • Cervical ripening is associated with decreased collagen fiber alignment, decreased collagen fiber strength and diminished tensile strength of the extracellular cervical matrix. (medscape.com)
L'administration2
  • L'administration de misoprostol est une méthode clinique efficace pour interrompre une grossesse compliquée au deuxième trimestre. (who.int)
  • Les traitements utilisés dans le groupe d'induction étaient (1) l'administration par voie vaginale de 50 microg misoprostol (n = 100), (2) l'induction à l'ocytocine (n = 100) et (3) l'insertion transcervicale d'un ballonnet de Foley (n = 100). (afar.info)