Diseases
Cerebellar Neoplasms
CerebellumVermisTumorLymphomaCarcinomaTumorsParaneoplasticMalignantHemispheresPosteriorMedulloblastomaSyndromeBenignAstrocytomaCystic neoplasmsCortexMidlineFourth ventricleCystsMucinousBrainstemLesionsComputed TomographyLesionImmunohistochemistryCommonlyIntracranialPostoperativeCerebralPilocyticVestibularOlder children and adultsImagingBoneMutation
Cerebellum9
  • GAD65 is involved in the synthesis, packaging, and release of GABA, whereas the other three play important roles in the induction of long-term depression (LTD). Thus, the auto-antibodies toward these synaptic molecules likely impair fundamental synaptic machineries involved in unique functions of the cerebellum, potentially leading to the development of cerebellar ataxias (CAs). (springer.com)
  • Autoimmunity affects the cerebellum, leading to the manifestations of the cerebellar ataxias (CAs), termed immune-mediated cerebellar ataxia (IMCAs). (springer.com)
  • The cerebellar vermis (from Latin vermis, "worm") is located in the medial, cortico-nuclear zone of the cerebellum, which is in the posterior fossa of the cranium. (wikipedia.org)
  • The cerebellum develops in a rostro-caudal manner, with rostral regions in the midline giving rise to the vermis, and caudal regions developing into the cerebellar hemispheres. (wikipedia.org)
  • Postnatally, proliferation and organization of the cellular components of the cerebellum continues, with completion of the foliation pattern by 7 months of life and final migration, proliferation, and arborization of cerebellar neurons by 20 months. (wikipedia.org)
  • Anomalies of the cerebellar vermis are diagnosed in this manner and include phenotypes consistent with Dandy-Walker malformation, rhombencephalosynapsis, displaying no vermis with fusion of the cerebellar hemispheres, pontocerebellar hypoplasia, or stunted growth of the cerebellum, and neoplasms. (wikipedia.org)
  • They have important implications for our understanding of the cognitive sequelae of early cerebellar damage as well as the involvement of the cerebellum in task switching. (tau.ac.il)
  • Cerebellar glioblastoma multiforme (GBM) is extremely rare in the cerebellum at any age but especially in children. (openneuroimagingjournal.com)
  • In the reported bovine, after necropsy, this neoplasm was found in cerebellum, region of cerebellar vermis. (ufsc.br)
Vermis7
  • The majority of medulloblastomas arise from the inferior cerebellar vermis, from which they extend into and typically fill the fourth ventricle. (medscape.com)
  • The vermis is intimately associated with all regions of the cerebellar cortex, which can be divided into three functional parts, each having distinct connections with the brain and spinal cord. (wikipedia.org)
  • This region comprises the vermis and intermediate parts of the cerebellar hemispheres. (wikipedia.org)
  • Medulloblastomas most commonly occur in the cerebellar vermis. (uab.edu)
  • Imaging studies depict the typical location in the cerebellar vermis, with filling and enlargement of the fourth ventricle. (uab.edu)
  • About one half arise in the optic pathways or hypothalamus, and one third arise in the cerebellar hemispheres or vermis. (uab.edu)
  • We report a case of a 10-year-old girl who suffered a cerebellar haemorrhage and subsequent CMS following surgical treatment of a ruptured arteriovenous malformation (AVM) in the cerebellar vermis. (regionh.dk)
Tumor6
  • [ 5 ] Other, rarer cystic lesions, such as solid pseudopapillary epithelial neoplasm and cystic pancreatic neuroendocrine tumor (cPNET), tend to harbor features that suggest a specific diagnosis, usually leading to surgical removal. (medscape.com)
  • Cerebral meningioma is the most frequently reported primary brain tumor of cats and accounts for almost 10% of all nonhematopoietic neoplasms. (vin.com)
  • Boor, PJ & Schoene, WC 1975, ' Fetal Cerebellar Tissue Associated with a Primitive Neuro-epithelial Tumor in an Ovarian Teratoma ', Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques , vol. 2, no. 2, pp. 139-141. (utmb.edu)
  • there was a negative correlation with cerebellar hemisphere tumor location. (psu.edu)
  • The V600E point mutation is also observed in other low-grade gliomas and glioneuronal neoplasms, including approximately two-thirds of pleomorphic xanthoastrocytomas, and lower percentages of ganglioglioma, desmoplastic infantile ganglioglioma, dysembrioplastic neuroepithelial tumor, and papillary craniopharyngioma. (blogspot.com)
  • She was submitted for posterior fossa craniotomy and microsurgical resection of cerebellar tumor and then to 18 Gy adjuvant radiotherapy to the tumor bed and 23 Gy to the neuroaxis. (surgicalneurologyint.com)
Lymphoma2
  • The histologic type of the associated neoplasm is usually carcinoma or lymphoma. (childrensmercy.org)
  • 1 B cell neoplasms other than multiple myeloma including non-Hodgkin's lymphomas, and acute and chronic leukaemias might also exhibit lytic bone lesions, hypercalcaemia, and monoclonal gammopathy via the particular actions of interleukin (IL-1), IL-6, or tumour necrosis factor-α secreted by the neoplastic B cell clone, but not reported previously secondary to a primary cerebral lymphoma. (bmj.com)
Carcinoma1
  • Paraneoplastic cerebellar syndrome and sensory ganglionopathy with papillary thyroid carcinoma. (ox.ac.uk)
Tumors6
  • Medulloblastomas are primarily childhood tumors, where they account for one third of all posterior fossa neoplasms. (uab.edu)
  • Pituitary gland neoplasms and tumors arising from cranial nerves are considered secondary brain tumors. (vin.com)
  • Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. (embl.de)
  • The clinical features of patients with cerebellar GBM are similar to those of other aggressive fast growing infratentorial tumors. (openneuroimagingjournal.com)
  • Cerebellar hemispheric tumors of older children and adults show similar imaging features, except that contrast enhancement is more variable than in young children. (medscape.com)
  • Medulloblastoma is an embryonal neoplasm and accounts for 1% of all adult intracranial tumors. (surgicalneurologyint.com)
Paraneoplastic6
  • Paraneoplastic Cerebellar Degeneration" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Paraneoplastic Cerebellar Degeneration" by people in this website by year, and whether "Paraneoplastic Cerebellar Degeneration" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Paraneoplastic Cerebellar Degeneration" by people in Profiles. (childrensmercy.org)
  • Paraneoplastic Neurological Syndromes (PNSs) are rare syndromes caused by or associated with an underlying neoplasm. (athenslab.gr)
  • The following table summarizes the anti-neural antibodies, the associated paraneoplastic neurological syndromes, and the most common underlying neoplasms. (athenslab.gr)
  • Paraneoplastic syndromes are rare disorders that are triggered by an altered immune system response to a neoplasm. (medscape.com)
Malignant2
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • Glioblastoma Multiforme is a highly malignant central nervous system neoplasm. (openneuroimagingjournal.com)
Hemispheres1
  • A smaller proportion of medulloblastomas occur in one of the cerebellar hemispheres of patients who are typically older (adolescents or young adults), a subset in which the desmoplastic/nodular variant predominates. (medscape.com)
Posterior2
  • Neoplasms of the posterior fossa. (medlineplus.gov)
  • Cerebellar mutism syndrome (CMS) is a well-known complication of posterior fossa (PF) tumour surgery. (regionh.dk)
Medulloblastoma1
  • Magnetic resonance image showing a lateral cerebellar mass with a "grapelike" lobular appearance characteristic of the extensively nodular medulloblastoma. (medscape.com)
Syndrome1
  • Cerebellar mutism syndrome occurred in 107 (24%) of 450 children. (psu.edu)
Benign2
  • 1. A benign, slowly growing, cerebellar neoplasm composed of capillary-forming endothelial cells. (wordinfo.info)
  • Objective and Importance: Aneurysmal bone cysts (ABC) are benign bone neoplasms which typically involve the spine and long bones. (johnshopkins.edu)
Astrocytoma1
Cystic neoplasms3
  • Pancreatic cystic neoplasms represent a small yet increasingly detected entity of pancreatic abnormalities. (medscape.com)
  • Approximately 70% of pancreatic cystic neoplasms are discovered incidentally. (medscape.com)
  • 1 2 3 Lack of a solid component and complete suppression on FLAIR differentiates them from cystic neoplasms. (hkmj.org)
Cortex2
  • It sends fibers to deep cerebellar nuclei that, in turn, project to both the cerebral cortex and the brain stem, thus providing modulation of descending motor systems. (wikipedia.org)
  • Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. (childrensmercy.org)
Midline3
  • This axial T2 magnetic resonance image shows a cerebellar vermian midline mass with contrast enhancement and obstruction of the fourth ventricle. (medscape.com)
  • Aberrant constitutive activation of BRAF tends to be seen in cerebellar and midline pilocytic astrocyomas whereas the activating point mutation at BRAF V600E is more likely to be seen in cerebral examples. (blogspot.com)
  • Brain magnetic resonance imaging (MRI) showed an intra-axial left hemisphere cerebellar lesion causing midline shift tonsilar herniation. (surgicalneurologyint.com)
Fourth ventricle1
  • Medulloblastomas appear as hyperdense, noncalcified lesions of the fourth ventricle or cerebellar hemisphere on computed tomography (CT) scans. (medscape.com)
Cysts1
  • The most frequently encountered neoplastic pancreatic cysts include intraductal papillary mucinous neoplasm (IPMN), serous cystadenoma (SCA), mucinous cystic neoplasm with ovarian stroma (MCN), and solid pseudopapillary epithelial neoplasm. (medscape.com)
Mucinous1
  • Note the smooth external contour typical of a mucinous cystic neoplasm. (medscape.com)
Brainstem1
  • The neoplasm can also invade adjacent brainstem structures, including the cardiorespiratory centers of the fourth ventricular floor. (medscape.com)
Lesions2
  • On imaging studies the cerebellar lesions are cystic with variably enhancing mural nodules. (uab.edu)
  • Overall, hamartomatous lesions or low-grade neoplasms predominate in this disease complex. (cap.org)
Computed Tomography1
  • Computed tomography, magnetic resonance imaging and angiogram showed an expansile bone neoplasm involving the left petrous temporal bone. (johnshopkins.edu)
Lesion1
  • Brain magnetic resonance imaging (MRI) showed an intra-axial left hemisphere cerebellar lesion. (surgicalneurologyint.com)
Immunohistochemistry1
  • My feeling is that if you have a histomorphologically classic pure astrocytic neoplasm, there is no need for p53 immunohistochemistry. (blogspot.com)
Commonly2
  • Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)
  • What neoplasm is commonly associated with this inherited disorder? (cap.org)
Intracranial1
  • Neurofibromatosis 1 is an autosomally dominated inherited genetic condition that predisposes those involved to the development of intracranial neoplasms. (medlink.com)
Postoperative1
  • Conclusion: The postoperative course was uneventful, and the imaging studies demonstrated total removal of the neoplasm. (johnshopkins.edu)
Cerebral1
  • They occur in characteristic locations alongside penetrating vessels in the mesencephalothalamic area, cerebral white matter, and cerebellar dentate nuclei. (hkmj.org)
Pilocytic1
  • Pilocytic astrocytomas are slowly growing neoplasms of children and young adults which usually arise around the third and fourth ventricles. (uab.edu)
Vestibular1
  • Difficulties with balance or gait suggest cerebellar or vestibular involvement. (vin.com)
Older children and adults1
  • In older children and adults they may occur laterally in the cerebellar hemisphere. (uab.edu)
Imaging1
Bone3
  • We present a rare case of an ABC in the temporal bone with significant cerebellar compression. (johnshopkins.edu)
  • This diagnosis should be considered in the differential of bone neoplasms in this region. (johnshopkins.edu)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
Mutation1
  • Nodular follicular thyroid neoplasm with a somatic NRAS mutation. (ocu-radiology.jp)