• The researchers' work expands the rapidly growing field of using biomolecules as nanoscale scaffolding to organize inorganic nanocrystals, said Shuguang Zhang, a principal research scientist and associate director of the Center for Biomedical Engineering at the Massachusetts Institute of Technology. (trnmag.com)
  • Sierin Lim is an Associate Professor of Bioengineering at the School of Chemical and Biomedical Engineering at Nanyang Technological University, Singapore (NTU). (ntu.edu.sg)
  • Milan Mrksich , the Henry Wade Rogers Professor of Biomedical Engineering, Chemistry, and Cell and Molecular Biology at Northwestern's McCormick School of Engineering, is a co-author on the paper. (northwestern.edu)
  • Jonathan Silva, associate professor of biomedical engineering at the McKelvey School of Engineering, has been selected to serve as a permanent member of the Electrical Signaling, Ion Transport and Arrhythmias Study Section with the Center for Scientific Review. (wustl.edu)
  • The MRC Centre for Protein Engineering (or CPE) was a pioneering research unit in Cambridge, England, with a main focus on the structure, stability and activity of proteins and engineering of antibodies. (wikipedia.org)
  • All of Sir Alan's work on protein folding and much of Sir Greg's pioneering work to humanise antibodies was carried out at CPE. (wikipedia.org)
  • In addition, traditional protein therapeutics research (still somewhat new as well), has expanded complexity to include Bispecific and Multispecifc antibodies, fusion proteins, and peptide therapeutics. (epivax.com)
  • Get high medical value with Access SARS-CoV-2 IgG assay as it detects antibodies against the virus spike protein that may be more likely to confer immunity. (beckmancoulter.com)
  • Studies have also shown that the S protein plays the most important roles in viral attachment, fusion and entry, and it serves as a target for development of antibodies, entry inhibitors and vaccines. (beckmancoulter.com)
  • The coronavirus spike protein mediates entry into host cells by attaching to a receptor on respiratory cells called angiotensin-converting enzyme 2, or ACE2, 11 the existence of antibodies against it may suggest neutralization of SARS-CoV-2 infection. (beckmancoulter.com)
  • The Access SARS-CoV-2 IgG assay is designed to detect antibodies to the RBD (receptor-binding domain) of the spike protein, which may be important for immunity. (beckmancoulter.com)
  • Beulah's began working with Dr. Stottmann at Cincinnati Children's Hospital Medical Center in 2019 as a research fellow. (nationwidechildrens.org)
  • Like Charlotte, he is also Programme Co-Director for the EPSRC & MRC SABS CDT (Systems Approaches to Biomedical Science Centre for Doctoral Training), which as renewed in 2019 as the ESPRC & MRC Sustainable Approaches to Biomedical Science: Responsible and Reproducible Research Centre for Doctoral Training, or EPSRC & MRC SABS R3 CDT. (icml.cc)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • His research interest was polyelectrolytes and long-chain molecules in which every repeat unit carries a charge, with focus on their interaction with oppositely charged molecules such as surfactant micelles, nanoparticles and proteins, with the objective of fundamental understanding of solution behavior. (umass.edu)
  • Our vaccine candidate delivers antigens to trigger an immune response via nanoparticles engineered from ferritin--a protein found in almost all living organisms," said Jae Jung, PhD, director of the Global Center for Human Health & Pathogen Research and co-senior author on the study. (eurekalert.org)
  • Other benefits of the protein nanoparticles include minimizing cellular damage and providing stronger immunity at lower doses than traditional protein subunit vaccines against other viruses, like influenza. (eurekalert.org)
  • The team's vaccine uses the ferritin nanoparticles to deliver tiny, weakened fragments from the region of the SARS-CoV-2 spike protein that selectively binds to the human entry point for the virus (this fragment is called the receptor-binding domain, or RBD). (eurekalert.org)
  • Protein nanoparticles are promising targeted drug delivery carriers due to their low toxicity, biodegradability, and abundance of proteins in natural sources. (bvsalud.org)
  • Alexander Bengtsson, Material and technique development for ultrasound optical tomography using spectral hole burning filters , PhD thesis, Faculty of Engineering, Lund University 2022. (lu.se)
  • Lectures and computer-based exercises covering biotechnological methods and the structure and function of proteins. (uu.se)
  • We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)
  • Researchers have long had tools to look at nucleic acids at the single-cell level, but studying single cells' proteins hasn't been as easy. (acs.org)
  • But proteins are a tougher challenge than nucleic acids. (acs.org)
  • Though the coronavirus uses many different proteins to replicate and invade cells, the spike protein is the major surface protein that it uses to bind to a receptor. (beckmancoulter.com)
  • Using a computer modeling approach that they developed, MIT biologists identified three different proteins that can bind selectively to each of three similar targets, all members of the Bcl-2 family of proteins. (mit.edu)
  • Centre for Protein Engineering was established in 1990 as one of the MRC's first interdisciplinary research centres and one of the first research laboratories to bring together molecular biology, molecular genetics, biophysics and structural biology into one cohesive unit. (wikipedia.org)
  • Nearly all of the CPE staff, including those maintaining the Structural Classification of Proteins database, and its infrastructure were incorporated into the MRC Laboratory of Molecular Biology (LMB). (wikipedia.org)
  • RNA Biology: Tertiary Structure and RNA-Protein. (hhmi.org)
  • Probing Proteins at the Interface of Biology and. (hhmi.org)
  • My Ph.D. projects centered on using computational structural biology tools to develop protein engineering methods for targeted therapeutic delivery, emphasizing delivering molecules to the brain. (caltech.edu)
  • First, utilizing computational structural biology techniques, I investigate the molecular mechanism that enables engineered adeno-associated viral (AAV) capsids to cross the blood-brain barrier (BBB). (caltech.edu)
  • Around 120 postdocs work at the MRC Laboratory of Molecular Biology (LMB) and Centre for Protein Engineering (CPE). (vitae.ac.uk)
  • https://cen.acs.org/analytical-chemistry/structural-biology/Structure-novel-coronavirus-spike-protein/98/i8. (beckmancoulter.com)
  • This strategy generates a larger number of candidates and also offers greater control over a variety of protein traits, says Amy Keating, a professor of biology, a member of the Koch Institute, and the leader of the research team. (mit.edu)
  • This is an exciting new method that accelerates the design and engineering of potential medicines and vaccines using glycosylation," said Michael Jewett , the Charles Deering McCormick Professor of Teaching Excellence, professor of chemical and biological engineering, and director of Northwestern's Center for Synthetic Biology , who led the research. (northwestern.edu)
  • The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)
  • CMPS is a highly integrated center comprising the divisions of Biochemistry and Structural Biology (Faculty of Science) and Biophysical Chemistry (Faculty of Engineering, LTH). (lu.se)
  • After the spike protein binds to the human cell receptor, the viral membrane fuses with the human cell membrane, allowing the genome of the virus to enter human cells and begin infection. (beckmancoulter.com)
  • For crystallisation, the facility is equipped with state-of-the-art nanolitre pipetting equipment with capability to handle lipidic cubic phases for membrane proteins, as well as a plate hotels with the capacity to store and automatically image crystallisation plates. (lu.se)
  • LP3 is colocalised with and closely collaborates with the DEMAX platform of the ESS on production of deuterium labeled biomolecules (proteins, lipids) for neutron scattering experiments and the development of methods for crystal growth for neutron crystallography. (lu.se)
  • Heinrich Heine University Researchers Use JUWELS to Advance Protein Engineering by Studying Aqueous Ionic Liquids: Gauss Centre for Supercomputing e.V. (gauss-centre.eu)
  • A team of researchers led by Prof. Dr. Holger Gohlke and Till El Harrar have been using high-performance computing (HPC) resources at the Jülich Supercomputing Centre (JSC) to better understand how aqueous ionic liquids and seawater interact with enzymes relevant for a host of biotechnological applications. (gauss-centre.eu)
  • Several Polytechnic Institute of NYU researchers presented their work and explored the potential for relationships between engineering sciences and biological sciences at a research showcase on Monday, March 22 at the NYU Langone Medical Center. (nyu.edu)
  • NYU-Poly Provost Dianne Rekow began the "Collaborative Opportunities in Science and Engineering" showcase by give an overview of Polytechnic's relationship with New York University (the two became affiliated in 2008 and Polytechnic aims to became a school of NYU in the next few years) and discussed collaborative opportunities between researchers at NYU-Poly and the School of Medicine and College of Dentistry. (nyu.edu)
  • This new CFI funding will support the activity of researchers both in the Neuroscience and Mental Health Institute (NMHI) and in the laboratories affiliated with the Centre for Prions and Protein Folding Diseases. (ualberta.ca)
  • The researchers used a protein from Sulfolobus shibatae, an extremophile organism that can grow in temperatures as hot as 85 degrees Celsius. (trnmag.com)
  • The researchers used one of the three types of proteins that make up the chaperonin subunits. (trnmag.com)
  • The researchers engineered two variants of the protein. (trnmag.com)
  • The researchers used a well-understood protein complex that can assemble itself into useful structures, he said. (trnmag.com)
  • Proteins are particularly useful because researchers can modify their structures in precise locations without significantly altering their folding behavior, said Zhang. (trnmag.com)
  • This advance was pioneered by researchers at the Wellman Center for Photomedicine at Massachusetts General Hospital. (technovelgy.com)
  • The aim of the Social, Genetic, Developmental Psychiatry Centre (SGDP) Postdoc Forum is to foster communication between postdoctoral researchers and provide support, networking and training opportunities that will facilitate career development, and contribute to the strength of the centre. (vitae.ac.uk)
  • The researchers found they could prevent this behavior by switching off a gene called KLF4 , which encodes for a gene regulatory protein that manages transcription of many other genes and is important for perivascular cells' ability to turn rogue. (cancer.gov)
  • Now, researchers to want to analyze a single cell's proteins too. (acs.org)
  • This brief is inspired by a ground-breaking study on the anti-plague system of the former Soviet Union conducted by a team of researchers from the Monterey Institute of International Studies and the Kazakh Scientific Center of Quarantine and Zoonotic Infections in Almaty, Kazakhstan, under the supervision of the study's principal investigators, Dr. Sonia Ben Ouagrham and Dr. Raymond A. Zilinskas. (nti.org)
  • CLEVELAND - Researchers from Cleveland Clinic's Global Center for Pathogen Research & Human Health have developed a promising new COVID-19 vaccine candidate that utilizes nanotechnology and has shown strong efficacy in preclinical disease models. (eurekalert.org)
  • Northwestern Engineering researchers have now developed a quick, cell-free system to build and study these pathways. (northwestern.edu)
  • The researchers used this process to develop a protein vaccine candidate modified with a sugar structure that could trigger the immune system, as well as a therapeutic antibody fragment with a sugar that can stabilize proteins as they circulate in the body. (northwestern.edu)
  • Not bound by departmental divisions, the new Computational Science and Engineering building allows researchers and students from a variety of disciplines to find inspiration at the intersections of their fields. (jhu.edu)
  • One floor above, in the Swirnow Mock Operating Room, researchers from the Center for Computer- Integrated Surgical Systems and Technology (CISST) develop and test robotic surgical techniques. (jhu.edu)
  • It is well established now that the receptor-binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) as its first step of entry. (biorxiv.org)
  • While that method works well, it usually produces proteins that are optimized for only a single trait: how well it binds to the target. (mit.edu)
  • When the SARS-CoV-2 RBD binds with the human protein called ACE2 (angiotensin-converting enzyme 2), the virus can enter host cells and begin to replicate. (eurekalert.org)
  • The 'big' gold in its normal state is the yellow colored metal that does not interact with the body but nano-sized gold is purple or red, depending on its nanosize, and binds proteins very easily 1 . (cdc.gov)
  • The New York University Tandon School of Engineering (commonly referred to as Tandon ) is the engineering and applied sciences school of New York University . (wikipedia.org)
  • Chemical Engineering Journal , 316 pp. 481-498. (ucl.ac.uk)
  • Glycosylation - the attachment of sugars to proteins - plays a critical role in both cellular function and in the development of therapeutics, like vaccines. (northwestern.edu)
  • Weston Kightlinger, a PhD student in the Jewett lab, developed a new approach to build, test, and assess sets of enzymes that can modularly build sugars for protein therapeutics. (northwestern.edu)
  • Future works will use other pathways developed in this paper to create glycosylated protein vaccines and therapeutics that can target certain areas within the body. (northwestern.edu)
  • Unnatural Amino Acid Engineering for Intracellular Delivery of Protein Therapeutics. (bvsalud.org)
  • Recombinant elastin-based proteins (ELPs) are used in applications that include therapeutics, drug delivery, and tissue engineering due to their biocompatibility and unique ability to undergo simple coacervation. (bvsalud.org)
  • The school's main campus is in Brooklyn 's MetroTech Center , an urban academic-industrial research park . (wikipedia.org)
  • As the industrial revolution took shape, the school formalized its engineering curriculum and the school's first dean, Charles H. Snow , changed the name of the school to the School of Applied Science. (wikipedia.org)
  • Unlike its neighboring buildings, the CSE building is not dedicated to a particular department, but to four of the Whiting School's interdisciplinary institutes and centers. (jhu.edu)
  • Engineering Momentum is the school's bi-annual magazine featuring stories about research, faculty, students and alumni. (wustl.edu)
  • It was formed around the research of two prominent scientists who invented protein engineering, Sir Alan Fersht and Sir Greg Winter. (wikipedia.org)
  • The Research Center of Cognitive Computing in Life Sciences develops and applies computational methods and models inspired by learning and self-organisation principles of biological neural systems to problems in life sciences, such as activity recognition, bio-signal processing, environment monitoring and assistive autonomous systems. (zhaw.ch)
  • The concept of using self-assembling biomolecules for materials science is not new," said Andrew McMillan, a research scientist at NASA's Ames Research Center. (trnmag.com)
  • Research also shows that the S protein undergoes dramatic conformational changes to expose the RBD and key residues for receptor binding to enter the host cell. (beckmancoulter.com)
  • ICORD is a world leading health research centre focused on spinal cord injury. (ubc.ca)
  • Located at Vancouver General Hospital in the Blusson Spinal Cord Centre, ICORD is supported by UBC Faculty of Medicine and Vancouver Coastal Health Research Institute. (ubc.ca)
  • In this research project, we successfully developed several original methods (or synthetic small molecules) based on chemistry that allow for selective labeling and imaging target proteins under nearly natural conditions. (nii.ac.jp)
  • It has been a key center of research in the development of microwave , wireless , radar , electronics in general, polymers , industrial engineering , operations research and the US space program . (wikipedia.org)
  • She will establish and lead basic and translational research at the Stanford Amyloid Center, which will integrate clinical, research and training efforts related to amyloidosis. (stanford.edu)
  • Each floor has a wide central corridor, and the individual labs, offices, and conference rooms that sit like vertebra along this backbone are home to various engineering research groups. (jhu.edu)
  • Explore the latest news from the school with stories ranging from groundbreaking research to how McKelvey Engineering students are making an impact in the world. (wustl.edu)
  • In 1991 he moved to The Scripps Research Institute, California, to work on developing the protein-ligand dockingsoftware, AutoDock. (icml.cc)
  • She is also a co-director of the Systems Approaches to Biomedical Research Centre for Doctoral Training which she founded in 2009. (icml.cc)
  • Clean Energy Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea. (bvsalud.org)
  • The service facility is integrated with research training and development of skills in experimental protein science for PhD students and postdocs. (lu.se)
  • LP3 is a unique entry point and partner for both research aiming at conventional x-ray protein structure determination, as well as for enabling research using neutron scattering techniques that require deuterated bioreagents. (lu.se)
  • Lund Protein Production Platform (LP3) is a cross-faculty expert center and user facility of Lund University (LU). (lu.se)
  • Genetic engineering of the processing site of D1 precursor protein of photosystem II reaction center in Chlamydomonas reinhardtii. (bio.net)
  • Genetic engineering usually means experimental drugs, altered food crops and the specter of a new race of superhumans. (trnmag.com)
  • 1 Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China. (nih.gov)
  • This protein is an attractive biomaterial for vaccine and drug delivery for many reasons, including that it does not require strict temperature control. (eurekalert.org)
  • Over the years SCOP has supported the development of computational tools and contributed to the understanding of protein repertoire, of how proteins relate to each other and how their structures and functions evolved. (wikipedia.org)
  • Crystal structures of the three mutant proteins have been solved. (rcsb.org)
  • In the very stable mutant 85-102, there is no significant difference between the mutant and wild-type structures: these data do not explain the large stability of this protein. (rcsb.org)
  • We were able to alter the protein without destroying its ability to form interesting structures," he said. (trnmag.com)
  • Sugar structures allow these proteins to remain stable while enabling them to perform tasks, like attack a cancer cell or retrain the immune system. (northwestern.edu)
  • These mammalian cells naturally produce glycosylated proteins, but are slow-growing and can be difficult to engineer, limiting the number and diversity of glycosylation structures that can be built and tested. (northwestern.edu)
  • In just a few months, Kightlinger used the system to construct 37 pathways, creating 23 unique sugar structures, 18 of which have never been synthesized on proteins. (northwestern.edu)
  • LP3 can further process data, solve and refine protein structures. (lu.se)
  • The disulfide bond at 43-80 induces small structural rearrangements close to the site of the disulfide bond, associated with some local disorder: the crosslink appears to decrease the stability of the native form of the protein. (rcsb.org)
  • Our studies do not support the view that the conformation of the disulfide bond is crucial in determining the stability of the mutant proteins. (rcsb.org)
  • However, much effort is still needed to reduce the high cost of production and [improve the] stability of proteins in their complexes," said Zhang. (trnmag.com)
  • Their predominant function is thought to be facilitating protein folding inside cells, he said. (trnmag.com)
  • To track the cells' behavior, Murgai studied mice whose perivascular cells had been engineered to produce an easy-to-follow fluorescent protein. (cancer.gov)
  • The cells switched on new genes and changed their behavior, most notably generating large amounts of an extracellular matrix protein called fibronectin. (cancer.gov)
  • In the case of SARS-CoV-2, the spike proteins bind angiotensin-converting enzyme 2 (ACE2 receptor) on human cells with high affinity. (beckmancoulter.com)
  • We apply our technique to an in silico motor control neuroscience experiment, using the algorithm to estimate both timings of DNA-based data and the directional tuning of motor cortical cells during a center-out reaching task. (mit.edu)
  • Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation. (ucl.ac.uk)
  • Individual cells' proteins vary. (acs.org)
  • People have been able to detect a handful of proteins in individual cells using fluorescence- or antibody-based methods. (acs.org)
  • These methods may contribute to analyzing protein structure and functions in living cells. (nii.ac.jp)
  • Jewett's lab has developed cell-free systems that create enzymes needed to create certain proteins, but up until now, these processes could not create glycosylated products without the need to reengineer living cells. (northwestern.edu)
  • LP3 is fully equipped for recombinant protein production in E. coli and insect cells (BEVS) and protein purification using state of the art chromatography systems. (lu.se)
  • LP3 is the only academic protein production platform in Sweden providing specialisation in protein production using the baculovirus expression vector system (BEVS, insect cells) and perdeuteration of biological macromolecules. (lu.se)
  • Method combines a bright fluorescent nanoparticle with expansion microscopy to image secreted proteins with high sensitivity, precision and accuracy. (wustl.edu)
  • As such, we provide services and make equipment available in the areas of recombinant protein production, crystallisation, biophysical characterization, and structure determination. (lu.se)
  • LP3 and PPS offer services for the entire process chain of production, purification, characterization, protein crystallisation and protein structure determination and structure refinement, or each individual step in the chain. (lu.se)
  • Engineered nanomaterials are fascinating. (cdc.gov)
  • Protein is one of the central biomolecules that is involved in almost all biological events and thus its quantitative analysis has been actively conducted for many years. (nii.ac.jp)
  • The kinesin- homologous protein encoded by the Chlamydomonas FLA10 gene is associated with basal bodies and centrioles. (bio.net)
  • The altered bacteria gene produces a protein that automatically constructs orderly arrays of microscopic bits of gold or zinc. (trnmag.com)
  • To get one variant, they removed a portion of the gene that causes bits of protein to partially block the openings at the ends of the chaperonin. (trnmag.com)
  • Third, I show an example to engineer a genetically encoded transmitter indicator (GETI), which may eventually be a cargo delivered to the brain. (caltech.edu)
  • A single cell genetically engineered to express green fluorescent protein (GFP) can amplify photons into nanosecond-long pulses of laser light. (technovelgy.com)
  • A melatonin indicator was then created by integrating the repurposed receptor with a fluorescent protein. (caltech.edu)
  • Engineering Transketolase for Industrial Biotechnology. (ucl.ac.uk)
  • I have been working in different projects in biotechnology/chemical/food engineering in both upstream and downstream processes aiming for process optimization. (lu.se)
  • In a paper appearing in the Proceedings of the National Academy of Sciences the week of Oct. 15, Keating and her colleagues used this approach to generate several peptides that can target different members of a protein family called Bcl-2, which help to drive cancer growth. (mit.edu)
  • I repurposed an antibiotic-sensing repressor protein to bind a neurotransmitter, melatonin, using machine-learning-guided directed evolution. (caltech.edu)
  • Certain portions of the protein bind to certain metals. (trnmag.com)
  • These viruses use the spike protein to bind to proteins on the host cell to gain entry. (beckmancoulter.com)
  • New approach generates a wider variety of protein sequences optimized to bind to drug targets. (mit.edu)
  • Designing synthetic proteins that can act as drugs for cancer or other diseases can be a tedious process: It generally involves creating a library of millions of proteins, then screening the library to find proteins that bind the correct target. (mit.edu)
  • This involves engineering viruses or yeast to produce each of the proteins, then exposing them to the target to see which ones bind the best. (mit.edu)
  • Another desirable feature is the ability to identify proteins that bind tightly to their target but not to similar targets, which helps to ensure that drugs do not have unintended side effects. (mit.edu)
  • The usual method for identifying such drugs is to screen millions of proteins, either randomly chosen or selected by creating variants of protein sequences already shown to be promising candidates. (mit.edu)
  • I show that APPRAISE is capable of distinguishing between receptor-dependent and receptor-independent adeno-associated viral vectors and ranking various engineered proteins, such as miniproteins binding to the SARS-CoV-2 spike and nanobodies binding to a G-protein-coupled receptor. (caltech.edu)
  • However, there are questions about which viral protein to use as an antigen for serology testing. (beckmancoulter.com)
  • Some diagnostic developers are not able to be definitive because this is a new virus, although based on the information we have, the viral protein is perceived as the obvious candidate. (beckmancoulter.com)
  • Protein drugs are a critically important therapeutic modality due to the sophisticated binding recognition, catalytic properties, and disease relevance of proteins. (bvsalud.org)
  • Recently, we built an engineered Saccharomyces cerevisiae (yeast) which can produce both santalenes and santalols, with 35.7% Z - α -santalol and 17.8% Z - β -santalol which is very close to the standard of ISO 3518:2002 22 . (nature.com)
  • Proteins fold to change shape at the molecular level, which allows them to carry out specific life processes. (trnmag.com)
  • Glycosylation is important in the development of protein medicines, which include everything from anti-cancer drugs like Herceptin to flu and tetanus vaccines. (northwestern.edu)
  • The new strategy involves first creating a computer model that can relate peptide sequences to their binding affinity for the target protein. (mit.edu)
  • Reactivity of nonstructural protein 1 antigens to ZIKV and DENV plasma in study of Zika diagnosis, Singapore. (cdc.gov)