Cellular stem cells. Medical search. Frequent questions

Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer cell de-differentiation and migration. (nature.com)
Tumor initiation and progression often involve the dysregulation of developmentally important genes in cancer cells, endowing them with stem cell-like features such as enhanced self-renewal, invasiveness, and an aberrant differentiation state [ 1 ]. (nature.com)
The MYC proto-oncogene is a transcription factor essential in stem/progenitor cell maintenance and differentiation [ 11 ]. (nature.com)
Developmentally, it is well established that expression of the ID members is strongest in stem/progenitor cells, while their levels decrease upon differentiation. (nature.com)
Together with the transcriptome analysis of differentially expressed genes reflecting the relatedness of TSCM and Tn cells, these data support the existing hierarchical model of human T cell differentiation: naïve T cells (Tn) → stem cell like memory T cells (T scm) → central memory T cells (Tcm) → effector memory T cells (Tem) / effector T cells (Teff). (wikipedia.org)
However, the use of bFGF for human ES cell culture, particularly at the high levels used by some for 'feeder-free' culture, must be considered carefully, as bFGF may drive ES cells towards differentiation. (ddw-online.com)
The need to control differentiation of embryonic stem cells in vitro presents another set of challenges. (ddw-online.com)
We show that the commonly used high glucose media profoundly mask cellular phenotypes in TSC2-/- cultures during neuronal differentiation. (ox.ac.uk)
M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)
Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
Downloaded from plays a mechanistic role in cellular decision-making processes ( a ) 2 during differentiation is currently the object of intense study. (lu.se)
In early blood cells, called hematopoietic stem cells, the methylation patterns established by DNA methyltransferase 3 alpha promote maturation (differentiation) into different blood cell types. (medlineplus.gov)
As in cytogenetically normal acute myeloid leukemia (described above), the mutations disrupt the normal pattern of methylation in cells, which blocks differentiation. (medlineplus.gov)
Objective: To establish cultures of cells from the pulp of permanent teeth by the explant method assessing parameters usually presented by stem cells, such as the expression of certain markers and the differentiation ability into osteogenic, adipogenic, and chondrogenic lineages. (bvsalud.org)
In addition, cells were assessed for multi-differentiation potential. (bvsalud.org)
Similarly, the cells showed differentiation ability into all three lineages of cells tested. (bvsalud.org)
The isolated cells may be considered stem cells, based on the current criteria for their characterization, such as plastic adherence, expression of certain markers, and the absence of others, as well as multi-differentiation potential, which showed to be promising for the application in tissue regeneration. (bvsalud.org)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)

We proposed to use the classical embryonic stem cell-based gene-targeting technology to generate rat models mimicking human heart failure, diabetes and neurodegenerative diseases. (ca.gov)
4) Generated a motor neuron reporter human embryonic stem cell line. (ca.gov)
The embryonic stem cell-based gene-targeting technology was used for the generation of these rat models. (ca.gov)
First, we introduced targeted genetic mutations into rat embryonic stem cells. (ca.gov)
Next, we produced rats from these gene-targeted embryonic stem cells. (ca.gov)
Using the small animal model embryonic stem cell-based gene-targeting technology that we developed, we will create small animal models for heart failure, diabetes and neurodegenerative diseases. (ca.gov)
We previously reported a MYC-centered regulatory network in mouse embryonic stem (ES) cells that accounts for the similarity between the ES cells and cancer cells, and is associated with a worse prognosis in cancer, including cancers of the breast [ 20 ]. (nature.com)
Stem cells, and in particular human embryonic stem (ES) cells, have earned a reputation for being labour intensive and difficult to grow and control in culture. (ddw-online.com)
Progenitor cells are similar to embryonic stem cells in their capacity to differentiate into various cell types. (ddw-online.com)
However, it will not include embryonic stem cells. (pharmaceutical-technology.com)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)

The laboratory has focused on optimizing the conditions for viral transduction, including selecting and modifying viral strains for study in animal models, optimizing growth conditions for transduced hematopoietic cells, and designing gene vectors to ensure appropriate placement and expression of the inserted gene. (nih.gov)

It is an honor to bring stem cell transplantation and cellular therapies to adults in the Lehigh Valley and its surrounding communities," Dr. Toor says. (lvhn.org)

Once generated, we will use these rat models to assess the safety and therapeutic potential of cells derived from human pluripotent stem cells. (ca.gov)
Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)
Recent breakthroughs in human pluripotent stem cells (hPSCs)-derived cerebral organoids offer a promising approach for investigating the mystery of human brain ( 19 ). (frontiersin.org)
Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens. (ox.ac.uk)
Here we explore the potential of human induced pluripotent stem cell derived macrophages (iPSDMs) to study such pathogen interactions. (ox.ac.uk)
CET already manufactures a variety of human somatic stem cells, induced pluripotent stem (IPS) cells, cancer cells and specialised tissue culture media to grow and differentiate stem cells. (pharmaceutical-technology.com)
The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. (bvsalud.org)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)

The Cellular and Molecular Therapeutics Laboratory, led by Dr. John F. Tisdale, is working on multiple strategies both in the laboratory and in the clinic to cure sickle cell disease by repairing or replacing the precursor bone marrow cells that give rise to sickled red blood cells. (nih.gov)
In addition, strategies to correct the underlying mutation which causes sickle cell disease are being pursued utilizing newly developed gene editing tools, and work in the laboratory to develop methods for efficient editing of hematopoietic stem cells is underway. (nih.gov)
Sickle cell disease (SCD) has its roots in genetic mutations that cause a single amino acid change in the β-globin chain of hemoglobin A and thereby confer protection against malaria. (nih.gov)
Dr. Tisdale and his colleagues recently completed a modified bone marrow transplant strategy for the first time in adult patients with sickle cell disease. (nih.gov)
Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy? (nih.gov)
2019 sickle cell disease guidelines by the American Society of Hematology: methodology, challenges, and innovations. (nih.gov)
Apheresis is also available for the treatment of a variety of disorders including sickle cell disease, Waldenstrom's macroglobulinemia, and cryoglobulinemia. (bmc.org)

Dr. Toor and Dr. Nair hope to launch the Stem Cell Transplant and Cellular Therapy Program in fall 2023. (lvhn.org)
The International Society for Stem Cell Application (ISSCA) is excited to announce the much-anticipated World Congress 2023, further establishing its role as the primary global hub for regenerative medicine. (stemcellslab.net)

Use of progenitor cell lines can eliminate the need to culture challenging human ES cells. (ddw-online.com)
However, progenitor cells can only differentiate into a limited number of cell types. (ddw-online.com)
Progenitor cells can be far easier to handle in culture than ES cells. (ddw-online.com)
For example, neural progenitor cells derived from a human ES cell line are easily propagated and require less handling than human ES cells. (ddw-online.com)
cDNA data suggest that GPR56 has potential to become a neural stem cell (NSC) or neural progenitor cell (NPC) marker. (nih.gov)
endothelial progenitor cell dysfunction and platelet-endothelial progenitor cell interplay in atherosclerotic disease. (stemcelltherjournal.com)
Researchers have for the first time identified progenitor cells in mouse stomachs in a region where cancer often begins. (sciencedaily.com)
They have been able to show that these cells, which they call "gastric progenitor cells," can give rise to all the different types (or lineages) of specialized cells needed to form the functional stomach glands that line the lower portion of the stomach. (sciencedaily.com)
The identification of these progenitor cells will not only aid in our understanding of normal cell turnover in the stomach, but could potentially open some new and exciting doors in our investigation of the origins of gastric cancer," says Deborah Gumucio, Ph.D., a U-M developmental biologist and senior author of a study which appears online ahead of print in the journal Gastroenterology. (sciencedaily.com)
For these reasons, the ability to identify and manipulate stomach progenitor cells has been an important goal for decades. (sciencedaily.com)
There were no effective markers or tags that we could use to clearly discriminate the stem or progenitor cells from other cells. (sciencedaily.com)
Now, for the first time, we have the experimental tools to ask important questions, like, 'Does stomach cancer really arise from mutations in this progenitor cell population? (sciencedaily.com)
Interestingly, the progenitor cells that the Gumucio lab has identified are concentrated precisely in this tumor-prone area. (sciencedaily.com)
To spot and watch the progenitor cells at work, Gumucio's team, under lead author Xiaotan T Qiao, Ph.D., a U-M Medical School research associate, had to get past the hurdle that has deterred the search for stomach stem cells so far -- finding effective markers, which act like identification tags to make tracing possible. (sciencedaily.com)
Qiao was able to identify the gastric progenitor cells and later explore their behavior because the cells could be effectively marked using a mouse model developed earlier in Gumucio's lab. (sciencedaily.com)
Since gastric cancers often occur in the context of inflammation, we were interested to determine whether these progenitor cells are affected by inflammatory conditions," says Qiao. (sciencedaily.com)
Just what specific role these progenitor cells may play in inflammation and cancer is not clear yet. (sciencedaily.com)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

Among our innovative treatments is Human Cellular Tissue (HCT) therapy, a regenerative method that capitalizes on the unique properties of mesenchymal stem cells (MSCs). (nmstemcell.com)
But what is Human Cellular Tissue and where does it come from? (nmstemcell.com)
Mesenchymal Stem Cells found in this tissue are stem cells that have the potential to differentiate into multiple types of tissue cells, enabling the body's innate repair and rejuvenation processes. (nmstemcell.com)
If you would like to learn more about our regenerative medicine treatments, including human cellular tissue in Albuquerque, Rio Rancho or anywhere in New Mexico, call us at (505) 404-9555 to schedule your free consultation. (nmstemcell.com)
Dr. Quinones-Hinojosa's lab has research platforms on novel therapeutics for glioblastoma, cell migration and invasion, cellular therapy, and models of brain and spine cancers, and maintains a human tissue bank. (mayo.edu)
The Brain Tumor Stem Cell Research Laboratory has created a human tissue bank to preserve tissue and cell cultures for use in present and future experiments. (mayo.edu)
Are Human Cellular Tissue products (i.e. (watersedgemedicalclinic.com)
Stem cells, or Wharton's Jelly Allografts, or Human Cellular Tissue, all are the same thing. (watersedgemedicalclinic.com)
Where does Human Cellular Tissue (formerly known as "stem cells") come from? (watersedgemedicalclinic.com)
Stem cells, or Human Cellular Tissue or Wharton's Jelly Allograft as they are now called, can come from several sources. (watersedgemedicalclinic.com)
The Institute has launched its Give Cures programme that has created a network of doctors in several private clinics and hospitals around the country to recruit patients to procure tissue to create the stem cell lines. (pharmaceutical-technology.com)
Materials and method: The pulp tissue, obtained from wisdom teeth, was placed in a 6-well plate containing proper culture medium, and stored at 37 °C and 5% CO2 for cell proliferation and plastic adherence. (bvsalud.org)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)

In-vitro cultures of primary endometriotic stromal cells, immortalized endometrial stromal (St-T1b) and endometriotic epithelial (12Z) cells were used to assess the effects of resveratrol on endometrial cell mechanisms. (nih.gov)
Resveratrol showed inhibitory effects on cell behaviour related to the development of endometriosis by differentially affecting growth, apoptosis, migration and stem cell phenotype of endometrial and endometriotic cells in vitro. (nih.gov)
Every cell type has its own unique needs when grown in vitro and stem cells are no exception. (ddw-online.com)
These results show that human brain organoids can be applied as an in vitro model for CNS drug screening to evaluate structural, cellular, and molecular changes in the normal brains or brains of patients with neuropsychiatric disorders after drug treatments. (frontiersin.org)
Animal models of TSC insufficiently capture the neurodevelopmental biology of cortical tubers, and hence, human stem cell-based in vitro models of TSC are being increasingly explored in attempts to recapitulate tuber development and epileptogenesis in TSC. (ox.ac.uk)
However, in vitro culture conditions for stem cell-derived neurons do not necessarily mimic physiological conditions. (ox.ac.uk)

Abstract: The use of cellular allograft containing mesenchymal stem cells is gaining popularity as an augmentation to foot and ankle arthrodesis. (ipodiatry.org)
The Brain Tumor Stem Cell Research Lab at Mayo Clinic engineers human mesenchymal stem cells with nanotechnology to serve as Trojan horses for the treatment of cancer. (mayo.edu)
Dr. Quinones-Hinojosa's lab is evaluating the efficacy of a gel for administering human fat-derived mesenchymal stem cells within the brain cancer resection cavity during surgery. (mayo.edu)
In a recent study published in Cell, first author, Hao Huang, PhD, and senior author, Rani George, MD, PhD , show that extracellular domain (ECD) cleavage of the ALK cell surface tyrosine kinase receptor mediates neuroblastoma cell migration through induction of an epithelial-to-mesenchymal transition (EMT) gene signature. (dana-farber.org)
Role of iron and iron-related proteins in mesenchymal stem cells: Cellular and clinical aspects. (cdc.gov)

Unlike sunblocks and filters, It protects your skin on the cellular level and restores the skin's regenerative capacity . (com.ng)
Global Stem Cells Group (GSCG), a renowned leader in regenerative medicine, is thrilled to unveil its groundbreaking product, Cellgenic Lyophilized Exosomes - The Regen Series. (stemcellslab.net)
At NM Stem Cell, we are dedicated to pioneering the integration of regenerative medicine and advanced technology. (nmstemcell.com)
At NM Stem Cell, we're committed to utilizing regenerative medicine's potential to offer innovative solutions for health and wellness. (nmstemcell.com)
It's a multi-specialty training center for cellular therapies and regenerative medicine, offering the most advanced treatments in cell therapy. (issca.us)
The facility's main objective is to incorporate different treatments basing on regenerative medicine, and serve as a training center for cellular therapies and regenerative medicine. (issca.us)
His experience is expected to make this facility one of the best cellular therapy centers worldwide, and provide more specialized treatment for patients requiring regenerative medicine. (issca.us)
The remarkable potential of stem cells to generate several hundred differentiated cell types is driving their use for regenerative medicine and for supporting the traditional drug discovery and development process (Figure 1). (ddw-online.com)

Miami, Florida - Global Stem Cells Group (GSCG) is thrilled to announce the grand opening of its latest state-of-the-art Stem Cell Center, located in Jakarta, Indonesia. (stemcellslab.net)
Global Stem Cells Group headquarters are located in Miami, Florida and is a marketing resource company and provider network for Cellular Hope Institute, in Cancun Mexico. (cellularhopeinstitute.com)
Global Stem Cells Group in Miami Lakes, Florida is not a stem cell treatment facility or surgical center. (cellularhopeinstitute.com)
I have full confidence in the appointment of Dr Rafael Moguel as the CMO of Cellular Hope Institute Cancun," said Benito Novas, CEO of Global Stem Cells Group. (issca.us)
Global Stem Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products, and solutions. (issca.us)
With a singular focus on this exciting new area of medical research, Global Stem Cells Group and its subsidiaries are uniquely positioned to become global leaders in cellular medicine. (issca.us)
Global Stem Cells Group is a publicly traded company operating under the symbol MSSV. (issca.us)
To learn more about Global Stem Cells Group, Inc.'s companies visit our website . (issca.us)

Our pediatric stem cell transplant and cellular therapy specialists have performed more than 2,200 stem cell transplants -- also known as bone marrow transplants -- in children and young adults from across the U.S. and from countries around the world. (dukehealth.org)
Welcome to the Stem Cell Transplant and Cellular Therapy Program at BMC. (bmc.org)
Experts in our Stem Cell Transplant and Cellular Therapy Program work closely with other cancer programs to help ensure everyone can get the care they need. (bmc.org)
That changes this year with the development of Lehigh Valley Topper Cancer Institute's Stem Cell Transplant and Cellular Therapy Program. (lvhn.org)
The Cancer Institute's membership in the Memorial Sloan Kettering Cancer Alliance will also connect the new program to additional stem cell transplant and cellular therapy education and resources. (lvhn.org)
New graduates will be considered if they have a strong desire to work in the cutting-edge field of stem cell transplant and cellular immunotherapy. (simplyhired.com)

Consequently, in order to develop effective targeted therapy, there is a pressing need to identify all molecular regulators that define cancer stem cell traits in TNBC. (nature.com)
Projects in the Brain Tumor Stem Cell Research Lab investigate the effect of ion transporters in brain tumor cell migration and the molecular engines that drive tumor invasion. (mayo.edu)
Dr. Quinones-Hinojosa's lab is studying how the NKCC1 protein maneuvers the cell during migration and using findings to develop new molecular targets for targeted cancer therapy. (mayo.edu)
This barcode can be read by another technique called single cell RNAseq, which gives molecular information of each cells - the cell biography. (childrenshospital.org)
Although with little evidence at the molecular and cellular levels, high-dose tranylcypromine may cause brain damage and inhibit brain development ( 25 - 27 ). (frontiersin.org)
It aims to decipher the molecular, cellular and tissular effects of ionizing radiation and radionuclides and the development of associated pathologies in order to improve their prevention, diagnosis and/or treatment. (cea.fr)
She completed her post-doctoral fellowship in cellular and molecular imaging at the Johns Hopkins University School of Medicine, Department of Radiology and Radiological Science. (hopkinsmedicine.org)
Our studies are focused on the cellular and molecular mechanisms underlying pathophysiological and physiological processes in the cardiovascular system, to define new therapeutic approaches for atherosclerosis regression and prevention of cardiovascular disease events. (stemcelltherjournal.com)
American Journal of Respiratory Cell and Molecular Biology. (lu.se)

A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. (nature.com)
These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)
Several avenues of investigation are being explored in Dr. Quinones-Hinojosa's Brain Tumor Stem Cell Research Laboratory at Mayo Clinic. (mayo.edu)
Researchers in the Brain Tumor Stem Cell Research Lab are investigating the oncostatic effects of melatonin on glioblastoma to improve treatment and provide better quality of life for patients. (mayo.edu)
The Brain Tumor Stem Cell Research Lab studies genetic controls and mediators of tumor growth, invasion, and migration to understand how tumors move into the healthy brain. (mayo.edu)
The lab is creating models to better understand cancer migration and progression, to study invasive cell populations, and to uncover novel therapeutic targets to impact tumor progression. (mayo.edu)
Cellular therapies being offered as standard of care or being evaluated in clinical trials include CAR T-cell therapy, engineered T cell receptors (TCRs), natural killer (NK) cells, cytotoxic lymphocytes, and tumor infiltrating lymphocytes. (dana-farber.org)

0.001 to P = 0.0193) in both cell lines and primary cultures. (nih.gov)
Alternatively, stem cell cultures can be grown on extracellular matrix extracts and supplemented with conditioned medium from mouse fibroblast cultures. (ddw-online.com)
These phenotypes only become apparent when differentiating TSC2+/+ and TSC2-/- cultures in more physiologically relevant conditions of 5 mM glucose suggesting that the careful consideration of culture conditions is vital to ensuring biological relevance and translatability of stem cell models for neurological disorders such as TSC. (ox.ac.uk)
We use an integrated approach from animal models and cell cultures to preclinical studies for pathophysiological and pharmacological investigations. (stemcelltherjournal.com)
Our expertise includes human stem cell cultures, viral vectors, gene editing, cellular reprogramming and bioinformatical analysis of transposons. (lu.se)

This cell line will be used for the generation and purification of motor neurons. (ca.gov)
Moreover, tranylcypromine treatment affects neurons and astrocytes, which impairs cell density and arrangement. (frontiersin.org)
Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)

While many of the Cancer Institute's patients are able to receive the most advanced therapies for their diagnosis close to home, people who needed hematopoietic cell transplant or cellular immunotherapy have always needed to travel outside of the Lehigh Valley for these treatments. (lvhn.org)
Treatments are not conducted in our offices or in the U.S.A since these advanced cellular therapies using high-concentrated cultured and expanded cells are not yet approved by the FDA. (cellularhopeinstitute.com)
As CMO with vast knowledge and experience, Dr Moguel is expected to change the direction of Cellular Hope Institute Cancun, which offers patients the best treatments in multiple areas, such as sports medicine, pediatric care, chronic degenerative disease, and autoimmunity. (issca.us)
Founded in 2012, the company combines dedicated researchers, physician and patient educators, and solution providers with the shared goal of meeting the growing worldwide need for leading edge stem cell treatments and solutions. (issca.us)
With each of GSCG's six operating companies focused on a separate research-based mission, the result is a global network of state-of-the-art stem cell treatments. (issca.us)
Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
While all medical treatments have benefits and risks, unapproved stem cell and exosome products expose patients to potential risks without a clear benefit. (cdc.gov)
Currently, the only stem cell treatments approved by the Food and Drug Administration (FDA) are products that treat certain cancers and disorders of the blood and immune system. (cdc.gov)
If you are considering stem cell treatments, check to make sure the product you are considering is on the FDA's approved list of stem cell treatments external icon . (cdc.gov)

Our inpatient unit is designed specifically for children and young adults receiving stem cell transplants or cellular therapies and for other immunocompromised patients. (dukehealth.org)
Stem cell transplants and cellular therapy can help treat - and even cure - certain types of cancer, such as leukemia. (bmc.org)

The team of hematologists works closely with the blood bank and has developed innovative techniques for harvesting, storing, and re-infusing blood and its components, most notably for autologous peripheral blood stem cell infusion. (bmc.org)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

If your child has a serious blood disease, cancer, or a life-threatening disorder and needs a stem cell transplant -- also called a bone marrow transplant -- or advanced cell therapy such as CAR T-cell therapy , our experts can offer you hope. (dukehealth.org)
These multiple layers of control create a balance between inhibitory BMP (bone morphogenic protein) signaling that keeps hair stem cells in quiescent state and activating Wnt signaling that wakes them up. (usc.edu)
In a recent study, they demonstrated that they could transplant bone marrow cells from HLA-matched sibling donors without needing to completely destroy the patient's immune system. (nih.gov)
After extracting and isolating precursor CD34+ cells from patients, they use viral transduction to insert a correct copy of the β-globin gene before returning the cells to the patient's bone marrow. (nih.gov)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)

BMC offers chimeric antigen receptor (CAR) T-cell therapy, an innovative cancer treatment, to all patients who qualify for this new and powerful therapy. (bmc.org)
The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. (nature.com)
ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. (nature.com)
Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. (nature.com)
Despite ZNF148 being an established node of the MYC-network in ES cells, and the significance of MYC in driving cancer stem cells traits, the role of ZNF148 in breast cancer remains elusive. (nature.com)
Dr. Quinones-Hinojosa's lab is studying ways to engineer human fat cells to turn them into cancer-fighting Trojan horses and evaluating a gel to locally administer to patients during brain cancer surgery. (mayo.edu)
When functioning normally, the Hippo pathway is important to cell growth, but when malfunctioning, the Hippo pathway can also play a role in diseases such as liver cancer and liver fibrosis. (childrenshospital.org)
They are now utilizing barcoding technologies to generate family trees of cancer and aging models to understand the ancestry and the function of the cells involved in these diseases. (childrenshospital.org)
Somatic DNMT3A gene mutations are also found relatively frequently in another form of blood cancer called T-cell acute lymphoblastic leukemia. (medlineplus.gov)

Inpatient Nurse Practitioner Stem Cell Transplant & Cellular Immunotherapy Opportunity, Washington, D.C. (simplyhired.com)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)

Your hair - or lack of hair - is the result of a lifelong tug-of-war between activators that wake up, and inhibitors that calm, stem cells in every hair follicle on your body, according to Cheng-Ming Chuong , MD, PhD, professor of pathology at the Keck School of Medicine of USC . (usc.edu)
However, patient-derived cells may be more prone to develop disease-associated pathology after grafting. (lu.se)
Lastly, we evaluated the strategy of knocking out a-syn as a means to protect the cells from transfer of pathology upon grafting. (lu.se)

TSCM are considered as a promising approach in immune cell therapy in cancers due to their high proliferation capacity, longevity and increased survival as well as more potent antitumor effects compared with Tcm and Tem in vivo. (wikipedia.org)
We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)
Conclusion: Our results suggest that the explant method - or cell proliferation method - is suitable for the isolation and culture of stem cells from dental pulp of permanent teeth. (bvsalud.org)

The effect of resveratrol on the expression of genes related to cell migration, angiogenesis and cell stemness was evaluated by qRT-PCR. (nih.gov)
They have discovered novel genes that control blood forming stem cells and uncovered new cell populations that produce platelets. (childrenshospital.org)
The activities of transcription factors and other genes involved in cell fate decisions can be measured by a number of different gene expression quantification experiments. (lu.se)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)

Dr. Tisdale has an active research program in trying to characterize tolerance and create conditions in which patients will more easily tolerate donor cells and tissues without the need for destroying the immune system or perpetual use of immunosuppressant drugs. (nih.gov)
Be The Match® connects patients with a matching donor for a life-saving blood stem cell transplant. (bethematch.org)
Our registry is the connection between patients searching for a cure and their life-saving blood stem cell or marrow donor. (bethematch.org)
Longitudinal studies on TSCM dynamics in patients undergoing hematopoietic stem cell transplantation (HSCT) have shown that donor-derived TSCM cells were highly enriched early after HSCT, differentiated directly from Tn, and that Tn and TSCM cells (but not central memory or effector T cells) were able to reconstitute the entire heterogeneity of memory T cell subsets including TSCM cells. (wikipedia.org)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)

0.001 to P = 0.0225) and increased the number of apoptotic cells (P = 0.0031 to P = 0.0432) in both cell lines. (nih.gov)

Long-term studies on T cells in a cohort of patients vaccinated against yellow fever revealed that vaccine-induced CD8+ TSCM cells specific to yellow fever antigens were stably maintained for 25 years, capable of self-renewal ex vivo, and preserved surface markers and mRNA profiles closest to naïve T cells. (wikipedia.org)
The focus-forming cells exhibited stem properties as indicated by stem cell markers expression, sphere formation, and ALDH activity assays. (cdc.gov)
Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
Cells were tested for the expression of surface markers and for ALDH1 enzyme activity, by flow cytometry. (bvsalud.org)

Duke's pediatric stem cell and cellular therapy program is internationally recognized for its innovative use of stem cells to treat a wide range of potentially fatal diseases. (dukehealth.org)
To refer your patient to the Stem Cell Transplantation & Cellular Therapy Program, please complete the following steps. (texaschildrens.org)

The main goal of this project is to develop rat models for assessing the safety and efficacy of human stem cell grafts. (ca.gov)

In cellular environment protein abundance and half-life are determined by ubiquitin-proteasomal system. (lu.se)

The use of mouse feeder layers and animal serum are particularly problematic in the culturing of stem cells for possible therapeutic applications. (ddw-online.com)

What is the best way to study the metabolism of bird blood cells? (lu.se)

This article will examine advances taking place on both the lab bench and the pharmaceutical production floor that are helping to bring the promise of stem cells closer to reality. (ddw-online.com)
Ngen EJ and Artemov D.Advances in monitoring cell-based therapies with magnetic resonance imaging: Future perspectives. (hopkinsmedicine.org)

Miami, Florida - The International Society for Stem Cell Applications (ISSCA) is thrilled to announce the launch of its newest program, the Advanced Turkish Hair Transplant Certification. (stemcellslab.net)

As stem cell-based therapies move towards clinical application, it is clear that more relevant animal models are required to demonstrate the safety and efficacy of stem cells for specific human diseases. (ca.gov)
Before human stem cells can be used in clinical trials, however, their safety and efficacy need to be tested in animal models. (ca.gov)
Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
CET, a stem cell biotech company, and non-profit organisation JP2MRI hope that the stem cell biobank will help overcome obstacles facing personalised medicines by enabling testing on patient-specific stem cells instead of the currently used model that involves animal testing and expensive clinical trials. (pharmaceutical-technology.com)
The Cellular Therapies Program team leads clinical care and research of promising cellular therapies across all adult disease centers. (dana-farber.org)
Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)

By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates ("STEMCELL") to collect and use your information, and send you newsletters and emails in accordance with our privacy policy . (stemcell.com)

Such heterogeneity could originate from extrinsic factors, such as cell-to-cell signalling and surrounding temperature and pressure, but also from the intrinsic noise generated by having few copies of molecules involved in transcription and translation. (lu.se)

Cellular Reprogramming. (lu.se)

He also has expertise with cellular therapies for hematologic malignancies, specifically chimeric antigen receptor (CAR) T-cell therapy. (lvhn.org)

Scientists have identified and described stem cells specific to several tissues and organs of the body -- key master cells that give rise to the specialized cell types characteristic of that organ. (sciencedaily.com)
[ 1 ] Antigen-presenting cells or histiocyte-like cells containing Birbeck granules have been identified within inflamed synovial tissues. (medscape.com)
Over the last years, dentistry has been exploring the potential application of stem cells from different origins in the regeneration of oral tissues that were lost or damaged by disease or trauma 1 . (bvsalud.org)

Journal of cellular physiology 2021 0 0. (cdc.gov)

The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)
The bank will hold 5,000 patient and disease-specific stem cell lines and other human cell lines derived from adult sources. (pharmaceutical-technology.com)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)

The pathogenic mechanisms involve a wide range of cells and soluble factors. (mdpi.com)
This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)

F urther complicating matters, human ES cells are typically co-cultured with feeder layers of mouse fibroblast cells. (ddw-online.com)
Several growth factors have been identified that promote growth of human ES cells in culture, most notably basic fibroblast growth factor (bFGF). (ddw-online.com)
Predicting nanotube fibrogenicity through stem cell-mediated fibroblast focus and spheroid formation. (cdc.gov)
Fibroblast stem cells or stemlike cells (FSCs) are proposed to play a pivotal role in extracellular matrix (ECM) regeneration by serving as a key source of ECM-producing fibroblasts. (cdc.gov)

Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)

Multiparametric flow cytometry and TCR sequencing studies showed that more than 30% of naïve T cells primed by antigen directly differentiate into TSCM cells. (wikipedia.org)

Global Stem Cells Group's corporate mission is to make the promise of stem cell medicine a reality for patients around the world. (issca.us)

In addition, since the stem cells are the longest-lived of the gastric cells, it is thought that these are the only cells that live long enough to accumulate the multiple mutations that can cause cancers. (sciencedaily.com)
DNMT3A gene mutations that cause DNMT3A overgrowth syndrome are found in all of the body's cells and lead to a decrease in normal enzyme function. (medlineplus.gov)
they are typically found in a small percentage of cells and the mutations are not inherited. (medlineplus.gov)

To this end, iRCM teams use various cell models, organoids, as well as preclinical models and benefit from state-of-the-art facilities , which are open to external teams. (cea.fr)

The programmes governing the function and fate of cells are to a large extent driven by the coordinated activity of transcription factors forming complex and dynamic gene regulatory networks (GRNs). (lu.se)

A process where fully differentiated or specialized cells revert to pluripotency or a less differentiated cell type. (bvsalud.org)

Under the right conditions - winter season or a new physiological stage in an organism's life such as puberty - a collective regeneration wave can sweep through the skin, activating hair stem cells in individual follicles and those in front of them, by the tens of thousands. (usc.edu)
Double StemCell is a must-use supplement for the regeneration process of dead or damaged cells, which keeps our body healthy and young. (com.ng)

The success of the cellular automaton method could be applied to a broad range of biological pattern formation situations, including the spread of infectious diseases or neural networking in the developing brain, said Chuong. (usc.edu)
Our data suggest that GPR56 can be used as an NSC/NPC marker within the neural cell lineage, especially in combination with nestin. (nih.gov)

Results: The isolated cells showed high expression of CD44 (98.8%), CD73 (100%), and CD90 (97.2%), and moderate expression of STRO-1 (18.4%) and ALDH1 (16.2%), by flow cytometry. (bvsalud.org)

He is also heavily involved in researching novel cellular therapies that could lead to better outcomes and quality of life for patients in the near future, and his work in this area will be a major asset to our program. (lvhn.org)
Patients with blood disorders receive consultation and treatment for a broad range of benign conditions, such as hemoglobinopathies (sickle cell anemia and thalassemia), hemochromatosis, bleeding and thrombotic disorders (von Willebrand's disease and hemophilia), hypercoagulable states, myeloproliferative disorders, myelodysplasia and anemia, and malignancies such as leukemia, lymphoma and myeloma. (bmc.org)
It also revealed that in type I diabetes patients there was an enrichment of self-reactive clonotypes in TSCM rather than in Tm, suggesting that TSCM might serve as a pool of autoreactive T cells. (wikipedia.org)
CET and JP2MRI hope the biobank stem cell lines will be better models to predict the outcome of drug therapies in patients and advance research to bring new drugs to the market much more quickly and cheaply. (pharmaceutical-technology.com)
Stem cell donations to the bank will come directly from patients recruited from private practice doctors and private hospitals. (pharmaceutical-technology.com)
Patients who have had stem cell or exosome therapy should discuss any concerns and abnormal reactions with their healthcare provider. (cdc.gov)
CDC is investigating bacterial infections in patients who have received stem cell products from the ReGen Series® (distributed by Liveyon, LLC). (cdc.gov)
Most of these patients developed symptoms such as pain, swelling, or chills within a few days of receiving the stem cell products. (cdc.gov)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)

The effects of resveratrol on 12Z and St-T1b cell viability were assessed by MTT assay, apoptosis by FITC Annexin V assay and cleaved caspase-3 levels and cell migration by wound healing assay. (nih.gov)
During early-stage cell apoptosis, PS is translocated from the inner to the outer leaflet of the plasma membrane, exposing it to the external environment. (stemcell.com)
Annexin V, a characteristic marker for early cell apoptosis, detects the translocation of PS to the external environment. (stemcell.com)
Therefore, as cells progress through apoptosis and towards necrosis, the cell membrane is compromised and consequently, viability dyes pass into the cell. (stemcell.com)
Thus, cells undergoing early apoptosis stain positive for Annexin V and negative for viability dyes, while apoptotic death or necrosis is characterized by positive staining for both Annexin V and the viability dye. (stemcell.com)

We will use these models to assess human cellular therapies. (ca.gov)
The human body is derived from a single cell. (childrenshospital.org)
After primary antigen exposure and elimination, antigen-specific TSCM preferentially survive among memory T cells and stably persist for a long term throughout the human lifespan. (wikipedia.org)
Pathogen-specific TSCM cells have been identified in a number of studies of human acute and chronic infections caused by viruses, bacteria and parasites. (wikipedia.org)
Xeno-free media that do not rely upon high levels of bFGF have been developed that contain only humanised or synthetic components and are engineered to support the undifferentiated growth and expansion of human ES cells. (ddw-online.com)

Anatomy57

Organisms16

Diseases12

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science2

Named Groups1

Health Care1

Differentiation18

Embryonic12

Hematopoietic cells1

Transplantation and cellular therapies1

Pluripotent9

Sickle cell di7

20232

Progenitor18

Tissue14

Vitro6

Mesenchymal5

Regenerative8

Global Stem Cells Group8

Transplant and cellular6

Molecular9

Tumor7

Cultures5

Neurons4

Treatments9

Transplants2

Autologous4

Bone7

Cancer9

Immunotherapy2

Pathology3

Proliferation4

Genes4

Donor6

Apoptotic cells1

Markers4

Therapy program2

Assessing the safety a1

Protein1

Therapeutic1

Metabolism1

Advances2

ISSCA1

Clinical6

Subsidiaries1

Extrinsic factors1

Reprogramming1

Hematologic malignancies1

Tissues3

Physiology1

Adult3

Mechanisms2

Fibroblast4

Somatic cell1

Differentiate1

Promise of stem1

Mutations3

Organoids1

Regulatory1

Pluripotency1

Regeneration2

Neural2

Flow cytometry1

Patients9

Apoptosis5

Human5