• Different influence of CSP 310-like proteins on mitochondrial energetic activity and lipid peroxidation presumably depend on the various subunit combinations in their composition. (biomedcentral.com)
  • 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
  • These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. (au.dk)
  • Lipids and proteins are attacked and oxidized, resulting in loss of chlorophyll and carotenoids and in leaky membranes which allow cells and cell organelles to dry and disintegrate rapidly. (weedscience.org)
  • Benzofuranes (WSSA Group 16), chlorocarbonic acids (Group 26), phosphorodithioates (Group 8), and thiocarbamates (Group 8) are examples of herbicides that are known inhibitors of several plant processes including: 1) biosynthesis of fatty acids and lipids which may account for reported reductions in cuticular wax deposition, 2) biosynthesis of proteins, isoprenoids (including gibberellins), and flavonoids (including anthocyanins), and 3) gibberellin synthesis inhibition which may result from the inhibition of kaurene synthesis. (weedscience.org)
  • These ROS react with cellular macromolecules including DNA, RNA, membrane lipids, and proteins, leading to cellular dysfunction and DNA damage, resulting in chromosomal abnormalities and mutations that cause cancers. (e-algae.org)
  • This study establishes an oxidative mode of Cr toxicity in S. cerevisiae , which primarily involves oxidative damage to cellular proteins. (microbiologyresearch.org)
  • 10] This is the most toxic component due to high reduction-oxidation (redox) potential that generates oxygen-free radicals such as superoxide anion in the cells, which damages DNA, proteins, and membrane lipids in the cell. (medscape.com)
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
  • In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)
  • With this greater abundance of metabolic substrate, cellular respiration becomes elevated, and as a consequence, reactive oxygen species (ROS) are generated [ 3 ]. (biomedcentral.com)
  • Mangrove derived berberine enhances lipid peroxidative markers such thiobarbituric acid reactive substance conjugated diene, and lipid hydroperoxide in AGS cell lines. (pdfplayer.org)
  • Peroxide and malondialdehyde levels are often increased by freezing and thawing stress suggesting peroxidation of lipids [ 2 ] that result in structural and functional membrane and membrane protein changes [ 3 ]. (biomedcentral.com)
  • The membrane lipid changes and the associated production of signalling metabolites clearly have a pivotal function to modify the heat stress response [27].In addition, dietary protein level is also known to have profound influence on antioxidant system and membrane composition and stability[28]. (ijcrr.com)
  • In its reduced form, CoQ 10 H 2 (ubiquinol) can transfer electrons to acceptors such as complex III in mitochondrial ETC or, for example, to α-tocopherol in other cellular membranes 2 . (fusabil.org)
  • Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
  • Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved. (silverchair.com)
  • 20423 bioactive compound berberine was determined by MTT assay, and the oxidative stress was determined by lipid peroxidation method along with assessment of changes in the enzymatic and non enzymatic antioxidant status. (pdfplayer.org)
  • Lu, C., Chan, S.L., Fu, W. and Mattson, M.P. (2002) The lipid peroxidation product 4-Hydroxyneal facilitates op- ening of voltage dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. (scirp.org)
  • The aim of the present study was to determine the effects of CoQ 10 and vitamin E on lipid peroxidation and antioxidant profile in rats treated with the chemotherapeutic agent doxorubicin, along with the biochemical parameters of albumin, globulin, total protein, alanine aminotransferase (ALT) and glucose levels. (fusabil.org)
  • ROS have been shown to impair protein synthesis by preventing mRNA translation [14, 15, 16, 17,18].Acute heat-stressed broiler chickens had a 2-fold increase in malondialdehyde, a marker of lipid peroxidation, in skeletal muscle [19]. (ijcrr.com)
  • End-product of lipid peroxidation, acts as a heat shock protein (hsp) inducer [20]. (ijcrr.com)
  • The peroxidation of lipids (16, 17), protein oxidation, and the formation of peroxinitrites frequently occur after liver ischemia and reperfusion. (ectrx.org)
  • The inference that protein oxidation is a primary mechanism of Cr toxicity was corroborated by an observed ∼20-fold increase in the cellular levels of protein carbonyls within 30 min of Cr exposure. (microbiologyresearch.org)
  • In addition to lipid and protein damage, ROS (namely secondary, injurious derivatives) have the capability of causing DNA single-stand breaks (SSB) and base oxidation [ 10 ]. (biomedcentral.com)
  • 2002. Concentrations of conjugated linoleic acid (cis-9, trans-11-octadecadienoic acid) are not increased in tissue lipids of cattle fed a high-concentrate diet supplemented with soybean oil. (raw-milk-facts.com)
  • 2002) which leads to cellular and tissue damage (Tkaczyk andVizek, 2007). (ijcrr.com)
  • 2002), which is associated with a loss of ability at the molecular, cellular and whole organism levels (Hall et al . (scialert.net)
  • If the electron transport chain does not function, aerobic metabolism will decrease resulting in the cytoplasmic shunting of pyruvate to lactate (lactic acid) in order to replenish the NAD+ needed generate the net 2 ATP available from glycolysis.12 If the net production of 2 ATP is not sufficient to maintain cellular metabolism, then the myocyte will theoretically suffer resulting in muscle pains/aches and/or cell death. (ebmconsult.com)
  • Insulin is the hormone that regulates cellular nourishment by aiding in the absorption and metabolism of nutrients from the blood. (vitalitymagazine.com)
  • Biomarkers of oxidative damage (DNA single-strand breaks, lipid peroxidation and free radical metabolism) and inflammation were determined using conventional biochemistry techniques. (biomedcentral.com)
  • The aim of this study was to determine the effect of short-term pomegranate supplementation on lipid damage and antioxidant capacity following a session of exhaustive exercise in non-athletes. (sportrc.ir)
  • Therefore, pomegranate capsules supplementation can be used to reduce lipid damage due to severe physical exercise. (sportrc.ir)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)
  • Molecular and Cellular Biochemistry, 276(1-2), 205-210. (scirp.org)
  • Diltiazem and EDTA inhibited the increased responses of lipid peroxidation and hemolysis due to Ca2+. (scirp.org)
  • Each class of enzymatically produced eicosanoids governs a specific set of functions and is thought to serve as a mediator or autacoid, acting within a local microenvironment to orchestrate key cellular responses. (jci.org)
  • However, spermatozoa's lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm. (scialert.net)
  • An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
  • With the observed increase in cellular respiration during the postprandial period, it is conceivable that SSB are exacerbated during these conditions. (biomedcentral.com)
  • In turn, this can promote a more efficient uptake of glucose into the cells where it can be used for cellular fuel and converted into energy. (peoplesrx.com)
  • Cellular targets of herbicide action and herbicide classification by mode of action according to the Herbicide Resistance Action Committee (HRAC). (weedscience.org)
  • Red cells are always under high oxygen pressure and extremely susceptible to peroxidation and the conditions that favour peroxidation, are seemingly optimal in red cells [1]. (ijcrr.com)
  • Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. (oncotarget.com)
  • The study of an influence of infiltration by different plant uncoupling system activators (pyruvate, which activates AOX, and linoleic acid which is a substrate and activator for PUMP and CSP 310) showed that all of these decreased lipid peroxidation during cold stress. (biomedcentral.com)