Cells protein structure tertiary. Medical search. Frequent questions

The expressed receptors displayed both high- and low-affinity states for [3H]5-HT, suggesting that the receptors were coupled to endogenous G-proteins. (nih.gov)
Measurements of adenylyl cyclase activity in membranes from cells expressing m5-HT1B receptors showed that serotonergic agonists mediated the inhibition of adenylyl cyclase activity with a rank order of potency comparable to their affinity constants. (nih.gov)
Immunoblot analysis of membranes prepared from cells expressing m5-HT1B receptors and photoaffinity labeling of the immunoprecipitated material revealed photolabeled species at approximately 95 and at approximately 42 kDa. (nih.gov)
Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell's external membrane. (agemed.org)

When a protein possesses several polypeptide chains, then the manner in which they are sequenced is called the quaternary structure. (vedantu.com)
Among others, it provides insights for: Omics Clinical diagnostics Structural biology Amino acid Polypeptide chains α-Helixes Complex of protein molecule PRIMARY STRUCTURE TERTIARY STRUCTURE SECONDARY STRUCTURE QUATERNARY STRUCTURE PRIMARY STRUCTURE MS is a key tool for the detection of many environmental contaminants, both well known and emerging. (technologynetworks.com)
Protein synthesis, folding, and tertiary and quaternary structure ultimately determine much of the body's structure and function. (msdmanuals.com)

RNA testing looks for changes in gene expression, and protein analysis assesses structural changes in the protein product of the gene. (jax.org)
for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)
Class I and class II molecules allow antigen presentation to the specific T-cell receptor via a specific structural groove in its tertiary structure. (medscape.com)
The emphasis is on the structural characterization of proteins and post-translational modifications as well as the investigation of protein complexes and protein interactions important in e.g. protein folding, protein ligand binding, and the formation of tertiary and quaternary structures. (uu.nl)
Advancements in areas such as ionization have helped to create growing applications of MS in the clinic, including: Cross-linking MS (XL-MS) is an important a tool in structural biology, revealing information on protein interaction networks within biological samples, from proteins to macromolecular complexes, cells and even tissues. (technologynetworks.com)
In addition, current spectroscopic analysis makes it difficult to distinguish between secondary and tertiary structural information. (pharmamanufacturing.com)
The BPI/LBP family of proteins: a structural analysis of conserved regions. (innspub.net)
Cloning of the cDNA of a human neutrophil bactericidal protein: structural and functional correlations. (innspub.net)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)

One of the thyroid hormones principal functions is to stimulate the consumption of oxygen and, thus, the metabolism of all cells and tissues in the body. (medscape.com)

Generally, peptides tend to be linear though lariat structures are observed. (vedantu.com)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)

Functional analyses use stem cells and other biological systems in vitro . (jax.org)
Proteins are vital components to nearly every biological process. (visionlearning.com)
focuses on the development and implementation of innovative mass spectrometric methods for the more efficient and detailed characterization of proteins in relation to their biological function. (uu.nl)
The biological role of a new protein can often be deduced by comparing its shape with that of proteins with known functions. (sciencedaily.com)
Despite its biological importance, transfer RNA (tRNA) could not be adequately sequenced by Author Manuscript standard methods due to abundant post-transcriptional modifications and stable structure, which interfere with cDNA synthesis. (cdc.gov)

Because protein molecules are highly dynamic, constant chaperone surveillance is required to ensure protein homeostasis (proteostasis). (nature.com)
Class I MHC molecules include HLA-A, HLA-B, or HLA-C and serve as the antigen-presenting platform for CD8 or suppressor T cells. (medscape.com)
Class I molecules are present on all nucleated cells. (medscape.com)
Class II MHC molecules, the HLA-D region, serve as the antigen-presenting cells for CD4 or helper T cells. (medscape.com)
Class III MHC molecules include several proteins with other immune functions, such as cytokines, heat shock proteins, and parts of complement system. (medscape.com)
Proteins are large molecules made up of hundreds, even thousands, of amino acids combined in different ways. (visionlearning.com)
6 Keratin is especially rich in cysteine, which is a sulfur-containing amino acid capable of forming disulfide bonds between molecules, thus adding strength and elasticity to the entire structure (Figure 1). (naturalmedicinejournal.com)
Bases These are molecules with one or two nitrogen-containing ring structures. (agemed.org)
Biochemistry is a science whose boundaries now encompass all aspects of biology, from molecules to cells, to organisms, to ecology, and to all aspects of health care. (com.pk)
It aims to provide an understanding of the basic chemical properties of molecules that make life possible and a description of the key components of the cell and their biochemical interactions. (manchester.ac.uk)
To understand basic chemical properties of molecules that make life possible, and how these properties relate to specific macromolecular structures and functions. (manchester.ac.uk)

Jan. 11, 2022 Tertiary lymphoid structures are formations that occur outside of the lymphatic system. (sciencedaily.com)

3D fluorescence studies showed that the HSA structure was altered at the secondary and tertiary levels upon binding with the complexes. (rsc.org)
Molecular docking studies indicated that all three complexes primarily bind to HSA in subdomain IIA with amino acid residues such as Arg218 and Lys199 which are located at the entrance of Sudlow's site I. The in vitro cytotoxicities of complexes 1-3 against HeLa cells showed promising anticancer activity (IC 50 = 3.5, 3.9 and 16.9 μM for 1 , 2 and 3 , respectively). (rsc.org)
The Heck group evelops mass spectrometers dedicated for this work and applies these technologies to study the structure and dynamics of for instance transcription complexes and virus assembly. (uu.nl)
The keratin protein is a helicoidal group of cysteine-containing protein complexes with primary, secondary, and tertiary structures held together by peptide bonds, disulfide bonds, and hydroxide bonds. (naturalmedicinejournal.com)
2002. The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes. (innspub.net)
The mode of action of enzymes and macromolecular complexes as protein machines will be investigated. (manchester.ac.uk)
As one of the two distinct complexes, namely, Polycomb Repressive Complex 1 (PRC1) and PRC2, PRC2 mediates gene silencing by modulating chromatin structure [ 2 ]. (hindawi.com)

A polypeptide helps make proteins by bonding several amino acids together. (vedantu.com)
The tertiary structure is considered the 3-dimensional structure of a polypeptide chain. (vedantu.com)
A polypeptide bonds many amino acids together for creating proteins, and it also gives them their exclusive shape. (vedantu.com)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (bvsalud.org)

Proteins are macromolecules and have four different levels of structure - primary, secondary, tertiary and quaternary. (herz-uptodate-berlin.de)
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Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene. (wikipedia.org)
The HLA system is genetically encoded in humans by the major histocompatibility complex (MHC), which is found on chromosome 6, and plays a determining role in immunity and in self-recognition in virtually all cells and tissues, with the exception of erythrocytes. (medscape.com)
In humans, somatic (nongerm) cell nuclei normally have 46 chromosomes in 23 pairs. (msdmanuals.com)

For example, any given protein may have three oligosaccharides attached but 20 different structures or isoforms, each of which will have a different activity. (pharmamanufacturing.com)
Two splice isoforms of the ninth member of the regulator of G protein signaling (RGS) protein family are expressed in the nervous system, where they are engaged in such diverse functions as vision and behavior. (duke.edu)
The main goal of this review is to illustrate how these functions are fulfilled through the interplay between the intrinsic molecular properties of RGS9 isoforms and their interactions with several key protein partners in the cells in which they are expressed. (duke.edu)

The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. (wikipedia.org)
The predicted effects of a variant on functional areas of the protein such as binding sites for DNA or other proteins can also be analyzed. (jax.org)
Cloning and characterization of the homologue of mammalian lipopolysaccharide binding protein and bactericidal permeability increasing protein in rainbow trout Oncorhynchus mykiss . (innspub.net)
To elucidate the ligand-binding surface of the CC chemokine-binding proteins Evasin-1 and Evasin-4, produced by the tick Rhipicephalus sanguineus, we sought to identify the key determinants responsible for their different chemokine selectivities by expressing Evasin mutants using phage display. (unige.ch)
The results also suggest that phage display may offer a useful approach for rapid investigation of the pharmacophores of small inhibitory binding proteins. (unige.ch)
Goethe-Universita¨t, DE-60439 tein (I-LBP) and intestinal fatty acid-binding protein (I-FABP). (lu.se)
Hydration of Lipid-binding Proteins by ten anti-parallel b-strands. (lu.se)
In the blood, T4 is either free (not bound) or protein-bound (primarily bound to thyroxine-binding globulin). (medscape.com)

Finding a similar 90° kink in a region of ribosomal RNA that binds factors necessary for the initiation of protein synthesis, the researchers speculate that the SARS virus may use the s2m element to hijack its host cell's protein synthesis machinery. (sciencedaily.com)
7. In a eukaryotic cell, protein synthesis occurs in the A. nuclear envelope. (nursingdons.com)
Significant obstacles for the sequencing of tRNA include the presence of numerous post-transcriptional modifications and its stable and extensive secondary structure, which interfere with cDNA synthesis and adapter ligation. (cdc.gov)
tRNAs are essential for cells and their synthesis is under stringent cellular control. (cdc.gov)

This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). (wikipedia.org)
Leptin, the protein product of the ob gene, is a hormone that is secreted principally by adipose tissue (adipocyte-derived hormone). (researchgate.net)
To deliver the candidate antigen on the surface, we fused the mpt64 gene to the sequence encoding the PE domain of the PE_PGRS33 protein of M. tuberculosis (to create strain (H)PE-ΔMPT64-BCG), which we have previously shown to transport proteins to the bacterial surface. (unicatt.it)
In this study, the sp2 gene was cloned and expressed in Escherichia coli to produce a 6xHis-tagged fusion protein, which was then used to generate a polyclonal antibody. (hindawi.com)
Polycomb Group (PcG) proteins are a family of protein complex that regulate gene expression, especially repressing gene transcription [ 1 ]. (hindawi.com)
Furthermore, the decreased expression of the EZH2 gene is crucial for stem cell differentiation into specific cell lineages involved in myogenesis, adipogenesis, osteogenesis, neurogenesis, and haematopoiesis [ 9 ]. (hindawi.com)
Alternative splicing of gene can generate multiple transcripts and proteins to regulate tissue and organ development [ 17 ]. (hindawi.com)
RNA-guided Gene Regulation: Structure and. (hhmi.org)
A gene is a segment of DNA that provides the code to construct a protein or RNA molecule. (msdmanuals.com)

When it is the secondary structure, then it is the shape of the peptide chain. (vedantu.com)

Macrophages and dendritic cells are the important class II antigen-presenting cells. (medscape.com)
To improve the current vaccine against tuberculosis, a recombinant strain of Mycobacterium bovis bacillus Calmette-Guérin (rBCG) expressing a Mycobacterium tuberculosis vaccine candidate antigen (MPT64) in strong association with the mycobacterial cell wall was developed. (unicatt.it)

This family of proteins is responsible for enhancing the turnover rate of actin in vivo. (wikipedia.org)

The yeast mating cell provides a simple paradigm for analyzing mechanisms underlying the generation of surface polarity. (ox.ac.uk)
Selected variants were then produced as purified proteins and characterized by surface plasmon resonance analysis and inhibition of chemotaxis. (unige.ch)
Cell Surface Receptor-Ligand Recognition and. (hhmi.org)

Protein analyses examine the primary structure (amino acids) as well as the secondary folded structure, more complex tertiary structures, and protein interactions. (jax.org)
Proteins can have four types of structures: (1) Primary, the sequence of amino acids, (2) Secondary, hydrogen bonds among the strands of amino acids form beta sheets or alpha-helixes, (3) Tertiary, the three-dimensional, twisted structure based on bonding interactions between amino acid strands, and (4) Quartnerary, the complex structure made up of multiple folded subunits. (visionlearning.com)
Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)

Analysis of the primary protein structure of the human serotonin1B (5-HT1B) receptor reveals consensus sites for phosphorylation and a putative site for palmitoylation. (nih.gov)
To investigate these posttranslational modifications, we have expressed a c-myc epitope-tagged 5-HT1B (m5-HT1B) receptor in Sf9 cells. (nih.gov)
In addition, we demonstrate that the infectious stage of T. cruzi inhibits the lectin pathway activation and complement killing expressing the complement C2 receptor inhibitor trispanning (CRIT) protein. (herts.ac.uk)
The insulin receptor (IR) and JAK1 tyrosine kinases and STAT3 can serve as direct substrates for the T-cell protein tyrosine phosphatase (TCPTP). (diabetesjournals.org)
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. (uchicago.edu)
However, both proteins appear to target chemokine N termini, presumably because these domains are key to receptor signaling. (unige.ch)

The cell wall of pathogenic mycobacteria is abundant with complex glycolipids whose roles in disease pathogenesis are mostly unknown. (ed.ac.uk)
To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. (nature.com)
Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
Really excited today to talk about breakthrough in stem cell activation through an oral protein complex. (chiroeco.com)
And then it's going to be followed by epidemiology and pathology, followed by the actual overview of how this protein complex works, so the osteoinductive protein complex. (chiroeco.com)
So the complex itself is composed of what's called bone morphogenetic proteins. (chiroeco.com)
So these are the components that make up this protein complex, this oral protein complex known as Cyplexinol. (chiroeco.com)
Live cell time lapse imaging for 1 was done to capture the dynamic behavior of the cells upon treatment with the complex. (rsc.org)
These then fold and bend in three dimensions to form complex tertiary structures. (sciencedaily.com)
We first designed alanine mutants based on the Evasin-1·CCL3 complex structure and an in silico model of Evasin-4 bound to CCL3. (unige.ch)
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (bvsalud.org)

And TGF-β, just going back to that, is specific to cellular function in terms of cell growth, proliferation, differentiation. (chiroeco.com)
Negative WT1 staining implies a nonproliferative nature of the oral lymphangiomas, thus growth is most likely secondary to enlargement of lymphatic vessels and not neoplastic proliferation of lymphatic endothelial cells. (medscape.com)

PGL-1 binds specifically to the native laminin-2 in the basal lamina of Schwann cell-axon units. (ed.ac.uk)
Instead, Fus1p localization to the tip of the mating projection was determined by its cytosolic domain, which binds to peripheral proteins involved in mating tip polarization. (ox.ac.uk)

But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. (nature.com)
Figure 1: Competing reactions of protein folding and aggregation. (nature.com)

Proteins are polymers composed of building blocks called amino acids, of which life on Earth uses just twenty. (visionlearning.com)
Today, we know that proteins are polymers composed of building blocks called amino acids (Figure 1). (visionlearning.com)

Mouse IgG2a - a structure of a complete mouse IgG antibody. (lu.se)

The Journal of cell biology. (ed.ac.uk)
RNA Biology: Tertiary Structure and RNA-Protein. (hhmi.org)
Probing Proteins at the Interface of Biology and. (hhmi.org)

Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. (nih.gov)
We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. (nih.gov)
The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling. (biologists.com)

32P]ADP-ribosylation experiments identified a major approximately 41-kDa ADP-ribosylated protein present in Sf9 membranes that comigrated with partially purified bovine brain Gi alpha/G(o) alpha subunits. (nih.gov)

Recent advances suggest that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease. (nature.com)
This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
This work will lay a foundation for the development and utilization of protein drugs from economically important insects for treatment of vascular diseases. (hindawi.com)

Oxidative stress is a plethora of reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, hydroxyl radical, and inducible nitric oxide species that exert a constellation of aberrant changes in the oxidation-reduction status of the cell. (molvis.org)
Taken at face value, senile cataract is intimately associated with the increased risk of oxidative stress, which levies irrevocable changes in the lenticular proteins that impel the lens epithelial cells to the apoptotic phase. (molvis.org)
Many factors, such as peroxide, ox-low density lipoprotein (LDL), angiotensin I, and tumor-necrosis-factor-(TNF-) α can induce the production of reactive oxygen species (ROS) by NADPH oxidase in endothelium and vascular smooth muscle [ 2 ], which results in oxidative stress to the endothelial cells (ECs) and, thus, the induction of cell apoptosis. (hindawi.com)
Acute solvent exposure induced activation of cytochrome P4502E1 causes proximal tubular cell necrosis by oxidative stress. (cdc.gov)

Using techniques like electrophoresis and chromatography, Frederick Sanger discovered that proteins were built of specific amino acid sequences and that changing the sequence would make it a different protein. (visionlearning.com)
en] The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. (uni.lu)
This strong sequence conservation indicates that the tertiary structure of s2m could be important for viral function, and when the researchers solved the three-dimensional crystal structure of the element, they found that it had a unique tertiary structure. (sciencedaily.com)
PrPSC accumulates in compact, protease-resistant aggregates within neural tissue and has a different secondary and tertiary structure from PrPC, but an identical primary sequence. (biolegend.com)

This group of genes code for proteins found on the surfaces of cells that help the immune system recognize foreign substances. (medscape.com)

Already, the European Medicines Evaluation Agency (EMEA) [3], expects manufacturers to be able to demonstrate comparability between pre- and post-change medicinal products that contain biologically derived proteins as active ingredients. (pharmamanufacturing.com)

We investigated the functionality of the Jak1 SH2 domain by stably reconstituting Jak1-defective human fibrosarcoma cells U4C with endogenous amounts of Jak1 in which the crucial arginine residue Arg466 within the SH2 domain has been replaced by lysine. (uni.lu)
Moreover, the SH2 R466K mutation does not affect the subcellular distribution of Jak1 as assessed by cell fractionation and confocal microscopy of cells expressing endogenous levels of non-tagged or a yellow fluorescent protein (YFP)-tagged Jak1-R466K, respectively. (uni.lu)

risk of esophageal squamous cell carcinoma. (who.int)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)

Nacre and Biodentine were reported as a stimulator of TGF-ß1 expression to induce tertiary dentin formation. (rjptonline.org)
To evaluate the ability of Nacre and Biodentine in inducing the TGF-ß1 expression of tertiary dentin formation. (rjptonline.org)
Researchers have also proposed roles for PrP in cell signaling or in the formation of synapses. (biolegend.com)

Storage protein 2 (SP2) not only is an important source of energy for the growth and development of silkworm but also has inhibitory effects on cell apoptosis. (hindawi.com)

However, for a discrete number of patients whose results are uninformative, it may be possible to get a more definitive answer about the consequences of a variant using additional methods like RNA sequencing, protein analysis and predictive or functional studies. (jax.org)
Most proteins must fold into defined three-dimensional structures to gain functional activity. (nature.com)
We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. (lu.se)

Polypeptides and their specific amino acid groups have similarities in structure, but they are linked by electron-sharing bonds or covalent bonds. (vedantu.com)

disulfide bridge bonds hold proteins together. (visionlearning.com)
Prior to Sanger's major discoveries, biochemists learned about a feature in proteins called a disulfide bridge (Figure 3). (visionlearning.com)
They also found that treatment with chemicals called reducing agents severs a disulfide bridge between two cysteines and also causes a large proteins to split into smaller proteins, arguing that these bonds exist in proteins to help hold them together. (visionlearning.com)
The cuticle comprises 8-10 layers of flat, overlapping cells stabilized and held in place by disulfide bonds. (naturalmedicinejournal.com)
The disulfide bonds impart covalent bonding between adjacent protein chains and confer rigidity to the hair structure. (naturalmedicinejournal.com)

Proteins happen to be vital in contracting muscles, the immune system, and transporting oxygen. (vedantu.com)
Bactericidal/permeability increasing protein (BPI) is known as the important arm of the innate immune system that provides the first line of defense against various gram-negative bacterial infections in mammalians. (innspub.net)
A significant increase in humoral immune response against Mce protein was also observed in vaccinated goats. (bvsalud.org)

Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
The sensitivity of the SAXS-TT method to small differences in periodicity of the myelin structure also enables it to distinguish between the central and peripheral nervous system (CNS/PNS) myelin. (stanford.edu)

Spider silk, hemoglobin, keratin in your nails and hair, actin and myosin in muscle fibers - all these are proteins . (visionlearning.com)

The general structure of an amino acid. (visionlearning.com)

Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
Genes are contained in chromosomes in the cell nucleus and mitochondria. (msdmanuals.com)

The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
True stem cells are both pluripotent-that is they can give rise to all cell types-and capable of self-renewal. (justia.com)
Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
Dr. Patterson, thank you for taking the time to participate in our webinar, and for sharing your expertise in stem cells, and helping our audience get a better understanding of stem cells and tissue regeneration. (chiroeco.com)
I will go through these BMPs and their stem cell signaling pathway, and then we're going to talk about just principles of bone and cartilage. (chiroeco.com)
So one is to activate stem cells and the second is to regenerate tissue. (chiroeco.com)
He has an extensive track-record in quantitative proteomics, introducing metabolic stable isotope labeling in multicellular organisms such as Drosophila and C. elegans, using SILAC for studying stem cell and B cell differentiation, and stable isotope labeling by using chemical approaches, for example to follow differential pTyr phosphorylation in differentiating stem cells. (uu.nl)
Carbapenem-resistant Klebsiella pneumoniae colonization and infection is associated with lower overall survival in a cohort of haematopoietic stem-cell transplantation patients: mechanism of resistance and virulence by whole-genome sequencing. (cdc.gov)

Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)

Overexpression of Nischarin alters actin organization and inhibits Rac-driven cell migration and tumour cell invasion. (nih.gov)
The secondary and tertiary structures of destrin are similar to the gelsolin family which is another actin-regulating protein family. (wikipedia.org)

This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)

The Heck laboratory is also a pioneer in macromolecular or native mass spectrometry, which enable the analysis of intact protein assemblies by mass spectrometry. (uu.nl)

Superficial lesions consist of dilated lymph vessels lined by flat endothelial cells in a discontinuous layer immediately subjacent to the oral epithelium. (medscape.com)

Anatomy6

Organisms10

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology1

Phenomena and Processes85

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science33

Health Care11

Receptors4

Quaternary structure3

Structural9

Metabolism1

Peptides2

Biological5

Molecules11

Lymphoid structures1

Complexes7

Polypeptide5

Secondary tertiary2

Humans3

Isoforms3

Binding8

Synthesis4

Gene9

Peptide1

Antigen2

Family of proteins1

Surface3

Interactions3

Receptor6

Complex11

Proliferation2

Binds2

Folding and aggregation2

Polymers2

Mouse IgG2a1

Biology3

Kinase3

Subunits1

Diseases3

Oxidative stress4

Sequence4

Substances1

Biologically1

Endogenous2

Squamous cell carc3

Formation3

Inhibitory1

Functional3

Specific amino acid1

Disulfide5

Immune3

Peripheral7

Muscle fibers1

Amino acid1

Genes2

Stem13

Differentiation2

Actin2

Tissue and organ1

Mass spectrometry1

Endothelial cells1