Cells drug synergism. Medical search. Frequent questions

Effects of RAD001 and letrozole (alone and in combination) on the proliferation and survival of MCF7/Aro and T47D/Aro cells were evaluated using proliferation assays, flow cytometry, immunoblotting, and apoptosis analyses. (aacrjournals.org)
End points are proliferation, cell cycle allocation, induction of apoptosis and necrosis. (uni-marburg.de)
Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by TCEE. (hindawi.com)
This TCEE also demonstrates antitumor properties such as the induction of cell cycle arrest and activation of apoptosis on human colon, lung, melanoma, osteosarcoma, and pancreatic cancer cells [ 16 - 19 ]. (hindawi.com)
As a consequence of treatments, the most frequent mechanism of cell death is apoptosis, followed by autophagy. (frontiersin.org)
Sphingolipids are remarkably diverse and have crucial roles in maintaining barrier function and fluidity, as well as regulating the cell cycle, cell motility, differentiation, adhesion, and apoptosis ( 1 ). (frontiersin.org)
Ibudilast showed modest anti-proliferative activity however, when combined with TMZ, significant synergism was observed, resulting in cell cycle arrest and apoptosis. (nature.com)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
A substantial synergistic interaction between Amy and Sor was observed (CI 50 = 0.56), which was connected to cell cycle arrest at the S and G2/M stages and increased apoptosis and potential necroptosis. (biomedcentral.com)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
Furthermore, the combination of cisplatin and pirfenidone in NSCLC cells (A549 and H157 cells) leads to increased apoptosis and synergistic cell death. (biomedcentral.com)
FoxM1 inhibitor, thiostrepton, induces apoptosis in cancer cell lines and enhances sensitivity to cisplatin in these cells. (unm.edu)
We showed that RNAi-mediated knockdown of SPHK1 inhibits cell proliferation and induces apoptosis in both breast CSCs and non-CSCs, while ectopic expression of SPHK1 enhances breast CSC survival and mammosphere forming efficiency. (strath.ac.uk)
This proadifen-MTX synergism was also mediated by the inhibition of various cellular proteins engaged in apoptosis, including Mc-1, Bcl-xL, survivin and activation of procaspase-3. (spandidos-publications.com)
We examined the impacts of miR-1825 deregulation on the cancer-associated phenotypes using in vitro tests evaluating cell viability, clonogenicity, cell migration, invasion, apoptosis, and stem cell characteristics. (bvsalud.org)
Enhanced apoptosis was correlated with loss of pro-survival factors (XIAP, bcl-2, bcl-xL), expression of pro-apoptotic markers (caspases 3/7, PARP cleavage) and enhanced cell cycle regulators p21 and p27. (biomedcentral.com)
In cisplatin-resistant cell lines, BT potentiated cisplatin-induced cytotoxicity at most drug ratios via enhanced ROS generation and modulation of key regulators of apoptosis. (biomedcentral.com)

Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNγ production, and elicited durable immunologic memory upon tumor rechallenge. (aacrjournals.org)
The reported synergism of the precursor spectinomycin with other antibiotics prompted us to examine whether spectinamides sensitize M. tuberculosis to other antibiotics not traditionally used in the treatment of tuberculosis to potentially expand therapeutic options for MDR/XDR Tuberculosis. (uzh.ch)
The effectiveness or lack of a major therapeutic effect of sphingolipid modulation by some drugs as a cancer therapy and other aspects related to their mechanism of action are discussed in this review. (frontiersin.org)
Methods Demographic, clinical and pharmacological variables, including tacrolimus whole blood concentrations obtained from therapeutic drug monitoring and data from dense-sampling pharmacokinetic profiles, were recorded in 26 paediatric patients with biliary atresia who underwent liver transplantation between 2016 and 2021. (unav.edu)
New Therapeutic Procedure To Eliminate Cancer Cells Infiltrated In Brain. (usherbrooke.ca)
Thus, therapeutic approaches which can effectively target CSCs and tumour cells could be the key towards efficient tumour treatment. (strath.ac.uk)
Zhoujiang Chen,a,b Zhanlin Zhang,a Maohua Chen,a Songzhi Xie,a Tao Wang,a Xiaohong Lia,* The term synergism means that the overall therapeutic benefits should be greater than the sum of the effects of individual agents and that the optimal therapeutic efficacy can be achieved at reduced doses. (statsignals.com)
Drug combinations have become a standard regimen in clinical practice to treat multi-factorial diseases and address the limitations of single-drug therapy.1 Drugs that are typically used in combination act through different therapeutic mechanisms to produce complementary and synergistic effects, thus strengthening the treatment outcome.2 In addition, liposomes, nanoparticles and micelles have been developed to enhance drug accumulation in tumors and retard the drug resistance. (statsignals.com)
The ototoxicity of therapeutic drugs has been recognized since the nineteenth century. (cdc.gov)
The most clinically important interactions involve drugs with a low therapeutic ratio (ie, toxic levels are close to therapeutic levels). (msdmanuals.com)
In order to mitigate the side effects and resistance resulting from cisplatin-based chemotherapy, it is essential to investigate new drugs which are non-toxic and work in alternative/similar pathways to cisplatin, thus providing additional therapeutic options in ovarian cancer. (biomedcentral.com)

The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)
This low survival may result from the metastasis of cancer cells and arising resistance to drugs. (oncotarget.com)
We identified STAT1 and IFN signalling as key regulatory targets of SPHK1 and demonstrated that an important mechanism by which SPHK1 promotes cancer cell survival is through the suppression of STAT1. (strath.ac.uk)
In conclusion, we provide important evidence that SPHK1 is a key regulator of cell survival and proliferation in breast CSCs and non-CSCs and is an attractive target for the design of future therapies. (strath.ac.uk)
We catalog both SV breakpoint patterns involving patient survival and genes with nearby SV breakpoints associated with increased cell dependency in cancer cell lines. (bvsalud.org)
Accordingly, Stat3 is needed for endothelial cell survival and their arrangement into new vascular structures, though nuclear Stat3 correlates with enhanced VEGF expression and microvessel density in gastric cancer. (mirnaarray.com)
Drug resistance to currently used chemotherapies is the fundamental cause of recurrence and poor overall survival in ovarian cancer patients [ 1 - 3 ]. (biomedcentral.com)

Gemcitabine (Gemzar) and irinotecan (CPT-11, Camptosar) are active cytotoxic drugs against pancreatic cancer. (cancernetwork.com)
The synergism was independent of TLR-4 expression in pancreatic cancer cells. (rcsi.com)

have identified a subset of breast and ovarian cancer cell lines that show synergistic response to the combination of doxorubicin and GDC-0941, a class IA phosphatidylinositol 3-kinase (PI3K) inhibitor. (nih.gov)
SKOV-3 and BG1 were used as ovarian cancer cell lines. (uni-marburg.de)
This study supports evidence in literature pointing to a certain activity of these drugs and at the same time emphasizes the different sensibility of human ovarian cancer cell lines to targeted therapeutics in vitro. (uni-marburg.de)
Low doses of BT and cisplatin enhanced efficiency of cisplatin treatment in all the ovarian cancer cell lines tested. (biomedcentral.com)

Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
However, co-culture in vitro experiments and co-implantation in vivo experiments showed that the combination of low doses of cisplatin (10 μM) and low doses of pirfenidone (0.5 mg/mL), in both CAFs and tumors, lead to increased cell death and decreased tumor progression, respectively. (biomedcentral.com)

Drug combinations are increasingly important in disease treatments, for combating drug resistance, and for elucidating fundamental relationships in cell physiology. (embopress.org)
Further studies indicated that mismatched drug exposure profiles likely permitted induction of phenotypic clarithromycin resistance and subsequent loss of synergism. (uzh.ch)
Multidrug resistance caused by the overexpression of ABC transporter proteins in cancer cells remains a major obstacle limiting chemotherapy efficacy. (spandidos-publications.com)
Chemotherapy is one of the most common strategies in the treatment of cancer, although it is frequently unsuccessful due to the development of chemoresistance, and especially multi-drug resistance (MDR). (spandidos-publications.com)
it exposes patients to drug complications without any benefit and contributes to bacterial resistance. (msdmanuals.com)
Scholars@Duke publication: DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance. (duke.edu)
Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. (biomedcentral.com)
Subsequent treatment with second-line or third-line agents (after interim non-platinum therapy) results in less than 33% response rate due to the increase of resistance to these drugs [ 6 - 9 ]. (biomedcentral.com)

Moreover, treatment with TCEE is found to enhance the cytotoxic effects of amphotericin B in human colon cancer cell both in vitro and in vivo [ 17 ]. (hindawi.com)
Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)

These studies highlight the importance of validating in vitro synergism and the challenge of matching drug exposures to obtain a synergistic outcome in vivo. (uzh.ch)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
Thiostrepton downregulates FoxM1 expression in several cancer cell lines and enhances sensitivity to carboplatin in vivo. (unm.edu)
The indole analog inhibited ex vivo colony formations of primary bone marrow cells from heterozygous JAK2 V617F knock-in mice. (eurekaselect.com)
These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models. (researchgate.net)
In addition, we investigated the effects of miR-1825 overexpression on the tumor formation capacity of head and neck cancer cells in vivo using nude mice. (bvsalud.org)
By contrast, Stat3 abla tion in intestinal epithelium in vivo or in tumour cell lines in vitro resulted in cell cycle arrest in the G2/M transition and it is linked with histone H3 phosphorylation asso ciated mitotic arrest. (mirnaarray.com)

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. (lookformedical.com)

Our data suggest caution in the use of the standard alkaline elution technique (with 6 hrs between drug exposure and irradiation) to measure BCNU-induced DNA-ISC induction in highly BCNU-resistant cell lines. (duke.edu)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). (lu.se)

Although drugs within each class share structural and functional similarities, they often have different pharmacology and spectra of activity. (msdmanuals.com)
The great variety of drugs available in the market and the knowledge in Pharmacology would help the dentists provide comfort and demystifying the pain and fear of dental treatment. (bvsalud.org)

The combined treatment of Flavopiriol and Lonafarnib in BG1-cells showed a slightly increased cell cycle arrest in the subG1-fraction in selected concentrations. (uni-marburg.de)
In the present study, the TCEE treatment induced cell cycle arrest and suppressed cell growth on both Hep3B and HepJ5 cells. (hindawi.com)

The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
Cancer stem cells (CSCs) represent rare tumour cell populations capable of self-renewal, differentiation and tumour initiation, and are highly resistant to chemotherapy and radiotherapy. (strath.ac.uk)

The following methods were applied: at first proliferation assays with photometric analysis were conducted, then an annexin-V-detection was applied for differentiation of the treated cells in vital, necrotic and apoptotic groups. (uni-marburg.de)
Transcriptomic profiling of the organoids reveals elevated pathways involved in stem cell regeneration and differentiation such as the bone morphogenetic protein (BMP) and retinoic acid signaling (RA) pathways. (bvsalud.org)
Therefore, TGFß family signaling via SMAD2/3 controls signaling networks which are integral for endometrial cell regeneration and differentiation. (bvsalud.org)

We show for the first time that proadifen is able to enhance the cytotoxic properties of MTX in cBCRP cells, particularly through the inhibition of BCRP expression and activity. (spandidos-publications.com)
The cytotoxic effects of drugs either alone or in combination were evaluated using presto-blue assay. (biomedcentral.com)

Conclusion: This screen has identified a monoamine receptor inhibitor that can inhibit viability of cells with active TpoR or EpoR signalings. (eurekaselect.com)
Hormones and incident cell DNA and inhibit cancer cell practical list of ingredients. (nationalalgaeassociation.com)
Several compounds have been shown to inhibit the efflux activity of ABC transporters, thereby increasing intracellular drug accumulation and sensitising cancer cells to therapy. (spandidos-publications.com)
It was previously reported that proadifen (SKF-525A), a well-known cytochrome P450 monooxygenase inhibitor, not only has anti-proliferative potential in some cancer cell lines, but it is also able to inhibit BCRP and MRP1 transporter proteins ( 8 ). (spandidos-publications.com)

A number of mechanisms involved in the occurrence of MDR have been described, including the overexpression of one or more ATP binding cassette (ABC) transporter proteins that mediate the efflux of many clinically relevant drugs. (spandidos-publications.com)
We examined not just the effect of proadifen and MTX on the expression of BCRP, but we were also interested in other molecular mechanisms involved in the possible antitumour activity of proadifen alone and in combination with MTX, such as the expression of anti-apoptotic proteins, proteins involved in the regulation of BCRP and proteins involved in the reparation of chemotherapeutic drug-induced DNA damage. (spandidos-publications.com)

Drugs inhibiting these transporters have been shown to increase the anti-proliferative properties of chemotherapeutics. (spandidos-publications.com)
In our previous study, we demonstrated the anti-proliferative and pro-apoptotic activity of proadifen in the HT-29 cancer cell line ( 9 ). (spandidos-publications.com)

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant cancer type worldwide. (bvsalud.org)

In a humanized mouse non-small cell lung carcinoma model, TSR-033 boosted the antitumor efficacy of PD-1 monotherapy, with a concomitant increase in immune activation. (aacrjournals.org)
Such drug interactions are crucial for treatment efficacy, but their underlying mechanisms remain largely unknown. (embopress.org)
We employed combinatorial drug screening to identify synergistic combination partners to enhance the efficacy of venetoclax in T-PLL patients. (haematologica.org)
Micellar systems usually fail to deliver multiple drugs to target sites at synergistic doses and thus are not able to maximize the antitumor efficacy. (statsignals.com)
The efficacy of the BT-cisplatin combination depends upon the cell type and concentrations of cisplatin and BT. (biomedcentral.com)
Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug delivery in the treatment of chronic periodontitis: A placebo-controlled, split-mouth trial. (medlineplus.gov)

We analysed the combined effect of doxorubicin and enzastaurin on cell death of four melanoma cell lines, namely G361, SK-MEL3, A375 and SAN. (unina.it)
1) or additive effect (CI = 1) with all melanoma cell lines, with enzastaurin doses ≥0.6 μM and doxorubicin doses ≥1 μM. (unina.it)

We assessed the effects of individual and combined drugs administered post-infection, at a clinically relevant concentration range (10(-6)-10(-10) m), on the production of CCL5, CXCL10, CXCL8, IL-6 and the remodelling-associated VEGF and bFGF, using ELISA and RT-PCR. (nih.gov)
The combination of BUD and FORM had concentration-dependent, additive or synergistic effects in the suppression of RV-induced CCL5, CXCL8 and CXCL10 in both cell types as well as VEGF in NHBE only. (nih.gov)
When drugs are combined, their individual effects on cells may be amplified or weakened. (embopress.org)
To uncover the causes of drug interactions, we developed a systematic approach based on precise quantification of the individual and joint effects of antibiotics on growth of genome-wide Escherichia coli gene deletion strains. (embopress.org)
The aim of this study is to investigate potential synergistic effects of Flavopiridol and Lonfarnib inhibiting the proliferation of human ovarian cancer cells in vitro. (uni-marburg.de)
Analysing the results of the proliferation assays synergistic effects when combining Flavorpiridol and Lonafarnib could not be shown in SKOV3-cells but in BG1-cells. (uni-marburg.de)
Via flow cytometry in both cell lines a clear transformation of cell cycle induced by treatment with the drugs could be demonstrated, but these effects seem to be rather a single effect of flavopiridol. (uni-marburg.de)
The ethanolic extract of T. camphoratus (TCEE) which contains abundant bioactive compounds including triterpenoids and polysaccharides also has antitumor effects in various human cancer cell lines. (hindawi.com)
The aims of this preclinical study are to evaluate the capability of TCEE to suppress human hepatocellular carcinoma cells and clarify the related antitumor effects. (hindawi.com)
Since clinical trials involving ibudilast have shown no adverse side effects and the drug readily penetrates the blood brain barrier, treatment of GBM with this combination is clinically achievable. (nature.com)
Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
The effects of pirfenidone alone and in combination with cisplatin on human patient-derived CAF cell lines and non-small cell lung cancer (NSCLC) cell lines were examined. (biomedcentral.com)
Objective: A cell-based phenotypic approach to identify specific TpoR inhibitors was implemented and a library of 505,483 small molecules was screened for inhibitory effects on cells transformed by TpoR mutants. (eurekaselect.com)
Drug synergistic effects were observed when cells were stimulated to proliferate through both the IL3 and TpoR pathways. (eurekaselect.com)
We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
The effects of ions and antischistosomal drugs on adenosine- triphosphatase (ATPase) activity in Schistosoma-mansoni were investigated. (cdc.gov)
These findings reveal that cysLTs, in particular LTE(4), have a significant proinflammatory impact on T cells and demonstrate their effects on Th2 cells are mediated by a montelukast-sensitive receptor. (ox.ac.uk)
Hearing loss can occur after ingestion of certain drugs due to their effects on the peripheral auditory system or central nervous system. (cdc.gov)
Most of them (antibiotics, chemotherapeutics, diuretics, and antimalaria drugs) are used despite these negative side effects to treat other serious, sometimes life-threatening conditions. (cdc.gov)
In the developed nations, and in some developing ones, the prescription of these drugs will trigger "ototoxicity monitoring" of patients to allow early detection of auditory effects and, when necessary, audiologic interventions to address the hearing impairment (AAA 2009). (cdc.gov)
It is well known that the effects of many drugs or agents, when given concurrently, cannot necessarily be predicted on the basis of their individual effects. (cdc.gov)
The production of DNA interstrand crosslinks (ISC) by BCNU and other bifunctional alkylators and the effects of these drugs on the repair of radiation-induced DNA-single strand breaks (SSB) were studied in two human glioblastoma used to assess both DNA-ISCs and DNA-SSBs. (duke.edu)
In contrast, in cisplatin-resistant cells, BT-cisplatin combination treatment displayed synergistic effects at most of the drug ratios/concentrations. (biomedcentral.com)
Although the ototoxic effects of aminoglycosides are well documented, this class of drugs is still widely used today. (medscape.com)
Of all ototoxic drugs, the aminoglycosides are the most vestibulotoxic, although they vary greatly in their differential effects on the vestibular and cochlear systems. (medscape.com)
However, with an adeq battery of necf expsre blmarkers, prospective studies of en- vironmental effects on pregnancy outcomes might be possible. (cdc.gov)

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. (unm.edu)
In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and medulloblastoma (MB) cells. (prinsesmaximacentrum.nl)

This robustness is encapsulated in a general principle of bacterial growth, which enables the quantitative prediction of mutant growth rates under drug combinations. (embopress.org)
These results provide a new conceptual framework for the design of multidrug combinations and suggest that there are universal mechanisms at the heart of most drug interactions. (embopress.org)

Results from this study indicate that a 1599 clarithromycin combination is potentially viable, providing the drug exposures can be carefully monitored. (uzh.ch)
To this topic, lycopene had been demonstrated to have synergism from the combination of oxaliplatin in a human ovarian cancer cell line ( 20 ), suggesting that the adjuvant property on the anticancer of lycopene. (frontiersin.org)
Cisplatin is a platinum-based chemotherapeutic drug that has been used as the standard of care in late stages of NSCLC in combination with paclitaxel, vinorelbine, gemcitabine, docetaxel, pemetrexed, or irinotecan [ 20 ]. (biomedcentral.com)
In addition, rhodomycin A rendered gefitinib-resistant lung adenocarcinoma cells more sensitive to gefitinib treatment, implying a synergistic effect of the combination therapy. (oncotarget.com)
Drug combination treatment study was performed using ruxolitinib and the indole analog. (eurekaselect.com)
Combination of the two drugs resulted in increase in caspase 3 and 8 activation, in comparison with activation by single agents. (unina.it)
In combination, synergism may be schedule dependent. (cancernetwork.com)
The most potent extracts was tested along with gemcitabine using our established drug combination analysis. (rcsi.com)
Synergism is usually defined as a more rapid and complete bactericidal action from a combination of antibiotics than occurs with either antibiotic alone. (msdmanuals.com)

4 Here ibrutinib demonstrated the strongest synergism with venetoclax, whereas cisplatin appeared the most antagonistic ( Figure 1B and C, Online Supplementary Figure S1B ). (haematologica.org)
In cisplatin-sensitive cell lines, BT and cisplatin were mostly antagonistic except when used at low concentrations, where synergy was observed. (biomedcentral.com)

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. (frontiersin.org)

The analogs showed about five-fold preferential inhibition of cell viability towards Ba/F3 cells expressing the TpoR W515L mutation compared to the parental cells. (eurekaselect.com)

In vitro models of RV infection of BEAS-2B and primary normal human bronchial epithelial (NHBE) cells were used. (nih.gov)
BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, synergistic or additive manner. (nih.gov)
C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells. (oregonstate.edu)

The tumor microenvironment or tumor stroma comprises various cell types, including cancer-associated fibroblasts (CAFs), immune cells, endothelial cells, and mesenchymal cells. (biomedcentral.com)
It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)

We found that drug interactions between antibiotics representing the main modes of action are highly robust to genetic perturbation. (embopress.org)
Drug interactions between antibiotics are highly robust to genetic perturbations. (embopress.org)
Whole cell synergy checkerboard screens were performed using the laboratory strain M. tuberculosis H37Rv, lead spectinamide 1599, and a broad panel of 27 antibiotics. (uzh.ch)
Also, other drugs can increase or decrease levels of antibiotics. (msdmanuals.com)

Review of anti-ageing industry practices discontinuing treatment helps chlorpropamide by pharmacodynamic synergism. (nationalalgaeassociation.com)

There was no significant difference in inhibition of cell viability between the TpoR wild type and the TpoR W515L mutant cells. (eurekaselect.com)

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)

Today there are many well known ototoxic drugs used in clinical situations. (cdc.gov)
Permanent hearing loss or balance disorders caused by ototoxic drugs may have serious communication, educational, and social consequences. (medscape.com)
Therefore, the benefits of ototoxic drugs must be weighed against the potential risks, and alternative medications should be considered when appropriate. (medscape.com)

Because mitoxantrone (MTX) is a strong BCRP substrate and is often used in the treatment of leukemia, we investigated the effect of 24 h proadifen pre-treatment on the cytotoxicity of MTX in leukemic cell lines that are sensitive to MTX (HL-60) and MTX-resistant ABCG2-overexpressing subclone (cBCRP). (spandidos-publications.com)

Pirfenidone alone induced apoptotic cell death in lung CAFs at a high concentration (1.5 mg/mL). (biomedcentral.com)
Addition of the pan-caspase inhibitor zVAD.fmk significantly decreases GANT61/A-1210477-stimulated cell demise, indicating apoptotic cell death. (prinsesmaximacentrum.nl)

PGD(2) exerts a number of proinflammatory responses through a high-affinity interaction with chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and has been detected at high concentrations at sites of allergic inflammation. (ox.ac.uk)

The objective of this review was to analyze the results from preclinical and clinical trials of these drugs for the treatment of cancer. (frontiersin.org)
Aslthough all these drugs have produced good results in preclinical studies of multiple cancers, the outcomes of clinical trials have not been similar. (frontiersin.org)
Twenty-four candidate compounds were selected based on their clinical approval status, literature data, and mechanisms of drug action. (haematologica.org)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
We found that miR-1825 expression is upregulated in head and neck cells and clinical tumor samples in comparison to corresponding controls, where it potentially acts as an oncogene. (bvsalud.org)
We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future. (lu.se)

In this study, we showed that MDM2 inhibitor Nutlin-3 upregulated p53 protein and downregulated FoxM1 expression in several cancer cell lines with wild type TP53 but not in cell lines with mutant TP53. (unm.edu)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
prostate cancer cell lines and a synergistic effect between both was also o bserved. (researchgate.net)

Rare violations of this principle exposed recurring cellular functions controlling drug interactions. (embopress.org)
In particular, we found that polysaccharide and ATP synthesis control multiple drug interactions with previously unexplained mechanisms, and small molecule adjuvants targeting these functions synthetically reshape drug interactions in predictable ways. (embopress.org)
Rare violations of this principle expose cellular functions that control drug interactions and can be targeted by small molecules to alter drug interactions in predictable ways. (embopress.org)
Rare violations of this principle expose cellular functions that control drug interactions. (embopress.org)
Diverse drug interactions are controlled by recurring cellular functions, including LPS synthesis and ATP synthesis. (embopress.org)

We repurposed ibudilast, a specific MIF inhibitor, and treated patient derived cell lines. (nature.com)
However, it was found that pancreatic ductal adenocarcinoma, PDAC (AsPC1, BxPC3 and SW1990) were the cell lines most sensitive cell lines to SN extracts. (rcsi.com)
There was no enhancement of radiation-induced DNA-SSBs in both cell lines after treatment with cis-DDP, CHZ, or MNU. (duke.edu)

For example, in the "test tube", the organism is exposed to the same conditions, including drug concentrations throughout the incubation period, a situation which does not occur in the patient. (vin.com)
Among the most problematic concern is the fact that determination and interpretation of minimum inhibitory concentrations (MIC and MIC BP ) are based on assumed plasma drug concentrations (PDC), yet infections generally are located in extracellular fluid (ECF) and occasionally intracellular. (vin.com)

Line 177: the fact that DMSO concentration was not constant through out the experiments may affect the results as DMSO alone at high concentration can affect cell viability. (peerj.com)
Preferential inhibition of viability was observed in Ba/F3 cells expressing erythropoietin receptor (EpoR) when stimulated with Epo compared to stimulation with interleukin-3 (IL3). (eurekaselect.com)

Properties and drug sensitivity of adenosine triphosphatases from Schistosoma mansoni. (cdc.gov)

Lonafarnib inhibits the farnesylation of H-Ras and the attachment of Ras to the cell membrane. (uni-marburg.de)
Human promyelocytic leukemia cell line HL-60 was purchased from the American Type Culture Collection (ATCC, Rockville, MD, USA) and its ABCG2-overexpressing subclone (here referred to as cBCRP) was kindly provided by Dr Balazs Sarkadi (Membrane Research Group, Hungarian Academy of Sciences, Budapest, Hungary) ( 10 ). (spandidos-publications.com)

FLT3 ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. (biomedcentral.com)
BCRP expression was detected in several different solid tumours ( 1 - 5 ), as well as in malignant hematopoietic and lymphoid cells ( 6 ). (spandidos-publications.com)

We find that NFATC1 governs FLT3 ITD -driven precursor cell expansion and transformation, causing a fully penetrant lethal AML. (biomedcentral.com)

Therefore, a combined therapy that targets both the tumor cell and the CAFs might lead to novel therapies in cancer. (biomedcentral.com)
Hyaluronic acid (HA) is conjugated with CPT or TOS-TPP via disulfide linkages for tumor cell targeting and intracellular reduction-triggered release. (statsignals.com)

2014. Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. . (oregonstate.edu)
The intradermal route has the potential to be an outstanding route of vaccination due to the localization of potent antigen present cell (APC) and other immune cells in the dermis. (pulsusconference.com)
Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)

Treatment of MCF7/Aro cells with estradiol or androstenedione caused modulation of the mTOR pathway, a phenomenon reversed by letrozole or RAD001. (aacrjournals.org)
It is known that adjuvant is defined as a substance that helps and enhances the effect of a drug or treatment ( 19 ). (frontiersin.org)
Anti-fibrotic drugs such as pirfenidone have been developed for the treatment of idiopathic pulmonary fibrosis. (biomedcentral.com)
In 2011, pirfenidone was the first drug approved in Europe for the treatment of idiopathic pulmonary fibrosis [ 18 ] following its approval in the United States in 2014. (biomedcentral.com)
however, nearly all cases eventually relapse, and allogeneic stem cell transplantation remains the only curative treatment option for a small subset of patients. (haematologica.org)
Indeed, BIM proved to be required for GANT61/A-1210477-induced cell death, as genetic silencing of BIM using siRNA significantly rescues cell death upon GANT61/A-1210477 co-treatment. (prinsesmaximacentrum.nl)
Moreover, BCRP is very often upregulated in cells undergoing mitoxantrone (MTX) treatment ( 7 ). (spandidos-publications.com)
In the 1940s, permanent damage to the cochlea was reported in several patients treated with the newly discovered drug for treatment of tuberculosis, the aminoglycoside antibiotic streptomycin (Hinshaw and Feldman 1945). (cdc.gov)
BCNU-treated UWR2 and UWR3 cells showed a significant BCNU dose-dependent increase in radiation-induced DNA-SSBs at 6 hrs post-drug treatment, and at 100 microM BCNU DNA-ISC was completely masked in UWR2 cells. (duke.edu)

Lymphocyte activation gene-3 (LAG-3) is a coinhibitory receptor associated with impaired T-cell function and is frequently coexpressed with programmed cell death protein-1 (PD-1) in the context of human cancers. (aacrjournals.org)
We have generated a high affinity and selective humanized monoclonal IgG4 antibody, TSR-033, which binds human LAG-3 and serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. (aacrjournals.org)
IRE1α-XBP1 were essential for expansion of activated mouse and human NK cells and are situated downstream of the mammalian target of rapamycin signaling pathway. (cancerindex.org)
Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2. (ox.ac.uk)
Because cysteinyl leukotrienes (cysLTs) are also produced during the allergic response, we investigated the possibility that cysLTs may modulate the response of human Th2 cells to PGD(2). (ox.ac.uk)

The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)

Anatomy4

Organisms5

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes18

Technology, Industry, Agriculture1

Information Science2

Apoptosis17

Therapeutic11

Survival7

Pancreatic cancer2

Ovarian cancer cell lines4

Tumors2

Resistance8

Vitro and in vivo2

Vivo7

Neoplasms1

Induction2

Metastasis4

Pharmacology2

Cycle arrest2

Chemotherapy5

Differentiation3

Cytotoxic2

Inhibit4

Proteins2

Anti-proliferative2

Squamous cell carc1

Efficacy6

Doxorubicin2

Effects26

Induces2

Combinations2

Combination9

Cisplatin2

Sphingolipids1

Mutation1

Epithelial3

Endothelial cells2

Antibiotics4

Pharmacodynamic1

Inhibition of cell1

Neoplastic1

Ototoxic drugs3

Cytotoxicity1

Apoptotic2

Inflammation1

Clinical6

Cancer cell3

Interactions5

Lines3

Concentrations2

Viability2

Sensitivity1

Membrane2

Hematopoietic2

Precursor1

Tumor cell2

Immune3

Treatment9

Human5

Proliferate1