Cell line tumor. Medical search. Frequent questions

Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Benign and malignant tumors of muscle and other mesenchymal origin usually do not distinguish themselves from other malignancies based on appearance alone. (radiologykey.com)
Boron neutron capture therapy (BNCT) is a promising method for treating tumors, in particular, infiltrative malignant tumors, due to the selective destruction of tumor cells without damaging the surrounding normal tissues. (isnct.net)
Rare malignant tumors require resection, as well as, possibly, adjunctive therapy and referral to an oncologist. (medscape.com)
Surgery is the primary treatment of malignant tumors of the salivary glands. (medscape.com)
Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)

EGFR-ERK signaling act downstream of berberine/pro-inflammatory cytokines axis to regulate CACRC cell proliferation. (nih.gov)
In vivo, poly(I:C) treatment increased intratumoral chemokine expression, NK-cell activation and tumor infiltration, and proliferation of tumor-infiltrating T and NK cells. (nih.gov)
Proliferation of tumor parenchyma cells was decreased. (nih.gov)
We showed that overexpression of DKK3 can decrease cell invasion, proliferation, and colony forming ability of GBC cells. (amrita.edu)
Decreasing RT activity in cancer cells, by either LINE-1-specific RNA interference, or by RT inhibitory drugs, was previously found to reduce proliferation and promote differentiation and to antagonize tumor growth in animal models. (unife.it)
Remarkably, hybrid molecules fail to form in tumor cells treated with EFV under the same conditions that repress proliferation and induce the reprogramming of expression profiles of coding genes, microRNAs (miRNAs) and ultraconserved regions (UCRs). (unife.it)
IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
Silence of miR-769-5p conspicuously suppresses glioma cell proliferation and fosters cell apoptosis [ 8 ]. (hindawi.com)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Cell proliferation was determined by trypan blue dye exclusion test. (biomedcentral.com)
In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose dependent manner and induced apoptosis. (biomedcentral.com)
Thereafter, the downstream signaling pathways are activated promoting cell proliferation and/or survival. (biomedcentral.com)
The Wnt pathway is known as to become evolutionally conserved and regulates many natural procedures extremely, including cell axis formation, cell proliferation, cell migration, cell morphology, and organ advancement [2C4]. (thetechnoant.info)
Furthermore, the nuclear -catenin binds to lymphoid enhancer binding aspect (LEF) and T-cell aspect (TCF) and activates the transcription of its focus on genes, which regulate cell proliferation, invasion and migration [6, 26, 27]. (thetechnoant.info)
Here we survey a deubiquitination enzyme, USP20, regulates individual cancer tumor cell proliferation, L-Homocysteine thiolactone hydrochloride migration, invasion, and response to healing medications through the -catenin pathway. (thetechnoant.info)
Furthermore, USP20 regulates individual cancer tumor cell proliferation, tumorigenesis, and chemoresistance within a -catenin-dependent way. (thetechnoant.info)

Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
ICE is a bispecific engager of CD16A+ natural killer (NK) cells and macrophages and tumor antigens. (onclive.com)
We show herein the retrospective application of a prediction algorithm to a large set of bona fide T cell-defined mutated human tumor antigens that induced immune responses, most of which were associated with tumor regression or long-term disease stability. (broadinstitute.org)
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)

Primary tumors: most of these tumors are benign and slow growing. (medlineplus.gov)
Childhood extracranial germ cell tumors may be benign or malignant. (cigna.com)
Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
Most of these tumors are benign teratomas in the sacrum or coccyx. (cigna.com)
Carcinoid Tumors and Carcinoid Syndrome Carcinoid tumors are noncancerous (benign) or cancerous (malignant) growths that sometimes produce excessive amounts of hormone-like substances (such as serotonin), resulting in the carcinoid. (msdmanuals.com)
Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)

Medium (200 mm 3 ) and large (800 mm 3 ) tumors were collected and tumor composition was determined by flow cytometry. (genoway.com)
Peripheral blood mononuclear cells (PBMCs) of various healthy donors were plated in the upper compartment and after six hours the transwell migration was quantified by flow cytometry. (bmj.com)
Here we investigated the characteristics of a population of pancreatic cancer tumorspheres derived from different human pancreatic cancer cell lines and a primary line from a genetically engineered KPC mouse model, using flow cytometry and western blotting to analyse surface and stemness markers. (lu.se)
Enzyme-linked immunoabsorbent analysis of the amount of IL-2 secreted into the medium by transfected tumor cells correlated with the percentage of tumor cells expressing intracellular IL-2 as measured by flow cytometry. (arizona.edu)

An in vitro study on cell lines identified that berberine treatment of Raw 264.7 macrophages resulted in conditioned media with fewer proliferative effects on a cell line with a heterozygous Apc mutation (Immorto-Min colonic epithelium, IMCE). (nih.gov)
HCC cell death, and natural killer (NK) cell activation and cytotoxicity were assessed in vitro after treatment with the TLR3 ligand poly(I:C). The effect of TLR3 on the tumor parenchyma and infiltrating immune cells was investigated in a spontaneous liver tumor mouse model and a transplanted tumor mouse model (n = 3-9 mice per group). (nih.gov)
Although the link between the cancer and metabolism was observed in the early days of cancer research by Otto Heinrich Warburg, which is also known as Warburg hypothesis, not much substantial research was carried out until the late 1990s because of the lack of in vitro tumor models and the difficulty in creating environments that lack oxygen. (wikipedia.org)
We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
We created an in vitro model of acquired cisplatin resistance by long term exposure of three well established germ cell tumor cell lines to cisplatin, resulting in sublines with significantly increased resistance to cisplatin. (biomedcentral.com)
Our studies optimize in vitro transfection of primary tumor cells using cationic lipids and a plasmid encoding the gene for human interleukin-2 (IL-2). (arizona.edu)
Natural News) In this study, researchers from The First Hospital of China Medical University evaluated the anti-tumor effect and mechanism of action of elemene on pancreatic carcinoma in vitro and in vivo. (naturalnews.com)
To evaluate the biological behavior of carcinomas in vitro, permanent tumour cell lines are required. (elsevierpure.com)

More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
Recent reports have shown that the sensitivity of non-small-cell lung cancer cell lines to EGFR inhibitors such as erlotinib (Tarceva, OSI Pharmaceuticals) is dependent on inhibition of the phosphatidylinositol 3′-kinase-phosphoinositide-dependent kinase 1-Akt-mTOR pathway. (aacrjournals.org)
Therefore, inhibiting EGFR alone may not be sufficient for substantial inhibition of all tumor cells, highlighting the need for multipoint intervention. (aacrjournals.org)
Therefore, in select cell lines, inhibition of both S6 and Akt was achieved only with the combination of erlotinib and rapamycin. (aacrjournals.org)
Intraperitoneal administration of IL-15cx results in a moderate inhibition of breast cancer growth that is associated with an increase in the frequency of cytotoxic CD8 T cells and the improvement of their function. (frontiersin.org)
Systemic and local administration of IL-15cx shows two distinct therapeutic responses, a moderate tumor growth inhibition or heterogeneous tumor regressions with survival improvement. (frontiersin.org)
Therefore, to search for indole compounds with more efficacy and less side effect for cancer therapy, we developed a novel indole compound SK228 and examined its effects and mechanisms on antitumor growth and invasion inhibition in cell and tumor xenografts in nude mice models. (ntnu.edu.tw)

Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Hypoxic adaptation by cancer cells is essential for survival and progression of a tumor. (wikipedia.org)
It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). (whiterose.ac.uk)
Furthermore, there is an absence of a cellular hierarchy in cell lines and all cells in culture are able to drive tumor progression. (whiterose.ac.uk)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
The European Commission's approval of KEYTRUDA plus chemotherapy for the treatment of certain patients with esophageal and HER2-negative GEJ cancer provides a new option in the first-line setting that has shown significant improvements in progression-free and overall survival. (merck.com)
However, the effectiveness of cfDNA versus standard single-lesion tumor biopsies has not been directly compared in larger-scale prospective cohorts of patients following progression on targeted therapy. (broadinstitute.org)
The RET kinase inhibitor selpercatinib (Retevmo) more than doubled progression-free survival (PFS) compared with standard chemotherapy with or without pembrolizumab (Keytruda) in the first-line setting among patients with RET fusion advanced/metastatic non-small cell lung cancer (NSCLC). (medscape.com)

In this analysis, investigators evaluated the ability of AFM24 to elicit antibody-dependent cellular phagocytosis in solid tumor cell lines expressing EGFR wild-type or EGFR signaling pathway mutations. (onclive.com)
A solid tumor developed at the site of injection after 1 month (red arrow). (rochester.edu)
Multiple solid tumor types were successfully transfected, but normal blood mononuclear cells and leukemic blasts were resistant to transfection. (arizona.edu)

Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. (cigna.com)
This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). (cigna.com)
Extracranial germ cell tumors are most common in adolescents, with rates in this age group lower for females than males. (cigna.com)
For information on intracranial (inside the brain) germ cell tumors, see Childhood Central Nervous System Germ Cell Tumors Treatment. (cigna.com)
Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
Malignant extracranial germ cell tumors are tumors that form outside the brain. (cigna.com)
Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (cigna.com)
Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
Testicular germ cell tumors in adolescents (11 years and older) and young adults are different from those that form in early childhood. (cigna.com)
Ovarian germ cell tumors are more common in adolescent girls and young women. (cigna.com)
Extragonadal extracranial germ cell tumors form in areas of the body other than the brain or gonads (testicles and ovaries). (cigna.com)
Most extragonadal extracranial germ cell tumors form along the midline of the body. (cigna.com)
In children younger than 11 years, extragonadal extracranial germ cell tumors usually occur at birth or in early childhood. (cigna.com)
In older children, adolescents, and young adults (11 years and older), extragonadal extracranial germ cell tumors are often in the mediastinum. (cigna.com)
Moreover, we describe for the first time an association of the up-regulation of micro-RNA species such as hsa-miR-512-3p/-515/-517/-518/-525 and down-regulation of hsa-miR-99a/-100/-145 with a cisplatin resistant phenotype in human germ cell tumors. (biomedcentral.com)
Our approach was designed to characterize the role of micro-RNAs on the presumably multifactorial phenomenon of acquired cisplatin resistance in germ cell tumors. (biomedcentral.com)
Germ cell tumors of the brain include germinoma, teratoma, embryonal carcinoma and yolk-sac tumors. (cincinnatichildrens.org)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
However, whether the anti-inflammatory effect of berberine contributes to its anti-tumor effect on colitis-associated colorectal cancer (CACRC) remains unknown. (nih.gov)
High amount of aerobic glycolysis (also known as the Warburg effect) distinguishes cancer cells from normal cells. (wikipedia.org)
Rather than oxidizing glucose for ATP production, glucose in cancer cells tends to be used for anabolic processes, such as ribose production, protein glycosylation and serine synthesis. (wikipedia.org)
In this regard, cancer cells and stromal cells can symbiotically recycle and maximize the use of nutrients. (wikipedia.org)
In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed that alterations in whole-organism metabolism such as obesity are associated with heightened risks for a variety of cancers. (wikipedia.org)
LINE-1 are poorly expressed in normal cells and abundantly in cancer cells. (unife.it)
Using CsCl density gradients, we selectively identify Alu and LINE-1 containing DNA:RNA hybrid molecules in cancer but not in normal cells. (unife.it)
In cancer cells the abundant RT reverse-transcribes retroelement-derived mRNAs forming RNA:DNA hybrids. (unife.it)
The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)
The depletion of myeloid-derived suppressor cells (MDSCs) has no impact on mouse breast cancer growth. (frontiersin.org)
One of these poorly immunogenic tumors is breast cancer with response rates of only 0%-18.5% to CPI therapy alone ( 2 - 4 ). (frontiersin.org)
PD-L1 is expressed mainly on tumor-infiltrating immune cells in roughly 41% of patients with triple negative breast cancer ( 5 ). (frontiersin.org)
Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Multifunctional magnetic iron-oxide nanoparticles (IONPs) can be directly imaged by magnetic resonance imaging (MRI) and designed to therapeutically target cancer cells. (oncotarget.com)
Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. (bmj.com)
Secondary tumors or metastasis: these tumors are cancer cells coming from other areas of the body. (medlineplus.gov)
Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. (lu.se)
In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. (lu.se)
The sensitivity of the test results depends on the ability to completely lavage all regions of the peritoneal cavity and to detect cancer cells being shed into the peritoneal cavity by the tumor. (medscape.com)
Only the has-miR-10b involved in breast cancer invasion and metastasis and has-miR-512-3p appeared to be up-regulated (2-3-fold) in all three cell lines. (biomedcentral.com)
Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent widely used in the treatment of several solid tumors, among them testicular cancer, lung cancer, breast cancer, and bladder cancer. (biomedcentral.com)
Atypical teratoid rhabdoid tumor (ATRT) is a rare and aggressive type of cancer that can appear in the brain or spinal cord. (cincinnatichildrens.org)
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)
We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
Cancer vaccines that utilize genetically modified tumor cells require gene transfer methods capable of producing immunostimulatory doses of transgenes from fresh or short-term cultures of human tumor cells. (arizona.edu)
The effect of p53 gene therapy on chemosensitivity and apoptotic response of PANC-1 tumor cells, which express high amount of mutant p53, to cancer chemotherapeutic agents of Etoposide and Doxorubicin was investigated. (ijbiotech.com)
Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)
It is estimated approximately 5-15% of colorectal cancer patients have tumors that score as either MSI-H or dMMR when testing is performed. (merck.com)
Colorectal cancer often begins with growths on the inner lining of the colon or rectum called polyps, which can change into cancer over time. (merck.com)
There are several types of lung cancer, but non-small cell (NSCLC) is the most common form. (naturalnews.com)
According to a study published in Nature Cell Biology, activating transcription factor 4 (ATF4) could be the key to conquering cancer. (naturalnews.com)
Cancer genome sequencing has enabled the rapid identification of the complete repertoire of coding sequence mutations within a patient's tumor and facilitated their use as personalized immunogens. (broadinstitute.org)
We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). (broadinstitute.org)
During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor subclones harboring unique resistance mechanisms in an individual patient. (broadinstitute.org)
Molecular and functional profiling of cancer cell lines is subject to laboratory-specific experimental practices and data analysis protocols. (ntnu.no)
The current challenge therefore is how to make an integrated use of the omics profiles of cancer cell lines for reliable biological discoveries. (ntnu.no)
We demonstrated the power of the integrative analyses by identifying a novel driver gene, ECHDC1, with tumor suppressive role validated both in breast cancer cells and patient tumors. (ntnu.no)
The multi-modal meta-analysis approach also identified synthetic lethal partners of cancer drivers, including a co-dependency of PTEN deficient endometrial cancer cells on RNA helicases. (ntnu.no)
SK228 significantly inhibited growth of different lung and esophageal cancer cell lines at sub-micromolar range, but not normal lung cells. (ntnu.edu.tw)
Moreover, low-dose SK228 significantly reduced the invasion of cancer cells. (ntnu.edu.tw)
Our study provides the first evidence that SK228 exhibits cancer cell-specific cytotoxicity by inducing mitochondria-mediated apoptosis. (ntnu.edu.tw)
In addition, SK228 inhibits cancer cell invasion via FAK/Paxillin disruption at noncytotoxic doses. (ntnu.edu.tw)
diagnostic prediction of small round blue cell tumors (SRBCT) of childhood and determining the estrogen receptor (ER) status of sporadic breast cancer. (lu.se)
Leiomyosarcoma (cancer of smooth muscle cells) can develop in the wall of the small intestine. (msdmanuals.com)
Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. (bvsalud.org)

Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
Furthermore, the scracht assay result suggested that ATRA was a potential reagent to prevent the invasion or metastasis of GIST cells. (biomedcentral.com)

succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. (ed.ac.uk)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
Differential PCR was performed to study gene amplification and expression of several proto-oncogenes (K-ras, c-jun, c-fos, c-myc, c-sis and erb-B2) and tumor suppressor genes (p53 and p16). (cdc.gov)
None of the genes studied were amplified in tumor cells. (cdc.gov)
Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)

A mechanistic study identified that these inhibitory effects of berberine occurred through blocking interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) expression in colonic macrophages. (nih.gov)
Cell death caused by PDT (through the generation of reactive oxygen species) can occur either by apoptosis (interphase death or as a secondary event following mitosis) and/or necrosis depending on the cell type, concentration and intracellular localization of the sensitizer, and the light dose. (elsevierpure.com)
However, a decrease was observed at a concentration of 10 μg/ml, possibly due to a shift in the mode of cell death from apoptosis to necrosis. (elsevierpure.com)

Loss of DKK3 gene is associated with a possible tumor suppressor role in human cancers. (amrita.edu)
The antitumor efficacy was studied in mouse mammary carcinoma models (Her2/neu transgenic and 4T1-luc mammary cancers) treated with systemic recombinant protein with/without the depletion of myeloid-derived suppressor cells or intra-tumoral gene electrotransfer (GET). (frontiersin.org)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. (broadinstitute.org)
Here, in a prospective cohort of 42 patients with molecularly defined gastrointestinal cancers and acquired resistance to targeted therapy, direct comparison of postprogression cfDNA versus tumor biopsy revealed that cfDNA more frequently identified clinically relevant resistance alterations and multiple resistance mechanisms, detecting resistance alterations not found in the matched tumor biopsy in 78% of cases. (broadinstitute.org)
Open in another window Fig. multiple cancers cell individual and lines examples. (thetechnoant.info)
A new form of 5-fluorouracil called fluoropyrimidine that has increased activity against malignant cells and while having fewer gastrointestinal side effects has shown to be efficacious against malignant salivary cancers and to potentiate the effects of radiotherapy by increasing apoptosis. (medscape.com)

The innate cell engager AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS-mutant tumor cells compared with cetuximab. (onclive.com)
The innate cell engager ® (ICE) AFM24 showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS -mutant tumor cells compared with cetuximab (Erbitux), according to preclinical findings from a study presented in a poster during the 2021 SITC Annual Meeting . (onclive.com)
AFM24 enhances macrophage-mediated antibody-dependent cellular phagocytosis of various EGFR-expressing tumor cell lines, irrespective of the EGFR signaling pathway," wrote lead study author Sheena Pinto, PhD, translational project leader at Affimed, and coauthors, in the poster. (onclive.com)
To do so, monocyte-differentiated macrophages from healthy donor peripheral blood mononuclear cells were co-cultured for 4 hours with CMFDA-labeled, wild-type EGFR-expressing or KRAS -mutant tumor cells in the presence of 10 µg/mL of AFM24 or cetuximab. (onclive.com)
Additional results showed that AFM24 increased antibody-dependent cellular phagocytosis of EGFR -positive tumor cells regardless of macrophage subtype. (onclive.com)
Moreover, AFM24 was superior to cetuximab in eliciting phagocytosis in EGFR -positive cells in live cell imaging analysis over 24 hours. (onclive.com)
Given these findings, AFM24 is now being evaluated in a phase 1/2 trial (NCT04259450) in patients with advanced EGFR -positive solid tumors. (onclive.com)
Altogether, the results of our studies have revealed that berberine inhibits the development of CACRC by interfering with inflammatory response-driven EGFR signaling in tumor cell growth. (nih.gov)

We could validate these findings by immunofluorescence analyses in patient tumors and by increased expression in the hypoxic core of GBM spheroids. (lu.se)

Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
Patients come from around the world come to Cincinnati Children's for expert treatment for brain tumors in children or young adults. (cincinnatichildrens.org)

Gastrointestinal neuroendocrine tumors often secrete hormones that cause diarrhea and flushing of the skin. (msdmanuals.com)
Some gastrointestinal neuroendocrine tumors can be removed surgically. (msdmanuals.com)

Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. (lu.se)

Tumor growth was measured every 2 to 4 days. (genoway.com)
Also, expression of chemokines or treatment with poly(I:C) decreased tumor growth. (nih.gov)
Akt also regulates the mammalian target of rapamycin (mTOR)-S6K-S6 pathway to control cell growth in response to growth factors and nutrients. (aacrjournals.org)
As neoplastic cells accumulate in three-dimensional multicellular masses, local low nutrient and oxygen levels trigger the growth of new blood vessels into the neoplasm. (wikipedia.org)
Activated mTOR stimulates protein and lipid biosynthesis and cell growth in response to sufficient nutrient and energy conditions and is often constitutively activated during tumorigenesis. (wikipedia.org)
In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)
A spinal tumor is a growth of cells (mass) in or around the spinal cord. (medlineplus.gov)
Low level of miR-381-3p constrains oral squamous cell carcinoma growth [ 10 ]. (hindawi.com)
Growth of an A549 tumor cell xenograft was markedly inhibited without significant side effects. (ntnu.edu.tw)

The use of radiation in T1 and T2 parotid gland tumors found that 5-year disease-free survival increased from 70% to 92% with postoperative radiation. (medscape.com)
The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)

Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. (biomedcentral.com)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms occurring throughout the entire region of the gastrointestinal tract and are considered to originate from intestitial cells of Cajal, the pacemaker cells of the gut [ 1 ]. (biomedcentral.com)

The protein AKT1 (also known as Protein Kinase B or PKB) in the PI3K/AKT/mTOR pathway is an important driver of the tumor glycolytic phenotype and stimulates ATP generation. (wikipedia.org)
Last, we show that established UM cell lines and UM STCs are plastic in nature and switch their phenotype in response to environmental stimuli. (whiterose.ac.uk)

Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
ICE molecules are made to boost the activity of innate antitumor immune cells. (onclive.com)
The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
2 3 Tumors with low copy number changes have generally been associated with high immune infiltration scores, 4 but for CNA-silent versus CNA-high HPV-negative HNSCC such data are lacking.In this study we aim to unravel by functional assays immunological differences between HPV-negative and HPV-positive HNSCC, as well as between CNA-silent and CNA-high HPV-negative HNSCC. (bmj.com)
We analyzed the immune cell subsets attracted by HNSCC cell lines and by tumor-conditioned supernatants. (bmj.com)
Methods Eight HNSCC cell lines (3 HPV-positive, 3 HPV-negative CNA-high, 2 HPV-negative CNA-silent) and 24-hour supernatants of thirteen HNSCC biopsies were used to characterize their ability to attract immune cells in a transwell migration system. (bmj.com)
Tumor-conditioned supernatants promoted immune cell migration with no apparent differences between tumor sites or HPV-status. (bmj.com)
No difference in immune cell attraction between HPV-positive and -negative HNSCC was observed. (bmj.com)
Interestingly, one HPV-negative CNA-silent cell line induced robust immune cell migration. (bmj.com)
Our data could provide a means to identify patients who might most likely respond to immune checkpoint blockade and to find clues to improve CD8+ T-cell attraction. (bmj.com)
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. (bmj.com)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)

These cells form tumors in syngeneic models, upon subcutaneous and systemic (i.v.) injection, in immunocompetent mice. (genoway.com)
Humanized CD3 C57/Bl6 mice were injected (s.c.) with 1x10 6 EL4-hCD19-LZ cells. (genoway.com)
SK228-induced apoptosis was confirmed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry of cleaved caspase-3 in tumors from treated mice. (ntnu.edu.tw)
Further, studies were performed to identify the tumorigenic potential, if any, of MWF-induced transformed cells in mice. (cdc.gov)
Athymic nude mice, approximately 3-4 weeks, were injected either with MWF-induced transformed cell lines or non-transformed BALB/c-3T3 cells. (cdc.gov)
The mice were observed for tumor formation and sacrificed when the tumor size was between 1-1.5 cm. (cdc.gov)
All mice injected with transformed cells developed tumors within 34 days of injection. (cdc.gov)
Mice injected witih non-transformed BALB/c-3T3 cells did not develop any tumors. (cdc.gov)
Increased incidences of pulmonary bronchioloalveolar tumors have been observed in mice, but not in rats. (cdc.gov)
The model-based analysis suggests that humans would be expected to be 100- fold less sensitive to ST-inducted lung tumors than mice, based on pharmacokinetic differ- ences. (cdc.gov)
Recently the Styrene Information and Re- search Center (SIRC) conducted subchronic and chronic inhalation studies exposing both rats and mice to various concentrations of ST. No evidence of treatment-related increases in any type of tumor was observed in rats, com- pared to controls, at the end of the 2-yr inhalation study (Cruzan et al. (cdc.gov)
1998). However, the chronic inhalation study with mice resulted in statisti- cally significantly increased incidences of bronchioloalveolar tumors in both male and female mice at the end of 2 yr, but not after 12 or 18 mo (Cruzan et al. (cdc.gov)

Any type of tumor may occur in the spine, including primary and secondary tumors. (medlineplus.gov)
The symptoms depend on the location, type of tumor, and your general health. (medlineplus.gov)
Chemotherapy has not been proven effective against most primary spinal tumors, but it may be recommended in some cases, depending on the type of tumor. (medlineplus.gov)

Apart from being as a general tumor suppressor gene, p53 also plays an important part in regulating of metabolism. (wikipedia.org)
Since, apoptosis induced by PDT treatment plays an important role in determining the photodynamic efficacy, in the present work we have investigated the role of apoptotic cell death in relation to the observed differences in sensitivity to HpD-PDT between a human glioma cell line (BMG-1) carrying wild-type tumour suppressor gene p53 and a human squamous carcinoma cell line (4451) with mutated p53. (elsevierpure.com)
Some primary spinal tumors occur with certain inherited gene mutations. (medlineplus.gov)
Except for the B3B3 line that has undergone unproductive gene rearrangement, all other lines express IgH and L mRNAs but do not synthesize any Ig protein (Robert et al. (rochester.edu)
In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)
This evidence reinforce the view that combining p53 gene therapy with conventional chemotherapeutic agents may yield a more beneficial response than conventional treatments alone in pancreatic tumor cells with high amount of mutant p53. (ijbiotech.com)
Hagi-Sharifia Taghavi, M., Mirshahi, M., Davoodi, J. Wild type p53 gene transfer increases chemosensitivity and apoptotic response of PANC-1 pancreatic tumor cell line. (ijbiotech.com)
These results indicate that MWF is capable of inducing cellular changes and changes in gene expression of certain oncogenes in BALB/c-3T3 cells and that these cells possess neoplastic potential. (cdc.gov)
The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. (lu.se)
Infinium data for four matched tumor-normal pairs and a dilution series of a tumor cell line mixed with its paired normal cell line are available in NCBI's Gene Expression Omnibus with accession GSE11976 . (lu.se)

Background Head and neck squamous cell carcinomas (HNSCC) are classified in human papillomavirus (HPV)-positive and HPV-negative tumors. (bmj.com)
Peritoneal carcinomas are divided into primary and secondary peritoneal tumors. (medscape.com)
Primary peritoneal carcinomas originate from the cells lining the peritoneum. (medscape.com)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)

An early increase of local cytotoxic cells correlates with GET treatment and an increase of long-term memory T cells results from animals with complete tumor regression. (frontiersin.org)
Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)

Previous case reports and small case series have suggested that liquid biopsy (specifically, cell-free DNA (cfDNA)) may better capture the heterogeneity of acquired resistance. (broadinstitute.org)

These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
We compared microRNA expression patterns in three cisplatin resistant sublines derived from paternal cisplatin sensitive germ cell tumor cell lines in order to improve our understanding of the mechanisms of cisplatin resistance. (biomedcentral.com)
This new and unprecedented evidence for a link between SdhD dysfunction and p21(WAF1/Cip1) will open new avenues for the study of the mechanisms that cause tumors in Sdh mutants. (ed.ac.uk)
however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)

Background/Aim: Yolk sac tumour (YST) is a rare malignant ovarian germ cell tumour that often occurs in young women or adolescents and exhibits an unfavourable outcome. (elsevierpure.com)

Importantly, some of these differences in sensitivity were in concordance with high expression of the targets or activation of the corresponding pathways in primary tumor samples of the same subtype. (tudelft.nl)
Importantly, transfection of primary tumor cells produced immunostimulatory levels of IL-2 as determined by increased thymidine incorporation by autologous peripheral blood mononuclear cells and lymphokine-activated killer cell activity. (arizona.edu)

The paternal cell lines are (1) the p53-wt (wild type) pluripotent gonadal germ cell tumor cell line NTERA-2, (2) the p53-mutated pluripotent extragonadal nonseminomatous germ cell tumor cell line NCCIT and (3) the p53-wt nullipotent embryonal cell carcinoma 2102EP, derived from a primary human testicular teratocarcinoma. (biomedcentral.com)
The least differentiated of these tumors, embryonal rhabdomyosarcoma, is composed of small, round cells and in the past may be mistaken histopathologically for lymphoma, melanoma, and fibrosarcoma, among others. (radiologykey.com)

The conversion of glucose to lactate rather than metabolizing it in the mitochondria through oxidative phosphorylation, (which can also occur in hypoxic normal cells) persists in malignant tumor despite the presence of oxygen. (wikipedia.org)
Subependymal giant cell tumors may occur in children and adults who have a condition called tuberous sclerosis . (cincinnatichildrens.org)
An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)

Other partners of the intracellular metabolism of gemcitabine in relation to the cell cycle effects and DNA repair could be more responsible for the radiosensitising effect than dCK activity. (biomedcentral.com)
The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in tumor cells. (wikipedia.org)
C. Peterson, M. Ringne´r / Artificial Intelligence in Medicine 28 (2003) 59-74 structure and function, cellular metabolism, development of cells and tissues, and response of organisms to their environments. (lu.se)

Secondary tumors that have spread to the spine from another site (metastatic tumors) often progress quickly. (medlineplus.gov)

X. laevis is the only amphibian where true lymphoid tumors have been discovered and cell lines have been obtained opening new avenues for tumor biology and tumor immunity. (rochester.edu)
BMC Cell Biology, 9 , 45. (springer.com)

Human cell cultures: glioblastoma (U87), colorectal human adenocarcinoma (SW-620), human melanoma (SK-Mel28) and primary embryonic cell lines were irradiated with a neutron flux at the presence of BPA, BSH and liposomal BSH with a concentration of10B 40 μg/ml. (isnct.net)
For the primary transplanted embryonic line, high toxicity was revealed when BNCT was performed with borphenylalanine and borcaptate. (isnct.net)

13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)

To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological and clinical characteristics and second match these subtypes to cell lines for which extensive pharmacological data is available, thus linking targeted therapies to patients most likely to respond to treatment. (tudelft.nl)
With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)

In contrast, fucosyl-GM1 was not found to restrict to small cell lung carcinoma cells. (karger.com)
Herein, we sought to determine if rapamycin, an inhibitor of mTOR, could enhance erlotinib sensitivity for cell lines derived from a variety of tissue types (non-small-cell lung, pancreatic, colon, and breast). (aacrjournals.org)

The tumor may press on the spinal cord or nerve roots, causing damage. (medlineplus.gov)
In other cases, part of the tumor may be removed to relieve pressure on the spinal cord. (medlineplus.gov)
Ependymomas , which usually begin in the lining of the ventricles (large open structures deep in the brain) or in the spinal cord, near the cerebellum. (cincinnatichildrens.org)
Meningeal tumors , such as meningioma, which arise from the membranes (meninges) surrounding the brain and spinal cord. (cincinnatichildrens.org)

The imperfect neovasculature in the tumor bed is poorly formed and is inefficient. (wikipedia.org)

Multimodality therapy is currently the most commonly accepted therapeutic approach for these tumors. (medscape.com)

To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)
dCK activity of the cells was determined by an enzyme activity assay. (biomedcentral.com)
To be able to recognize the deubiquitinase of -catenin, we overexpressed a -panel of HA-tagged deubiquitinases in HEK293T cells independently and performed co-immunoprecipitation (co-IP) assay to recognize potential DUB(s) that connect to -catenin. (thetechnoant.info)

However, AFM24 engages CD16A on NK cells and macrophages with a higher affinity than monoclonal antibodies, causing NK cell-mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent cellular phagocytosis. (onclive.com)
The hsa-miR-371-373 cluster (counteracting cellular senescence and linked with differentiation potency), as well as hsa-miR-520c/-520h (inhibiting the tumor suppressor p21) were 3.9-16.3 fold up-regulated in two of the three cisplatin resistant cell lines. (biomedcentral.com)

Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. (frontiersin.org)

Methods We applied a new unsupervised, iterative approach to stratify CRC tumor samples into subtypes based on genome-wide mRNA expression data. (tudelft.nl)
Methods: Expression of postulated stem cell markers aldehyde dehydrogenase (ALDH), CD44, and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples. (whiterose.ac.uk)
Materials and Methods: We established a novel YST cell line, TC587, from an adolescent patient with ovarian YST. (elsevierpure.com)

Cell survival was determined 7, 8, or 9 days after RT by the sulforhodamine B test. (biomedcentral.com)
Activation of Akt leads to the stimulation of antiapoptotic pathways, promoting cell survival. (aacrjournals.org)
Mammalian cells require oxygen and nutrients for their survival and are therefore located within 100 to 200 m of blood vessels, the diffusion limit of oxygen. (hindawi.com)
Cell survival 96 hours after irradiation was determined using MTT test, and survival fraction was evaluated using the clonogenic test. (isnct.net)

The anti-inflammatory and anti-tumor effects of berberine, a traditional Chinese medicine, were separately discovered in pathological intestinal tissues. (nih.gov)
The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
These include gamma-knife stereotactic radiosurgery and brachytherapy (radioactive seeds or sources are placed in or near the tumor itself, giving a high radiation dose to the tumor while reducing the radiation exposure in the surrounding healthy tissues). (medscape.com)

Randomization was stratified by tumor histology (squamous cell carcinoma vs. adenocarcinoma), geographic region (Asia vs. ex-Asia), and Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0 vs. 1). (merck.com)

Canonically, functioning ST6GAL1 resides within the intracellular ER-Golgi secretory complex, where sialylation of nascent cell surface and secreted components occurs cell-autonomously. (nature.com)

Whole-exome sequencing of serial cfDNA, tumor biopsies and rapid autopsy specimens elucidated substantial geographic and evolutionary differences across lesions. (broadinstitute.org)

In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
Immunohistochemistry and quantitative polymerase chain reaction were used to analyze tumor samples from 172 HCC patients. (nih.gov)
We found that DKK3 expression levels were low in GBC patients and cell lines. (amrita.edu)
The noted lack of CD8+ T-cell attraction may explain why current treatments with PD-1 inhibitors are effective in only a minority of HNSCC patients. (bmj.com)
Some patients are newly diagnosed and others seek care for recurrent or treatment-resistant tumors. (cincinnatichildrens.org)
These results suggest that a clinical vaccine trial using autologous tumor cells genetically modified to secrete IL-2 is feasible in patients with solid tumors. (arizona.edu)
KEYTRUDA plus chemotherapy is the first anti-PD1 therapy approved in Europe in this first-line setting, allowing these patients to be treated with immunotherapy earlier in the course of their treatment," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (merck.com)
Patients may exhibit neurologic deficits secondary to tumor emboli. (medscape.com)
Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)

HLA-binding properties of tumor neoepitopes in humans. (broadinstitute.org)
In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)

Sulfated glucuronosyl glycosphingolipids (SGGLs) are cell surface molecules that are endowed with the Human Natural Killer-1 (HNK-1) carbohydrate epitope. (karger.com)
We generated an EL4-hCD19-LZ clonal cell line expressing high levels of human CD19 (NCBI GeneID: 930), and an optimized dual fusion reporter luciferase-ZsGreen (LZ). (genoway.com)
Human CD19 expression was assessed in EL4 parental cell line (left), human control cells - PBMC (center), and EL4-hCD19-LZ cell line (right). (genoway.com)
In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. (biomedcentral.com)
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines. (hsanmartino.it)
LINE-1 elements make up the most abundant retrotransposon family in the human genome. (unife.it)
We utilized a quantitative RT-PCR (RTQ-PCR) based platform for detection of almost all currently known (738) human micro-RNA species on these 6 cell lines. (biomedcentral.com)
However, previously, only a few human YST cell lines have been established. (elsevierpure.com)

The degree of radiosensitisation was also cell line dependent and seemed to correlate with the sensitivity of the cell line to the cytotoxic effect of dFdC. (biomedcentral.com)
It also delivers its function without activating regulatory T cells (Tregs) ( 9 ) and mediating activation-induced cell death of effector cytotoxic T cells ( 10 ). (frontiersin.org)
Early cytotoxic effects of irradiation were not observed for all 4 cell lines. (isnct.net)
Clara cells lining the respiratory epithelium metabolize ST to styrene 7,8- oxide (SO), which is cytotoxic and weakly genotoxic. (cdc.gov)

Adenocarcinomas develop in the glandular cells of the lining of the small intestine. (msdmanuals.com)
Using paclitaxel (Taxol), another antimicrotubule drug, alone has had moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma. (medscape.com)

Present results show that the higher sensitivity to PS-3-PDT in glioma cells arise on account of a higher level of apoptosis and suggest that induction of apoptosis is an important determinant of photodynamic sensitivity in certain cell types. (elsevierpure.com)
In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. (hindawi.com)
Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)
miR-381-3p-mimic, oe-ANTXR1, and corresponding negative controls (NCs) (NC-mimic and oe-NC) were ordered from GeneChem (Shanghai, China) and transfected into glioma cells U87 at 50 nM using Lipofectamine 2000 (Invitrogen, Carlsbad, USA). (hindawi.com)
The most common type of brain tumor is glioma. (cincinnatichildrens.org)

Anatomy23

Organisms12

Diseases68

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Health Care4

Malignant tumors6

Proliferation21

Antigens4

Benign6

Flow cytometry4

Vitro9

Inhibition7

Progression14

Solid tumor3

Germ cell t18

Cancer51

Metastasis3

Genes5

Necrosis3

Cancers7

EGFR8

Patient tumors1

Brain tumors2

Neuroendocrine tumors2

Microenvironment2

Growth12

Parotid gland2

Stromal2

Phenotype2

Immune13

Mice12

Type of tumor3

Gene10

Carcinomas6

Regression2

Acquired resistance1

Mechanisms4

Ovarian germ1

Primary tumor2

Embryonal2

Occur3

Metabolism3

Metastatic1

Biology2

Embryonic2

Mononuclear cells1

Heterogeneity2

Lung2

Spinal cord4

Poorly1

Therapeutic1

Assay3

Cellular2

Systemic1

Methods3

Survival4

Tissues3

Squamous cell1

Intracellular1

Biopsies1

Patients9

Humans2

Human8

Cytotoxic4

Adenocarcinomas2

Glioma5