• Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. (wikipedia.org)
  • Due to increased risk of developing azithromycin resistant strains and the high efficacy of higher doses of ceftriaxone the guidance has been updated to mono-antibiotic therapy with a higher dose of ceftriaxone. (wikipedia.org)
  • Antibiotics such as ceftriaxone injection will not work for colds, flu, or other viral infections.Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. (medlineplus.gov)
  • Ceftriaxone for Injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. (nih.gov)
  • Since B. burgdorferi first infects skin, the possible protective effect of skin fibroblasts from an antibiotic commonly used to treat Lyme disease, ceftriaxone, was examined. (nih.gov)
  • Antibiotic Ceftriaxone Linked to Acute Renal Failure in Children April 1, 2014 Antibiotics can help us overcome many illnesses, but some types of these drugs have been linked to adverse health events and Antibiotic Drug Injuries. (lawyerworks.com)
  • I have a bit of diahrrea after taking cephalexin a week ago now ive been put on iv rosephin (ceftriaxone) antibiotic. (healthtap.com)
  • However, the data on the use of ceftriaxone as an outpatient parenteral antibiotic therapy (OPAT) agent for S aureus bacteremia have been limited. (contagionlive.com)
  • Ceftriaxone is a broad-spectrum cephalosporin antibiotic with a very long half-life. (ncats.io)
  • Ceftriaxone is an antibiotic. (pharmakhabar.com)
  • The percentage of isolates with elevated cefixime MICs increased during 2009-2010, then decreased during 2012-2013 after treatment recommendations were changed in 2010 to recommend dual therapy (with a cephalosporin and a second antibiotic) and a higher dosage of ceftriaxone. (cdc.gov)
  • INOCEF 1g Injection (Ceftriaxone Sodium) is a semi-synthetic third-generation cephalosporin antibiotic. (fareedpharma.com)
  • Ceftriaxone And Sulbactam For Injection is an antibacterial antibiotic dosage, it consists of sodium salts of Ceftriaxone and Sulbactam. (genixcare.in)
  • ceftriaxone is a cephalosporin antibiotic that is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia , or meningitis . (rednirusmart.com)
  • Children receiving intravenous antibiotics as part of the UHS paediatric intravenous antibiotic service, including 10-minute infusions of ceftriaxone, will routinely have clinical observations and any side effects recorded on a proforma. (piernetwork.org)
  • The FDA updated the full prescribing information of ceftriaxone (Rocephin and generics). (pharmacologycorner.com)
  • To purchase Rocephin (Ceftriaxone) 1g Injection, you must have a prescription from your doctor or medical professional. (beybeepharmacy.com)
  • In combination with doxycycline or azithromycin, ceftriaxone used to be recommended by the United States Centers for Disease Control and Prevention (CDC) for the treatment of uncomplicated gonorrhea. (wikipedia.org)
  • Both the US Centers for Disease Control and Prevention and the World Health Organization recommend the combination therapy of intramuscular ceftriaxone and oral azithromycin. (umn.edu)
  • Azithromycin, which has a different mechanism of action than ceftriaxone, was added to the regimen to improve treatment efficacy and to slow the emergence of ceftriaxone resistance. (umn.edu)
  • Participants were randomly assigned 1:1 to receive a single intramuscular dose of either 240-milligrams (mg) gentamicin or 500-mg ceftriaxone, with both groups also receiving a single oral dose of 1 gram (g) of azithromycin. (umn.edu)
  • However, gentamicin combined with 1 g azithromycin achieved a cure rate of 94% for genital gonorrhoea, and its use might be appropriate in patients who are allergic, intolerant, or harbour a ceftriaxone-resistant infection. (umn.edu)
  • This finding from the trial was among the reasons cited by the British Association for Sexual Health and HIV in its decision to drop the recommendation for dual therapy with azithromycin in patients with uncomplicated gonorrhea in its 2019 guidelines, which now recommend a 1-g intramuscular shot of ceftriaxone as the first-line treatment. (umn.edu)
  • Because dual therapy with ceftriaxone plus azithromycin is the only recommended gonorrhea treatment, increases in azithromycin and cephalosporin MICs are cause for concern that resistance to these antimicrobial agents might be emerging. (cdc.gov)
  • Before therapy with ceftriaxone for injection is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins or other drugs. (nsrawpowder.com)
  • Although not being used as first line therapy against Staphylococcus aures, ceftriaxone retains activity against isolates of methicillin-resistant S. aureus and is used in clinic for infections sustained by this bacterium. (wikipedia.org)
  • There are few data regarding non-invasive ceftriaxone-resistant E. coli (CR-EC) isolates in the Australian community. (monash.edu)
  • We aimed to describe the prevalence, phenotype, geographic variation, and sociodemographic predictors of ceftriaxone-resistance among E. coli isolates recovered from urine specimens. (monash.edu)
  • No Azi-RS isolates exhibited reduced cefixime or ceftriaxone susceptibility (Cfx-RS and Cro-RS, respectively). (cdc.gov)
  • Geographic distribution of ceftriaxone resistance among urinary Escherichia coli isolates in Victoria ( a ) and the Greater Melbourne area (b). (biomedcentral.com)
  • Scale represents percentage of E. coli isolates that are resistant to ceftriaxone. (biomedcentral.com)
  • None of the isolates was resistant to ceftriaxone or cefixime. (who.int)
  • Like other third-generation cephalosporins, ceftriaxone is active against Citrobacter spp. (wikipedia.org)
  • For patients with a diagnosis of gonorrhea and a concomitant reported allergy to penicillin, ceftriaxone is often avoided, even though the cross-reactivity between penicillin allergy and third-generation cephalosporins is low ( 652 - 654 ). (cdc.gov)
  • If you will be using more than one dose of ceftriaxone injection, use the medication until you finish the prescription, even if you feel better. (medlineplus.gov)
  • Average plasma concentrations of ceftriaxone following a single 30-minute intravenous (IV) infusion of a 0.5, 1 or 2 g dose and intramuscular (IM) administration of a single 0.5 (250 mg/mL or 350 mg/mL concentrations) or 1 g dose in healthy subjects are presented in Table 1. (nih.gov)
  • Ceftriaxone was completely absorbed following IM administration with mean maximum plasma concentrations occurring between 2 and 3 hours post-dose. (nih.gov)
  • Multiple IV or IM doses ranging from 0.5 to 2 g at 12- to 24-hour intervals resulted in 15% to 36% accumulation of ceftriaxone above single dose values. (nih.gov)
  • Thirty-three percent to 67% of a ceftriaxone dose was excreted in the urine as unchanged drug and the remainder was secreted in the bile and ultimately found in the feces as microbiologically inactive compounds. (nih.gov)
  • After a 1 g IV dose, average concentrations of ceftriaxone, determined from 1 to 3 hours after dosing, were 581 mcg/mL in the gallbladder bile, 788 mcg/mL in the common duct bile, 898 mcg/mL in the cystic duct bile, 78.2 mcg/g in the gallbladder wall and 62.1 mcg/mL in the concurrent plasma. (nih.gov)
  • Two hundred patients randomly received either ceftriaxone (single dose) or ampicillin/cloxacillin (3 doses) intravenously at induction of anaesthesia. (who.int)
  • One dose of ceftriaxone was as effective as ampicillin/ cloxacillin in preventing post-caesarean section complications and is easier to administer. (who.int)
  • Deux cent patientes ont reçu de manière aléatoire soit de la ceftriaxone (dose unique) soit de l'ampicilline-cloxacilline (3 doses) par voie intraveineuse à l'induction de l'anesthésie. (who.int)
  • Une dose de ceftriaxone était aussi efficace que l'ampicilline- cloxacilline dans la prévention des complications de la césarienne et elle est plus facile à administrer. (who.int)
  • Patients were randomized to receive ei- the efficacy of ceftriaxone with ampicillin/ ther ceftriaxone as single dose of 1 g or 1 g cloxacillin in preventing post-operative ampicillin/cloxacillin every 8 hours. (who.int)
  • The dose of IV cefazolin was 2 g every 8 hours, and the dose of IV ceftriaxone was at 2 g every 24 hours. (contagionlive.com)
  • [ 19 ] This limits treatment of gonorrhea to drugs in the cephalosporin class (eg, ceftriaxone 125 mg IM once as a single dose). (medscape.com)
  • Dose adjustment of CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection may be needed. (genixcare.in)
  • Dose adjustment of CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection is not recommended in patients with mild to moderate liver disease. (genixcare.in)
  • Ceftriaxone was given intramuscularly in a dose of 80mg/kg/day for five days and chloramphenicol was given via oral route in a daily dose of 50-100 mg/kg/day in three divided doses for three weeks (21 days). (medicotips.com)
  • Cefoperazone and ceftriaxone , which have significant biliary excretion, do not require such dose adjustment. (msdmanuals.com)
  • failed verification] The manufacturer recommends that caution be exercised when administering ceftriaxone to women who breastfeed. (wikipedia.org)
  • Ceftriaxone and other third-generation cephalosporin antibiotics are used to treat organisms that tend to be resistant to many other antibiotics. (wikipedia.org)
  • Ceftriaxone injection is in a class of medications called cephalosporin antibiotics. (medlineplus.gov)
  • In most clinical settings, patients with reported penicillin allergy are precluded from treatment with such cephalosporin antibiotics as ceftriaxone. (cdc.gov)
  • The group of drugs known as cephalosporin antibiotics includes ceftriaxone. (rednirusmart.com)
  • If you stop using ceftriaxone injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • With CefTRIaxONE in DUPLEX®, doses can be stored conveniently and are immediately available for emergency IV purposes. (infectioncontroltoday.com)
  • The Gentamicin in the Treatment of Gonorrhea (G-ToG) trial was conducted as part of an effort to find an acceptable alternative to ceftriaxone, which is the current recommended treatment for gonorrhea infections. (umn.edu)
  • Cefotaxime is a third-generation cephalosporin used as an alternative to ceftriaxone for treatment of DGI or gonococcal arthritis. (medscape.com)
  • Low concentrations of ceftriaxone are excreted in breast milk that are "not expected to cause adverse effects in breastfed infants. (wikipedia.org)
  • At scPharmaceuticals we are evaluating the subcutaneous administration of ceftriaxone with a proprietary, on-body delivery system. (scpharmaceuticals.com)
  • The administration of ceftriaxone as a 10 minute infusion has been approved by both the Southampton Children's Hospital Governance group and the University Hospital Southampton (UHS) Medicines committees. (piernetwork.org)
  • Ceftriaxone injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously (into a vein) over a period of 30 or 60 minutes.Ceftriaxone injection can also be given intramuscularly (into a muscle). (medlineplus.gov)
  • Ceftriaxone for Injection, USP is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. (nih.gov)
  • Each Pharmacy Bulk Package is supplied as a dry powder in bottles containing sterile ceftriaxone sodium, USP equivalent to 10 grams of ceftriaxone and is intended for intravenous infusion only. (nih.gov)
  • According to the package insert, clinical studies did not show differences in efficacy and safety of ceftriaxone in geriatrics compared to younger patients but "greater sensitivity of some older individuals cannot be ruled out. (wikipedia.org)
  • ABSTRACT We carried out a prospective, randomized, controlled clinical trial to evaluate the clinical efficacy of ceftriaxone and ampicillin/cloxacillin prophylaxis in decreasing the frequency of post-caesarean section infection-related morbidity. (who.int)
  • Since cefoxitin has been shown to be an effective alternative to spectinomycin for the treatment of infections due to penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) its efficacy was compared with that of a new cephalosporin, ceftriaxone (R013-9904). (bmj.com)
  • In the present study, efficacy of ceftriaxone in neuroprotection of dopaminergic neurons and amelioration of motor deficits in a rat model of Parkinson's disease were investigated. (edu.hk)
  • In a study, conducted by Department of Paediatrics and Child Health and Faculty of Medicine of the University of Natal (situated in Durban, Republic of South Africa) compared the efficacy of chloramphenicol and ceftriaxone for the treatment of typhoid fever. (medicotips.com)
  • An alternative is needed because Neisseria gonorrhoeae -which is known for its ability to develop resistance quickly and has cycled through several antibiotics-is becoming increasingly resistant to ceftriaxone. (umn.edu)
  • Avoid mixing ceftriaxone with IV fluids that have calcium in them (such as Ringer's solution, Hartmann's solution, parenteral nutrition -TPN/PPN). (webmd.com)
  • Ceftriaxone injection is contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium-containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone-calcium. (nsrawpowder.com)
  • Ceftriaxone is available for administration via the intramuscular or the intravenous routes. (wikipedia.org)
  • Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Ceftriaxone against bacteria. (pharmakhabar.com)
  • To place your order for Ceftriaxone And Sulbactam For Injection contact us on the provided number, we will be glad to serve you. (genixcare.in)
  • Ceftri Nix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection is a combination of two medicines: Ceftriaxone and Sulbactam. (genixcare.in)
  • Consuming alcohol with CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection does not cause any harmful side effects. (genixcare.in)
  • CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection is generally considered safe to use during pregnancy. (genixcare.in)
  • CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection should be used with caution during breastfeeding. (genixcare.in)
  • CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. (genixcare.in)
  • There is limited information available on the use of CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection in patients with kidney disease. (genixcare.in)
  • CeftriNix-SB (Ceftriaxone+Sulbactam 1000mg/500mg) Injection should be used with caution in patients with severe liver disease. (genixcare.in)
  • Before using ceftriaxone, it is important to determine the susceptibility of the bacteria. (wikipedia.org)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of ceftriaxone for injection and other antibacterial drugs, ceftriaxone for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Ceftriaxone has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. (ncats.io)
  • Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
  • Ceftriaxone was completely effective in treating both penicillin-sensitive and penicillin-resistant gonococcal urethritis. (bmj.com)
  • Ceftriaxone thus seems to be an effective and safe alternative to either spectinomycin or cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
  • Background: Ceftriaxone-resistant Enterobacteriaceae are priority pathogens of critical importance. (monash.edu)
  • Moreover, resistant strains to chloramphenicol have emerged but resistant strains to ceftriaxone are not yet reported (2013). (medicotips.com)
  • Due to emergent resistance, ceftriaxone should not be used for the treatment of Enterobacter infections. (wikipedia.org)
  • In addition to patient-level predictors of ceftriaxone resistance, we mapped patient postcodes to community-level indicators including Index of Relative Socioeconomic Deprivation, remoteness, and proportion of residents born overseas. (monash.edu)
  • We used Poisson regression with log link and robust standard errors to quantify the association between ceftriaxone resistance and patient- and community-level factors. (monash.edu)
  • Extended spectrum ß-lactamase (ESBL) -production was the most common mechanism for ceftriaxone resistance (89%, 341/382). (monash.edu)
  • Gonococcal Antimicrobial Surveil ance Programme has antimicrobials representing four different classes, namely operated in the Western Pacific and South-East Asian penicil in (PEN), ciprofloxacin (CIP), tetracycline (TCY), regions since 1992, but surveil ance of gonococcal anti- ceftriaxone (CRO) and cefixime (CFX), by disc diffusion microbial resistance (AMR) remains limited in the Asia- and gradient diffusion (Etest, BioMerieux). (who.int)
  • After 2 weeks of treatment, the infection was cleared in 299 (98%) of the 306 patients in the ceftriaxone arm, compared with 267 (91%) of 292 patients in the gentamicin group, for an adjusted risk difference of -−6.4 percentage points (95% confidence interval [CI], −10.4 to −2.4), indicating inferiority. (umn.edu)
  • More than half (54%) of the IV ceftriaxone group had a bone and joint infection vs less than a third (29%) in the IV cefazolin group. (contagionlive.com)
  • In addition, the IV cefazolin group had a higher proportion of endocarditis and central line-associated bloodstream infection (CLABSI) than the IV ceftriaxone group (32% vs 11%, respectively). (contagionlive.com)
  • Ceftriaxone is also used to prevent infection in people having certain types of surgery. (rednirusmart.com)
  • To see all strengths visit the cefTRIAXone Sodium for Injection BP page. (sterimaxinc.com)
  • Subsequently, the treatment recommendations were changed again in 2012 to no longer recommend cefixime as part of first-line therapy (leaving ceftriaxone-based dual therapy as the only recommended therapy). (cdc.gov)
  • However, unlike ceftazidime and cefoperazone, ceftriaxone does not have useful activity against Pseudomonas aeruginosa. (wikipedia.org)
  • Diluents containing calcium should not be used to reconstitute ceftriaxone, and it must not be administered in intravenous lines containing other calcium-containing solutions, as a ceftriaxone-calcium precipitate could form. (wikipedia.org)
  • Precipitation of Ceftriaxone-calcium can occur when Ceftriaxone for Injection is mixed with calcium-containing solutions in the same intravenous administration line. (ncats.io)
  • In patients older than 28 days of age ceftriaxone and calcium-containing solutions may be administered sequentially one after another through a different IV site or through the same IV site if thoroughly flushed with normal saline. (piernetwork.org)
  • Medical uses include: lower respiratory tract infections acute bacterial otitis media skin and skin structure infections urinary tract infections uncomplicated gonorrhea pelvic inflammatory disease bacterial sepsis intra-abdominal infections meningitis surgical prophylaxis Lyme disease Ceftriaxone is also a choice drug for treatment of bacterial meningitis caused by pneumococci, meningococci, Haemophilus influenzae, and "susceptible enteric Gram-negative rods, but not Listeria monocytogenes. (wikipedia.org)
  • Ceftriaxone for Injection, USP contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity. (nih.gov)
  • Vials containing 1 gram Ceftriaxone, 10/box. (vaccineshoppe.com)
  • Contact the manufacturer of ceftriaxone sodium 2 gm injections with your needs for injection manufacturing . (rednirusmart.com)
  • One hundred and twenty eight men with culture-confirmed gonococcal urethritis were treated with either 250 mg of ceftriaxone intramuscularly or 2 g of cefoxitin intramuscularly with oral probenecid 1 g. (bmj.com)
  • Unos biotech is one of the top leading and well-known PCD Pharma company that is offering PCD Pharma franchise for Ceftriaxone Sodium 2 gm Injection. (rednirusmart.com)
  • Nothing new needs to be done in order to launch a Ceftriaxone sodium injection pharma franchise business . (rednirusmart.com)
  • Although generally well tolerated, the most common adverse reactions associated with ceftriaxone are changes in white blood cell counts, local reactions at site of administration, rash, and diarrhea. (wikipedia.org)
  • What is the safety profile of ceftriaxone in pediatric patients, as determined by the frequency and type of adverse drug reactions documented in the published literature? (beem.ca)
  • Serious adverse effects are possible with ceftriaxone sodium injection. (rednirusmart.com)
  • 2 Subsequently, a larger study (N = 243) comparing ceftriaxone with cefazolin/ oxacillin as OPAT agents in patients with MSSA bacteremia showed no difference in rates of treatment failure. (contagionlive.com)
  • A total of 368 patients were included in the study and were selected in a 3:1 ratio of cefazolin to ceftriaxone. (contagionlive.com)
  • They had 286 patients (77.7%) in the IV cefazolin group and 82 patients (22%) in the IV ceftriaxone group. (contagionlive.com)
  • Patients were classified under each group based on what antibiotics they received at discharge because none of the patients received IV ceftriaxone initially during their admission. (contagionlive.com)
  • The ceftriaxone group contained 29 patients and the chloramphenicol group contained 30 patients. (medicotips.com)
  • In the ceftriaxone group twenty-three patients became culture negative and free of disease, 2 improved significantly, one failed to improve and two patients relapsed. (medicotips.com)
  • In another study (Treatment of typhoid fever with ceftriaxone for 5 days or chloramphenicol for 14 days, a randomized clinical trial by Aslam, T butler, I Kabir), All patients treated with ceftriaxone became culture negative on third day of treatment while 60 % of those patients who were treated with chloramphenicol were still culture positive. (medicotips.com)
  • Fever persisted in some patients treated with ceftriaxone for prolong period of time. (medicotips.com)
  • The patients become culture negative earlier with ceftriaxone as compared to chloramphenicol. (medicotips.com)
  • You may receive ceftriaxone injection in a hospital or doctor's office, or you may administer the medication at home. (medlineplus.gov)
  • If you will be receiving ceftriaxone injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • If ceftriaxone is mixed with a numbing medication (such as lidocaine ) before injection into a muscle, it may rarely cause a serious blood problem (methemoglobinemia). (webmd.com)
  • penicillin antibiotics, or any other medications.Also tell your doctor if you are allergic to any of the ingredients in ceftriaxone injection. (medlineplus.gov)
  • Ceftriaxone arrests bacterial growth by binding to 1 or more penicillin-binding proteins. (medscape.com)
  • Ceftriaxone interferes with the biosynthesis of the bacterial cell wall by binding and inactivating penicillin-binding proteins (PBPs). (genixcare.in)
  • This study was one of the largest to address the use of IV ceftriaxone in the context of MSSA bacteremia compared with cefazolin. (contagionlive.com)
  • To better assess the role of ceftriaxone in treating MSSA bloodstream infections, Ganguly et al 4 conducted a noninferiority retrospective study comparing ceftriaxone to IV cefazolin. (contagionlive.com)
  • The ceftriaxone and cefazolin groups were similar in basic demographics, comorbidities, length of stay (~15 days), and duration of outpatient treatment (~35 days). (contagionlive.com)
  • The results of a randomized clinical trial conducted in the United Kingdom indicate that gentamicin is not a suitable alternative for ceftriaxone as part of first-line treatment for gonorrhea. (umn.edu)
  • Ceftriaxone, a third-generation cephalosporin, is recommended for gonorrhea treatment. (cdc.gov)
  • Hyperbilirubinemic neonates are contraindicated for the use of ceftriaxone. (wikipedia.org)
  • This is an update to a previous ( september 2007) alert on the risk of interaction between ceftriaxone and calcium-containing IV products, the 2007 alert was based on reported fatal cases in neonates. (pharmacologycorner.com)
  • Would You Try Ceftriaxone for Methicillin-Susceptible Staphylococcus aureus Bacteremia? (contagionlive.com)
  • The manufacturer recommends that caution be used when administering ceftriaxone to nursing women. (nsrawpowder.com)
  • Ceftriaxone injection is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. (nsrawpowder.com)
  • Ceftriaxone can be given by injection into a vein or into a muscle. (wikipedia.org)