• Formation and maintenance of caveolae was initially thought to be primarily due to caveolin, a 21 kD protein. (wikipedia.org)
  • 2010 ). Results from cav-1 (caveolin-1, the key structural protein of caveolae)-deficient mice indicated that cav-1 in endothelium is essential in the translocation of LDL-derived cholesterol into the vessel wall and in the development of atherosclerosis, and this result was further confirmed in apoE-/- mice (Fernandez-Hernando et al. (springer.com)
  • The hyperpermeability effect was prevented in mice with conditional, endothelial deletion of GC-A (EC GC-A KO) or with deleted caveolin-1 (cav-1), the caveolae scaffold protein. (uni-wuerzburg.de)
  • Finally, preparation of caveolin-enriched lipid rafts from mouse lung and western blotting showed that GC-A and cGMP-dependent protein kinase I partly co-localize with Cav-1 in caveolae microdomains. (uni-wuerzburg.de)
  • It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (lookformedical.com)
  • Specifically, regulation of eNOS within caveolae by the coat protein, caveolin-1 (Cav-1), is an important physiological mechanism for control of vascular reactivity, and this pathway is intimately involved with the progression of pathologies likely through suppression of pro-inflammatory signalling pathways. (blogspot.com)
  • Estrogen binding to estrogen receptors (ER) in caveolae also activates eNOS and this occurs through G protein coupling and kinase activation. (elsevierpure.com)
  • PV1 protein is an essential component of stomatal and fenestral diaphragms, which are formed at the plasma membrane of endothelial cells (ECs), on structures such as caveolae, fenestrae and transendothelial channels. (dartmouth.edu)
  • Removal of caveolae in mice by knocking out caveolin-1 or cavin-1 resulted in a dramatic reduction of PV1 protein level in lungs but not kidneys. (dartmouth.edu)
  • The absence of caveolae in the lung ECs did not affect the transcription or translation of PV1, but it caused a sharp increase in PV1 protein internalization rate via a clathrin- and dynamin-independent pathway followed by degradation in lysosomes. (dartmouth.edu)
  • Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. (thermofisher.com)
  • Caveolin-1 (Cav-1) is regarded as a major structural protein of caveolae and participated in lipid transport, signal transduction and tumor progression. (nih.gov)
  • However, some bacteria do not use typical caveolae but only caveolin-rich areas of the plasma membrane. (wikipedia.org)
  • A caveolin that is expressed exclusively in MUSCLE CELLS and is sufficient to form CAVEOLAE in SARCOLEMMA. (lookformedical.com)
  • Internalisation of Rac binding sites is mediated by caveolin-1, a structural component of a subtype of rafts termed caveolae. (europa.eu)
  • Integrin-mediated retention of phosphorylated caveolin in focal adhesions inhibits raft internalisation, which occurs upon its recruitment to caveolae after cell detachment. (europa.eu)
  • Caveolae, Fenestrae and Transendothelial Channels Retain PV1 on the Su" by Eugene Tkachenko, Dan Tse et al. (dartmouth.edu)
  • and Stan, Radu V., "Caveolae, Fenestrae and Transendothelial Channels Retain PV1 on the Surface of Endothelial Cells" (2012). (dartmouth.edu)
  • The Cav-1/eNOS interaction tonically inhibits eNOS activity resulting in sequestering of eNOS in caveolae and reduced NO production. (blogspot.com)
  • Mineo, C & Shaul, PW 2012, Regulation of eNOS in caveolae . (elsevierpure.com)
  • Caveolae are one source of clathrin-independent raft-dependent endocytosis. (wikipedia.org)
  • Over-represented proteins were involved in the C-jun-amino-terminal kinase pathway, caveolae-mediated endocytosis signaling, cardiovascular-cancer-respiratory pathway, regulation of clathrin-mediated endocytosis, non-small cell lung cancer signaling, pulmonary hypertension, glutamate receptor, immune response and angiogenesis. (cdc.gov)
  • Here we studied the role of caveolae-mediated transendothelial albumin Aims Cardiac atrial natriuretic peptide (ANP) participates in the maintenance of arterial blood pressure and intravascular volume homeostasis. (uni-wuerzburg.de)
  • Here we studied the role of caveolae-mediated transendothelial albumin transport in the hyperpermeability effects of ANP. (uni-wuerzburg.de)
  • Conclusion ANP enhances transendothelial caveolae-mediated albumin transport via its GC-A receptor. (uni-wuerzburg.de)
  • Some known inhibitors of the caveolae pathway are Filipin III, Genistein and Nystatin. (wikipedia.org)
  • The above results demonstrate that RSV ameliorates caveolae-mediated hyperpermeability induced by high glucose via VEGF/KDR pathway. (springer.com)
  • It was reported that LDL-derived cholesterol, the major component of atherosclerotic plaque, enters the subendothelial space through the caveolae-mediated pathway (Sun et al. (springer.com)
  • 1999 ). Report showed that VEGF increased the permeability through caveolae-mediated transcellular pathway in the blood-tumor barrier (Zhao et al. (springer.com)
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  • Caveolae/lipid rafts are membrane-rich cholesterol domains endowed with several functions in signal transduction, and Cav-1 has been reported to be implicated in regulating multiple cancer-associated processes, ranging from cellular transformation, tumor growth and metastasis, to multidrug resistance and angiogenesis. (unibo.it)
  • As the dissociation of VEGFR-2 from caveolae has been shown to be essential for receptor autophosphorylation and activation of downstream signalling events, we investigated the presence and the role of VEGFR-2 in caveolae/lipid rafts, focusing our attention on the correlation between reactive oxygen species (ROS) production and glucose transport modulation by VEGF. (unibo.it)
  • Results showed that the disassembly of caveolae/lipid rafts by methyl-cyclodextrin induces an increase in intracellular ROS levels, glucose uptake and VEGFR-2 phosphorylation. (unibo.it)
  • To deeply analyse the role of caveolae/lipid rafts in redox signaling promoted by VEGF, the effect of Cav-1 scaffolding domain peptide was studied. (unibo.it)
  • Cavin1 has been shown to be the main regulator of caveola formation in multiple tissues, with the sole expression of Cavin1 sufficient for morphological caveola formation in cells lacking caveolae but abundant in Cav1. (wikipedia.org)
  • singular, caveola), which are a special type of lipid raft, are small (50-100 nanometer) invaginations of the plasma membrane in the cells of many vertebrates. (wikipedia.org)
  • Caveolae, referring to the 50-100 nm sized, flask-shaped, and non-clathrin-coated invaginations of the plasma membrane, regulates the kinetics of vesicle transport. (springer.com)
  • Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells. (elsevierpure.com)
  • Cavin proteins emerged in the late 2000s to be the main structural components controlling caveola formation. (wikipedia.org)
  • β-Cyclodextrin, a structural inhibitor of caveolae, reduced the hyperpermeability caused by high glucose. (springer.com)
  • The main structural proteins of CAVEOLAE. (lookformedical.com)
  • In terms of endothelial cell function, caveolae function, caveolae are important regulators of vascular tone through modulation of endothelial nitric oxide synthase (eNOS) activity. (blogspot.com)
  • Thus, signaling events in caveolae invoked by known circulating cardiovascular disease risk factors have major impact on eNOS and endothelial cell phenotypes of importance to cardiovascular health and disease. (elsevierpure.com)
  • Caveolae are also involved in regulation of channels and in calcium signaling. (wikipedia.org)
  • Caveolae also participate in lipid regulation. (wikipedia.org)
  • Regulation of eNOS within caveolae is an important mechanism. (blogspot.com)
  • In particular, high density lipoprotein cholesterol (HDL) maintains the lipid environment in caveolae, thereby promoting the retention and function of eNOS in the domain and it also causes direct activation of eNOS via scavenger receptor class B, Type I (SR-BI)-induced kinase signaling. (elsevierpure.com)
  • As early as 1 h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. (fujita-hu.ac.jp)
  • Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis. (fujita-hu.ac.jp)
  • Caveolae in CNS arterioles mediate neurovascular coupling. (ucsf.edu)
  • however, there are evidences indicating that caveolae was indispensable to the process, and it was suggested that VEGF-induced permeability was mediated by caveolae (Feng et al. (springer.com)
  • Caveolae-mediated permeability plays a major role in the transport of large molecules across endothelium (Komarova and Malik 2010 ). (springer.com)
  • Caveolae are abundant in many cell types which must withstand membrane stress. (edu.au)
  • Describing lower back pumps as painful and overall sense from caveolae to the Golgi apparatus in response to cholesterol oxidation. (zapthink.com)
  • They compartmentalize signal transduction molecules which regulate multiple endothelial functions including the production of nitric oxide (NO) by the caveolae resident enzyme endothelial NO synthase (eNOS). (elsevierpure.com)
  • We are using zebrafish and mouse models to understand the role of caveolae in protecting tissues from damage, with a particular focus on muscle and the zebrafish notochord. (edu.au)
  • The relationship between caveolae and eNOS is one of the cornerstones of caveolae involvement in cardiovascular function. (blogspot.com)
  • Caveolae have a role in the cell signaling, too. (wikipedia.org)
  • A tyrosine phosphoprotein that plays an essential role in CAVEOLAE formation. (lookformedical.com)
  • Cavin-1 is required for the formation of caveolae in all mammalian and plays a critical role in regulating caveolae function in endothelial cells. (blogspot.com)
  • Cavin-1 is required for the formation of caveolae. (blogspot.com)
  • Caveolae have been shown to be required for the protection of cells from mechanical stress in multiple tissue types such as the skeletal muscles, endothelial cells and notochord cells. (wikipedia.org)
  • Caveolae can also serve as mechanosensors in various cell types. (wikipedia.org)
  • Caveolae can be used for entry to the cell by some pathogens and so they avoid degradation in lysosomes. (wikipedia.org)