AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, Agriculture
Bone RegenerationCartilageCartilage, ArticularRegenerationBone and BonesOsteogenesisGuided Tissue RegenerationBone SubstitutesCartilage DiseasesBone Marrow CellsNerve RegenerationBone Morphogenetic Protein 2Tissue ScaffoldsBone RemodelingLiver RegenerationX-Ray MicrotomographyCalcium PhosphatesSkullBone MarrowBone MatrixTissue EngineeringMesenchymal Stromal CellsBone DensityBone DiseasesOsteoblastsChondrocytesBone TransplantationBiocompatible MaterialsBone DevelopmentFemurDurapatiteCell DifferentiationBone Morphogenetic ProteinsParietal BonePlatelet-Rich PlasmaCalcification, PhysiologicImplants, ExperimentalBone ResorptionAbsorbable ImplantsNasal CartilagesGuided Tissue Regeneration, PeriodontalFracture HealingAlkaline PhosphataseCells, CulturedTibiaOsteoarthritisBone NeoplasmsMandibleEar CartilageHyaline CartilagePeriosteumOsseointegrationWound HealingProteoglycansLaryngeal CartilagesBone Morphogenetic Protein 7Knee JointCollagenPorosityChondrogenesisOsteogenesis, DistractionMesenchymal Stem Cell TransplantationNanofibersMaterials TestingAggrecansAlveolar Bone LossCartilage Oligomeric Matrix ProteinMicroscopy, Electron, ScanningCollagen Type IICompressive StrengthNanocompositesCalcium SulfateCore Binding Factor Alpha 1 SubunitDental ImplantsOsteoarthritis, KneeCell ProliferationStem CellsBone Marrow TransplantationPolyglycolic AcidHematopoietic Stem CellsGlycosaminoglycansBony CallusBone CementsTime FactorsHematoceleStromal CellsCeramicsHydrogelsMaxillary SinusFractures, BoneExtracellular Matrix ProteinsIntegrin-Binding SialoproteinSkull FracturesMandibular InjuriesGelatinBiomechanical PhenomenaOsteocytesApatitesOsteocalcinMandibular Osteotomy
ArticularTissuesHyalineDefectsChondrocytesVivoExtracellularOsteoarthritisMeniscus regenerationHydrogelsVitroLigamentsStromalAutologousPieces of cartilageConnectiveSubchondral BoneLimb regenerationTissue EngineeringForm cartilage2019GraftsBiomaterialRegenerative MedicineDifferentiationCraniofacialCellsOsteogenesisReconstructionPlatelet-rich plasmaRepairBiomaterialsMSCsScaffoldsMoleculesEmbryonic developmentReconstructive surgeryFunctionalTransplantsClinicalPromoting bone formationProteoglycansLesionsRegenerateCollagenRegrowFavorableJointsEndochondralLesionOsteoarthriticStem cellHealsArtificial
Articular19
  • Replacement of hyaline cartilage (articular cartilage) is the most common application of synthetic cartilage. (wikipedia.org)
  • Chondrocytes vary in size, shape and concentration depending on their location in articular cartilage. (wikipedia.org)
  • There are three structural zones in articular cartilage including a superficial tangential zone, a middle transitional zone and a deep zone. (wikipedia.org)
  • Therefore, this study was designed to investigate the regeneration of articular cartilage and subchondral bone, using three-dimensional constructs of autologous adipose. (koreamed.org)
  • This is because articular cartilage of the type found in joints has a very poor ability to self-repair. (thenakedscientists.com)
  • This is similar to articular cartilage but with one important exception: it seems to have an enhanced potential for regeneration and growth. (thenakedscientists.com)
  • Studying the implanted nose cartilage also showed that it appeared to have remodelled itself to become more like articular cartilage and had increased the production of spongy molecules called glycosaminoglycans, which are highly abundant in normal cartilage. (thenakedscientists.com)
  • Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational. (thenakedscientists.com)
  • Tissue engineering and regeneration of bone and articular cartilage are the top priorities in the research conducted at the Center. (ucdavis.edu)
  • Superficial zone protein is produced by the top layer or articular cartilage and serves as a boundary lubricant, reducing friction. (ucdavis.edu)
  • One segment of the lab is analyzing the relationship between friction and wear of articular cartilage due to changes in mechanical loading, SZP expression, and the greater biomechanical environment. (ucdavis.edu)
  • Previous work by this lab has shown that SZP is produced by loading-bearing regions of articular cartilage. (ucdavis.edu)
  • In recent years, the lab has identified stem and progenitor cells in articular cartilage, muscle and synovial tissues. (ucdavis.edu)
  • Building upon this work we are exploring the differentiation of embryonic and adult stem cells for articular cartilage and bone repair. (ucdavis.edu)
  • Cucchiarini, M., Madry, H. Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair. (uniklinikum-saarland.de)
  • Successful Fixation of Traumatic Articular Cartilage-Only Fragments in the Juvenile and Adolescent Knee: A Case Series. (mayo.edu)
  • Another example is articular cartilage damage as a result of trauma or chronic degenerative changes. (openorthopaedicsjournal.com)
  • Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. (udc.es)
  • On these bases, the combined use of autologous non-expanded tissue products made of whole bone marrow and human white adipose tissue derivatives, such as the Lipogems product, can be considered as an autologous/homologous strategy for improving the natural capacity for self-healing in damaged osteo-articular tissues. (jnanoworld.com)
Tissues11
  • But research progressed and different trials explore the clinical potential of human MSCs isolated from bone marrow but also from other tissues including adipose tissue. (hindawi.com)
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • However, this technique comes with its limitations, as these structures can often have inappropriate mechanical integrity and don't allow the formation of new bone tissues. (medicaldevice-network.com)
  • The human musculoskeletal system is comprised mainly of connective tissues such as cartilage, tendon, ligaments, skeletal muscle and skeletal bone. (ibecbarcelona.eu)
  • Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
  • The collagen meshwork plays a central role in the functioning of a range of tissues including cartilage, tendon, arteries, skin, bone and ligament. (ox.ac.uk)
  • Here, we have used second harmonic generation (SHG) to image human tissues on the hundreds of micron scale, and developed a numerical model to quantitatively interpret the images in terms of the underlying collagen structure on the tens to hundreds of nanometer scale. (ox.ac.uk)
  • The results may be important to the design of materials to induce the regeneration of lost or damaged tissues in the body. (materialstoday.com)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
Hyaline6
Defects3
  • Large bone defects can often not sufficiently be repaired by the body itself and require new clinical therapies 1 . (nature.com)
  • An innovative clinical procedure has provided evidence that wide areas of severe cartilage defects due to osteoarthritis of the inferior limb, Kellgren stage I to III, in particular knee and ankle, can be successfully restored through transplant of human bone marrow combined with a defined human fat tissue product, like the Lipogems product. (jnanoworld.com)
  • Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Chondrocytes9
Vivo12
  • After bone fractures mesenchymal stromal cells (MSCs) take on a key role in the in vivo bone repair process 1 . (nature.com)
  • The use of donor derived MSCs for triggering the bone regeneration in vivo is a promising tool for assisting the healing process. (nature.com)
  • Interaction of MSCs with bone morphogenic proteins (BMPs) in an alginate scaffold mimicking the extracellular matrix (ECM) in vivo enhances their differentiation into bone cells 9 . (nature.com)
  • BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. (prospecbio.com)
  • For this purpose, an ex vivo defect model with osteochondral grafts is used, in which a defect is generated in these bone-cartilage cylinders and the hydrogels are cultivated in 3D-printed and injected form over several weeks. (donau-uni.ac.at)
  • We developed techniques to isolate mouse OMSCs derived from mandibles and verified their MSC characteristics by single colony formation, multi-lineage differentiation, and in vivo tissue regeneration. (ca.gov)
  • Our study suggests that both OMSCs and host cells contribute to bone formation in vivo. (ca.gov)
  • However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
  • In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
  • In vivo regeneration of epithelium and cartilage were demonstrated in animal models. (biomedcentral.com)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • Olsson E, Folkesson E, Peterson P, Önnerfjord P, Tjörnstrand J, Hughes HV, Englund M, Svensson J. Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci. (lu.se)
Extracellular6
Osteoarthritis2
Meniscus regeneration2
Hydrogels3
  • Artificial cartilage is a synthetic material made of hydrogels or polymers that aims to mimic the functional properties of natural cartilage in the human body. (wikipedia.org)
  • While the broader category of "gels" could be filled with anything, including chemical solvents, water is the key ingredient that sets hydrogels apart, making them ideal for, as some scientists put it, "merging humans and machines. (webmd.com)
  • The composition and properties of the hydrogels should ultimately enable their future use in traumatic cartilage damage (e.g., as a result of an accident) as well as in osteoarthrosis, which develops under overloading, pathological wear and tear or as a result of cartilage damage. (donau-uni.ac.at)
Vitro5
  • Dynamic Compressive Loading Improves Cartilage Repair in an in vitro Model of Microfracture: Comparison of Two Mechanical Loading Regimens on Simulated Microfracture Based on Fibrin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells. (chop.edu)
  • Engineering in vitro vascularized bone models for drug screening and predictive toxicology. (chop.edu)
  • The most commonly used type of stem cells, mesenchymal stem cells (MSCs), can be easily isolated from bone marrow or synovium and cultured in vitro . (openorthopaedicsjournal.com)
  • Abstract] The unavailability of sufficient numbers of human primary cells is a major roadblock for in vitro repair of bone and/or cartilage, and for performing disease modelling experiments. (udc.es)
  • Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. (udc.es)
Ligaments1
  • Ligaments bind bones together and tendons bind muscle to bone. (360activ.com)
Stromal10
Autologous3
  • Therefore, effective autologous nerve replacement is critical in the field of peripheral nerve regeneration. (biomedcentral.com)
  • In collaboration with investigators in Taiwan, we implanted one type of autologous OMSCs (periodontal ligament progenitors, PDLPs) to treat an orofacial infectious bone defect disease periodontitis. (ca.gov)
  • This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Pieces of cartilage2
Connective2
  • This tissue has cells that have the unique ability to transform into other cell types, including bone, cartilage, muscle, and connective tissue. (drlynellemcsweeney.com)
  • Additional next steps will be replicating our success in muscle regeneration with human cells and expanding that to other tissue types, such as bone, cartilage and connective tissue," Ott said. (well.org)
Subchondral Bone1
  • PURPOSE: The purpose of this study is to evaluate the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) after microfracture on the remodeling of subchondral bone and cartilage healing in. (koreamed.org)
Limb regeneration1
Tissue Engineering6
Form cartilage1
  • Developed by scientists at the University of Texas Health Science Center at Houston (UTHealth), Monash University and RIKEN Centre for Developmental Biology, the technique allowed the creation of cells that have the appearance and behaviour of normal cells in the stage just before they form cartilage. (futurism.com)
20191
Grafts2
Biomaterial3
  • Bioprinting refers to 3D printers which deposit layers of biomaterial to build complex bodily structures like skin, bones and even corneas. (medicaldevice-network.com)
  • A team from Swansea University in the UK has developed a bioprinting process which can create an artificial bone matrix, using durable, regenerative biomaterial. (medicaldevice-network.com)
  • The bioprinted bones can be printed in the exact structure needed with a durable and regenerative biomaterial. (medicaldevice-network.com)
Regenerative Medicine2
  • Regenerative medicine and surgery are emerging areas of medicine that are based on design and development of spare parts for the human body. (ucdavis.edu)
  • Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. (udc.es)
Differentiation9
  • This pure protein-based and chemically modifiable, fibrous ECM model allows the investigation of MSC behavior on biomimetic materials to unfold new vistas how to direct cells' differentiation for the development of new bone regenerating strategies. (nature.com)
  • Therefore, it is important to understand how MSC differentiation into bone cells is controlled and how this process can be guided or improved by externally added factors. (nature.com)
  • Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
  • We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Therefore, it is not surprising to find that human OMSCs are distinct from BMMSCs in terms of differentiation traits and immunoregulation. (ca.gov)
  • To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
  • Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
  • The practice of dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. (bvsalud.org)
Craniofacial1
  • Embryologic development and amalgamations of the complex array of bones and cartilage in the craniofacial region have revealed that the molecular mechanisms controlling skeletogenesis in the orofacial bones are quietly unique and different from in the axial and appendicular bones. (ca.gov)
Cells39
  • Biologists have shown for the first time in the laboratory that they can convert some adult human neural stem cells to brain cells that can produce dopamine, the brain chemical missing in Parkinson's disease. (scienceblog.com)
  • Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
  • BMP-7 Human Recombinant produced in HEK cells is a glycosylated disulfide-linked homodimer, having a molecular weight range of 30-38kDa due to glycosylation. (prospecbio.com)
  • Collaboratively developed by at St Vincent's, The University of Melbourne, University of Wollongong, and Swinburne University of Technology, the Biopen uses 3D technology to print live cells to repair damage to cartilage, muscles, tendons and bones. (svhm.org.au)
  • The BioPen is a handheld device which uses 3D-printing methods to let surgeons 'draw' live cells and growth factors directly onto the site of an injury - to help accelerate the regeneration of functional bone and cartilage. (svhm.org.au)
  • To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • Under local anaesthetic, and using standard knee operating techniques, the patches were implanted into the damaged knee joint, "butter side down" so that the new cells were in contact with the underlying bone at the injury site. (thenakedscientists.com)
  • Like other stem cells, these fat-derived cells can transform into many different kinds of specialized cells - including fat, bone, and cartilage cells, among others - and could be used for an expanding range of reconstructive and cosmetic procedures. (plasticsurgery.org)
  • In contrast, they were less likely to develop into bone and cartilage cells. (plasticsurgery.org)
  • Based on those qualities, high-pressure oxygen treatment of belly-fat stem cells is a feasible option for procedures where regeneration of fat cells is needed. (plasticsurgery.org)
  • Morscheid S., Rey-Rico A., Schmitt G., Madry H., Cucchiarini M., Venkatesan J.K. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells. (uniklinikum-saarland.de)
  • The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
  • Stem cells are special cells that act as building blocks and have the potential to distinguish the types of cells within the human body. (selfgrowth.com)
  • Then the physician will extract a sample of your bone marrow from the iliac crest which is considered one of the most fruitful sites to harvest stem cells. (selfgrowth.com)
  • The blood samples and bone marrow samples are used for the total knee replacement surgery in Chennai to prepare an injection of growth factors from the blood and stem cells processed out of the bone marrow. (selfgrowth.com)
  • When the researchers transplanted these special proto-cartilage cells - more accurately known as chondrocyte precursor cells - into mice, they developed into structures that had the appearance and characteristic of bone. (futurism.com)
  • According to the researchers, the technique can be easily scaled up to generate large numbers of these cells at once, giving it serious potential for human use. (futurism.com)
  • Using BV system and sodium butyrate treatment we expressed human VEGF165 in mADSC (production of VEGF165 reached ≈ 25-27 ng/ml/10 5 cells) and optimized conditions to ensure cells' viability after transduction. (biomedcentral.com)
  • MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
  • The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
  • If he can successfully identify what could go wrong in bone regeneration treatments, his research could provide clinical solutions for patients with bone trauma, created from patients' own cells. (journalrecord.com)
  • In his experiments, he will take adult stem cells from bone marrow and mix them with a nutrient soup of sugar and oxygen, which encourages the stem cells to turn into bone cells. (journalrecord.com)
  • The new cells are then placed on a porous scaffolding-type material in the gap between bones. (journalrecord.com)
  • The expectation is that the new bone cells will grow over the degradable scaffolding, forming new bone. (journalrecord.com)
  • Using a patient's own stem cells means less chance of rejection, which is often a risk with cadaver bones. (journalrecord.com)
  • Krampera M, Glennie S, Dyson J et al Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T cells to their cognate peptide. (seffiline.com)
  • Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killer-mediated lysis. (seffiline.com)
  • Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. (seffiline.com)
  • Chemical cues have been known to work in cases where researchers have identified the proper additives-a hormone in the case of bone cells. (materialstoday.com)
  • The experiments at NIST are believed to be the first head-to-head comparison of five popular tissue scaffold designs to examine the effect of architecture alone on bone marrow cells without adding any biochemical supplements other than cell growth medium. (materialstoday.com)
  • Mature bone cells are characteristically long and stringy with several extended branches. (materialstoday.com)
  • Being in the shape of a bone cell seems to induce the cells to activate the genes that ultimately produce bone tissue. (materialstoday.com)
  • The specialized olfactory epithelial cells characterize the only group of neurons capable of regeneration. (medscape.com)
  • There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)
  • The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
  • To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)
  • It stimulates the cells in the cartilage to make more cartilage," says Marc Hochberg, MD, primary investigator of the study and head of rheumatology and clinical immunology at the University of Maryland School of Medicine. (medscape.com)
Osteogenesis7
  • It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
  • BMP-7 (Bone Morphogenetic Protein-7), also known as Osteogenic Protein 1 or BMP-7, is a potent growth factor that plays a crucial role in various biological processes, particularly in osteogenesis and tissue regeneration. (prospecbio.com)
  • BMP-7, also known as Osteogenic Protein 1 or BMP-7, is a growth factor with multifaceted roles in osteogenesis, tissue regeneration, and disease. (prospecbio.com)
  • BMP-7 plays critical roles in various physiological processes, particularly in osteogenesis and tissue regeneration. (prospecbio.com)
  • Therefore, Fgfr3 + endosteal SSCs are abundant in young bone marrow and provide a robust source of osteoblasts, contributing to both normal and aberrant osteogenesis. (nature.com)
  • In this study, we report a novel population of SSCs with osteoblast-chondrocyte transitional (OCT) identities in the bone marrow endosteal space, which highly expresses Fgfr3 and contributes to both normal and aberrant osteogenesis. (nature.com)
  • Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
Reconstruction1
  • Inhibition to tracheal surgery before 1960 was explained by difficulties related to perioperative ventilation, the poor healing capacity of cartilage and, finally, the "2-cm Belsey rule" stipulating that it was not possible to remove more than 2 cm of the trachea with primary reconstruction [ 1 ]. (biomedcentral.com)
Platelet-rich plasma1
Repair5
  • First, cartilage is an avascular structure in the body and therefore does not repair itself. (wikipedia.org)
  • Large or complex bone fractures often need clinical treatments for sufficient bone repair. (nature.com)
  • The UC Davis Center for Tissue Regeneration and Repair focuses on regeneration for the musculoskeletal system to restore function to tissue diseased or damaged from cancer, trauma, and arthritis. (ucdavis.edu)
  • The research has particular potential for the repair of damaged cartilage and bone in joints and the spine - conditions that plague professional athletes and those who do a lot of manual labour as part of their jobs. (futurism.com)
  • Another treatment, sprifermin, is a type of human fibroblast growth factor, which plays a role in cell growth and tissue repair. (medscape.com)
Biomaterials1
  • Biomaterials for meniscus and cartilage in knee surgery: state of the art. (mayo.edu)
MSCs3
  • We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
  • Activated T-lymphocytes impaired OMSCs via the Fas/Fas ligand pathway, as occur in long bone MSCs. (ca.gov)
  • Furthermore, we found that OMSCs are distinct from long bone MSCs with respect to regulating T-lymphocyte survival and proliferation. (ca.gov)
Scaffolds1
  • Electrospun Scaffolds in Tendons Regeneration: a review. (chop.edu)
Molecules1
Embryonic development2
  • Reporting in the January issue of Developmental Dynamics, Northwestern researchers Hans-Georg Simon and Stuart Stock showed that bone formation in a regenerated forelimb combines elements of embryonic development and of adult wound healing. (scienceblog.com)
  • Regeneration recapitulates embryonic development and morphogenesis. (ucdavis.edu)
Reconstructive surgery1
  • Nonunion and segmental bone loss after fracture, reconstructive surgery, or lesion excision can present complex orthopedic problems, and the multiple surgical procedures often needed are associated with patient morbidity and reduced quality of life. (who.int)
Functional3
Transplants2
  • Also in some cases, total knee replacement surgery in Chennai includes knee cartilage transplants in which the damaged cartilage will be replaced with a new one. (selfgrowth.com)
  • Ott and his team of researchers made a rat leg with functioning muscular and vascular tissue, and although they have a long way to go before using it for transplants, they believe the rat limb can help humans and primates in the future. (well.org)
Clinical3
  • Ultimately, there is a need for randomised controlled trials on human populations to apply these findings to a clinical setting. (openorthopaedicsjournal.com)
  • We have successfully established BRONJ minipig and mouse models treated with oncologic doses of zolendronate (Zometa)/Dexamethasone (Dex) developed BRONJ-like pathological lesions with similar clinical, radiographic, and histological features as described in the human disease. (ca.gov)
  • Sikavitsas said he hasn't yet envisioned a business plan for the clinical uses of regenerating bone tissue. (journalrecord.com)
Promoting bone formation1
  • This section provides an in-depth analysis of BMP-7's contributions to these processes, emphasizing its role in promoting bone formation, cartilage development, renal function, and wound healing. (prospecbio.com)
Proteoglycans2
  • Proteoglycans: Proteoglycans are the second most abundant macromolecule in the ECM of cartilage. (wikipedia.org)
  • Prof Mauro Alini graduated with a degree in chemistry from the University of Lausanne in 1983 and started his PhD research work on the isolation and characterization of proteoglycans extracted from both normal human mammary glands and related carcinomas. (aofoundation.org)
Lesions1
  • Most of the musculoskeletal injuries require surgical intervention facing a limited post-surgery tissue regeneration, especially for widespread lesions. (ibecbarcelona.eu)
Regenerate2
  • While we're not quite there with natural regrowth of certain functions, scientists have found a way regenerate meniscus in sheep using human growth factors. (orthopedicsurgerysandiego.com)
  • However, a similar technique without the use of scaffolding is already in use to regenerate damaged cartilage. (journalrecord.com)
Collagen2
Regrow1
Favorable1
Joints1
Endochondral1
  • Endochondral bone formation seems to be affected in MPS IV. (medscape.com)
Lesion1
  • Osteochondral lesion is a major joint disease in humans. (koreamed.org)
Osteoarthritic1
  • Focusing on osteoarthritic changes in cartilage, we have demonstrated that this combination of polarized SHG imaging and numerical modeling can estimate fibril diameter, filling fraction, orientation and bundling. (ox.ac.uk)
Stem cell3
  • The project, led by St Vincent's Professor Peter Choong is focused on creating a hand-held 3D printer pen filled with stem cell ink, to 'draw' new cartilage into damaged knees. (svhm.org.au)
  • This project also incorporates Biosphere, a novel stem cell technology developed by Swinburne University and St Vincent's Hospital to refine the cell numbers for tissue regeneration. (svhm.org.au)
  • Scientists have successfully formed 'bone-like structures' in mice using a new stem cell-based technique, which they believe could be transferred to humans. (futurism.com)
Heals1
Artificial1
  • During the surgery, the ends of the thighbone are ejected and replaced with an artificial metal shell the edge of the leg bone is replaced with a plastic piece over a manmade metal stem. (selfgrowth.com)