• Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • All of these factors are known to result in myocardial apoptosis(5) and the acceleration of allograft rejection or chronic allograft dysfunction. (researchsquare.com)
  • During extended myocardial ischemia combinations of hypoxia and acidosis drive cardiac cell loss by apoptosis and necrosis that contribute importantly to myocardial infarction (MI). (biomedres.us)
  • Here we investigated roles for miR-126 in stress kinase activation, induction of inflammatory cytokines and apoptosis caused by exposure of cultured cardiac myocytes to hypoxia/acidosis or acidosis alone. (biomedres.us)
  • Obligatory roles for acidosis in promoting apoptosis confirmed our previous reports that hypoxia alone does not confer a lethal signal. (biomedres.us)
  • Acidosis with or without hypoxia increased apoptosis that was paralleled by elevated miR-126, increased phosphorylation of p38-MAPK and JNK, enhanced expression of IL-6, IL-8, and TNF, and downregulation of Bcl-2. (biomedres.us)
  • Our group reported that severe chronic hypoxia alone does not cause apoptosis of cardiac myocytes in culture. (biomedres.us)
  • Miranda J, Paules C, Nair S, Lai A, Palma C, Scholz-Romero K, Rice GE, Gratacos E, Crispi F, Salomon C. Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth. (ac.ir)
  • Shalom-Paz E, Weill S, Ginzberg Y, Khatib N, Anabusi S, Klorin G, Sabo E, Beloosesky R. IUGR induced by maternal chronic inflammation: long-term effect on offspring's ovaries in rat model-a preliminary report. (ac.ir)
  • 12 HELIOS-Klinikum, Berlin, Germany.Preeclampsia, with the hallmark features of new-onset hypertension and proteinuria after 20 weeks of gestation, is a major cause of fetal and maternal morbidity and mortality. (jci.org)
  • We evaluated whether siRNA targeting maternal hepatic angiotensinogen (Agt) could ameliorate symptoms of preeclampsia without adverse placental or fetal effects in 2 rodent models. (jci.org)
  • The myocardial nicheplays a critical role in directing the function and fate of cardiomyocytes;therefore, engineering a biomimetic scaffold holds excellent promise.We produced an electroconductive cardiac patch of bacterial nanocellulose(BC) with polypyrrole nanoparticles (Ppy NPs) to mimic the naturalmyocardial microenvironment. (ibecbarcelona.eu)
  • Our latest study (7) discovered that chronic high-fat nourishing impairs myocardial blood sugar metabolism which was connected with ventricular hypertrophy and cardiac dysfunction in obese mice. (cancer-ecosystem.com)
  • Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
  • Essentially, by providing excessive cholinergic stimulation throughout fetal life, nicotine discoordinates the numerous events in cell replication, differentiation and synaptic development that are necessary to the proper assembly of the mammalian brain. (nature.com)
  • Objective: To investigate the induction of tanshinone [1 A (Tan fl A) on the differentiation of human placenta-derived mesenchymal stem cells (hPDMSCs) into cardiomyocytes, and to provide an experimental basis for Tan IT A as a cardiomyocytc differentiation inducer. (researchgate.net)
  • Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
  • The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
  • Chronic hypoxia in the presence of high glucose leads to progressive acidosis of cardiac myocytes in culture. (biologists.com)
  • Methods: A total of 320 cases of single fetal pregnant women within 11-40 weeks were selected as the objects. (researchgate.net)
  • BACKGROUND: The association between chronic anterior cruciate ligament (ACL) injury and inferior postoperative outcomes following ACL reconstruction (ACLR) has been highlighted in the literature. (bvsalud.org)
  • Thus, an RNAi therapeutic targeting Agt ameliorated the clinical sequelae and improved fetal outcomes in 2 rodent models of preeclampsia. (jci.org)
  • Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)
  • Metallothionein expression is upregulated during fetal development, particularly in liver tissue. (wikipedia.org)
  • Second, the larger amounts of tissue available from fetal monkey brain enables determinations to be carried out more readily in specified regions and subregions. (nature.com)
  • In these cardiomyocytes, we will determine renal potential reference in studies during tissue and the hypertonic Body, and in cytokines with chronic remodeling engraftment, growth, neurodegenerative matrix, and died chronic SLE sphingosine surgical to infusion body or vivo ideal Severe tissue Density. (augenta.net)
  • Longitudinal follow-up of infants with Zika virus exposure in utero is important to characterize neurodevelopmental delay not apparent in early infancy, but logistically challenging in surveillance models. (cdc.gov)
  • When the cardiorespiratory system becomes compromised due to noxious environmental conditions (hypoxia, hypercarbia) during sleep, such infants may not become aroused to defend against these conditions, resulting in sudden death. (medscape.com)
  • Our results indicate that nicotine elicits neurodevelopmental damage that is highly selective for different brain regions, and that dietary supplements ordinarily thought to be neuroprotectant may actually worsen some of the adverse effects of nicotine on the fetal brain. (nature.com)
  • Hypoxia (low oxygen availability) can occur in physiologica. (uc.edu)
  • Cells have to cope with challenging changes in their environment such as alterations in osmolarity, ion homeostasis, redox state, oxygen or nutrient supply, or exposure to ionizing radiation or potentially toxic substances. (cell-stress.com)
  • It thus would require a comprehensive understanding of developmental biology and a development of new approaches to activate the critical players to rejuvenate the self-repair mechanism in the elder or under chronic injury condition. (biomedcentral.com)
  • information, heart, and mode of chronic edema baseline blood in elderly new nitrotyrosine condition. (siriuspixels.com)
  • Objective: To explore the correct test ways of the ductus venosus (DV) blood flow spectrum of the normal fetal and the rule of changes of the normal fetal DV blood flow spectrum along with gestational week, and to establish the reference ranges of the parameters of blood flow. (researchgate.net)
  • Results: The doppler spectrum of normal fetal DV blood flow showed the same three-phase waves, SV was increased with the increase of gestational age (F=27. (researchgate.net)
  • Conclusion: The performance of color Doppler flow imaging of normal fetal DV showed that the blood flow peak speed is increased along with the increase of gestational age and PI, RI and S/a are reduced with the increase of gestational age, and RI has the largest decline, which has important diagnosis value. (researchgate.net)
  • Fetal brain regions and peripheral tissues were examined for nAChR subtypes, other neurotransmitter receptors, and indices of cell signaling and cell damage. (nature.com)
  • 1. Role of ion channels in T cell response and adaptation to hypoxia. (uc.edu)
  • Conclusion: LITA appears to attenuate the harmful chronic neuroinflammation observed during brain remodeling after a focal ischemic insult. (westminster.ac.uk)
  • Biochemicalanalyses revealed that H9c2 cells showed different cardiomyocyte phenotypesand distinct levels of maturity depending on the amount of Ppy inthe substrate used. (ibecbarcelona.eu)
  • Cardiomyocytes were randomly assigned to the control group, ISO group (100 nM ISO for 48 h), Res + ISO group (50 μM Res and 100 nM ISO for 48 h) and Res group (50 μM Res for 48h only). (karger.com)
  • AV coaptation, whether phasic or chronic, preserved phenotypic gene expression. (stanford.edu)
  • There must be some critical elements that are involved in the repair process, but are suppressed in the elder or under the chronic injury condition. (biomedcentral.com)
  • Increasing evidence signifies the function of chronic irritation and macrophage activation in insulin level of resistance (8 9 A cohort of latest studies (10-13) showed boosts in macrophage infiltration and cytokine appearance in adipose tissues and their association with insulin level of resistance in obese human beings and animal versions. (cancer-ecosystem.com)
  • These results demonstrate that IUGR leads to exaggerated chronic hypoxia pulmonary arterial hypertension (CH-PAH) in association with decreased Kv1.5 expression in PASMCs. (scielo.br)
  • Pulmonary arterial hypertension (PAH) is associated with intrauterine growth retardation (IUGR), the fetal origin of adult disease ( 1 1. (scielo.br)
  • A rat model of chronic hypoxia (2 weeks of hypoxia at 12 weeks old) following IUGR was used to investigate the physiological and structural effect of intrauterine malnutrition on the pulmonary artery by evaluating pulmonary artery systolic pressure and vascular diameter in male rats. (scielo.br)
  • We found that IUGR increased mean pulmonary artery pressure and resulted in thicker pulmonary artery smooth muscle layer in 14-week-old rats after 2 weeks of hypoxia, while no difference was observed in normoxia groups. (scielo.br)
  • In the PASMCs of IUGR-hypoxia rats, Kv1.5 mRNA and protein expression decreased while that of tyrosine-phosphorylated Kv1.5 significantly increased. (scielo.br)
  • A reduction in placental 11β-HSD2 is observed in human pregnancies and complicated by intrauterine growth restriction (IUGR), [ 45 ] suggesting a physiological importance to altered GC exposure in the fetal programming of adult disease. (medscape.com)
  • Thompson LP , Crimmins S, Telugu B, Turan S. Intrauterine hypoxia: clinical consequences and therapeutic perspectives. (umaryland.edu)
  • Under conditions of intrauterine hypoxia (where oxygen levels are further reduced from normal), the fetus is vulnerable to hypoxic stress. (umaryland.edu)
  • The fetus's ability to adapt to this stress depends on the length and severity of the exposure, although may result in intrauterine growth restriction, fetal brain damage and altered cardiac function. (umaryland.edu)
  • Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms. (scielo.br)
  • MMP expression/activity can be modulated by venous hydrostatic pressure, hypoxia, tissue metabolites, and inflammation. (oaepublish.com)
  • MMP mRNA expression, protein levels and proteolytic activity can be modulated by numerous factors including venous hydrostatic pressure, hypoxia, tissue metabolites and the inflammatory response. (oaepublish.com)
  • Treadmill Exercise Attenuates α-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease. (molcells.org)
  • [ 27-29 , 41 ] Fetal responses to direct GC exposure leads to hypertension and a reduction in nephron number in the rat that does not always coincide, depending on the gestational age of insult and the length of exposure. (medscape.com)
  • We have identified that prolonged exposure to hypoxia increases gene expression of some of these factors, contributing to both adaptive and maladaptive responses in the fetal cardiovascular system. (umaryland.edu)
  • Hypoxia exposure is responsible for the high incidence of congenital heart defects (CHDs) in high-altitude areas, which is nearly 20 times higher than that in low-altitude areas. (nih.gov)
  • BACKGROUND: To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. (cdc.gov)
  • CONCLUSION: Understanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families. (cdc.gov)
  • Further, we are also interested in the effect of hypoxia on trophoblast invasion of the placenta and its impact on spiral artery remodeling, placental perfusion, and maternal and fetal consequences. (umaryland.edu)
  • Experimental studies demonstrate that excess exposure to GCs during gestation, either through direct administration of GCs or by inhibition of 11β-hydroxysteroid dehydrogenase type2 (11β-HSD2), an enzyme that serves as a barrier to fetal exposure to maternal GCs, leads to alterations in vascular function and blood pressure. (medscape.com)
  • Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. (jci.org)
  • Using a myocardial infarction (MI) model, we found that cardiac function and the number of proliferating cardiomyocytes were decreased in the neonatal LPA 3 KO mice and increased in the AAV9-mediated cardiac-specific LPA 3 overexpression mice. (thno.org)
  • By using lineage tracing and AAV9-LPA 3 , we further found that LPA 3 overexpression in adult mice enhances cardiac function and heart regeneration as assessed by pH3-, Ki67-, and Aurora B-positive cardiomyocytes and clonal cardiomyocytes after MI. (thno.org)
  • If not adequately treated, VVs could progress to chronic venous insufficiency (CVI) and lead to venous leg ulcer (VLU). (oaepublish.com)
  • The pathophysiological process of ischemia-reperfusion injury in prolonged myocardial ischemia results in cardiomyocyte loss, microcirculatory disturbances and post-ischemic inflammation [ 2 ]. (biomedcentral.com)
  • Notably, after myocardial infarction, cardiomyocytes are incapable of sufficient regeneration to correct losses. (biomedcentral.com)
  • Thus, excess fetal exposure to GCs mediated via a reduction in placental 11β-HSD2 may be a common mechanistic pathway programmed in response to fetal insult. (medscape.com)
  • Genome-wide transcriptional profiling and additional mechanistic studies showed that LPA induces cardiomyocyte proliferation through the PI3K/AKT, BMP-Smad1/5, Hippo/YAP and MAPK/ERK pathways in vitro , whereas only ERK was confirmed to be activated by LPA-LPA 3 signaling in vivo . (thno.org)
  • [ 41 ] Alterations in the function of the HPA axis also appear to occur in an age-dependent manner and demonstrate sex differences in response to GC exposure. (medscape.com)
  • Marked alterations in kidney morphology, such as a decrease in nephron number, is a common phenotypic outcome observed in response to fetal insult in many different animal models of fetal programming. (medscape.com)
  • If the force is a Web exercise that has readmission-free Consciousness of its receptors, PubMed will form patients to that Cerebral, functionally potentially as to cardiomyocytes exceeding responsible such alterations. (siriuspixels.com)
  • Prolonged exposure to reduced oxygen levels (hypoxic stress) is the leading cause of fetal morbidity and mortality. (umaryland.edu)
  • Transcriptional changes in hypoxic cancer cells are controlled by several well-understood hypoxia response pathways [ 12 - 14 ]. (biomedcentral.com)
  • Fetal exposure to excess glucocorticoids (GCs) may be a critical link between an adverse fetal environment and programming of CV disease and hypertension. (medscape.com)
  • [ 28 ] In addition, GC exposure during late gestation in the rat may not always result in programmed hypertension. (medscape.com)
  • Thus, a causative role for GCs in the fetal programming of adult disease is strongly suggested by experimental studies, with a role for GCs linked to the programming of potential mediators of CV and blood pressure regulation, including reduced nephron number, vascular function and the RAS. (medscape.com)
  • The developmental origins of chronic adult disease. (scielo.br)
  • Research progress of mitophagy in chronic cerebral ischemia. (molcells.org)
  • Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells. (amedeo.com)
  • In a sense, PPARs may be an evolutionary solution to something we call the 'hypoxia-lipid' conundrum, where the ability to store and burn fat is essential for survival, but is a 'double-edged sword', as fats are potentially highly toxic. (westminster.ac.uk)
  • [ 50 ] However, experimental studies demonstrate that fetal programming of reduced nephron number is sensitive to the timing of fetal insult. (medscape.com)
  • Role of sirtuin1 in impairments of emotion-related behaviors in mice with chronic mild unpredictable stress during adolescence. (molcells.org)
  • The aim of this study is to investigate whether chronic ACL injury is associated with an inferior tibiofemoral position measured on magnetic resonance (MR) images after primary ACLR. (bvsalud.org)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Most types of heart disease, especially prolonged ischemia and heart failure, are characterized by a loss of cardiomyocytes. (biomedcentral.com)
  • This can lead to the development of chronic heart failure among survivors of infarction. (biomedcentral.com)
  • Our study reports that LPA 3 -mediated LPA signaling is a crucial factor for cardiomyocyte proliferation in the early postnatal heart. (thno.org)
  • Thompson LP , Al-Hasan Y. Impact of oxidative stress in fetal programming. (umaryland.edu)
  • Glomerular hyperfiltration is a typical feature of several common forms of chronic kidney diseases exposing podocytes to increased fluid flow shear stress. (mdpi.com)
  • [ 46 , 52 ] Fetal exposure to GCs also results in a time-sensitive window of fetal exposure with administration of GCs during days 15-18 of gestation, leading to a reduction in nephron number that is not observed when GC exposure is administered prior to or after that critical time frame. (medscape.com)
  • RESULTS: No significant differences in preoperative LATS, MATS, GATS or IRTS were identified between the acute and chronic ACL-injured groups. (bvsalud.org)
  • The characterization and performance results of the membrane demonstrated an increase in ion selectivity and water flux, impressive stability of salt rejection after chlorine exposure, and improved antifouling performance. (ibecbarcelona.eu)
  • Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease. (jci.org)
  • The modified membrane demonstrated ameliorative chlorine resistance relative to the pristine one, with twice the increase in crosslinking degree, more than four times the enhancement of the oxidation resistance, negligible reduction in the salt rejection (0.83 %), and only 5 L/m2.h flux loss following a rigorous static chlorine exposure of 500 ppm.h under acidic conditions. (ibecbarcelona.eu)
  • Transcriptional activity is selectively and progressively dampened at bivalently marked loci upon repeated exposure to hypoxia, indicating that this subset of genes uniquely maintains the potential for epigenetic regulation by KDM activity. (biomedcentral.com)
  • Epidemiological studies and animal models have now identified a strong association between reduced fetal growth and an increased risk of disease in the adult, suggesting the importance of fetal health on adult well-being. (umaryland.edu)
  • Chronic venous disease (CVD) is a common venous disorder of the lower extremities. (oaepublish.com)
  • Chronic venous disease (CVD) is a common venous disorder characterized by dilation of the veins of the lower extremities and often varicose veins (VVs). (oaepublish.com)
  • Multivariate linear regression analyses showed that chronic ACL injury resulted in an estimated increase of 2.0 mm in postoperative MATS (p = 0.012) and 1.9 mm in postoperative GATS (p = 0.040). (bvsalud.org)
  • BACKGROUND: The association between chronic anterior cruciate ligament (ACL) injury and inferior postoperative outcomes following ACL reconstruction (ACLR) has been highlighted in the literature. (bvsalud.org)
  • The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection. (duke.edu)
  • METHODS: A total of 62 patients that underwent primary ACLR were included in this study based on the time from injury to surgery, namely the acute ACL-injured group (within 6 weeks) and the chronic ACL-injured group (more than 1 year) and were matched 1:1 according to sex, age (± 2 years), and time from surgery to follow-up (± 3 months). (bvsalud.org)
  • The chronic ACL-injured patients showed significantly increased postoperative MATS (p = 0.001) and GATS (p = 0.012), while no significant difference was identified in postoperative LATS or IRTS. (bvsalud.org)
  • CONCLUSION: Chronic ACL-injured patients showed increased MATS and GATS measured on 1-year postoperative MR images after primary single-bundle ACL reconstruction, while no difference was identified in rotational tibiofemoral position. (bvsalud.org)
  • the supervisor deals with the situation and, if there is neither a technical problem nor a false alarm, wakes the subject, as CCHS patients usually recover from hypoxia when roused from sleep. (nih.gov)
  • However, programming effects mediated via direct GC excess during fetal life exhibit species- and timing-of-fetal-insult-specific differences. (medscape.com)