• In addition, identical p53 and KRAS mutations have been identified in both epithelial and mesenchymal components of carcinosarcoma, findings that suggest an early alteration in the histogenesis of the tumor with late transformation or degeneration of the epithelial component into the sarcomatous component. (wikipedia.org)
  • Although carcinosarcoma is the preferred term for this group of tumors, according to the International Society of Gynecological Pathologists (ISGyP)/World Health Organization (WHO) classification, it is also referred to as malignant mixed müllerian tumor. (medscape.com)
  • True malignant mixed tumor (carcinosarcoma) of tonsillar minor salivary gland origin: diagnostic imaging and endovascular therapeutic embolization. (ajnr.org)
  • The coexistence of carcinomatous and sarcomatous elements within the same tumor is a rare entity, variably labeled as "carcinosarcoma", "metaplastic carcinosarcoma", "sarcomatoid carcinoma", "pseudosarcomatous carcinoma", "carcinoma with mesenchymal stroma", "carcinoma with sarcomatoid change", "spindle cell carcinoma", "pleomorphic anaplastic carcinoma" and "small cell carcinoma"[1]. (klinikitsekoura.gr)
  • The term carcinosarcoma implies a mixed malignant tumor that is composed of an epithelial element, typically the common form of carcinoma seen in the tissue harboring the neoplasm, close to or intermixed with a sarcomatous component. (klinikitsekoura.gr)
  • For all practical purposes in our review we consider carcinosarcomas as only cases where the sarcomatous component was stained negative for epithelial markers, irrespective of the term an author decided to utilize for describing the mixed tumor encountered. (klinikitsekoura.gr)
  • Carcinosarcoma of the uterine cervix is a rare tumor. (johnshopkins.edu)
  • The aim of the present systematic review was to summarize evidence on odontogenic carcinosarcoma , analyzing clinical, epidemiological, imaging, histopathological, immunohistochemical, therapeutic , and prognostic features of this tumor . (bvsalud.org)
  • Given its rarity, dentists , oral- maxillofacial surgeons , and physicians need to be aware of odontogenic carcinosarcoma in order to increase the diagnostic potential, preventing delays in diagnosis and treatment and thus contributing to lower morbidity of the tumor . (bvsalud.org)
  • Uterine carcinosarcoma (UCS) is a highly aggressive tumor that accounts for less than 5% of uterine malignancies [ 1 , 2 ]. (por-journal.com)
  • Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). (wikipedia.org)
  • Despite the remaining uncertainty on the mechanisms that generate these tumors, recent immunohistochemical, ultrastructural, and molecular genetic studies suggest and favor the notion of monoclonality in carcinosarcoma. (wikipedia.org)
  • Uterine carcinosarcomas are generally large, soft, broad-based, and polypoid tumors that expand the uterine cavity and, in some cases, protrude through the cervical os. (medscape.com)
  • Uterine carcinosarcomas, known as malignant mixed mullerian tumors (MMMT) show characteristics of both carcinomas and sarcomas. (e-roj.org)
  • Type II (high-grade serous G2/G3, high-grade endometrioid G3 or carcinosarcoma) tumors are highly aggressive and genetically unstable tumors that most often present at advanced stages and are responsible for the majority of EOC-associated deaths ( 3 , 4 ). (spandidos-publications.com)
  • Determine the impact on survival and the antitumor effects of thalidomide in patients with sarcomas or carcinosarcoma (mixed mesodermal tumors) of gynecologic origin. (knowcancer.com)
  • Type II tumors are usually high-grade and include grade 3 endometrioid carcinomas and tumors with nonendometrioid histology (eg, serous, clear cell, mixed cell, undifferentiated, carcinosarcoma). (msdmanuals.com)
  • The hormonal receptor status of uterine carcinosarcomas (mixed müllerian tumours): an immunohistochemical study. (bmj.com)
  • According to Western studies, uterine carcinosarcomas constitute less than 5% of all uterine malignancies and about a half of all uterine sarcomas [ 1 ]. (e-roj.org)
  • Uterine carcinosarcomas were conventionally considered as a subtype of uterine sarcomas. (e-roj.org)
  • However, unlike the uterine leiomyosarcomas, the uterine carcinosarcomas exhibit more isolated local recurrences or lymph node metastasis rather than distant failure, which is similar to the failure pattern in uterine carcinomas [ 4 ]. (e-roj.org)
  • Several pathological clues were found that support the idea that uterine carcinosarcomas can be categorized as a type of metaplastic carcinoma, since they are monoclonal in origin [ 5 , 6 ]. (e-roj.org)
  • Uterine carcinosarcomas are rare. (e-roj.org)
  • The GCS Project is dedicated to finding a cure for Gynecological Carcinosarcoma (aka MMMT), providing current scientifically valid information, and offering a place for the community impacted by this cancer to share stories and hope. (gcsproject.org)
  • Have you been diagnosed with gynecologic carcinosarcoma (MMMT) and want to seek expert medical advice? (gcsproject.org)
  • Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. (wikipedia.org)
  • Based on such findings, in 2009, the revised International Federation of Gynecology and Obstetrics (FIGO) staging system classified uterine carcinosarcoma separately from sarcoma and put it under the category of carcinoma [ 7 ]. (e-roj.org)
  • A case of carcinosarcoma of uterine cervix initially interpreted as sarcoma, NOS, is presented along with immunohistochemical findings. (johnshopkins.edu)
  • Uterine cancers were classified by histologic type (endometrioid carcinoma, other carcinoma, carcinosarcoma, and sarcoma). (cdc.gov)
  • Carcinosarcoma of the uterus is a biphasic neoplasm composed of malignant epithelial and mesenchymal elements. (medscape.com)
  • Carcinosarcomas comprise an admixture of histologically malignant epithelial and mesenchymal components, as depicted in the micrograph below. (medscape.com)
  • Both epithelial and mesenchymal components of carcinosarcoma show high-grade malignant cells. (medscape.com)
  • The role of adjuvant radiotherapy in the setting of uterine carcinosarcoma has not been clearly established. (nih.gov)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/431430/all/Chemotherapy_and_or_radiotherapy_in_combination_with_surgery_for_ovarian_carcinosarcoma. (unboundmedicine.com)
  • The cause proved to be a rectal carcinosarcoma that was treated by abdominoperineal resection and postoperative chemo-radiotherapy. (klinikitsekoura.gr)
  • To evaluate the impact of postoperative radiotherapy (PORT) on patterns of failure and survivals in uterine carcinosarcoma patients treated with radical surgery. (e-roj.org)
  • Considering that adjuvant radiotherapy after surgical resection was effective to decrease loco-regional recurrence and most treatment failures were distant metastasis, multimodal therapy including surgery, radiotherapy, and chemotherapy might be an optimal treatment for uterine carcinosarcoma patients. (e-roj.org)
  • Although a monoclonal origin of carcinosarcomas has generally been proposed, heterologous differentiation from a single clone might lead to the production of G-CSF only in the epithelial element in the present case. (nih.gov)
  • A retrospective review of 60 patients receiving definitive therapy for carcinosarcoma of the uterus was undertaken at a single institution. (nih.gov)
  • Gynecological Carcinosarcoma (GCS) is a rare and aggressive cancer found primarily in the ovaries and uterus and can also originate in the fallopian tubes and vagina. (gcsproject.org)
  • These findings highlight the importance of the dysregulation of chromatin remodelling in carcinosarcoma tumorigenesis and suggest new avenues for personalized therapy. (nih.gov)
  • Carcinosarcomas typically arise within the endometrial cavity. (medscape.com)
  • Histopathologic diagnosis was carcinosarcoma supported by positive immunohistochemistry (IHC) results for cytokeratin and vimentin. (avmi.net)
  • The earliest report of a possible, due to lack of immunohistochemistry, carcinosarcoma can be tracked back to 1864 by Virchow[4]. (klinikitsekoura.gr)
  • Background To examine recurrence patterns in women with stage I uterine carcinosarcoma (UCS) stratified by adjuvant therapy pattern. (elsevierpure.com)
  • Carcinosarcoma is unique in that it contains two types of cells: Carcinomatous (epithelial tissue) and sarcomatous (connective tissue). (gcsproject.org)
  • The common denominator of all carcinosarcomas is the lack of staining of the sarcomatous component for epithelial markers. (klinikitsekoura.gr)
  • Uterine carcinosarcoma tends to show poor prognosis compared to the high grade carcinoma, because it is diagnosed at the advanced stage and is also aggressive in nature [ 9 , 10 ]. (e-roj.org)
  • Uterine carcinosarcoma (UCS) is a rare but highly aggressive malignancy with biphasic growth pattern. (por-journal.com)
  • Objective: To evaluate the impact of adjuvant post-operative therapy in women with early stage uterine carcinosarcoma. (johnshopkins.edu)
  • Methods: After IRB approval was obtained at all sites, a multi-center retrospective study of women with FIGO stage I-II uterine carcinosarcoma diagnosed from 1997 to 2007 was conducted. (johnshopkins.edu)
  • Conclusions: In women with FIGO stage I-II uterine carcinosarcoma, adjuvant chemotherapy is associated with improved PFS compared to radiation or observation alone. (johnshopkins.edu)
  • An estimated 16% of carcinosarcomas have a low-grade stromal component. (medscape.com)
  • Between October 1998 and August 2010, 19 patients with stage I-III uterine carcinosarcoma received curative hysterectomy and bilateral salpingo-oophorectomy with or without PORT at Seoul National University Hospital. (e-roj.org)
  • Carcinosarcoma comprises less than 5% of malignant neoplasms of the uterine corpus . (medscape.com)
  • In general colonic carcinosarcomas constitute a rare category of malignant neoplasms whose nature is still incompletely understood. (klinikitsekoura.gr)
  • Carcinosarcoma with both a high-grade carcinomatous and sarcomatous component. (medscape.com)
  • Most patients with uterine carcinosarcoma present with abnormal vaginal bleeding. (medscape.com)
  • Malignant mixed Müllerian tumours, also known as carcinosarcomas, are rare tumours of gynaecological origin. (nih.gov)
  • According to laboratory results, the final diagnosis was mixed mammary carcinosarcoma with minimal expression of CD8+, notwithstanding, it showed the better prognosis after surgery and chemotherapy. (uwks.ac.id)
  • [ 19 ] Rare cervical carcinosarcomas manifest as vaginal bleeding, spotting, or an abnormal Papanicolaou test result. (medscape.com)
  • We report a case of carcinosarcoma of the minor salivary glands of the left palatine tonsil, an especially rare location. (ajnr.org)
  • Because carcinosarcoma is so rare, there has been limited research results and no cures or effective treatments for us. (gcsproject.org)
  • We report this case of rectal carcinosarcoma and review the literature on this rare malignancy. (klinikitsekoura.gr)
  • An autopsy case of carcinosarcoma of the liver producing granulocyte-colony stimulating factor (G-CSF) is reported. (nih.gov)
  • This is the fifth canine case of thyroid carcinosarcoma to be documented, but the first one to be confirmed by specific cell markers. (avmi.net)
  • To our knowledge, only 7 cases of colonic carcinosarcomas have been reported in the English literature, and this case is the 8th. (klinikitsekoura.gr)
  • Roque, DR & Matei, D 2022, ' Paclitaxel and Carboplatin for Uterine Carcinosarcoma: A Path to Inclusion ', Journal of Clinical Oncology , vol. 40, no. 9, pp. 924-926. (northwestern.edu)
  • Clinicopathological characteristics of odontogenic carcinosarcoma: A systematic review. (bvsalud.org)
  • Results: 111 women were identified: 94 (85%) had stage I and 17 (15%) had stage II uterine carcinosarcoma. (johnshopkins.edu)
  • [ 7 , 8 ] An association between long-term tamoxifen treatment and the development of carcinosarcoma has been suggested. (medscape.com)
  • Also, the current treatment guideline recommends treating uterine carcinosarcoma according to the guideline of high grade carcinoma [ 8 ]. (e-roj.org)
  • Carcinosarcoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from Dictionary of Cancer Terms. (wikipedia.org)