Carboplatin. Medical search. Frequent questions

In a phase II trial reported in JAMA Oncology , Locke J. Bryan, MD , and colleagues found that the combination of pembrolizumab with ICE chemotherapy (a regimen including ifosfamide, carboplatin, and etoposide) produced a high rate of complete response in patients with relapsed or refractory classical Hodgkin lymphoma who were candidates for autologous stem cell transplantation (SCT). (ascopost.com)
Chang, AY 1995, ' Introduction to ifosfamide/carboplatin/etoposide chemotherapy ', Seminars in oncology , vol. 22, no. 3 SUPPL. (johnshopkins.edu)

Some results show that cisplatin and carboplatin cause different morphological changes in MCF-7 cell lines while exerting their cytotoxic behaviour. (wikipedia.org)
In an accompanying editorial, Christopher Azzoli, M.D., and colleagues at the Memorial Sloan-Kettering Cancer Center in New York discuss the renewed rivalry between cisplatin and carboplatin, particularly in the face of new developments in adjuvant chemotherapy for NSCLC patients. (eurekalert.org)
Also, be aware that cisplatin and carboplatin are cousins of each other, so if someone has had cisplatin, and it has failed them, the odds of getting a response to carboplatin is in the 10-15% range. (lungevity.org)

The study, published in Breast Cancer Research and Treatment, retrospectively examined the effect of local carboplatin guidelines on pathological complete response (pCR) and toxicity in women with HER2+ breast cancer receiving neoadjuvant docetaxel, carboplatin, trastuzumab and pertuzumab (TCHP). (medscape.com)
Howell SJ, Coe F, Wang X, Horsley L, Ekholm M. Carboplatin dose capping affects pCR rate in HER2-positive breast cancer patients treated with neoadjuvant Docetaxel, Carboplatin, Trastuzumab, Pertuzumab (TCHP). (medscape.com)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

Carboplatin has also been used for adjuvant therapy of stage 1 seminomatous testicular cancer. (wikipedia.org)
This has led to carboplatin based adjuvant therapy being generally preferred over adjuvant radiotherapy in clinical practice. (wikipedia.org)
None of the patients had received prior adjuvant chemotherapy with thalidomide or carboplatin. (ajnr.org)
Adjuvant chemotherapeutic protocol, carboplatin at a dosage of 250 mg/m 2 and doxorubicin at a dosage of 60 mg/m 2 , alternating combination of a 3-week interval was given for 6 treatments. (vin.com)
Carboplatin adjuvant chemotherapy is a palliative treatment that can reduce burden and improve quality of life of melanoma affected dogs. (vin.com)

Carboplatin injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (nih.gov)
Anaphylactic-like reactions to carboplatin, USP have been reported and may occur within minutes of carboplatin injection administration. (nih.gov)
Carboplatin injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin, USP. (nih.gov)
Each mL contains 10 mg carboplatin, USP, 10 mg mannitol and water for injection, USP. (nih.gov)
Affliction, heaving, exhaustion, and extended liver impetus are some typical consequences of this Carboplatin 150mg Injection Kemocarb. (rizochem.com)
How is Kemocarb Carboplatin 150mg Injection used? (rizochem.com)
Uses: CARBOPLATIN 150MG INJECTION is used in the treatment of ovarian cancer and small cell lung cancer. (oceanpharmaproducts.com)
Carboplatin Injections is given as an injection into veins under the supervision of a doctor. (6degrepharma.com)

Roque, DR & Matei, D 2022, ' Paclitaxel and Carboplatin for Uterine Carcinosarcoma: A Path to Inclusion ', Journal of Clinical Oncology , vol. 40, no. 9, pp. 924-926. (northwestern.edu)

Kattan JG, Boutros CY, Farhat FS, Chahine GY, Musallam KM, Ghosn MG. Sequential Therapy with Gemcitabine and Carboplatin Followed by Paclitaxel as First Line Treatment for Advanced Urothelial Cancer. (jcancer.org)
In this study, we evaluate the efficacy and safety of gemcitabine and carboplatin followed sequentially by paclitaxel in 27 patients with advanced transitional cell carcinoma. (jcancer.org)
Twenty patients completed all 4 cycles of the gemcitabine and carboplatin sequence. (jcancer.org)

BACKGROUND: We hypothesized that the combination of bevacizumab, carboplatin, and pemetrexed will be an effective first-line regimen in fit, elderly patients with nonsquamous non-small-cell lung cancer. (healthpartners.com)
Carboplatin area under the curve 6, pemetrexed 500 mg/m, and bevacizumab 15 mg/kg were administered on day 1 of each 21-day cycle (up to six cycles) followed by maintenance pemetrexed and bevacizumab. (healthpartners.com)

in vitro: Carboplatin exhibits an inhibitory effect on cell proliferation in a human ovarian cancer cell line panel, including A2780, SKOV3, and IGROV-1 cells with IC50 of 6.1 ?M, 12.4 ?M and 2.2 ?M, respectively [1]. (chemspider.com)
Methods Patients with platinum-sensitive recurrent ovarian cancer received intravenous (IV) paclitaxel at 60 mg/m 2 followed by IV carboplatin at an area under the curve of 6 and IV pegylated liposomal doxorubicin at 30 mg/m 2 on day 1 in a 28-day cycle (DC-LOP) or IV gemcitabine at 1000 mg/m 2 on days 1 and 8 in a 21-day cycle (GC-LOP). (bmj.com)
3 , 4 The current therapy for ovarian cancer is debulking surgery followed by chemotherapy using carboplatin and paclitaxel (PTX). (nature.com)

Some patients with advanced non-small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the chemotherapy drug cisplatin than another platinum-based drug, carboplatin, according to a study in the June 6 Journal of the National Cancer Institute . (eurekalert.org)
Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism. (chemspider.com)
Carboplatin is a chemotherapy drug. (rizochem.com)

Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. (wikipedia.org)
It gained U.S. Food and Drug Administration (FDA) approval for carboplatin, under the brand name Paraplatin, in March 1989. (wikipedia.org)
Carboplatin (Paraplatin,10 mg/ml, Brystol Myers) was administered by a 30 min low infusion. (oae.it)

070201 Millie at UCSF 1st cycle Cetuximab and Carboplatin for IBC relapse. (welchco.com)
Millie at UCSF 1st cycle Cetuximab and Carboplatin for IBC relapse. (welchco.com)
750534 - cycle 1st treatment with cetuximab and carboplatin together 750535 - treating 4th relapse of IBC. (welchco.com)

This multicenter, randomized phase II trial compared carboplatin-paclitaxel with and without trastuzumab in patients with advanced or recurrent uterine serous carcinoma who overexpress HER2/neu. (nih.gov)
Participants were randomly assigned to receive carboplatin-paclitaxel (control arm) for six cycles with or without intravenous trastuzumab (experimental arm) until progression or unacceptable toxicity. (nih.gov)
Conclusion Addition of trastuzumab to carboplatin-paclitaxel was well tolerated and increased progression-free survival. (nih.gov)

Cisplatin Versus Carboplatin for Patients With Metastatic Non - Small-Cell Lung Cancer - An Old Rivalry Renewed. (eurekalert.org)
Topotecan and carboplatin were chosen for a three-drug combination with melphalan because they have been used successfully as single agents to treat both intraocular and metastatic retinoblastoma. (bmj.com)
Scholars@Duke publication: Trilaciclib prior to gemcitabine plus carboplatin for metastatic triple-negative breast cancer: phase III PRESERVE 2. (duke.edu)
Administration of trilaciclib prior to gemcitabine plus carboplatin (GCb) significantly improved overall survival (OS) compared with GCb alone in an open-label phase II trial in patients with metastatic TNBC, potentially through protection and direct activation of immune function. (duke.edu)
Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122). (bvsalud.org)

Calvert's formula is used to calculate the dose of carboplatin. (wikipedia.org)
This means that the dose of carboplatin must be adjusted for any impairment in kidney function. (wikipedia.org)
Calvert formula: D o s e ( m g ) = A U C ⋅ ( G F R + 25 ) {\displaystyle \mathrm {Dose} (\mathrm {mg} )=\mathrm {AUC} \cdot (\mathrm {GFR} +25)} The typical area under the curve (AUC) for carboplatin ranges from 3-7 (mg/ml)*min. (wikipedia.org)
Isotopic measurement of renal function is warranted in patients who would otherwise have their estimated glomerular filtration rate (eGFR) and carboplatin dose capped. (medscape.com)
The delivered area under the curve (dAUC) was calculated ([actual carboplatin dose at cycle 1÷dose calculated with uncapped/unbanded eGFR]×6) and dichotomised at the median value. (medscape.com)
However, they said, the results caution against the temptation to reduce the carboplatin dose in TCHP to area under the curve 5 as this is likely to reduce the pCR rate. (medscape.com)
Six patients (three men and three women, 27-64 years old, mean age, 46 years) undergoing high-dose carboplatin therapy without thalidomide for recurrent malignant gliomas served as a control group. (ajnr.org)
In the three-drug therapy, dose ranges were 2.5-7.5 mg for melphalan, 0.3-0.6 mg for topotecan, and 25-50 mg for carboplatin, and median infusions per eye was 2 (range 1-4). (bmj.com)
This report describes an examination of the cytoarchitecture of vestibular cells of cynomolgus monkeys that had chronic brainstem infusions with the maximum tolerated dose (MTD) of carboplatin. (psu.edu)
In this single study of eight monkeys, a dose-dependent reduction of vestibular hair cells or support cells was not observed in animals infused with brainstem infusions of 0.025 to 0.25 mg/kg of carboplatin. (psu.edu)
We conducted a pilot study to assess whether the addition of low-dose paclitaxel to carboplatin-based combination chemotherapy prevents thrombocytopenia. (bmj.com)
Purpose To determine the stability of carboplatin 0.2 mg/ml solution in 250 ml of 5% glucose and stored in polypropylene infusion bags (carboplatin 0.2 mg/ml solution is a 10-fold dilution for the standard desensitisation protocol using a total dose of 500 mg). (bmj.com)

Carboplatin differs from cisplatin in that it has a bidentate dicarboxylate (the ligand is cyclobutane dicarboxylate, CBDCA) in place of the two chloride ligands. (wikipedia.org)
CBDCA and chloride are the leaving groups in these respective drugs Carboplatin exhibits slower aquation (replacement of CBDCA by water) and thus slower DNA binding kinetics, although it forms the same reaction products in vitro at equivalent doses with cisplatin. (wikipedia.org)

RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (mayo.edu)
Since carbonate inhibits the binding of aged carboplatin and cisplatin to DNA, carbonate present in the body likely modulates the reactivity of these drugs with a variety of biological targets including DNA. (syr.edu)
Carboplatin and pemetrexed are a combination of two chemotherapy drugs. (ankr.us)
This is why many times oncologists do not use carboplatin and cisplatin as seperate drugs, because they are in a sense the same. (lungevity.org)

What is carboplatin 150mg good for? (rizochem.com)

Carboplatin was more likely to decrease blood platelet levels, while cisplatin was more likely to cause nausea, vomiting, and damage to the kidneys. (eurekalert.org)
In patients with creatinine clearances below 60 mL/min the total body and renal clearances of carboplatin, USP decrease as the creatinine clearance decreases. (nih.gov)
Objective Paclitaxel is known to produce the "platelet-sparing effect" that prevents the carboplatin-induced decrease in platelet count. (bmj.com)

They said consistent guidelines on calculating carboplatin doses are warranted. (medscape.com)

The aquation of carboplatin, USP, which is thought to produce the active species, occurs at a slower rate than in the case of cisplatin. (nih.gov)
The differences in potencies for carboplatin, USP and cisplatin appear to be directly related to the difference in aquation rates. (nih.gov)

Conclusions: This first large randomized trial suggests high efficacy and excellent tolerability of a neoadjuvant nabpaclitaxel/carboplatin regimen, superior to nab-paclitaxel/gemcitabine in TNBC. (uni-koeln.de)

We evaluated carboplatin vs gemcitabine with a nab-paclitaxel backbone as a short 12-week A-free regimen with a focus on early response. (uni-koeln.de)
Pennsylvania Diagnosis: Triple Negative Breast Cancer, Stage 1 - Recurrence Chemotherapy Regimen: Taxotere/Carboplatin Total Treatments: 6 Hearing I had breast cancer for the second time at the age of 34 was utterly devastating as you can imagine. (dignicap.com)

Andrea Ardizzoni, M.D., of University Hospital in Parma, Italy, and colleagues conducted a review of nine randomized trials comparing the survival of 2,968 NSCLC patients who received either cisplatin- or carboplatin-based chemotherapy. (eurekalert.org)
Given the palliative nature of chemotherapy treatment in advanced NSCLC and the unquestionable practical advantage of carboplatin in terms of ease of administration, it could be argued that the small benefit achieved with cisplatin relative to carboplatin does not justify its preferential use in clinical practice. (eurekalert.org)
NTNU Open: Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. (ntnu.no)
The multicenter, phase II, randomized, open-label ANTELOPE trial evaluates whether atezolizumab, carboplatin and nab- paclitaxel is superior to pembrolizumab, cis-/ carboplatin and pemetrexed in TTF-1 negative NSCLC/ADC. (bvsalud.org)

The purpose of our study was to compare postcontrast T1-weighted imaging with dynamic, contrast-enhanced T2*-weighted echo-planar imaging in the evaluation of the response of recurrent malignant gliomas to thalidomide and carboplatin. (ajnr.org)
Serial MR imaging was performed in 18 consecutive patients with recurrent malignant gliomas receiving both thalidomide and carboplatin for 12-month periods. (ajnr.org)
MR imaging studies were performed in 18 consecutive patients with recurrent malignant gliomas who were enrolled in a trial to investigate treatment with thalidomide and carboplatin (9) . (ajnr.org)
Carboplatin is utilized to treat different kinds of malignant growth. (rizochem.com)

The lower excretion rate of carboplatin means that more is retained in the body, and hence its effects are longer lasting (a retention half-life of 30 hours for carboplatin, compared to 1.5-3.6 hours in the case of cisplatin). (wikipedia.org)
The major route of elimination of carboplatin, USP is renal excretion. (nih.gov)

The nadir of this myelosuppression usually occurs 21-28 days after the first treatment, after which the blood cell and platelet levels in the blood begin to stabilize, often coming close to its pre-carboplatin levels. (wikipedia.org)
Cisplatin- Versus Carboplatin-Based Chemotherapy in First-Line Treatment of Advanced Non - Small-Cell Lung Cancer: An Individual Patient Data Meta-analysis. (eurekalert.org)
The authors said the high pCR rates in the study, particularly for the ER+/HER2+ subgroup, show that carboplatin is an important chemotherapy option in the treatment for early HER2+ breast cancer. (medscape.com)
This is the first case report that shows carboplatin can be used as an effective alternative in treatment of malignancy-associated bullous pemphigoid. (iasp-pain.org)
To present oral melanoma with pulmonary metastasis in two dogs applying carboplatin chemotherapy and treatment follow up. (vin.com)
Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog. (tue.nl)
has anyone heard about the combo of carboplatin and taxol for the treatment of sclc? (lungevity.org)

Methods A retrospective chart review was conducted of patients who received three-drug (melphalan, topotecan, and carboplatin) SIAC during 2006-2011. (bmj.com)

Patients received up to three cycles of vinorelbine 60 mg m−2 p.o.+gemcitabine 1000 mg m−2 i.v. day 1 and 8 (VG) or vinorelbine 60 mg m−2 p.o. day 1 and 8+carboplatin area under the curve=5 (Calvert's formula) i.v. day 1 (VC). (ntnu.no)

Aims To report outcomes with selective intra-arterial chemotherapy (SIAC) using simultaneous carboplatin, topotecan, and melphalan for advanced intraocular retinoblastoma. (bmj.com)

Bullous pemphigoid associated with squamous cell lung carcinoma showing remarkable response to carboplatin-based chemotherapy: a case report. (iasp-pain.org)
We report herein a case of squamous cell lung cancer diagnosed after being investigated for refractory bullous pemphigoid showing marked response to carboplatin-based chemotherapy. (iasp-pain.org)

Carboplatin was used at a dosage 250 mg/m 2 and given every 3 weeks for 8 treatments. (vin.com)
No data regarding the Paedriatic dosage details of Carboplatin is available. (druginfosys.com)

In patients with creatinine clearances of about 60 mL/min or greater, plasma levels of intact carboplatin, USP decay in a biphasic manner after a 30-minute intravenous infusion of 300 mg/m 2 to 500 mg/m 2 of carboplatin, USP. (nih.gov)
Your nurse will give you pemetrexed and carboplatin through a drip (infusion). (ankr.us)
Conclusion Carboplatin 0.2 mg/ml desensitisation solution can be considered stable for 24 hours at room temperature in 5% glucose polypropylene infusion bags. (bmj.com)

Patients who received cisplatin lived slightly longer than those treated with carboplatin, with a median survival of 9.1 months compared with 8.4 months. (eurekalert.org)

The apparent superiority of cisplatin over carboplatin demonstrated in this paper should not be taken lightly, particularly in patients being treated with curative intent. (eurekalert.org)
PURPOSE: This phase II trial is studying how well carboplatin given together with paclitaxel and everolimus works in treating patients with previously untreated cancer of unknown primary. (mayo.edu)
Six patients undergoing carboplatin therapy alone were chosen as control subjects. (ajnr.org)
Carboplatin is considered less nephrotoxic, yet it can still cause rounded injury and interstitial nephritis in patients who have recently been treated with cisplatin. (rizochem.com)

Carboplatin is in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA. (wikipedia.org)
It might take longer if you are taking carboplatin with different medications. (rizochem.com)

Stability was defined as retention of at least 95% of the initial carboplatin concentration. (bmj.com)

This phase II multicentre study was based on the doublet gemcitabine 800 mg/m2 and carboplatin area under the concentration-time curve 2 on days 1 and 8 every 21 days for 4 cycles, followed sequentially by paclitaxel 60 mg/m 2 /w for 12 consecutive weeks. (jcancer.org)

Weekly nab-paclitaxel vs conventional paclitaxel or addition of carboplatin to anthracycline-taxane results in higher pCR rates with uncertain survival impact. (uni-koeln.de)

Most clinicians in North America prefer carboplatin to cisplatin because it has fewer side effects and is easier to administer. (eurekalert.org)

After 24 hours, close to 70% of carboplatin is excreted in the urine unchanged. (wikipedia.org)
All of the platinum in the 24-hour urine is present as carboplatin, USP. (nih.gov)

Further investigation of the carboplatin-based combination chemotherapy including a drug with mild hematological toxicity is warranted. (bmj.com)

Carboplatin, a cisplatin analogue, was developed by Bristol Myers Squibb and the Institute of Cancer Research in order to reduce the toxicity of cis platin. (wikipedia.org)

Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. (tue.nl)

Data from an earlier study (Wake et al, 1996) from a chinchilla model support the hypothesis that carboplatin administration not only disrupts the IHC function but affects the efferent feedback loop to the cochlea, causing an amplification of the otoacoustic emission responses. (oae.it)

What are the drawn-out results of carboplatin? (rizochem.com)
These results allow carboplatin desensitisation solutions to be prepared in advance in order to optimise the workload in the chemotherapy preparation units. (bmj.com)

Relative to cisplatin, the greatest benefit of carboplatin is its reduced side effects, particularly the elimination of nephrotoxic effects. (wikipedia.org)

Diseases31

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes5

Information Science1

Health Care6

Etoposide2

Cisplatin and carboplatin3

Docetaxel3

Adjuvant5

Injection8

Paclitaxel and Carboplatin1

Gemcitabine and Carboplatin3

Bevacizumab2

Ovarian cancer3

Chemotherapy drug3

Paraplatin3

Cetuximab3

Trastuzumab3

Metastatic5

Dose12

CBDCA2

Drugs4

150mg1

Decrease3

Doses1

Aquation2

Neoadjuvant1

Regimen2

NSCLC4

Malignant4

Excretion2

Treatment7

Methods1

Vinorelbine1

Retinoblastoma1

Lung2

Dosage2

Infusion3

Median1

Patients4

Medications2

Stability1

Cycles1

Survival1

Fewer side effects1

Urine2

Combination1

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Anti-cancer1

Study1

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