• gacA-L , group A carbohydrate biosynthetic genes (putative functions described in van Sorge et al. (cdc.gov)
  • Encodes a putative membrane-anchored UDP-D-glucuronate 4-epimerase. (riken.jp)
  • Identification and characterization of a UDP-D-glucuronate 4-epimerase in Arabidopsis. (mpg.de)
  • This operon consists of eight genes araA-araH with the gene for Ribulose 5-phosphate 4-epimerase called araD. (wikipedia.org)
  • The 3 genes required for inclusion of the immunodominant N- acetylglucosamine side chain within the group A carbohydrate ( gacI, gacJ , and gacK ) are shown in red. (cdc.gov)
  • gccA-N , group C carbohydrate biosynthetic genes. (cdc.gov)
  • 2] "Carbohydrate utilization in Streptococcus thermophilus: characterization of the genes for aldose 1-epimerase (mutarotase) and UDPglucose 4-epimerase. (tcdb.org)
  • Transcriptome analyses showed that more than 61% of the lipid- and carbohydrate-related genes were regulated in rapeseed and castor bean, but only 20.1% of the lipid-related genes and 22.5% of the carbohydrate-related genes were regulated in maize. (researchsquare.com)
  • The team found that UDP-glucose 4-epimerase (Uge5), an enzyme known for its involvement in galactose metabolism, also regulates the expression of degrading enzyme genes in A. aculeatus. (asiaresearchnews.com)
  • The depletion of DOM over time was strongly correlated with increases in expression of many genes associated with heterotrophy (e.g., amino acid, fatty acid, and carbohydrate metabolism) belonging to a Hydrogenophaga strain that accounted for a relatively large percentage (~8%) of the metatranscriptome. (frontiersin.org)
  • This is consistent with the notion that both enzymes belong to a superfamily of epimerases/aldolases that catalyze carbon-carbon bond cleavage reactions via a metal-stabilized enolate intermediate. (wikipedia.org)
  • L-Ribulose-5-phosphate 4-epimerase and L-fuculose-1-phosphate (L-Fuc1P) aldolase are evolutionarily related enzymes that display 26% sequence identity and a very high degree of structural similarity. (wikipedia.org)
  • There are various different groups of epimerase enzymes and they each have a unique function. (prospecbio.com)
  • As there are numerous different types of epimerase enzymes, they all have individual structures. (prospecbio.com)
  • IBS further showed transcriptional upregulation of enzymes involved in fructose and glucan metabolism as well as the succinate pathway of carbohydrate fermentation. (biomedcentral.com)
  • UDP-GlcNAc 2-epimerase and GlcNAc 2-epimerase are two enzymes capable of generating ManNAc from UDP-GlcNAc and GlcNAc, respectively. (johnshopkins.edu)
  • An Osaka Metropolitan University research team analyzed the regulatory mechanisms of carbohydrate-hydrolyzing enzyme production in Aspergillus aculeatus, a filamentous fungus that produces enzymes with an excellent ability to degrade plant biomass. (asiaresearchnews.com)
  • Delving into this field, a research team led by Associate Professor Shuji Tani, from the Graduate School of Agriculture at Osaka Metropolitan University, analyzed the regulatory mechanisms of carbohydrate-hydrolyzing enzyme production in the filamentous fungus Aspergillus aculeatus , which produces enzymes that have an excellent ability to degrade plant biomass. (asiaresearchnews.com)
  • Professor Tani explained, "We constructed and screened a library containing approximately 9,000 gene-disrupted strains of Aspergillus aculeatus, and identified Uge5 as a novel regulatory factor that regulates the production of carbohydrate-hydrolyzing enzymes. (asiaresearchnews.com)
  • Uridine diphosphate (UDP) galactose-4-epimerase epimerizes UDP galactose to UDP glucose and is also uncommon. (medscape.com)
  • Uridine diphosphate (UDP)-glucose 4-epimerase (Uge5) is well known as an enzyme involved in galactose metabolism. (asiaresearchnews.com)
  • Consequently, we present here an optimized poly-LacNAc synthesis by the combination of two glycosyltransferases and a uridine-diphospho-glucose/N-acetylglucosamine 4'-epimerase as one-pot strategy resulting in long poly-LacNAc glycans with up to six LacNAc units in high yields while minimizing reaction time and product loss. (uni-koeln.de)
  • One example is UDP-galactose 4-epimerase dimer. (prospecbio.com)
  • GALM (glactose mutorotase, aldose1-epimerase) catalyzes the interconversion of the alpha and the beta anomers of hexose sugars like glucose and galactose and is not common. (medscape.com)
  • Carbohydrate intolerances with early onset and genetic cause include congenital sucrase-isomaltase deficiency (CSID), glucose-galactose malabsorption (GGM) and congenital lactase deficiency (CLD). (blueprintgenetics.com)
  • IBS is characterized by a multi-omics microbial signature indicating increased capacity to utilize fermentable carbohydrates-consistent with the clinical benefit of diets restricting this energy source-that also includes multiple previously unrecognized metabolites and metabolic pathways. (biomedcentral.com)
  • Our results indicate that, unlike UDP-GlcNAc 2-epimerase, which promotes biosynthesis of sialic acid, GlcNAc 2-epimerase can serve a catabolic role, diverting metabolic flux away from the sialic acid pathway. (johnshopkins.edu)
  • Furthermore, bacterial epimerase are also involved with the creation of complex carbohydrate polymers. (prospecbio.com)
  • Xylans are defined as carbohydrate polymers consisting of a β-1,4-xylosyl (Xyl p ) backbone, although xylans containing a β-1,3 and mixed linkage β-1,4-1,3 backbone structure have been found in algal species [ 9 ]. (biomedcentral.com)
  • The protein has ketose 3-epimerase activity. (justia.com)
  • The disclosure provides a method of producing allulose by contacting a protein having at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 6 with a fructose substrate, wherein the protein has allulose 3-epimerase activity, and at least partially purifying the allulose. (justia.com)
  • Poly-N-acetyllactosamine (Poly-LacNAc, [3Gal beta 1,4GlcNAc beta 1](n)) glycans play an essential role in carbohydrate-protein interactions. (uni-koeln.de)
  • Accepted August 23, 2012 ABSTRACT The catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria. (studyres.com)
  • Carbohydrate metabolism.nucleotide sugar. (ntu.edu.sg)
  • It is caused by pathogenic variants in the carbohydrate sulfotransferase 14 gene (mcEDS-CHST14) or in the dermatan sulfate epimerase gene (mcEDS-DSE). (bvsalud.org)
  • The 5‐carbon sugar phosphates are interconverted by the action of epimerase and isomerase to yield ribulose‐5‐phosphate, which is phosphorylated by the enzyme ribulose phosphate kinase to make RuBP, the acceptor of CO 2 . (cliffsnotes.com)
  • 5'-monophosphate deaminase from Streptomyces murinus, D-allulose 3-epimerase from Arthrobacter globiformis expressed in Escherichia coli , carbohydrate-derived fulvic acid, jagua (genipin-glycine) blue (Jagua blue), lipase from Mucor javanicus and phosphatidylinositol-specific phospholipase C expressed in Pseudomonas fluorescens ). (who.int)
  • In enzymology, a L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4) is an enzyme that catalyzes the interconversion of ribulose 5-phosphate and xylulose 5-phosphate in the oxidative phase of the Pentose phosphate pathway. (wikipedia.org)
  • Mechanism of ribulose 5-phosphate 4-epimerase in active site Aldol and dehydration mechanisms L-Ribulose 5-phosphate 4-epimerase catalyzes the epimerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate by retro-aldol cleavage and subsequent aldol reaction. (wikipedia.org)
  • An isomerase enzyme, epimerase catalyzes the stereochemistry inversion within biological chemicals. (prospecbio.com)
  • The systematic name of this enzyme class is L-ribulose-5-phosphate 4-epimerase. (wikipedia.org)
  • Other names in common use include phosphoribulose isomerase, ribulose phosphate 4-epimerase, L-ribulose-phosphate 4-epimerase, L-ribulose 5-phosphate 4-epimerase, AraD, and L-Ru5P. (wikipedia.org)
  • First, the retro-aldol cleavage mechanism is analogous to the reaction catalyzed by L-fuculose-phosphate aldolase which has high levels of sequence similarity with L-ribulose-5-phosphate 4-epimerase. (wikipedia.org)
  • Ribulose 5-phosphate 4-epimerase is found on the well studied L-arabinose operon. (wikipedia.org)
  • The rest of the Calvin cycle is involved in interconversion of carbohydrates to make glucose (or starch) and the regeneration of the ribulose‐bisphosphate acceptor. (cliffsnotes.com)
  • Inhibition of chloroplastic fructose 1,6-bisphosphatase in tomato fruits leads to decreased fruit size, but only small changes in carbohydrate metabolism. (mpg.de)
  • Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase. (uu.se)
  • N-terminal domain, C-terminal domain, FGGY family of carbohydrate kinases [InterProScan]. (ntu.edu.sg)
  • Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development. (uu.se)
  • Transformed potato plants as a model for studying the hormonal and carbohydrate regulation of tuberization. (mpg.de)
  • In the human body, epimerase has a wide range of interactions. (prospecbio.com)
  • Sialic acid is a major determinant of carbohydrate-receptor interactions in many systems pertinent to human health and disease. (johnshopkins.edu)
  • Chitin is a biological polymer consisting of carbohydrate molecules bonded together to form long chains of polysaccharides. (biomedcentral.com)
  • Belongs to the N-acylglucosamine 2-epimerase family. (expasy.org)
  • Here we study the effects of GlcNAc 2-epimerase expression on sialic acid production in cells. (johnshopkins.edu)
  • The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. (uit.no)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • A key tool we developed for this study is a cell-permeable, small molecule inhibitor of GlcNAc 2-epimerase designed based on mechanistic principles. (johnshopkins.edu)