Carbohydrate gene 3 protein binds galectin 1. Medical search. Frequent questions

Galectin-3 has one CRD and a long non-lectin domain. (wikipedia.org)
Galectin-3 can exist in monomeric form or can associate via the non-lectin domain into multivalent complexes up to a pentameric form. (wikipedia.org)
Galectin-3 belongs to the lectin family of carbohydrate binding proteins. (enquirebio.com)
The expression of this lectin is upregulated during inflammation, cell proliferation, cell differentiation and through transactivation by viral proteins. (liveconscience.com)
There is also a chimeric form of galectin (i.e. galectin-3) that contains one CRD connected to a non-lectin domain. (fdocuments.net)
Regulation of T lymphocyte function by galectin-1 and its dependence on the carbohydrate binding activity of lectin. (u-szeged.hu)
NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. (thermofisher.com)
Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. (thermofisher.com)
NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. (thermofisher.com)
Goose Lectin-Galactose Binding-Soluble three ELISA Equipment from MYBIOSOURCE INC. Product Identify Goose Lectin-Galactose Binding-Soluble three ELISA Equipment Description Assay Sort: Sandwich. (bioinfor.me)

This gene encodes a member of the galectin family of carbohydrate binding proteins. (origene.com)
Expression of galectins in normal lymphoid cells Each member of the galectin family exhibits a specific expression pattern in distinct tissues, and galectin expression is regulated during development. (fdocuments.net)

Full length human recombinant protein of human LGALS3(NP_002297) produced in HEK293T cell. (origene.com)
Homo sapiens galectin 3 (LGALS3), transcript variant 1, mRNA. (origene.com)

They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. (wikipedia.org)
Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. (wikipedia.org)
Carbohydrate binding is calcium independent, unlike C-type lectins. (wikipedia.org)
Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. (unige.ch)
Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. (unige.ch)
We were able to identify several classes of antimicrobial peptides, such as buforins, peroniins and brevinins, as well as PLA 2 , lectins and galectins, combining protein sequencing and RNA-seq analysis for the first time. (biomedcentral.com)
Galectins are a family of proteins that bind to carbohydrates on the surface of cells, regulating the amount of leukocytes through of apoptotic and non-apoptotic mechanisms being galectin-3 the most well studied of these lectins. (fapesp.br)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Introduction Galectins, formerly known as S-type lectins, rep- resent a family of evolutionarily conserved ani- mal lectins that are widely distributed from lower invertebrates to higher vertebrates. (fdocuments.net)
In 1994, a joint effort by several investigators in the field led to a new nomenclature in which the term "galectins" was used to define lectins with an affinity for - galactosides and with sequence similarity in the carbohydrate-binding site [3]. (fdocuments.net)
Changes in glycan structures and the interactions of these structures with endogenous carbohydrate- binding proteins, known as lectins, are now considered to be potential biomarkers on cancer cells for monitoring tu- mor progression. (fdocuments.net)
The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. (thermofisher.com)

It binds to adhesion proteins such as integrins and blocks further binding to other cells or the extracellular matrix. (wikipedia.org)
When concentrations of galectin-3 are high it forms large complexes that assist in adhesion by bridging between cells or cells and the extracellular matrix. (wikipedia.org)
This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. (origene.com)
Such biological functions depend on their lectinic properties (recognition of N-acetyllactosamine sequences displayed on the cell surface, in the extracellular matrix, or intracellular glycoconjugates) ( Table 1 ). (encyclopedia.pub)
FAs are structures composed of clustered transmembrane proteins called integrins that bind to the extracellular matrix and link to the actin cytoskeleton and control cell migration, proliferation, survival and differentiation (Gardel et al. (bio2009.org)

This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. (origene.com)
Galectin-3 has specific binding affinity for beta-galactoside sugar moieties and has functional roles during development, innate immunity, cell apoptosis, and tumor metastasis. (enquirebio.com)
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. (unige.ch)
This is particularly true for galectin family members because changes in their expression levels correlate with alterations in cancer cell growth, apoptosis, and cell-cell and cell-matrix interactions. (fdocuments.net)
and cell cycle and apoptosis [ 3 , 4 ]. (encyclopedia.pub)

This is because more Van der Waals interactions can occur between sugar and binding pocket. (wikipedia.org)
Crystallisation experiments of galectins in complex with N-acetyllactosamine show that binding arises due to hydrogen bonding interactions from the carbon-4 and carbon-6 hydroxyl groups of galactose and carbon-3 of N-acetylglucosamine (GlcNAc) to the side chains of amino acids in the protein. (wikipedia.org)
Here we review the interactions of metabolism, galectins and glycoprotein ligands as well as the utility of this model to predict and treat inflammation and autoimmunity. (gr.jp)
This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. (unige.ch)
loop_ _audit_author.name _audit_author.pdbx_ordinal 'Collins, P.M.' 1 'Blanchard, H.' 2 # _citation.id primary _citation.title 'Galectin-3 interactions with glycosphingolipids. (rcsb.org)
10 Galectins can function inside the cells by modulating signaling pathways, 11 although they also act extracellularly by establishing multivalent interactions with cell surface glycans and delivering signals that lead to disruption of cellular homeostasis. (nature.com)
This β -sandwich fold is conserved in all galectins and includes a gly- cine, which stabilizes the galectin-carbohydrate interactions [4]. (fdocuments.net)
Besides, and studied to a lesser extent, they also depend on non-lectinic properties mediated by interactions of galectins with nucleic acids, proteins, lipids, and complex biomolecules (reviewed in [ 4 ], Table 1 ). (encyclopedia.pub)
Some sequences are similar to those proven to be targets for effective intervention in other protozoan parasites, and include not only proteases, antioxidant enzymes, and heat shock proteins, but also those associated with relict plastids, such as acetyl-CoA carboxylase and methyl erythrithol phosphate pathway components, and those involved in glycan assembly, protein folding/secretion, and parasite-host interactions. (biomedcentral.com)
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. (cusabio.com)
He then received his Ph.D. in Chemistry in 2015 at the University of California, San Diego, under the supervision of Prof. Yitzhak Tor, where he studied the design, synthesis, and application of small molecule antagonists of heparin- and heparan sulfate-protein interactions. (glyco26.org)

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human Galectin-3 concentrations in biological fluids. (rndsystems.com)
At concentrations greater than 1 ug/ml, Galectin-3 significantly enhanced migration of PBMCs compared to control. (enquirebio.com)
Concentrations of galectin-3 in the sera of normal controls and cancer patients. (arjournals.org)
In addition there is MF1 no relationship between extracellular ATP concentrations and IL-1 discharge in THP-1 cells when examined more than a 6?h time frame. (bios-mep.info)

Galectins essentially bind to glycans featuring galactose and its derivatives. (wikipedia.org)
Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. (unige.ch)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, the roles of glycans in complex biological systems, and their analysis and manipulation. (cshlpress.com)

Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. (unige.ch)
Galectin-3 induces endothelial cell morphogenesis and angiogenesis. (arjournals.org)

Galectin-3 is expressed by a wide range of cell types including activated T cells, tumor cells, macrophages, osteoclasts, fibroblasts, and epithelial cells. (enquirebio.com)
Childress KO , Cencer CS , Tyska MJ , Lacy DB , Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for TcdB mBio. (vanderbilt.edu)

Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. (unige.ch)
Besides, this is a pioneer study that presented the in depth characterization of protein molecules richness from this toad secretion. (biomedcentral.com)
In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method. (sinica.edu.tw)
Molecular cloning, expression profiling and binding characterization of a Minus-C odorant binding protein from the oriental fruit moth, Grapholita molesta (Lepidoptera: Tortricidae) [J]. , 2018, 61(7): 771-783. (insect.org.cn)
Expression, purification and characterization of galectin AcGalectin in Apis cerana cerana (Hymenoptera: Apidae) [J]. , 2018, 61(5): 546-554. (insect.org.cn)

Animal's and microorganisms' secretions, as well as plant extracts, have been used as folk medicine since the dawn of the humanity [ 1 ].Therefore, molecules found in poisons and venoms are interesting, once they were selected by evolution to act in their molecular targets with high specificity [ 1 , 2 ]. (biomedcentral.com)
They were initially de- scribed in the electric eel, Electrophorus electri- cus , as low-molecular-weight, -galactoside- binding, soluble proteins (electrolectins) [1]. (fdocuments.net)
The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3. (gu.se)
Willet AH , Chen JS , Ren L , Gould KL , Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins Molecular biology of the cell. (vanderbilt.edu)
Research work in Lin's laboratory combines molecular biology and mouse gene knockout models to study the mechanisms of gene expression or post-translational modifications in the regulation of immune system development and functions. (sinica.edu.tw)

Abstract ARAP2 is an Arf GAP that has previously been reported to affect focal adhesions (FAs) by regulating Arf6 and integrin trafficking and to bind to the adaptor proteins APPL1. (bio2009.org)

The galectin lattice is a multi-valent interaction of galectins with glycoproteins at the cell surface that displays rapid exchange of binding partners with properties of liquid-liquid phase transitions, thereby acting as an intermediary between freely diffusing glycoproteins and stable complexes in the membrane. (gr.jp)
The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. (thermofisher.com)

This allows galectin-3 to bridge effectively between different ligands and form adhesive networks. (wikipedia.org)
This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. (origene.com)

Galectin-8 mediates fibrogenesis induced by cyclosporine in human gingival fibroblasts. (unige.ch)
Inohara H, Raz A. Functional Evidence That Cell-Surface Galectin-3 mediates homotypic cell-adhesion. (arjournals.org)

For example, galectin-9 binds to polylactosamine chains with stronger affinity than to an N-acetyllactosamine monomer. (wikipedia.org)
Members of this protein family have an affinity for beta-galactosides. (origene.com)

MiRNAs bind to 3′ untranslated regions (3′-UTRs) of mRNAs and decrease the translation and/or balance of this mRNA resulting in a decrease in proteins levels. (liveconscience.com)
Reduced mRNA expression of chondroitin sulfate proteoglycan 4 (CSPG4), carbohydrate sulfotransferase 15 (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase), and matrix metalloproteinases 2 and 9 resulted. (bvsalud.org)

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. (wikipedia.org)
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. (nature.com)
Glycosylation, galectins and cellular signaling. (arjournals.org)

A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers. (gu.se)
Nevertheless no proof was attained which would support the participation of either endogenous ATP discharge or P2X7 receptor activation as the system where LPS-induces IL-1 discharge in either the THP-1 cell series or in newly isolated individual monocytes. (bios-mep.info)

Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. (arjournals.org)
Although most patients with localized tumors can be cured with surgical therapies, 20-30 % of the patients without any evidence of metastasis will develop relapse and/or metastatic RCC in the future [ 3 ]. (biomedcentral.com)

Tandem galectins contain at least two distinct carbohydrate recognition domains (CRD) within one polypeptide, thus are considered intrinsically divalent. (wikipedia.org)
Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. (rndsystems.com)
The 15 members of the family are normally classified according to their struc- ture and number of carbohydrate recognition domains (CRDs). (fdocuments.net)

Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. (wikipedia.org)
The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. (rndsystems.com)
Recently, protein from toads' secretion has gaining attention. (biomedcentral.com)
In this study, we used a RNA-seq analysis from R. schneideri skin and biochemical tests with the gland secretion to unravel its protein molecules. (biomedcentral.com)
Furthermore, we performed caseinolytic activity test to assess the presence of serine and metalloproteases in skin secretion and it was fractionated by fast liquid protein chromatography using a reverse-phase column. (biomedcentral.com)

His research interests are in the field of chemical biology and synthetic chemistry, including the synthesis of complex carbohydrates and glycoproteins associated with disease progression. (glyco26.org)

14(1): 6425, 2023 Oct 13. (bvsalud.org)
Tumor-Derived Galectins" Encyclopedia , https://encyclopedia.pub/entry/14140 (accessed December 10, 2023). (encyclopedia.pub)

The type of galectin-8 that is expressed is dependent on the tissue. (wikipedia.org)
Different galectins have distinct binding specificities for binding oligosaccharides depending on the tissue in which they are expressed and the function that they possess. (wikipedia.org)
Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities. (rndsystems.com)
Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin-3 (GAL-3). (biomedcentral.com)
Cloning, prokaryotic expression and tissue expression profiling of an odorant binding protein gene BminOBP 25 from Bactrocera minax (Diptera: Tephritidae) [J]. , 2018, 61(5): 537-545. (insect.org.cn)
This scar tissue can restrict blood flow due to contraction of the organ, leading to progressive liver damage and cirrhosis (the end stage of fibrosis), complicated by liver failure, portal hypertension and/or hepatocellular carcinoma [ 1 ]. (biomedcentral.com)
Lipomas are common benign soft tissue tumors, with 15 to 20% of the cases affecting the head and neck region and 1 to 4% involving the oral cavity. (academicjournals.org)

Dr. Weiss began his independent career as an assistant professor at the Complex Carbohydrate Research Center at the University of Georgia in January 2021. (glyco26.org)

The concave side forms a groove in which the carbohydrate ligand can bind, and which is long enough to hold about a linear tetrasaccharide. (wikipedia.org)
HS and CS are attached to core proteins via a common linker tetrasaccharide, but differ in their polymer backbones. (bvsalud.org)

Expression of Po66-CBP, a type-8 galectin, in different healthy, tumoral and peritumoral tissues. (unige.ch)
Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. (unige.ch)
miRNAs are short single-stranded RNA molecules that function as grasp regulators of gene expression by post-transcriptional modifications of target mRNAs [15]. (liveconscience.com)
The pattern of regulation of gene expression is usually sequence-specific. (liveconscience.com)
miRNAs have a variety of tasks, highlighting the modulation of expression of several proteins by degrading or preventing the translation of mRNAs, being several of them involved in allograft rejection. (fapesp.br)
Based on a review of these and other published studies using gene expression analysis, we concluded that YKL-40, Gal-3, cytokeratin 19 (CK19), TIMP-1 and Ang-1 were consistently found to be upregulated. (biomedcentral.com)
ARSB, which removes the 4-sulfate group at the non-reducing end of C4S, acts as a tumor suppressor, and treatment with exogenous ARSB impacts on vital cell signaling and reduces the expression of critical genes associated with melanoma progression. (bvsalud.org)
T2CA inhibited the expression of phosphorylated galectin-3 expression in human glioblastoma cell line which in turn inhibits the activity of MMP2 and MMP9 proteins in zymography investigations and inhibits migration of cancer cells in in vitro scratch assay. (arjournals.org)
Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. (arjournals.org)
The inhibitory effect of T2CA on phopho-galectin-3 expression and the activation of T-cytotoxic and NK cells suggested its protective effects against pathogenic infections and human malignancies via its immune stimulating mechanisms. (arjournals.org)
It provides a very informative, albeit preliminary, glimpse into the expression of genes encoding functionally relevant proteins as potential targets for chemotherapy, and evidence for the presence of a relict plastid. (biomedcentral.com)
cDNA cloning and expression profiling of small heat shock protein genes and their response to temperature stress in Monochamus alternatus (Coleoptera: Cerambycidae) [J]. , 2018, 61(7): 749-760. (insect.org.cn)
Identification and expression profiling of chemosensory protein genes in Galeruca daurica (Coleoptera: Chrysomelidae) ( In English ) [J]. , 2018, 61(6): 646-656. (insect.org.cn)
Sequence analysis and expression profiling of pheromone binding protein genes in the litchi fruit borer, Conopomorpha sinensi (Lepidoptera: Gracillariidae) [J]. , 2018, 61(5): 527-536. (insect.org.cn)
Expression profiling and functional analysis of RR-1 cuticular protein genes ApCP 12 and ApCP 23 in Antheraea pernyi (Lepidoptera: Saturniidae) [J]. , 2018, 61(2): 188-199. (insect.org.cn)
The present results show high expression of ST3GAL-1 is associated with reduced overall survival ( p = 0.013) and disease free survival ( p = 0.004). (biomedcentral.com)
However, few studies dedicated to evaluate the expression of ST3GAL-1 and its correlation with ccRCC pathological characters, making the issue elusive. (biomedcentral.com)
In this study, we aimed to investigate the prognostic significance of sialyltransferase ST3GAL-1 expression and its correlation with clinical outcomes in patients with ccRCC. (biomedcentral.com)
ST3GAL-1 expression was assessed by immunohistochemistry, and nomograms integrating ST3GAL-1 with other prognostic parameters were generated to refine individual risk stratification in ccRCC patients. (biomedcentral.com)
Using immunohistochemistry, all of us learned that Mcl-1 appearance has been drastically increased throughout digestive tract adenoma and also carcinoma affected individual materials in comparison with healthy colonic epithelium, like the superior Switch expression we all lately affecting cancer of the colon. (inhibitorkit.com)
The ability to define cancer subtypes, recurrence of disease and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. (gsea-msigdb.org)
Various studies have also demonstrated the potential for using gene expression profiles for the analysis of oncogenic pathways. (gsea-msigdb.org)
Here we show that gene expression signatures can be identified that reflect the activation status of several oncogenic pathways. (gsea-msigdb.org)
When evaluated in several large collections of human cancers, these gene expression signatures identify patterns of pathway deregulation in tumours and clinically relevant associations with disease outcomes. (gsea-msigdb.org)
Gene expression profiles were obtained for 131 peripheral blood samples from pediatric patients with acute infections caused by influenza A virus, Gram-negative (Escherichia coli) or Gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) bacteria. (gsea-msigdb.org)
Furthermore, distinctive gene expression patterns were observed in patients presenting with respiratory infections of different etiologies. (gsea-msigdb.org)

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
The detection results in the activation and interplay of the seven main signalling cascades: the p38 mitogen-activated protein kinase (MAPK), the insulin-like receptor (ILR), the Toll-like receptor (TLR), a transforming growth factor-b (TGF-b), the programmed cell death (PCD), the extracellular signal-regulated kinase (ERK) and a c-Jun N-terminal kinase (JNK). (biomedcentral.com)

2009). APPL1 also binds directly to Akt, which inhibits signaling through Akt1 (Broussard et al. (bio2009.org)

Many isoforms of galectins have been found due to different splicing variants. (wikipedia.org)
Galectin-9 has three different isoforms which differ in the length of the linker region. (wikipedia.org)
Some galectins exist in multiple isoforms due to alternative splicing. (rndsystems.com)

Metabolic regulation of UDP-GlcNAc supply to Golgi N-glycan remodeling regulates glycoprotein affinities for galectins -and in turn, trafficking and presentation at the cell surface. (gr.jp)
Although we only have a partial understanding of this subject, an extensive compendium of the literature supports galectins as being prominent actors in the regulation of immune homeostasis in both central and peripheral organs (as discussed below). (encyclopedia.pub)
Regulation of the genes involved in brassinosteroid biosynthesis. (u-szeged.hu)
Research in the Weiss Laboratory focuses on studying the structure, function, and regulation of complex carbohydrates in human biology and disease. (glyco26.org)

When Galectin-3 is at a low concentration it is monomeric and likely to inhibit adhesion. (wikipedia.org)
oxidized ATP (100?uM) significantly inhibited 5?mM ATP-induced IL-1 launch by 81, 90 and 66% respectively, but didn't significantly inhibit LPS-induced IL-1 launch in both THP-1 cells and in freshly isolated human being monocytes. (bios-mep.info)
In both THP-1 cells and newly isolated human being monocytes, addition from the ATP degrading enzyme apyrase (0.4?U?ml?1) to cell supernatants ahead of LPS activation didn't significantly inhibit the LPS-induced IL-1 launch. (bios-mep.info)
To be able to research the participation of ATP and P2X7 receptors in the LPS-induced IL-1 discharge in individual monocytes, OxATP, PPADS and KN-62, aswell as the ATP degrading enzyme, apyrase, had been tested because of their capability to inhibit LPS-induced IL-1 discharge in both THP-1 cell series and in newly isolated adherent individual monocytes. (bios-mep.info)

Yamaoka K, Ohno S, Kawasaki H, Suzuki K. Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. (arjournals.org)

An alternative approach to tumor transcript profiling is protein profiling of serum. (biomedcentral.com)
Transcript of Review Article Galectins in hematological malignancies · 2016-11-23 · Galectins in hematological. (fdocuments.net)

Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. (biomedcentral.com)

Sialyltransferase ST3GAL-1, which adds a sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms an important role in modulating cellular behaviors. (biomedcentral.com)
These types of final results underscore the opportunity of Selleck Androgen Receptor Antagonist combining minimal doses associated with aspirin using sorafenib to slow down spreading along with concentrate on the anti-apoptotic proteins Switch as well as Mcl-1 inside cancer of the colon cellular material. (inhibitorkit.com)

activation from the pro-IL-1 gene (March the activation from the individual P2X7 receptor (Rassendren LPS-induced discharge of endogenous ATP, which eventually turned on P2X7 receptors. (bios-mep.info)

Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
Liu FT, Rabinovich GA. Galectins as modulators of tumor progression. (arjournals.org)

The amino acid sequences of human and mouse Galectin-3 proteins share 80% homology. (enquirebio.com)
Typically, CRDs are located at the C-terminal end of the protein and consist of a classic β -sandwich fold of approximately 130 amino acid residues. (fdocuments.net)

PRDM1/Blimp-1 Directs Germ Cell versus Neural Cell Pathway. (sinica.edu.tw)
The quantity of ATP released was been shown to be LPS concentration-dependent, and carefully mirrored the focus dependence of LPS-induced IL-1 launch in mouse microglial AM095 cells (Ferrari the MAP kinase signalling pathway, whereas on the other hand this same pathway had not been significantly triggered by LPS in monocytic cells (Willis & Nisen, 1996). (bios-mep.info)
Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. (unige.ch)

The transcriptional profile observed in renal allograft and peripheral blood lymphocytes, using microarrays, has been used to identify genes modulated in various stages of transplantation, and found hundreds of genes involved in the rejection. (fapesp.br)

The DNA sequence and biological annotation of human chromosome 1. (unige.ch)
Subsequently, several groups identified new members of the galectin family in protein extracts obtained from various tissues by using their ability to bind galactose residues on rabbit erythrocytes and cloning approaches based on sequence homology. (fdocuments.net)
Similarity searches revealed that 55% of these had hits in protein sequence databases, of which 1,729 had their best hit with proteins from the chromalveolates (E-value ≤ 1e-5). (biomedcentral.com)

For example, Galectin-8 has seven different mRNAs encoding for both tandem and dimeric forms. (wikipedia.org)

Due to the nature of the binding pocket, galectins can bind terminal sugars or internal sugars within a glycan. (wikipedia.org)

Change of carbohydrate, protein and lipid contents in Galeruca daurica (Coleoptera: Chrysomelidae) adults during oversummering [J]. , 2018, 61(7): 808-814. (insect.org.cn)
HE Hai-Min, XIAO Liang, CHEN Qian-Wu, XUE Fang-Sen. A life-history trait of the Asian corn borer, Ostrinia furnacalis (Lepidoptera: Pyralidae)-positive correlation between body weight and temperature [J]. , 2018, 61(3): 340-347. (insect.org.cn)
Identification of odorant binding protein genes in antennae of Corythucha ciliata (Hemiptera: Tingidae) [J]. , 2018, 61(10): 1121-1131. (insect.org.cn)

Synthesized peptide derived from the C-terminal region of Human Mucin 1. (cusabio.com)

In addition to the differential transcriptional analysis, several genes are potentially involved in the mechanisms of tolerance. (fapesp.br)

Galectin-8: a complex sub-family of galectins (Review). (unige.ch)
Galectin 3 is one of the more extensively studied members of this family and is a 30 kDa protein. (liveconscience.com)
The PD-1 and CTLA-4 are members of the CD28 receptor family. (fapesp.br)

Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1). (arjournals.org)
We've utilized the human being monocytic cell collection, THP-1, and freshly isolated adherent human being monocytes using the substances pyridoxalphosphate-6-azophenyl-2,4-disuphonic acidity (PPADS), oxidized ATP, and 1-(N,O-bis5-isoquinolinesufonyll-N-methyl-L-tyrosyl)-4-phenylpiperazine (KN-62) to pharmacologically characterize the P2 receptor involved with ATP-induced launch of interleukin 1 (IL-1). (bios-mep.info)
We conclude that in human being monocytes, exogenous software of ATP leads to the discharge of adult IL-1, as well as the pharmacological profile of the launch is in keeping with activation of the AM095 P2X7 receptor. (bios-mep.info)
The LPS-induced launch of IL-1 in human being monocytes, however, is apparently self-employed of LPS-induced AM095 ATP launch and following activation from the P2X7 receptor. (bios-mep.info)
Briefly, it is known that tol-1 , a homologue of the Drosophila Toll-receptor, plays a role. (biomedcentral.com)
KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. (inhibitorkit.com)
estrogen receptor binding si. (gsea-msigdb.org)

ARAP2 associates with adaptor protein with PH domain, PTB domain and leucine zipper motifs 1 (APPL1) in endosomes (Chen et al. (bio2009.org)
SHC adaptor protein 1 [Sourc. (gsea-msigdb.org)

Be the first to review Simple Plex Control for Human Galectin-3 and earn rewards! (rndsystems.com)
Have you used Simple Plex Control for Human Galectin-3? (rndsystems.com)
Activity of Galectin-3 was confirmed by measuring chemotaxis of human PBMCs. (enquirebio.com)
Furthermore apyrase didn't considerably alter LPS-induced launch of IL-1 in either the THP-1 cells or the adherent human being monocytes. (bios-mep.info)

The galectin lattice (i) regulates flow of receptors and solute transporters to coated-pit endocytosis and/or caveolin domains, and (ii) promotes turnover of cell-cell contacts such as immune synapses and focal adhesion complexes. (gr.jp)
To conclude our data confirm the participation of P2X7 receptors in ATP-induced IL-1 discharge in individual monocytes. (bios-mep.info)
G protein coupled receptors (GPCR's) may be part of a neural circuit, that integrates signals from infected areas or from pathogens and which subsequently converts these signals in an appropriate defence response [ 5 , 6 ]. (biomedcentral.com)

What is the precise role of intracellular and extracellular galectins in the control of cell death programs? (nature.com)
The protozoan parasite Perkinsus marinus is a facultative intracellular parasite of mollusks, and the causative agent of "dermo" disease in both wild and farmed Eastern oyster ( Crassostrea virginica ) populations along the Atlantic and Gulf coasts of the USA [ 1 - 4 ]. (biomedcentral.com)

FAK can directly bind to the p85 subunit of PI-3-kinase, which leads to the activation and production of the signaling phospholipid PIP3, resulting in the activation of Akt. (bio2009.org)
dynactin subunit 1 [Source:H. (gsea-msigdb.org)

However, physiologically, they are likely to require lactose or N-acetyllactosamine for significantly strong binding. (wikipedia.org)

The strength of ligand binding is determined by a number of factors: The multivalency of both of ligand and the galectin, the length of the carbohydrate and the mode of presentation of ligand to carbohydrate recognition domain. (wikipedia.org)

The secretions are composed mainly by biogenic amines and steroids, as bufodienolides and bufotoxines, but they also produce proteins and glicoconjugate molecules [ 9 , 10 ]. (biomedcentral.com)

Anatomy16

Organisms20

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes72

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science5

Health Care1

Lectin10

Member of the galectin family2

LGALS32

Lectins13

Extracellular matrix5

Apoptosis5

Interactions11

Concentrations4

Glycans5

Endothelial cell2

Epithelial2

Characterization5

Molecular5

Abstract1

Membrane2

Ligands2

Mediates2

Affinity2

MRNA2

Glycosylation3

Induces2

Metastasis2

Recognition domains3

Secretion5

Glycoproteins1

20232

Tissue7

20211

Tetrasaccharide2

Expression26

Mitogen-activa2

Inhibits1

Isoforms3

Regulation4

Inhibit4

Beta-galactoside1

Transcript2

Synthesis1

Cellular2

Endogenous1

Progression2

Amino acid2

Pathway3

Autophagy1

Identify genes1

Sequence3

MRNAs1

Glycan1

20183

Peptide1

Mechanisms1

Family3

Receptor7

Adaptor protein2

Human4

Receptors3

Intracellular2

Subunit2

Lactose1

Ligand1

Molecules1