• Comparative environmental risk assessment using angiotensin converting enzyme (ACE) inhibitors enalapril, ramipril, lisinopril and captopril from a Swedish perspective (Report Goodpoint 2019). (janusinfo.se)
  • Vasotec (enalapril maleate) is an ACE ( angiotensin converting enzyme ) inhibitor used to treat high blood pressure ( hypertension ), congestive heart failure , kidney problems caused by diabetes , and to improve survival after a heart attack . (rxlist.com)
  • VASOTEC® (Enalapril Maleate) is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin -converting enzyme inhibitor, enalaprilat. (rxlist.com)
  • Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. (nih.gov)
  • Existe alguma diferença entre os IECA (captopril e enalapril, especificamente) em relação à nefropatia diabética em pacientes DM-2 com microalbuminúria? (bvs.br)
  • Não foram encontrados na literatura estudos de adequado rigor metodológico tais como Ensaios Clínicos Randomizados e Revisões Sistemáticas que comparassem o uso do Captopril ao uso do Enalapril, em pacientes diabéticos portadores de microalbuminúria e cujo desfecho principal seria evitar a progressão da nefropatia diabética. (bvs.br)
  • Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. (wikipedia.org)
  • Captopril was the first oral ACE inhibitor found for the treatment of hypertension. (wikipedia.org)
  • A double-blind, randomized, parallel and active-controlled clinical study was conducted to evaluate the anti-hypertensive effect as well as the tolerability of Olive leaf extract in comparison with Captopril in patients with stage-1 hypertension. (nih.gov)
  • In conclusion, Olive (Olea europaea) leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twice daily. (nih.gov)
  • T cell function tests were performed in 6 patients with uncomplicated essential hypertension (EH) before and after treatment with captopril, an angiotensin-converting enzyme inhibitor. (biu.ac.il)
  • Inhibition of Angiotensin Converting Enzyme (ACE) is a modern therapeutic target in the treatment of hypertension. (scielo.br)
  • ACE inhibitors are considered 'first-line therapy' in the treatment of stage 1 hypertension . (cvpharmacology.com)
  • Alacepril is an angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension. (affygility.com)
  • In using VASOTEC consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that VASOTEC does not have a similar risk (see WARNINGS ). (rxlist.com)
  • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. (bvs.br)
  • Therefore, current recommendations are that ACE inhibitors and ARBs are appropriate for African Americans, but not as monotherapy. (cvpharmacology.com)
  • Due to the adverse drug event of causing hyperkalemia, as seen with most ACE Inhibitors, the medication is usually paired with a diuretic. (wikipedia.org)
  • A diuretic or calcium-channel blocker should be used with an ACE inhibitor or ARB to achieve the target reduction in blood pressure in these patient populations. (cvpharmacology.com)
  • Quinapril hydrochloride and hydrochlorothiazide is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide. (nih.gov)
  • ACE inhibitors are sold in large quantities but all the compared substances (except ramipril) and active metabolites are very water soluble with very low potential to accumulate in aquatic biota to levels that are considered to pose a risk. (janusinfo.se)
  • A maioria dos estudos que comparou os IECA com outra classe medicamentosa utilizou o Captopril ou o Ramipril como droga representante do grupo dos IECA. (bvs.br)
  • following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin-converting enzyme inhibitor. (rxlist.com)
  • Strippoli Giovanni FM, Bonifati Carmen, Craig Maria E, Navaneethan Sankar D, Craig Jonathan C. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease. (bvs.br)
  • His study led to the development of a selected class of analgesics, particularly the COX 2 inhibitor, considered to be a remarkable progress for all NSAIDs. (princemahidolaward.org)
  • Older people should be careful when taking medication that may affect potassium levels, such as non-steroidal anti-inflammatory drugs (NSAIDs) and ACE inhibitors. (stlukes-stl.com)
  • By reducing the effects of angiotensin II on the kidney, ACE inhibitors cause natriuresis and diuresis , which decreases blood volume and cardiac output, lowering arterial pressure. (cvpharmacology.com)
  • Other side effects are: Itching Headache Tachycardia Chest pain Palpitations Dysgeusia Weakness The adverse drug reaction (ADR) profile of captopril is similar to other ACE inhibitors, with cough being the most common ADR. (wikipedia.org)
  • The increase in bradykinin is also believed to be responsible for a troublesome side effect of ACE inhibitors, a dry cough. (cvpharmacology.com)
  • Captopril was patented in 1976 and approved for medical use in 1980. (wikipedia.org)
  • Squibb filed for U.S. patent protection on the drug in February 1976, which was granted in September 1977, and captopril was approved for medical use in 1980. (wikipedia.org)
  • After 2 weeks, if necessary, the dose of Captopril would be titrated to 25 mg twice daily, based on subject's response to treatment. (nih.gov)
  • The effects of mediator modifying drugs, as well as an angiotensin converting enzyme inhibitor (captopril), a calcium channel blocking agent (TMB8) and capsaicin were tested. (cdc.gov)
  • His discovery paved the way for the development of a new class of antihypertensive drugs, the angiotensin converting enzymes inhibitors (ACEI), the first of which is the drug called captopril. (princemahidolaward.org)
  • This vasoconstrictor is formed by the proteolytic action of renin (released by the kidneys) acting on circulating angiotensinogen to form angiotensin I. Angiotensin I is then converted to angiotensin II by angiotensin converting enzyme (ACE). (cvpharmacology.com)
  • The brain has shown the presence of various components of brain RAS such as angiotensinogen (AGT), converting enzymes, angiotensin (Ang), and specific receptors (ATR). (hindawi.com)
  • Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)
  • What Medicine is used for: The ACE-inhibitors (Angiotensin Converting Enzyme) are used to reduce the production of a substance called angiotensin II that causes the blood vessels to narrow. (kkh.com.sg)
  • A significant reduction of triglyceride level was observed in Olive group, but not in Captopril group. (nih.gov)
  • Capsaicin depleted irritant nerves of bronchoconstricting mediators, and also resulted in a modest reduction of WGE-induced constriction as did TMB8 and captopril. (cdc.gov)
  • Except for postural hypotension, which occurs due to the short and fast mode of action of captopril, most of the side effects mentioned are common for all ACE inhibitors. (wikipedia.org)
  • Available toxicity tests indicate low toxicity to aquatic organisms, but they are acute tests and are not designed to address the specific effects of ACE inhibitors. (janusinfo.se)
  • It was the first ACE inhibitor developed and was considered a breakthrough both because of its mechanism of action and also because of the development process. (wikipedia.org)
  • Therefore, ACE inhibitors, by blocking the breakdown of bradykinin, increase bradykinin levels, which can contribute to the vasodilator action of ACE inhibitors. (cvpharmacology.com)
  • Angiotensin converting enzyme, anti-hypertensive effect, hipotensive agents. (scielo.br)
  • With provisional use of glycoprotein IIb/IIIa inhibitor (GP IIb/IIIa inhibitor), bivalirudin is indicated for use as an anticoagulant in patients undergoing PCI. (medscape.com)
  • The ACEI and Cox-2 inhibitors are currently among the most widely used to relieve pain and inflammatory conditions, saving lives of millions of patients around the world. (princemahidolaward.org)
  • RÉSUMÉ Nous avions l'objectif d'étudier la prévalence des effets secondaires causés par les statines chez des patients iraniens admis dans un hôpital spécialisé en cardiologie et sous traitement par statines avant leur hospitalisation. (who.int)
  • Captopril has an L-proline group which allows for it to be more bioavailable within oral formulations. (wikipedia.org)
  • It is converted to captopril and desacetyl-alacepril in the body after oral doses. (affygility.com)
  • Angiotensin I is then converted to an octapeptide , angiotensin II by angiotensin-converting enzyme (ACE), [9] which is thought to be found mainly in endothelial cells of the capillaries throughout the body, within the lungs and the epithelial cells of the kidneys. (wikipedia.org)
  • All the components of brain RAS such as enzyme isorenin, ANG, Ang I, converting enzymes, and Ang II are found in the brain [ 5 - 9 ]. (hindawi.com)
  • captopril was safe and effective in 4 out of 5 episodes for AD management. (scireproject.com)
  • Captopril is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE). (scireproject.com)
  • When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. (nih.gov)
  • The principal metabolite of quinapril, quinaprilat, is an inhibitor of ACE activity in human subjects and animals. (nih.gov)
  • Six additional subjects received captopril 25 mg as a low-sodium comparison and also received aliskiren on a high-sodium (200 mmol/d) diet. (eur.nl)
  • Yuri N. Korystov In the present study, the activity of ACE ( angiotensin - converting enzyme ) in the aorta of senescent rats and rats treated with the NOS (NO synthase) inhibitor L -NAME ( N G. (portlandpress.com)