Cancer patients mesylates. Medical search. Frequent questions

Patients receive oral imatinib mesylate twice daily on days 1-28. (knowcancer.com)
Preclinical data shows improvements in response for the combination of imatinib mesylate (IM, Gleevec) and gemcitabine (GEM) therapy compared with GEM alone. (aacrjournals.org)
Imatinib mesylate (IM) is a small molecule inhibitor of protein tyrosine kinases. (prinsesmaximacentrum.nl)
It is used in patients whose condition has become worse while taking another drug called imatinib mesylate or who are not able to take imatinib mesylate. (news-medical.net)
Preliminary studies show that a vaccine made with leukemia cells may be able to reduce or eliminate the last remaining cancer cells in some chronic myeloid leukemia patients taking the drug Imatinib mesylate (Gleevec). (sciencedaily.com)
Imatinib mesylate is a novel anti-tumor agent useful in the clinical management of chronic myelogenous leukemia and gastrointestinal stromal tumors with minimal toxicity relative to other forms of cancer therapy. (oldcitypublishing.com)
In some patients, unexpected toxicities arise that are not associated with inhibition of any known cellular imatinib target. (oldcitypublishing.com)
COX-2 induction by imatinib in squamous tumors derived from the head and neck region is unique with respect to other target-specific agents and may represent one of the unintended toxic effects of imatinib described in some patients. (oldcitypublishing.com)
Locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate. (nih.gov)
Tasigna demonstrated that significantly fewer patients progressed to more advanced stages of the disease than the standard of care Gleevec (imatinib mesylate) tablets* at 12 months. (salesandmarketingnetwork.com)
Imatinib mesylate (IM) is a tyrosine kinase inhibitor, which inhibits phosphorylation of downstream proteins involved in BCR-ABL signal transduction. (tau.ac.il)
Tsimberidou AM, Medina J, Cortes J, Rios A, Glisson, B, Faderl S. Kantarjian H, Garcia-Manero G. Chronic myeloid leukemia in a patient with acquired immune deficiency syndrome complete cytogenetic response with imatinib mesylate: report of a case and review of the literature. (uth.edu)
Novartis, a Swiss pharmaceutical conglomerate, filed a patent application in 1997 for Glivec, an anticancer drug used to treat Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GIST), claiming that it invented the beta crystalline salt form (imatinib mesylate) of the free base, imatinib. (legalserviceindia.com)
The beta-crystalline form of imatinib mesylate was deemed unique and creative by IPAB, but the drug of Novartis was denied a patent due to Section 3(d) of the Act. (legalserviceindia.com)
On 20/7/2002, NATCO Pharma applied for an Indian patent on what is known as the A2 form of Imatinib Mesylate. (legalserviceindia.com)
Natco Pharma has again applied for a patent on novel crystalline forms I and II of Imatinib Mesylate and has also accepted that they exist in alpha and beta forms in NOVATIS Patent. (legalserviceindia.com)
Both parties challenging the application of Novartis themselves applied for the patenting of the crystalline forms of Imatinib Mesylate as novel inventions. (legalserviceindia.com)
The main issue before the court was whether the beta crystalline form of Imatinib Mesylate constitutes an innovation under section 2(j) and (j)(a), and if so, how does it affect section 3? (legalserviceindia.com)
The appellant claimed that imatinib Mesylate in beta crystalline form is a brand-new product. (legalserviceindia.com)
No crystalline form of Imatinib Mesylate was anticipated or disclosed in the Zimmerman patent. (legalserviceindia.com)
In the Zimmermann patent, there was no method for converting Imatinib to Imatinib Mesylate that worked. (legalserviceindia.com)
Furthermore, the parties opposing Novartis' application have filed for and received patents for crystalline versions of Imatinib Mesylate as a novel innovation. (legalserviceindia.com)
Due to the introduction of imatinib, a tyrosine kinase inhibitor (TKI), CML patients now benefit from treatment ( 2 ). (spandidos-publications.com)
Neoadjuvant imatinib therapy is preferred for marginally resectable tumors or patients with comorbidities for surgery. (medscape.com)
Surgery may be indicated in patients who have locally advanced or previously unresectable disease after a positive response to preoperative imatinib, or with limited disease progression on systemic therapy. (medscape.com)
In patients with a known PDGFRA D842V mutation conferring imatinib resistance, sunitinib is a reasonable option. (medscape.com)
In patients with an SDH-deficient or NF-related GIST, imatinib is not recommended because of resistance. (medscape.com)
Options are limited for patients with progressive disease whose GISTs are resistant to both imatinib, sunitinib, and regorafinib. (medscape.com)
[ 4 ] A study by Gugliotta et al examined the use of imatinib in patients aged 65 years or older and found that the response to imatinib was not affected by age. (medscape.com)
The DASISION study (DASatinib versus Imatinib Study In treatment-Naive CML patients) showed similar results: achieving major CyR by 3 or 6 months was a better predictor of PFS after initial treatment with first-line dasatinib in chronic-phase CML. (medscape.com)
They also looked at three drugs for chronic myeloid leukemia: dasatinib (Sprycel), imatinib mesylate (Gleevec), and nilotinib hydrochloride monohydrate (Tasigna). (medscape.com)

For example, an oncologist at her practice wants to treat a patient with Halaven (eribulin mesylate) for breast cancer. (managedhealthcareexecutive.com)
Halaven (eribulin mesylate) was approved by the FDA for the treatment of patients with unresectable or advanced liposarcoma . (shu.edu)
HALAVEN contains eribulin mesylate, a microtubule dynamics inhibitor. (shu.edu)
Eribulin mesylate is a synthetic analogue of halichondrin B, a product isolated from the marine sponge Halichondria okadai. (shu.edu)
Yung Lyou, M.D., Ph.D., is actively recruiting patients for a Phase 2 study on the benefits of atezolizumab, with or without eribulin mesylate, in treating patients with urothelial cancer that has come back, or spread to nearby tissues and lymph nodes, or other places in the body. (cityofhope.org)
Location: San Paulo, "Eisai Brazil") has launched the anticancer agent Halaven® (eribulin mesylate) in the country. (eisai.com)

To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
Gleevec, one of the first targeted cancer therapies with wide success in CML patients, destroys most leukemic cells in the body, but in most patients, some cancerous cells remain and are measurable with sensitive molecular tests. (sciencedaily.com)
The study vaccine was given to 19 CML patients with measurable cancer cells, despite taking Gleevec for at least one year. (sciencedaily.com)
According to the investigators, most patients with CML will need to remain on Gleevec therapy for the rest of their lives. (sciencedaily.com)
Gleevec also cannot be taken during pregnancy, and since one-third of CML patients are in their 20s and 30s, many patients hoping to start families would like to discontinue taking it. (sciencedaily.com)
Ultimately, should this vaccine approach prove to be successful, the ability to get patients off lifelong Gleevec therapy would be a significant advance," says Levitsky. (sciencedaily.com)
All filings are based on data showing superior efficacy for Tasigna in the first head-to-head comparison of the drug against the standard of care Gleevec in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
If approved for the first-line indication, Tasigna will be the first drug for newly diagnosed patients to become available since the approval of Gleevec in 2002. (salesandmarketingnetwork.com)
This randomized, open-label, multicenter trial compared the efficacy and safety of Tasigna versus Gleevec in adult patients with newly diagnosed Ph+ CML in chronic phase(1). (salesandmarketingnetwork.com)
In the ENESTnd clinical trial significantly fewer patients at 12 months progressed to accelerated or blastic phase on Tasigna 300 mg twice daily than on Gleevec 400 mg once daily (2 patients vs. 11 patients)(1), demonstrating a significant improvement in disease control. (salesandmarketingnetwork.com)
Fewer patients discontinued due to adverse events from the Tasigna 300 mg twice daily arm of the study compared to the Gleevec 400 mg once daily arm. (salesandmarketingnetwork.com)
Tasigna has been approved in more than 80 countries for the treatment of chronic phase and accelerated phase Ph+ CML in adult patients resistant or intolerant to at least one prior therapy, including Gleevec. (salesandmarketingnetwork.com)

With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
Sunitinib malate is approved by the Food and Drug Administration (FDA) to treat a type of stomach cancer called gastrointestinal stromal tumor (GIST). (news-medical.net)
Ultrasound and MRI are not able to differentiate a GIST from ovarian cancer. (scirp.org)

The goals of this study were to determine the maximum tolerated dose (MTD) of IL-2 combined with IM at a constant dose of 400 mg, the pharmacokinetics of IM and IL-2, as well as toxicity and clinical efficacy of this immunotherapeutic regimen in patients affected by advanced tumors. (prinsesmaximacentrum.nl)
Parlodel (bromocriptine mesylate) is a dopamine receptor agonist used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia), and to treat these disorders when they are caused by brain tumors that can produce prolactin. (rxlist.com)
In retrospect, the fact that cancer was viewed as a genetic disease for so long was likely an artifact of focus and technology: Chromosomal changes began to be detectable before we understood epigenetics at a molecular level, and the early focus on familial cancer and rapidly induced viral tumors favored the discovery of mutational carcinogenesis, which has largely colored our views over the past three decades ( 3, 4 ). (aacrjournals.org)
Each year, about 5047 cases of childhood cancer are leukemias and lymphomas, 2071 cases are brain and central nervous system (CNS) tumors, and 1612 cases are sarcomas. (sarcomahelp.org)
Though a similar number of children are affected by these cancers, brain and CNS tumors receive four times the funding as sarcomas do. (sarcomahelp.org)
Considering that only few patients with gastrointestinal stromal tumors have been reported in the obstetrical and gynecological literature, the awareness of such an entity by the obstetricians-gynecologists is necessary in order to facilitate coordinated approach with the general surgeons and oncologists for the optimal care of the patients. (scirp.org)

In Brazil, Halaven was approved for the treatment of patients with locally advanced or metastatic breast cancer who have progressed after at least two chemotherapy regimens for advanced disease. (eisai.com)
With the launch of Halaven, Eisai is committed to delivering innovative new treatments to patients in Brazil while enhancing its product lineup and marketing framework as it seeks to further increase the benefits it provides to patients and their families in the region. (eisai.com)
Halaven was first approved as a treatment for breast cancer in the United States in November 2010, and is now approved in more than 55 countries worldwide, including European Union member states, Japan and other Asian countries. (eisai.com)

This application is based on the results of the Phase 3 CLEAR study (Study 307/KEYNOTE-581) for the first-line treatment of patients with advanced RCC, which were presented at the 2021 Genitourinary Cancers Symposium (ASCO GU), and simultaneously published in the New England Journal of Medicine in February 2021. (itbusinessnet.com)

A Multi-center, Randomized, Double-blind, Placebo-controlled Phase III Trial of the FLT3 Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/ITD AML (BMT CTN 1506) Rochester, Minn., Scottsdale/Phoenix, Ariz. (mayo.edu)
Patients with advanced renal cell carcinoma who received the checkpoint inhibitor combination nivolumab (Opdivo) plus ipilimumab (Yervoy) experienced longer treatment-free survival (TFS) over a 42-month period than patients who received the targeted therapy sunitinib (Sutent), regardless of the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk group, according to new analysis of the CheckMate-214 clinical trial. (news-medical.net)
Similar to these drugs, eribulin is a microtubule inhibitor that induces apoptosis of cancer cells by stopping mitosis in the G2/M phase of the cell cycle . (shu.edu)
Tasigna is a potent and selective inhibitor of the Bcr-Abl protein that causes production of cancer cells in Ph+ CML(2,3). (salesandmarketingnetwork.com)
The Sarcoma Oncology Center collaborates with other centers to provide PD1 and PDL1 Inhibitor treatment and Hyperthermia Therapy for cancer. (sarcomaoncology.com)
Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD. (oncotarget.com)
Single-agent EGFR inhibitor therapy is effective mainly in patients with lung cancer and EGFR mutations. (oncotarget.com)
We therefore investigated the outcome of EGFR inhibitor-based combination regimens in patients with heavily-pretreated non-small cell lung cancer (NSCLC) referred to a Phase I Clinic. (oncotarget.com)
EGFR inhibitor-based combination regimens were administered to 15 patients with EGFR -mutant NSCLC and 24 with EGFR wild-type disease. (oncotarget.com)

EAST HANOVER, N.J., Feb. 19 -- (Healthcare Sales & Marketing Network) -- Novartis announced today that Tasigna (nilotinib) 200 mg capsules has been granted priority review by the US Food and Drug Administration (FDA) for the treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase. (salesandmarketingnetwork.com)
The regulatory submissions are based on data from the ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials of Newly Diagnosed Ph+ CML Patients) Phase III clinical trial. (salesandmarketingnetwork.com)
Sudden deaths have been reported in patients receiving nilotinib. (salesandmarketingnetwork.com)

Idhifa is indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. (pharmaceutical-technology.com)
Selumetinib in paediatric patients with BRAF -aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicenter, phase 2 trial. (medscape.org)
At $475,000, Novartis' Kymriah (tisagenlecleucel) is approved by FDA for patients up to 25 years of age with B-cell precursor acute lymphoblastic leukemia that's refractory or in second or later relapse. (managedhealthcareexecutive.com)
Gilead's Yescarta (axicabtagene ciloleucel), at $373,000, is approved for adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. (managedhealthcareexecutive.com)
TECENTRIQ used in the treatment of f patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer (DTC). (cancermedicinesnetwork.com)

Purpose: This dose-ranging trial of intravenous dolasetron mesylate (MDL73, 147EF) was performed to determine its adverse and antiemetic effects in patients receiving cisplatin at doses ≥ 100 mg/m 2 . (elsevierpure.com)
Patients and Methods: Eighty-nine patients treated with initial cisplatin received a single intravenous dose of dolasetron mesylate administered over 20 minutes beginning 30 minutes before chemotherapy. (elsevierpure.com)
The patient has already received two rounds of intravenous chemotherapy, she adds. (managedhealthcareexecutive.com)

The researchers focused on three drugs used to treat kidney cancer: sorafenib (Nexavar), sunitinib malate (Sutent), and pazopanib hydrochloride (Votrient). (medscape.com)

A study of the drugs selumetinib verus carboplatin/vincristine in patients with neurofibromatosis and low-grade glioma. (medscape.org)
QT Prolongation: Monitor for prolonged QT intervals in patients with congestive heart failure, bradyarrhythmias, drugs known to prolong the QT interval, and electrolyte abnormalities. (drugs.com)
With over 30 years of medical and clinical research experience, Dr. Chawla partners with the chemo experts at The Sarcoma Center to continue his pioneering work as a leader in experiential treatments and clinical trial drugs using some of the new advanced therapies for many of his cancer patients. (sarcomaoncology.com)
Over the next five years, Dr. Chawla's medical research will continue its focus on development of cancer gene therapy, vaccines, immunotherapies (treatments that use the body's own defenses to combat cancer) and anti-angiogenic agents (drugs to block development of blood vessels and starve the tumor) to treat soft-tissue sarcomas. (sarcomaoncology.com)
Reuters Health) - Some oncologists may be more likely to prescribe certain cancer medicines when they receive payments from the companies that make these drugs, a U.S. study suggests. (medscape.com)
Then, researchers looked at how often doctors prescribed different drugs for two types of cancers with multiple treatment options: kidney cancer and chronic myeloid leukemia. (medscape.com)
While others have studied industry payments in relation (to) prescribing of other kinds of drugs, like blood pressure and cholesterol medications, ours is the first study examining oncology drugs," said senior study author Stacie Dusetzina, a researcher at Vanderbilt University Medical Center and the Vanderbilt-Ingram Cancer Center in Nashville, Tennessee. (medscape.com)
Because oncology is a high-risk disease area and the drugs are very expensive, decisions about prescribing should ideally be determined by a doctor-patient discussion that is free from outside influences," Dusetzina said by email. (medscape.com)
While these payments have long been associated with prescriptions for more expensive brand-name drugs, the extent of this link for cancer drugs in particular has been unclear, the researchers noted April 9 online in JAMA Internal Medicine. (medscape.com)
Among the 354 physicians prescribing kidney cancer drugs, 32, or 9%, received research funding and 89, or 25%, received general payments for things like meals, travel or speaking or consulting gigs. (medscape.com)
Each drug has a unique risks and benefit profile, even when considering two drugs from the same class, and often costs to the patient and society vary as well," Jagsi, who wasn't involved in the study, said by email. (medscape.com)
This tape, called the drug mention tape, contains information on 37,429 drugs mentioned in the national sample of 33,795 patient visits. (cdc.gov)

Reduce dose in patients with hepatic impairment or with moderate or severe renal impairment. (drugs.com)
Renal Impairment: A lower starting dose is recommended for patients with moderate (CLcr 30-49 mL/min) or severe (CLcr 15-29 mL/min) renal impairment. (drugs.com)

In addition, the novel cancer stem cell paradigm raises the prospect of cell-targeted therapies instead of treatment directed against the whole tumour. (nature.com)
Subsequent improved understanding of the molecular alterations present in the cancer cell has enabled the development of targeted therapies for some forms of cancer. (nature.com)
These agents may be considered as an alternative in patients who have a contraindication or are concerned about using hormonal therapies. (allenpress.com)
Without access to these innovative therapies, many patients may have no other options. (managedhealthcareexecutive.com)
1997). The introduction of tyrosine kinase inhibitors (TKIs) in 2001 heralded the start of targeted therapies in hematopoietic cancers because of their distinct impact on tyrosine kinase, encoded by the CML-pathognomonic BCR-ABL gene (Kris et al. (ons.org)
Because the study was conducted in a limited number of patients and not compared with other therapies, the researchers warn they cannot be sure that the responses were a result of the vaccine. (sciencedaily.com)
However, as these therapies are only palliative, patients' quality of life and personal preferences should always be considered. (thieme-connect.com)
Our world-class experts offer bladder cancer patients, including those with complicated cases, access to a wide variety of trials, evaluating leading-edge treatments and innovative therapies. (cityofhope.org)
It is the largest global randomized comparison of two oral therapies ever conducted in newly diagnosed Ph+ CML patients. (salesandmarketingnetwork.com)
The Sarcoma Center's integrated treatment approach may include options for experiential therapies as part of a patient's comprehensive cancer care. (sarcomaoncology.com)

Lenvatinib is approved (since 2015) for the treatment of differentiated thyroid cancer that is either locally recurrent or metastatic, progressive, and did not respond to treatment with radioactive iodine (radioiodine). (cancermedicinesnetwork.com)
Patient, Physcian, distributor/supplier can buy and import Brand Name "LENVIMA (lenvatinib) capsules" from Verve Biosciences, if the drug has not been approved or is not available in your country. (cancermedicinesnetwork.com)

We provide comprehensive care through collaboration with members of the Divisions of Surgery, Radiation Oncology, Pathology, and Radiology and includes multidisciplinary tumor board conferences and coordination of care through the Memorial Hermann Cancer Center for the treatment of Acute and Chronic Leukemias, Malignant Lymphomas, and Plasma Cell Disorders (Multiple Myeloma, MGUS and Amyloid-related Disorders). (uth.edu)
See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)

Resistance to cancer chemotherapeutic treatment is a common phenomenon, especially in progressive disease. (nature.com)
Since then, chemotherapy has been one of the main therapeutic strategies in cancer treatment, but, to paraphrase Paul Ehrlich, resistance has followed as a faithful shadow. (nature.com)
2011). Even for patients showing resistance to first-line therapy, their life expectancy may improve because of modern TKI alternatives (Kantarjian et al. (ons.org)
Treating patients who develop resistance, or who are insensitive from the outset, often because of resistant mutations, other aberrations or the lack of an EGFR mutation, probably requires rational combinations. (oncotarget.com)
two with sensitive mutations and secondary resistance to prior erlotinib, and one with a resistant mutation), as well as 26% of evaluable patients (5/19) with wild-type disease. (oncotarget.com)

A randomized trial of 16 808 postmenopausal women receiving hormone replacement therapy (HRT) versus placebo demonstrated that HRT-treated patients experienced an increase in major adverse events, such as breast cancer, venous thromboembolism, and cardiovascular events. (allenpress.com)
It was previously approved for patients with breast cancer who had undergone at least two prior chemotherapeutic regimens, including an anthracycline and a taxane. (shu.edu)
Vinblastine and Oncovin - vincristine) have been reported to be highly effective against breast cancer as well as many other types of cancer. (shu.edu)
In Brazil, approximately 67,000 women are newly diagnosed with breast cancer each year, and this type of cancer is the cause of death for approximately 16,000 patients a year. (eisai.com)
Metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. (drugs.com)
3. No prior chemotherapy or targeted systemic therapy for metastatic or locally recurrent inoperable breast cancer. (who.int)

This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)

Based on the prevalence of the cancers in Figure 1, one would expect to see NCI investing about 1/3 of the amount of money into sarcomas as they do leukemias and lymphomas. (sarcomahelp.org)

Patients must have no evidence of metastatic disease based on screening computed tomography or magnetic resonance imaging. (cityofhope.org)
Patients with metastatic disease (most commonly to the liver) may also be candidates for surgery depending on the degree of liver involvement, tumor size, and surgical resectability. (msdmanuals.com)

This treatment was administered at three week intervals to 17 patients. (prinsesmaximacentrum.nl)
Cancer Treatment Reports. (wikipedia.org)
Parlodel (bromocriptine mesylate) is indicated for the treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism . (rxlist.com)
Parlodel treatment is indicated in patients with prolactin-secreting adenomas , which may be the basic underlying endocrinopathy contributing to the above clinical presentations. (rxlist.com)
A first-in-kind kidney cancer drug developed from laboratory and translational studies conducted at UT Southwestern Medical Center received approval from the Food and Drug Administration, providing a new treatment for patients with familial kidney cancer. (news-medical.net)
CAR T-cell therapy and other immunotherapies may cure patients who have endured multiple rounds of treatment. (managedhealthcareexecutive.com)
This is just one situation where her practice wants more flexibility with the appropriate treatment for patients. (managedhealthcareexecutive.com)
The treatment is approved for patients who previously had undergone chemotherapy with an anthracycline drug. (shu.edu)
Patients received treatment until disease progression. (shu.edu)
Further, 8% of the patients assigned eribulin and 5% of the patients assigned dacarbazine discontinued treatment due to a drug-related adverse event. (shu.edu)
As a National Cancer Institute-designated comprehensive cancer center, City of Hope's bladder cancer program is uniquely positioned to provide personalized and comprehensive treatment plans, along with access to groundbreaking clinical trials. (cityofhope.org)
Sumanta Pal, M.D., is actively recruiting patients for a Phase 3 trial studying the benefits of an oral targeted therapy for the adjuvant treatment of patients with invasive urothelial carcinoma with susceptible FGFR3 genetic alterations that is considered high risk for recurrence with surgery alone. (cityofhope.org)
Now this priority review designation brings us one step closer to offering patients who are newly diagnosed with Ph+ CML in the chronic phase a promising new treatment option. (salesandmarketingnetwork.com)
We partner with our patients for the most effective treatment plan encouraging them to participate with us for the best possible outcome. (sarcomaoncology.com)
We offer multiple cancer treatment options and analysis. (sarcomaoncology.com)
LENVIMA is used by itself as the first treatment for a type of liver cancer called hepatocellular carcinoma (HCC) when it cannot be removed by surgery. (cancermedicinesnetwork.com)
Current recommendations for treatment of young patients with polycythemia primarily rely on phlebotomy. (medscape.com)
There is a high relapse rate in patients in accelerated phase even after successful treatment. (medscape.com)

If the initial dose was too low, the patient would remain at continued risk for an embolism, while too high a dose would subject the patient to the risk of possible cerebral hemorrhage. (mlo-online.com)
Hepatic Impairment: A lower starting dose is recommended for patients with mild (Child-Pugh A) and moderate (Child-Pugh B) hepatic impairment. (drugs.com)
In patients with a known exon 9 KIT mutation, a dose of 800 mg PO daily can be considered if tolerated. (medscape.com)

Clin Cancer Res (2007) 13 (19): 5876-5882. (aacrjournals.org)
Clin Cancer Res (2009) 15 (12): 3938-3946. (aacrjournals.org)

SEE NAMCS PATIENT DATASET NAMES FOR DSN ABSTRACT General Information This material provides documentation for users of the Micro-Data tapes of the National Ambulatory Medical Care Survey (NAMCS) conducted by the National Center for Health Statistics. (cdc.gov)

Stacie Dusetzina, PhD, professor of health policy and cancer research at Vanderbilt University Medical Center, says patients often wait three months for a payer to approve CAR T therapy. (managedhealthcareexecutive.com)

Yung Lyou, M.D., Ph.D., is actively recruiting patients for a Phase 3 study on the benefits of a combination therapy to treat patients with untreated locally advanced or metastatic urothelial cancer. (cityofhope.org)

The drug is also approved in the US and in the European Union for hepatocellular carcinoma that cannot be removed surgically in patients who have not received cancer therapy by mouth or injection. (cancermedicinesnetwork.com)

Patients are evaluated to determine the lowest dosage that produces a therapeutic response. (rxlist.com)

Chemotherapy- and immunotherapy-related side effects can send patients to the emergency room-that is, if oncology practices don't proactively manage patients and provide timely triage. (managedhealthcareexecutive.com)
By having such transparency as to where costs are highest for these oncology patients, or patients who may be high utilizers of pharmacy or [emergency room] visits, the oncologist can provide navigation, education, or care management to direct care more appropriately where possible," she says. (managedhealthcareexecutive.com)
Ann McGreal, RN, oncology nurse clinician at Park Ridge, Illinois-based Advocate Lutheran General Hospital, expresses frustration with some payers' reluctance to approve medications outside National Comprehensive Cancer Network (NCCN) guidelines. (managedhealthcareexecutive.com)
Oncology nurses may help provide tailored support, thereby ameliorating care for these patients. (ons.org)
We want to get rid of every last cancer cell in the body, and using cancer vaccines may be a good way to mop up residual disease," says Hyam Levitsky, M.D., professor of oncology, medicine and urology at the Johns Hopkins Kimmel Cancer Center. (sciencedaily.com)
Often patients have low blood cell counts, fluid retention, significant nausea and other gastrointestinal problems," says B. Douglas Smith, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center. (sciencedaily.com)
Sarcoma Oncology Center offers patients the best possible solution while respecting the physical and emotional health of each patient. (sarcomaoncology.com)
The Malignant Hematology team in the Division of Hematology/Oncology at The University of Texas Health Science Center at Houston (UTHealth) provides comprehensive, patient-centered care for patients diagnosed with cancers of the blood. (uth.edu)

This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)

An adult patient with an Hct of over 48% (in women) or more than 52% (in men) is considered to be polycythemic. (medscape.com)
An adult patient in whom the hemoglobin concentration (Hgb) is above 16.5 g/dL (in women) or over 18.5 g/dL (in men) is considered to be polycythemic. (medscape.com)
New research out of VCU Massey Cancer Center indicates that many adolescent and young adult kidney cancer survivors are at a significantly elevated risk for heart issues. (news-medical.net)
Childhood polycythemia vera and essential thrombocythemia: does their pathogenesis overlap with that of adult patients? (medscape.com)

Metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type, an anti-EGFR therapy. (nih.gov)

BACKGROUND: Upper gastrointestinal neoplasia mainly includes esophageal cancer and gastric cancer, both of which have high morbidity and mortality. (bvsalud.org)

The purpose of this study is to evaluate the rate of complete MRD response by flow cytometry after 4 weekly doses of daratumumab-hyaluronidase (Day 29) among patients with MRD positive T-ALL in hematologic morphologic complete remission or complete remission with incomplete hematologic recovery. (mayo.edu)
In a recent study under review at the Scientific Reports journal and currently posted to the Research Square* preprint server, researchers synthesized and evaluated the antitumoral (against several cancer cell lines) and antiviral [against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] properties of 3-spiro-indolin-2-ones. (news-medical.net)
Trametinib in pediatric patients with neurofibromatosis type 1-associated plexiform neurofibroma: a phase I/II study. (medscape.org)
In a pilot study published in Clinical Cancer Research , the Johns Hopkins investigators used a vaccine made from CML cells irradiated to halt their cancerous potential and genetically altered to produce an immune system stimulator called GM-CSF. (sciencedaily.com)
The investigators will be testing blood samples taken from the study patients to identify the precise antigens that the immune system is recognizing. (sciencedaily.com)
No patients in the study had a prolongation of the QT interval >500 milliseconds(1). (salesandmarketingnetwork.com)
RESULTS: A total of 22 studies were included in our study, including 2986 patients. (bvsalud.org)
A study by Tang et al has determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
The study wasn't a controlled experiment designed to prove whether or how research funding or other payments from drug companies directly influences the medicines doctors prescribe for cancer. (medscape.com)
Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial. (cdc.gov)
Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial. (cdc.gov)
Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection - a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trial. (cdc.gov)

[ 37 ] Long-term followup data from IRIS that showed probability of loss of CCyR was only 3% for patients with MMR at 18 months compared with 26% for patients without MMR. (medscape.com)

More than 90 percent of them will achieve remission, but about 10 to 15 percent of patients cannot tolerate the drug long term. (sciencedaily.com)
Surgery is often a preferred therapy because it may cure or allow a long-term remission in patients with locoregional or isolated resectable distant metastases. (thieme-connect.com)

To refer a patient to one of our clinical trials, please call 626-218-1133 or visit CityofHope.org/Clinical-Trials . (cityofhope.org)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need. (news-medical.net)
Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial. (news-medical.net)
Receipt of research payments was associated with increased prescribing for kidney cancer but not leukemia. (medscape.com)

Patients with oral malignant melanoma often recall having an existing oral pigmentation months to years before diagnosis, and the condition may even have elicited prior comment from examining physicians and dentists (or healthcare providers, when considering the auxiliaries). (medscape.com)

Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
They have now provided proof of principle for epigenetic therapy, the final chapter in the long saga to provide legitimacy to the field of epigenetics in cancer. (aacrjournals.org)
We do not know yet how to select patients for this therapy and how to move it from life extension to cure. (aacrjournals.org)
But the idea of stably changing gene expression in vivo has transformative potential in cancer therapy and beyond. (aacrjournals.org)
Using a "trial and error" approach, the physician would initiate therapy and then monitor the patient by repeated PT/INR testing. (mlo-online.com)
Surgical removal of the primary sarcoma, which is sometimes followed by radiation therapy, cures many patients. (sarcomaoncology.com)
For any patient in whom systemic therapy is contemplated, mutational testing is recommended to help guide medication choices. (medscape.com)

1 ' While the 5-year relative survival rate for pediatric cancers was about 78.2% from 1996-2003, survival statistics for various childhood sarcomas ranged from 59.2% to 68.5% . (sarcomahelp.org)

Jean-Pierre J. Issa, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Unit 428 1515 Holcombe, Houston, TX 77030. (aacrjournals.org)
Dr. Haesun Choi joined MD Anderson Cancer Center in 1999 as a clinical radiologist. (mdanderson.org)
Her clinical experience is focused on male and female pelvic MRI, including the prostate, uterus, cervix and rectum, liver imaging, functional MRI including dynamic contrast enhanced (DCE) - MRI, DWI and spectroscopy (MRS). She has extensive clinical experience on prostate MRI parallels with building up a highly successful prostate imaging program at MD Anderson Cancer Center. (mdanderson.org)

Conclusion: Dolasetron mesylate can be administered safely at doses up to 5.0 mg/kg, with comparable complete protection rates and increased adverse effects at doses greater than 2.4 mg/kg. (elsevierpure.com)
Such testing can also help to reduce possible adverse effects that might have been experienced by patients not genetically predisposed to benefit from the drug. (mlo-online.com)

In pediatric patients, the Hct must be corrected for age, including gestational age for neonates. (medscape.com)

Such knowledge can be used by physicians to monitor patients for clinical signs of early disease that might have otherwise been overlooked, leading to more positive outcomes. (mlo-online.com)
Despite those issues, the availability of genetic data is transforming the drug development process by improving the manner in which all parties (pharmaceutical companies, diagnostic companies, physicians, payers, and regulatory agencies) strive to protect and meet the needs of patients. (mlo-online.com)
Physicians needing to transfer a patient for urgent care may contact the Memorial Hermann System Transference Center at 713-704-2500. (uth.edu)
Patients trust that their physicians will make objective and evidence-based decisions on their behalf, which reflect their interests and that these decisions will also limit harms," Unguru said by email. (medscape.com)
Gifts (payment) cloud our ability to remain objective and as such, (negatively) influence the patient-provider relationship, in particular trust that physicians will place patients' needs primary," Unguru added. (medscape.com)
Introduction I. DESCRIPTION OF THE NATIONAL AMBULATORY MEDICAL CARE SURVEY The (NAMCS) is a national survey of patient visits to physicians' offices. (cdc.gov)
Patient visit data were obtained through use of a patient encounter form (figure 1) completed by physicians for a sample of their patient visits. (cdc.gov)
Only visits in the offices of nonfederally employed physicians classified by the American Medical Association (AMA) or the American Osteopathic Association (AOA) as 'office-based, patient care' were included in the 1991 NAMCS. (cdc.gov)
The National Ambulatory Medical Care Survey provides data from samples of patient records selected from a national sample of office-based physicians. (cdc.gov)
The physician universe, sample size, and response rates by physician specialty are shown in table I. Of the participating physicians, 237 saw no patients during their assigned reporting period because of vacations, illness, or other reasons for being temporarily not in practice. (cdc.gov)

If all medications were offered to patients based upon a "personalized" approach, the total number of patients offered specific drug treatments would be reduced. (mlo-online.com)

Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas. (medscape.org)

Reduction in tumor size has been demonstrated in both male and female patients with macroadenomas. (rxlist.com)
Although it can never be certain which patients might harbor microscopic deposits of sarcoma, doctors can estimate whether a tumor might spread based on the size of a sarcoma and its appearance under the microscope. (sarcomaoncology.com)

EGFR mutations were detected in 16% of patients (21/131). (oncotarget.com)

Our Parlodel (bromocriptine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
The availability of such information is also encouraging the joint development of therapeutic treatments and corresponding "companion diagnostics" that can be used to predict if a particular drug should be administered to a specific patient in the first place. (mlo-online.com)
Such "gate-keeping" tests can be used to discriminate which patients are more likely to favorably respond to a particular drug, while at the same time excluding those patients not genetically equipped to respond. (mlo-online.com)
Denying drug treatments to a subset of patients, particularly those who might view the treatments as their only available lifesaving option, could be easily misconstrued by those patients as an impersonal, life-threatening, and possibly discriminatory decision, if the underlying facts are not clearly conveyed and understood. (mlo-online.com)

Patients receiving the trial vaccine experienced relatively few side effects that included injection site pain and swelling, occasional muscle aches and mild fevers. (sciencedaily.com)

Even patients who appear to have only a primary sarcoma could have microscopic metastases that cannot be detected even with advanced imaging techniques. (sarcomaoncology.com)

Anatomy4

Organisms1

Diseases36

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Psychiatry and Psychology1

Phenomena and Processes16

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science4

Named Groups1

Health Care23

Geographicals2

Imatinib31

Eribulin mesylate6

Gleevec12

GIST3

Tumors6

Halaven3

20211

Inhibitor9

Nilotinib3

Refractory5

Intravenous3

Sunitinib1

Drugs12

Renal2

Therapies10

Lenvatinib2

Chronic Leukemias2

Resistance5

Breast cancer6

Acute Myelogen1

Leukemias1

Metastatic disease2

Treatment18

Dose3

Clin Cancer Res2

Abstract1

Vanderbilt Univer1

Locally1

Hepatocellular1

Dosage1

Oncology8

Chemotherapy in treating1

Adult4

Previously treated1

Gastrointestinal1

Study12

Probability1

Remission2

Clinical Trials2

Kidney cancer3

Malignant melanoma1

Therapy7

Survival1

Anderson Cancer Center3

Adverse2

Pediatric patients1

Physicians10

Medications1

Unresectable1

Tumor2

Mutations1

Drug4

Injection1

Metastases1