• Researchers at Washington University School of Medicine in St. Louis have identified a drug compound that makes pancreatic cancer cells more vulnerable to chemotherapy. (wustl.edu)
  • Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer. (technologynetworks.com)
  • Researchers have discovered potential new drugs that target mitochondria in cancer cells. (sciencedaily.com)
  • Researchers from Rice University and the University of Texas MD Anderson Cancer Center have discovered potential new drugs that work in concert with other drugs to deliver a deadly one-two punch to leukemia. (sciencedaily.com)
  • When two or more drugs are given in combination, researchers can also administer them individually and compare the effectiveness of each regimen. (sciencedaily.com)
  • Researchers at Southern Methodist University have discovered three drug-like compounds that successfully reverse chemotherapy failure in three of the most commonly aggressive cancers - ovarian, prostate and breast. (smu.edu)
  • Researchers in the field have searched unsuccessfully for compounds to inhibit the pumps that could be used in the clinic as well. (smu.edu)
  • To test the compounds, the researchers used amounts of chemotherapeutic that would not kill these multi-drug resistant cancers if the pumps were not blocked. (smu.edu)
  • Researchers have invented computational tools to decode and rapidly determine whether natural compounds collected in oceans and forests are new - or if these pharmaceutically promising compounds have already been described and are therefore not patentable. (scienceblog.com)
  • Researchers can now separate known compounds from those that are unknown. (scienceblog.com)
  • Our algorithms can tell natural product researchers what their compounds are. (scienceblog.com)
  • Second, the researchers created "dereplication" tools for moving the other direction: taking the chemical structures of known NRPs and other related information and determining what the data signature would look like if a mass spectrometer had blown the compound part. (scienceblog.com)
  • By using these two approaches, the researchers have created tools that enable researchers to both characterize the compound they have isolated and check to see if it, or something similar, has been previously described. (scienceblog.com)
  • Within their library researchers from the Broad Institute recently identified hundreds of compounds that were originally developed for non-oncology indications and showed killing activity in human cancer cell lines. (nki.nl)
  • or instance, if researchers find a new application for a drug that is already licensed for patient use, it would mean that we could clinically develop it further at a much faster pace and with less costs involved. (nki.nl)
  • Bernards: "As cancer researchers, we are interested in very specific processes. (nki.nl)
  • The compound library is of great value to researchers", says Bernards. (nki.nl)
  • Within the Oncode Drug Repurposing programme researchers can get access to the library. (nki.nl)
  • Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule drug that prevents weight gain and adverse liver changes in mice fed a high-sugar, high-fat Western diet throughout life. (sciencedaily.com)
  • The drug, which the researchers call CPACC, accomplishes the same thing. (sciencedaily.com)
  • The researchers applied a wide array of DNA-specific drugs, including actinomycin D, also known as dactinomycin, to pea tissue. (frontiersin.org)
  • Researchers at the National Institute of Pharmaceutical Education and Research have successfully cleared a dilemma and paved way for the use of neem in cancer treatment. (ndtv.com)
  • However, researchers for long have neglected the use of Nimbolide in commercial drugs for cancer . (ndtv.com)
  • The unactivated compounds are fluorescent, which allowed the researchers to track them using a fluorescence microscope as the compounds were absorbed by the cancer cells. (dotmed.com)
  • Researchers have found a versatile workaround to create chemical compounds that could prove useful for medical imaging and drug development. (techbriefs.com)
  • In other work, a team of researchers had been pursuing a chemical process to produce a fluorine-containing compound called hexafluoroethane, used to etch silicon for computer chips, associated with a gold-containing molecule. (techbriefs.com)
  • The researchers think these gold compounds will be a powerful platform to prepare new tracers, and are working to improve the system and to identify promising, clinically-relevant drug targets. (techbriefs.com)
  • To overcome these hurdles, a team of SKI researchers has designed an entirely new type of CAR T cell that acts as a "micropharmacy": It can deliver a toxic drug payload directly to a tumor, killing both tumor cells that contain the cancer marker as well as those cancer cells nearby that do not. (worldhealth.net)
  • Researchers have discovered a way to effectively deliver staurosporine (STS), a powerful anti-cancer compound that has vexed researchers for more than 30 years due to its instability in the blood and toxic nature in both healthy and cancerous cells. (medindia.net)
  • A precious metal which has never before been used in a clinical setting is being developed as an anti-cancer agent by Warwick researchers. (warwick.ac.uk)
  • The finding offers researchers a direct way to investigate oxidative stress and its damaging effects in aging, cancer and other diseases. (rockefeller.edu)
  • Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body's cancer prevention system. (rockefeller.edu)
  • Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. (rockefeller.edu)
  • Stanford researchers have engineered the easy-to-grow tobacco plant to produce small amounts of a starting chemical, or "precursor," on which a particular cancer drug is based - one normally derived from an endangered plant. (stanforddaily.com)
  • Not only are scientists familiar with cultivating it, yeast also allows researchers to modify drug precursors in ways that plants do not support. (stanforddaily.com)
  • Both researchers hope to use their techniques to study the drug-producing mechanisms of other medicinally valuable plants. (stanforddaily.com)
  • Dr. Wrobel is one of the members of an international team of researchers who have recently carried out the 'impossible': they built a cage similar in shape to a sphere out of eleven-walled proteins. (eurekalert.org)
  • To do this, he scoured the catalogs of chemical manufacturers and lists of important compounds published by private companies, government agencies and scientific researchers. (nist.gov)
  • According to the BBC , a paper in Nature Chemical Biology describes how the researchers used training data that measured known drugs' action on the tough bacteria. (hackaday.com)
  • A team of researchers led by the Whitehead and Broad Institutes has discovered a chemical that works in mice to kill the rare but aggressive cells within breast cancers that have the ability to seed new tumors. (mit.edu)
  • However, researchers have struggled to study cancer stem cells directly in the laboratory. (mit.edu)
  • To overcome these hurdles, Broad and Whitehead Institute researchers drew upon recent findings from Weinberg and his colleagues that suggested a way to generate in the laboratory large numbers of cancer cells with stem cell-like qualities. (mit.edu)
  • In previous studies, the research groups of Rice biochemist Natasha Kirienko and MD Anderson physician-scientist Marina Konopleva screened some 45,000 small-molecule compounds to find a few that targeted mitochondria. (sciencedaily.com)
  • The results from our previously published cytotoxicity assay were helpful, but very little is known about these small-molecule compounds. (sciencedaily.com)
  • And indeed, we found that six of the eight small-molecule compounds were deadly to leukemia cells. (sciencedaily.com)
  • Now the research team, has developed a small-molecule drug that accomplishes the same effect in mice. (sciencedaily.com)
  • But getting CAR T cells to produce a small-molecule cancer drug is a trickier prospect. (worldhealth.net)
  • In contrast to small-molecule drugs, human cells are very good at making enzymes, so CAR T cells are able to produce it effectively," Dr. Tan adds. (worldhealth.net)
  • Dr. Buolamwini, professor and chair of pharmaceutical sciences in the College of Pharmacy, worked with an interdisciplinary team of scientists in discovering a new class of small molecule inhibitors of the rogue, cancer-causing protein MDM2, which opposes the effects of the famous tumor suppressor p53, a gene that is thought to regulate the cell cycle and stop damaged cells from dividing. (rosalindfranklin.edu)
  • This University of California, San Diego advance will finally enable scientists to rapidly characterize ring-shaped nonribosomal peptides (NRPs) - a class of natural compounds of intense interest due to their potential to yield or inspire new pharmaceuticals. (scienceblog.com)
  • Plant and animal genes are activated in similar ways, so the scientists assumed the drug would work the same on the plants as in humans. (frontiersin.org)
  • But most recently, scientists from Hyderabad made a startling discovery about this herb. (ndtv.com)
  • A team of scientists from Peter the Great St.Petersburg Polytechnic University (SPbPU) together with their colleagues developed a method of targeted drug delivery to cancer cells. (news-medical.net)
  • Now, scientists at Memorial Sloan Kettering Cancer Center's Sloan Kettering Institute (SKI) have developed new CAR T cells that can do something their predecessors cannot: Make drugs. (worldhealth.net)
  • After scouring more than 5,000 compounds, scientists have identified several new classes of therapeutics that may help treat fibrolamellar carcinoma. (rockefeller.edu)
  • scientists methodically injured lab animals aplenty and yet no new cancers grew. (popsci.com)
  • The death of Karl Thiersch , a German surgeon who correctly proposed that cancers grow through the spread of malignant cells, prompted other scientists to pick up his mantle and confirm the validity of his research. (popsci.com)
  • Skilfully used by an international team of scientists, the bonds have made it possible to construct molecular nanocages with a structure so far unparalleled in nature or even in mathematics. (eurekalert.org)
  • A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers. (medicalxpress.com)
  • Anxiety, addiction, and other psychiatric disorders are often characterized by intense states of what scientists call arousal: The heart races, blood pressure readings rise, breaths shorten, and "bad" decisions are made. (medicalxpress.com)
  • NIST research chemist Kelly Telu injects a sample into a mass spectrometer, a laboratory instrument that scientists use to identify unknown chemical compounds. (nist.gov)
  • Scientists from Harvard University have discovered how to create an entirely new class of non-toxic, high-capacity flow batteries to store electricity from solar and wind power. (naturalnews.com)
  • The search for new drugs to treat cancer, diabetes, depression and many other diseases often starts with basic research and scientists working to understand the fundamentals of our bodies' chemistry. (stanford.edu)
  • Drug discovery often starts when academic scientists make a basic health-related discovery - a new biochemical pathway related to cancer, for example. (stanford.edu)
  • The division of labor makes sense in a way - scientists want to answer basic questions surrounding the chemistry of life processes, while drug makers want to figure out how to produce the most effective treatment - but it also slows things down. (stanford.edu)
  • By encouraging academic and industry scientists to work more closely together, the new alliance hopes to identify promising new drugs sooner and with fewer false starts, Khosla said. (stanford.edu)
  • By bringing industry scientists together with Stanford's interdisciplinary teams of chemists, engineers, biologists and clinicians, Stanford AIM will accelerate the development of next-generation drugs and other therapeutics to combat the world's most serious diseases," she said. (stanford.edu)
  • Pancreatic cancer is extremely difficult to treat. (wustl.edu)
  • Studying mice, they found evidence suggesting that the drug also may reduce some of the damaging side effects of the chemotherapy cocktail FOLFIRINOX (a combination of folinic acid, 5-fluorouracil, irinotecan and oxaliplatin), commonly used to treat pancreatic cancer. (wustl.edu)
  • Lim and Grierson, who both treat pancreatic cancer patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, and their colleagues tested the drug's effects in pancreatic cancer cell lines growing in the lab, in mice harboring human pancreatic cancer cells, and in mice that developed pancreatic cancer naturally because they are genetically prone to the disease. (wustl.edu)
  • They can be used to treat all kinds of cancers because they inhibit not just the P-gp pump, but also the breast cancer protein pump. (smu.edu)
  • According to Santoro, the report's conclusion confirms previous medical beliefs and recommendations regarding the use of compound hormones to treat menopause symptoms. (biospace.com)
  • The metal, osmium, is closely related to platinum, which is widely used to treat cancers in the form of the drug cisplatin. (warwick.ac.uk)
  • Radiation therapy to treat childhood cancer may damage adipose tissue, causing diabetes and coronary heart disease decades later. (rockefeller.edu)
  • And his medical team at what is now Memorial Sloan Kettering Cancer Center in Manhattan, just a short train ride south from Yankee Stadium, intended to treat him as such. (popsci.com)
  • and the Department of Chemistry at The University of Texas at San Antonio (UTSA) are making compounds to hopefully one day treat GBM tumors. (reachmd.com)
  • This proposal will develop novel ER-beta drugs that promote tumor suppression, leading to a new therapeutic modality to treat GBM. (reachmd.com)
  • We've shown we can design compounds that can kill cancer and we can design compounds that treat Alzheimer's in mice. (rosalindfranklin.edu)
  • Celgene Corporation is a biopharmaceutical company focused on developing and marketing therapies to treat leprosy, cancer, and immunological diseases. (encyclopedia.com)
  • The Celgene pair went to discuss a project about developing a drug to treat tuberculosis, but Kaplan interjected. (encyclopedia.com)
  • These biologics treat all manner of vexing diseases, from cancer to rheumatoid arthritis. (pacificresearch.org)
  • Prior to that, Halpern worked on projects related to drug addiction, and the use of hallucinogens to treat it. (maps.org)
  • The overall focus of our laboratory investigates how the immune system is involved in the pathogenesis of human diseases, including asthma, autoimmunity and cancer, and novel ways to treat disease including nanotechnology based approaches. (boisestate.edu)
  • Monoclonal antibodies are a class of medicines that have transformed the way we prevent and treat diseases, from cancer and diseases of the immune system, to childhood viral infections. (iavi.org)
  • This is why they're sometimes called 'designer antibodies' - they are tailor-made to the disease they treat. (iavi.org)
  • Monoclonal antibodies have transformed the way we treat multiple cancers, including breast cancer, for which the drug Herceptin has been a game changer. (iavi.org)
  • Pfizer, Inc. announced on Mar. 21, 2022 that it was recalling three drugs used to treat high blood pressure due to an excessive amount of ​​nitrosamines found in the tablets. (lorphicweb.com)
  • When given to a person, the newly created fusion protein can be used to modify the natural immune response and treat many diseases. (msdmanuals.com)
  • It is therefore very likely that we pick up on active compounds which were initially missed by the pharmaceutical industry, as their assays are typically only 3-day assays. (nki.nl)
  • Professor Sadler, along with post-graduate researcher Sabine van Rijt, is working to develop new compounds using Osmium, which they hope will lead to the development of drugs which could be used in combination therapies alongside existing drugs such as cisplatin. (warwick.ac.uk)
  • If it has a model of the problem and some training data, it can select or even develop new compounds for basically any problem. (hackaday.com)
  • Trabectedin, sold under the brand name Yondelis, is an antitumor chemotherapy medication for the treatment of advanced soft-tissue sarcoma and ovarian cancer. (wikipedia.org)
  • The European Commission and the U.S. Food and Drug Administration (FDA) granted orphan drug status to trabectedin for soft-tissue sarcomas and ovarian cancer. (wikipedia.org)
  • In 2008, the submission was announced of a registration dossier to the European Medicines Agency and the FDA for Yondelis when administered in combination with pegylated liposomal doxorubicin (Doxil, Caelyx) for the treatment of women with relapsed ovarian cancer. (wikipedia.org)
  • It has shown huge promise in treating several different types of cancer cell, including ovarian and colon cancers which have been developed and tested in the laboratory. (warwick.ac.uk)
  • These treatments have energized cancer care, especially for people with certain types of blood cancers. (worldhealth.net)
  • If this proves to be true, there may be a role for intravenous vitamin C to help make treatments more effective against antibiotic-resistant drugs. (anh-usa.org)
  • Belviq (lorcaserin) was introduced in 2012, as the first new diet drug approved in years, after a steady stream of recalls and problems associated with other weight loss treatments. (aboutlawsuits.com)
  • This drug treats nausea and vomiting caused by chemotherapy in people who have not had relief from other treatments. (medlineplus.gov)
  • There is a tremendous need for new and better therapies for pancreatic cancer," said senior author and medical oncologist Kian-Huat Lim , MD, PhD, associate professor of medicine. (wustl.edu)
  • Custom-compounded' Bioidentical hormone therapies have recently been popularized by the celebrity Suzanne Somers' book "I'm Too Young for This! (biospace.com)
  • According to the statement released on April 1, 2016, "The Endocrine Society, the American College of Obstetricians and Gynecologists, American Society for Reproductive Medicine and North American Menopause Society have all concluded that there is no scientific evidence to support claims of increased efficacy or safety for custom compounded bioidentical estrogen or progesterone regimens over FDA-approved hormone therapies. (biospace.com)
  • Santoro says that custom-compounded therapies' lack of quality assurance put patients at significant risk of harm from under-dosing, overdosing or contaminations that can result in illnesses. (biospace.com)
  • The statement continues to recommend that the use of compounded hormone therapies should be limited to individual situations in which no FDA-approved products are available. (biospace.com)
  • This raises the prospect of new kinds of anti-cancer therapies. (mit.edu)
  • In addition to promoting tumor growth, these so-called cancer stem cells are largely resistant to current cancer therapies. (mit.edu)
  • We identified a new target in a subtype of non-Hodgkin lymphoma, and this target is also upregulated in other types of cancers besides lymphomas, and so potentially the drug we developed can be used for multiple cancers," Damania said. (technologynetworks.com)
  • SAN ANTONIO (Jan. 24, 2023) - Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with the worst overall survival rates among all human cancers. (reachmd.com)
  • The scientific review stated that extensive experimental data suggests that humans are susceptible to carcinogenesis by N-nitroso compounds and that the presence of these compounds in some foods may be regarded as a risk factor for certain human cancers, such as cancer of the esophagus, stomach and nasopharynx. (lorphicweb.com)
  • To test the resulting compounds as potential drugs, the chemists teamed up with breast cancer researcher Lindsay Hinck, a professor of molecular, cell, and developmental biology at UCSC. (dotmed.com)
  • Over time, we narrowed it down to ER-beta, and we brought in UTSA chemists to make molecules that mimic estrogen activity at ER-beta without the estrogen side effects, which include breast tenderness and vaginal bleeding in women and fatigue and sweating in men. (reachmd.com)
  • After NIST purchased samples of the compounds, chemists ran them through carefully calibrated mass spectrometers. (nist.gov)
  • By the time it is detected, the cancer often has reached an advanced stage, and patients usually do not survive longer than one year after diagnosis. (wustl.edu)
  • FOLFIRINOX is the front-line treatment for pancreatic cancer, but only about one in three patients will have tumor shrinkage following this therapy. (wustl.edu)
  • The potential drugs are still years away from being tested in cancer patients, but a recently published study in the journal Leukemia highlights their promise and the innovative methods that led to their discovery. (sciencedaily.com)
  • His death wasn't an exception: Just that March, at least another eight cancer patients took their lives. (themoscowtimes.com)
  • But Pechatnikov is still in office, and, just in February this year alone, a further 11 cancer patients took their own lives, with at least four more following in May including a pensioner, a nuclear scientist and a psychology professor. (themoscowtimes.com)
  • According to the head of palliative medicine at the Health Ministry, Diana Nevzorova, only 4 percent of cancer patients in Moscow receive adequate pain treatment. (themoscowtimes.com)
  • The federal health care watchdog found that only 3 percent of patients are receiving the drugs through the new, easier system in Moscow. (themoscowtimes.com)
  • Such foot-dragging poses unacceptable and avoidable risks to patients and public health. (aboutlawsuits.com)
  • For patients with breast cancer, the best that could be offered was total removal of the breasts. (popsci.com)
  • Neuro-oncologist Andrew Brenner, MD, PhD , professor of medicine who treats patients at the Mays Cancer Center, noticed the pattern of more men with GBM and approached Ratna K. Vadlamudi, PhD , professor in the Department of Obstetrics and Gynecology at UT Health San Antonio. (reachmd.com)
  • They can be much cheaper than brand-name biologics - and could save patients up to $7 billion every year if they achieved market share comparable to conventional generic drugs. (pacificresearch.org)
  • But after years of fundraising and petitioning for Food and Drug Administration (FDA) approval, this past February, under the auspices of Harvard, Halpern began administering MDMA (better known to the Glo-Stick crowd as Ecstasy) to dying cancer patients, to see how they psychologically benefit from the drug. (maps.org)
  • And now Halpern is also hoping to get approval from Harvard for a project that will evaluate the effects of LSD and psilocybin (the psychedelic compound found in hallucinogenic mushrooms) on patients suffering from the debilitating condition known as cluster headaches. (maps.org)
  • I'm a medical oncologist who focuses on the care of patients with breast cancer . (medscape.com)
  • So this is a drug that we use in patients with HER2-positive disease. (medscape.com)
  • And then very recently, we identified a significant subset of breast cancer patients who have what's called HER2-low. (medscape.com)
  • Although long- term ingestion of N-nitroso-quinapril may be associated with a potential increased cancer risk in humans, there is no immediate risk to patients taking this medication. (lorphicweb.com)
  • Takeda's alliance with Stanford demonstrates our commitment to advancing medicines as quickly and efficiently as possible - from drug discovery to development and ultimately to patients," said Juan Harrison, ‎vice president and head of strategic academic alliances, Center for External Innovation, Takeda. (stanford.edu)
  • Dietary management drugs have transformed Type 2 diabetes care, but daily injection routines are challenging for some patients. (stanford.edu)
  • ALBANY, N.Y. (Nov. 19, 2020) - A cancer therapy that uses a chemical compound developed with the help of a UAlbany scientist has entered a Phase I clinical trial for treating patients with advanced solid tumors. (albany.edu)
  • Patients then receive five daily infusions of TCO-modified doxorubicin, which circulates the drug through the body until it finds the sodium hyaluronate biopolymer and a click reaction occurs to bring the biopolymer and doxorubicin together. (albany.edu)
  • We also developed a compound that targeted Tyro3, and we found that it killed primary effusion lymphoma cells and tumors. (technologynetworks.com)
  • Wet-lab experiments confirm the accuracy of an earlier computational discovery that three drug-like compounds successfully penetrate micro-tumors of advanced cancers to aid chemo in destroying the cancer. (smu.edu)
  • The computational discovery was confirmed in the Wise-Vogel labs at SMU after aggressive micro-tumors cultured in the labs were treated with a solution carrying the molecules in combination with a classic chemotherapy drug. (smu.edu)
  • SP141, as reported in the journal Gastroenterology in 2014, reduced levels of MDM2 in pancreatic cancer cell lines and inhibited the growth of pancreatic tumors in mice. (rosalindfranklin.edu)
  • Evidence is accumulating rapidly that cancer stem cells are responsible for the aggressive powers of many tumors," says Robert Weinberg, a member of Whitehead Institute for Biomedical Research and one of the authors of the study. (mit.edu)
  • An emerging idea in cancer biology is that tumors (breast, prostate, colon, lung, etc.) harbor a group of cells with the unique ability to regenerate cancers. (mit.edu)
  • Max Royzen, an associate professor of Chemistry , partnered with San Francisco-based biotech firm Shasqi to develop an anticancer therapy that utilizes bio-orthogonal click chemistry to target a powerful drug at cancerous tumors. (albany.edu)
  • These PDXs retain the genotype, phenotype, tumorigenic, and metastatic properties of the tumors from which they were derived, making them authentic models for studying and targeting neuroblastoma metastasis and resistance. (lu.se)
  • The current battle to defeat cancer is thwarted by chemotherapy failure in advanced cancers. (smu.edu)
  • Pancreatic cancer cells are shown in green. (wustl.edu)
  • This new drug appears to weaken the cancer cells and make them more sensitive to this particular chemotherapy regimen. (wustl.edu)
  • The molecule is highly activated in pancreatic cancer cells, where it turns on signaling pathways that favor survival and dial down cell death. (wustl.edu)
  • ATI-450 is an attractive drug to test against these cancer cells because it is an MK2 inhibitor. (wustl.edu)
  • MK2 turns on pro-survival mechanisms that allow cancer cells to adapt to the severe stresses of chemotherapy," said first author and medical oncologist Patrick M. Grierson , MD, PhD, assistant professor of medicine. (wustl.edu)
  • This new drug inhibits MK2, so when the mice receive the drug at the same time that they receive chemotherapy, the tumor cells are much more susceptible to dying. (wustl.edu)
  • Primary effusion lymphoma is a highly aggressive subtype of non-Hodgkin lymphoma, a type of blood cancer involving abnormally growing white blood cells. (technologynetworks.com)
  • They collaborated with UNC Lineberger's Gary Johnson, PhD, Kenan Distinguished Professor in the UNC School of Medicine, to characterize the activity of the kinase signals in the cancer cells. (technologynetworks.com)
  • When they treated the cells with a compound they developed, UNC3810A, they saw a dose-dependent activation of cell death and significant suppression of tumor growth. (technologynetworks.com)
  • Their study in the journal Leukemia describes the compounds' potential for killing leukemia cells when administered by themselves or in combination with other chemotherapies. (sciencedaily.com)
  • In the new study, they chose eight of the most promising compounds, identified between five and 30 closely related analogs for each and conducted tens of thousands of tests to systematically determine how toxic each analog was to leukemia cells, both when administered individually or in combination with existing chemotherapy drugs like doxorubicin. (sciencedaily.com)
  • One of the big challenges was to establish optimal conditions and doses for testing on both cancer cells and healthy cells," said study lead author Svetlana Panina, a researcher at the University of Texas at Austin who conducted the research during her postdoctoral studies at Rice. (sciencedaily.com)
  • In prior work, Kirienko's lab had shown the eight compounds targeted energy-producing machinery inside cells called mitochondria. (sciencedaily.com)
  • The eight compounds induce mitophagy, the housekeeping routine cells use to decommission and recycle mitochondria that are past their prime. (sciencedaily.com)
  • Kirienko and Konopleva reasoned that mitophagy-inducing drugs might weaken leukemia cells and make them more susceptible to chemotherapy. (sciencedaily.com)
  • There is no death of healthy cells or cancer cells. (sciencedaily.com)
  • But administering those same concentrations in combination can kill a considerable amount of cancer cells and still not affect healthy cells. (sciencedaily.com)
  • The team started by testing the toxicity of its mitophagy-inducing compounds and combinations against acute myeloid leukemia (AML) cells, the most commonly diagnosed form of the disease. (sciencedaily.com)
  • They then tested the six most effective AML-killing compounds against other forms of leukemia and found five were also effective at killing acute lymphoblastic leukemia (ALL) cells and chronic myelogenous leukemia (CML) cells. (sciencedaily.com)
  • A botanical review of the food item found that compounds in saffron display high toxicity against cancer cells. (naturalnews.com)
  • Emphasis must also be made on saffron's ability to hinder cancer growth without damaging healthy cells. (naturalnews.com)
  • Nature designs all cells with survival mechanisms, and cancer cells are no exception," said Vogel, a professor in the SMU Department of Biological Sciences and director of SMU's Center for Drug Discovery, Design and Delivery . (smu.edu)
  • So it was incredibly gratifying that we were able to identify molecules that can inhibit that mechanism in the cancer cells, thereby bolstering the effectiveness of chemotherapeutic drugs. (smu.edu)
  • We saw the drugs penetrate these resistant cancer cells and allow chemotherapy to destroy them. (smu.edu)
  • Cancer cells initially treated with chemotherapy drugs ultimately evolve to resist the drugs. (smu.edu)
  • Key to cancer cell resistance are often certain proteins typically found in all cells - cancerous or otherwise - that are outfitted with beneficial mechanisms that pump away toxins to ensure a cell's continued survival. (smu.edu)
  • In the case of cancer cells on the first round of treatment, these pumps are typically not produced in high levels in the cells, which allows chemotherapy to enter most of the cells in the tumor. (smu.edu)
  • Unfortunately, in the cancer cells that don't die, the chemotherapeutic often changes the cell, which then adapts to protect itself by aggressively multiplying the production of its defensive pumps. (smu.edu)
  • They effectively bring the cancer cells back to a sensitivity as if they'd never seen chemotherapy before," said Vogel. (smu.edu)
  • The research team discovered the drug by first exploring how magnesium impacts metabolism, which is the production and consumption of energy in cells. (sciencedaily.com)
  • Lee Hadwiger and Kiwamu Tanaka from the WSU Department of Plant Pathology used anticancer drugs that change the DNA of cancer cells to slow or stop their growth when used in high levels on humans. (frontiersin.org)
  • Hinck and postdoctoral researcher Rebecca Marlow worked with Rose to test the dye-sensitized ruthenium nitrosyls against breast cancer cells growing in tissue culture. (dotmed.com)
  • The discovery is based on the use of mesenchymal stem cells and microcapsules made of polymeric compounds. (news-medical.net)
  • The CXCR4 receptor on the surface of MSC reacts with the SDF-1 chemokine and makes the cells move closer to the tumor. (news-medical.net)
  • The development of drug delivery systems based on living cells is a burning issue in biomed. (news-medical.net)
  • Targeted drug delivery can help reduce the toxic effects of chemotherapy by minimizing the negative impact on healthy cells. (news-medical.net)
  • 2019) Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers. (news-medical.net)
  • Chimeric antigen receptor (CAR) T cell therapy is a type of immunotherapy that uses genetically modified versions of a person's own immune cells to fight cancer. (worldhealth.net)
  • These new CAR T cells act as "micropharmacies," delivering small-molecular anticancer drugs directly to the site of a tumor. (worldhealth.net)
  • Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient's own immune cells to fight cancer. (worldhealth.net)
  • Standard-issue CAR T cells are designed in the lab to recognize specific markers on cancer cells. (worldhealth.net)
  • When these CAR T cells are given back to a patient, they proliferate and go on the attack, acting as a kind of "living drug. (worldhealth.net)
  • One is that the CAR T cells can only kill cancer cells that contain the marker they are designed to recognize. (worldhealth.net)
  • But it is not uncommon for cancer cells to stop making this marker and thus to "escape" from the therapy. (worldhealth.net)
  • A second problem is that CAR T cells can become "exhausted" -- and even inhibited by the cancer cells themselves. (worldhealth.net)
  • Lastly, existing CAR T cells work well only against blood cancers that the CAR T cells can easily reach. (worldhealth.net)
  • What's more, the engineered cells can produce the drug even after they become exhausted, and the drug is not suppressed by the cancer. (worldhealth.net)
  • These cells combine the target-seeking power of immune cells with the ability to locally generate a potent anticancer drug for double effect. (worldhealth.net)
  • But when it is produced locally just at the site of a tumor, it is effective at safely killing cancer cells in mice. (worldhealth.net)
  • Human cells cannot normally make this type of compound," Dr. Tan says. (worldhealth.net)
  • Then, they genetically engineered the T cells to make an enzyme that cuts the masking molecule from the drug. (worldhealth.net)
  • We're building a picture of how different compounds might interact with DNA in cancer cells. (warwick.ac.uk)
  • Birsoy is honored for groundbreaking research uncovering metabolic weaknesses of diseased cells, such as cancer, while shedding light on debilitating mitochondrial diseases and rare genetic disorders. (rockefeller.edu)
  • Birsoy's groundbreaking research has highlighted key nutrients that cancer cells need to survive, while shedding light on debilitating mitochondrial diseases and rare genetic disorders. (rockefeller.edu)
  • The compound works by hindering a key pathway that cancer cells rely upon to hoard energy, and is already undergoing clinical trials. (rockefeller.edu)
  • Some are now made not using chemical synthesis but living cells. (pacificresearch.org)
  • In an effort to understand the molecular basis for adverse side effects, we have determined that an important regulatory protein (CD40L) expressed on T cells of the immune system is abnormally regulated by these drugs. (boisestate.edu)
  • They work by binding to their specific targets - for example viruses, bacteria or cancerous cells - and making them harmless. (iavi.org)
  • These cells, known as cancer stem cells, are thought to enable cancers to spread - and to re-emerge after seemingly successful treatment. (mit.edu)
  • Although further work is needed to determine whether this specific chemical holds therapeutic promise for humans, the study shows that it is possible to find chemicals that selectively kill cancer stem cells. (mit.edu)
  • The ability to generate such cells in the laboratory, together with the powerful techniques available at the Broad Institute, made it possible to identify this chemical. (mit.edu)
  • If it were possible to identify chemicals that selectively kill cancer stem cells, such chemicals might become critical candidates for future drug development. (mit.edu)
  • A critical aspect of our work was to generate relatively homogenous and stable populations of cancer stem-like cells that could then be used for screening," says Tamer Onder, a former graduate student in Weinberg's lab and co-first author of the study. (mit.edu)
  • With an ample number of stem cells in hand, the Broad-Whitehead team undertook a large-scale analysis of thousands of chemical compounds, applying automated methods to search for ones with activity against breast cancer stem cells. (mit.edu)
  • According to Royzen, this makes the process incredibly valuable in medicinal chemistry and in particular cancer treatment, because it can target the cancerous cells while sparing healthy cells. (albany.edu)
  • We perform molecular and functional studies of primary and metastatic tumor cells, as well as in vitro and in vivo drug testing using PDXs as model system. (lu.se)
  • Tanaka said that while nobody expects to apply chemotherapy drugs on crops, this discovery will have an impact. (frontiersin.org)
  • also in phase II trials for prostate, breast, and paediatric cancers. (wikipedia.org)
  • The compound was tested for throat, pancreas and prostate cancers and the results revealed a high success rate for them all. (ndtv.com)
  • However, data actually identified a potential link between Belviq and pancreatic cancer, colorectal cancer and lung cancer. (aboutlawsuits.com)
  • He makes untold amounts of money from vaccines. (anh-usa.org)
  • Given that I also have partial Cystic Fibrosis and an underlying inflammatory condition, I have made the decision that I am not a candidate for the present Covid vaccines (I am also highly reactive to epinephrine, having an anaphylactic reaction to being injected with it). (vitalitymagazine.com)
  • Iron complexes are good in nature because they are highly reactive, but if you're trying to make a drug you want something that's more stable," Rose said. (dotmed.com)
  • Bio-orthogonal click chemistry is a process by which two highly reactive compounds, selective for each other, react inside a live organism. (albany.edu)
  • The compound was developed in the lab of UNC Lineberger's Xiaodong Wang, PhD, research associate professor in the UNC Eshelman School of Pharmacy and medicinal chemistry director of the UNC Center for Integrative Chemical Biology and Drug Discovery. (technologynetworks.com)
  • Hadwiger and Tanaka don't foresee using anticancer medications on crops, but this discovery helps build a deeper understanding of how the chemicals interact with plant DNA. (frontiersin.org)
  • Recent discovery shows that oral use of this compound may not be quite effective for cancer because that way, the body fails to absorb Nimbolide properly. (ndtv.com)
  • This discovery could aid in the synthesis of new "radiotracers" - chemical compounds that contain a radioactive isotope of an element - for use with PET (positron emission tomography) scanning. (techbriefs.com)
  • McHardy is director of the Center for Innovative Drug Discovery, a joint initiative of UTSA and UT Health San Antonio that is supported by funding from the Cancer Prevention and Research Institute of Texas (CPRIT). (reachmd.com)
  • The new compound SP141 is just such a discovery. (rosalindfranklin.edu)
  • Drug discovery and development are very risky," he said. (rosalindfranklin.edu)
  • The NIST Mass Spectral Library and its new version, called NIST20, is used in health care, drug discovery, foods and fragrances, oil and natural gas, environmental protection, forensic science and almost every other industry that manufactures or measures physical stuff. (nist.gov)
  • A new partnership between Stanford and one of the world's oldest and largest drug makers, Takeda Pharmaceutical Company Ltd., could help speed up the process of bringing drugs from discovery to market. (stanford.edu)
  • In very low doses (0.5 - 4.5 mg) it has successfully been used to benefit various autoimmune diseases like MS and Hashimoto's Thyroiditis, fibromyalgia, cancers and other suboptimal immune system disorders. (vitalitymagazine.com)
  • The majority of the monoclonal antibodies on the market are for noncommunicable diseases, such as autoimmune diseases, like rheumatoid arthritis and cancer. (iavi.org)
  • We wanted to make sure when using these really aggressive cancers that if we do knock out the pump, that the chemotherapy goes in there and causes the cell to die, so it doesn't just stop it temporarily," Wise said. (smu.edu)
  • Our overall aims are to unravel mechanisms leading to metastasis and treatment resistance of childhood cancer neuroblastoma, and to test compounds targeting aggressive neuroblastoma. (lu.se)
  • These finding should further our understanding of disease mechanisms, therapeutic intervention, and potentially lead to the identification of at-risk populations for adverse drug response. (boisestate.edu)
  • Nevertheless, striking new data from cer agents from Volume 100A of these studies show increased risks the IARC Monographs are used to Therapeutic applications and of almost all site-specific cancers make qualitative comparisons be- trends in use that emerge during the fol ow-up tween cancers induced in humans period. (who.int)
  • In fact, the mice treated with chemotherapy plus this drug appear to be healthier than mice receiving chemotherapy alone, so there's a chance the new drug is mitigating side effects. (wustl.edu)
  • That renders chemotherapy ineffective, allowing cancers to grow and spread. (smu.edu)
  • Previous MDM2 inhibitors targeted the interaction between MDM2 and p53 and were found ineffective against cancers with mutated or deficient p53. (rosalindfranklin.edu)
  • However, following a large number of reports involving users diagnosed with cancer in post-marketing studies, the FDA required the drug maker to issue a Belviq recall in February 2020. (aboutlawsuits.com)
  • The FDA issued the first Belviq cancer warnings in January 2020, and several weeks later it was determined the weight loss drug needed to be removed from the market. (aboutlawsuits.com)
  • Nonribosomal peptides (NRPs) often serve as chemical defenses for the bacteria that manufacture them. (scienceblog.com)
  • While studying chemical reactions of a gold-containing molecule, a research team happened upon a chemical mechanism that can be used to form trifluoromethyl (CF 3 ) compounds and attach them to other chemical compounds. (techbriefs.com)
  • Flourine-18 has a half-life of about 110 minutes, which means its radioactive output is halved every 110 minutes, and the chemical processes incorporating it as a label must be designed to rapidly attach it to compounds of interest. (techbriefs.com)
  • This fragment, they observed, can then bond with other chemical compounds and in a next step form a new CF 3 -containing compound. (techbriefs.com)
  • The research team learned how to incorporate the fluorine-18 marker atoms into the chemical mechanism they used to create new compounds. (techbriefs.com)
  • The cancer-fighting molecule is one that SKI Chemical Biology Program Chair Derek Tan -- Dr. Scheinberg's collaborator on the project -- discovered previously while developing antibiotics. (worldhealth.net)
  • They linked the cancer drug to another chemical that "masks" its function. (worldhealth.net)
  • Some products on this website contains progesterone, a chemical known to the State of California to cause cancer. (herbspro.com)
  • Assistant professor of chemical engineering Elizabeth Sattely and her fifth-year graduate student Warren Lau M.S. '12 began studying the widely-used, plant-based cancer drug called etoposide two years ago. (stanforddaily.com)
  • Etoposide relies upon a chemical defense compound produced by a rare Himalayan plant, the mayapple. (stanforddaily.com)
  • Acetone is a manufactured chemical that is also found naturally in the environment. (cdc.gov)
  • Celgene began as a unit of Celanese Corp., a major chemical company that specialized in man-made fibers. (encyclopedia.com)
  • The National Institute of Standards and Technology (NIST) has updated its database of chemical fingerprints, called mass spectra, that are used to identify unknown chemical compounds. (nist.gov)
  • Plant metabolites make up an even larger universe of chemical compounds. (nist.gov)
  • Are combinatorial libraries actual chemical compounds? (hackaday.com)
  • They are not chemical compounds, as most drugs are. (iavi.org)
  • Max Royzen, second from right, worked with his lab team and biotech firm Shasqi to develop a chemical compound used in a cancer treatment currently in clinical trials. (albany.edu)
  • The Electron Ionization (EI) Library is used for identifying volatile compounds such as those you can smell in air. (nist.gov)
  • Specifically, the drugs contained NDMA, a manufacturing by-product and potential carcinogenic that was once used to make rocket fuel. (safehaven.com)
  • 50 sure to carcinogenic compounds is mg/kg body weight [bw]/day) that is hampered. (who.int)
  • As there is no vaccine, drug treatment ogy have grown rapidly in the last decade. (who.int)
  • they are created by compounding pharmacies, which are subject to relatively few regulations. (biospace.com)
  • The next stage of this compounding problem lies with the pharmacies. (themoscowtimes.com)
  • A prescription is only valid for a specific pharmacy - strict anti-drug regulations make it difficult for pharmacies to stock morphine-based drugs. (themoscowtimes.com)
  • The consumer watchdog group Public Citizen is calling on the FDA to add the active pharmaceutical ingredient in Belviq to an official list of banned or withdrawn medications, to prevent the recalled weight loss drug from being used by compounding pharmacies. (aboutlawsuits.com)
  • The group indicates the list is consistently out-of-date, often by years, which means the banned drugs can still legally be made by physicians and compounding pharmacies for special orders, even though the agency has recalled Belviq from the market due to the unreasonable risk that users may develop cancer. (aboutlawsuits.com)
  • The use of estrogen therapy without progesterone (progestin), is associated with an increase in the risk of uterine cancer (endometrial cancer , cancer of the lining of the uterus). (medicinenet.com)
  • Treatment with progesterone along with estrogen substantially reduces the risk of uterine cancer (endometrial cancer) so that the risk of developing this cancer is equivalent to that of women not taking estrogen. (medicinenet.com)
  • Because ET alone can cause uterine cancer (endometrial cancer) (see below), a progestin is administered together with estrogen in women who have a uterus (those who have not undergone a hysterectomy ) to eliminate the increased risk. (medicinenet.com)
  • The new compounds mimic activity of the sex hormone estrogen on a cell protein called estrogen receptor-beta (ER-beta). (reachmd.com)
  • The drug, ATI-450, is an anti-inflammatory therapy and also is being investigated in clinical trials as a treatment for rheumatoid arthritis. (wustl.edu)
  • The first ruthenium nitrosyls he made released nitric oxide only under ultraviolet light, so Rose spent several years developing ways to sensitize them to specific wavelengths of visible light that could be used in photodynamic therapy. (dotmed.com)
  • Groundbreaking hormone therapy research study warns millions of menopausal women not to use bioidentical compound hormones inappropriately promoted by Suzanne Somers and biomedical companies. (biospace.com)
  • Users of oral hormone therapy (HT) (in the doses of the Women's Health Initiative) for more than five years are at slightly increased risk of breast cancer , heart disease , and stroke than are nonusers. (medicinenet.com)
  • Novartis has suspended production at its radioligand therapy production sites in Ivrea, Italy and Millburn, New Jersey as it addresses potential quality issues identified in its manufacturing processes. (europeanpharmaceuticalreview.com)
  • The grant, which began Jan. 1, 2023, follows previous NCI funding of $2 million that supported lab studies yielding fundamental understandings needed to progress to drug development. (reachmd.com)
  • In 2021, Pfizer recalled all lots of its drug Chantix (also known as varenicline) due to the presence of high levels of nitrosamines. (lorphicweb.com)
  • Unexpectedly, they found a mechanism by which the boron compound acts on a CF 3 compound to produce a CF 3 fragment associated with the gold catalyst. (techbriefs.com)
  • If you accept certain inaccuracies in the solid figure being constructed, you can create structures with shapes that are not found in nature, what's more, with very interesting properties," says Dr. Tomasz Wrobel from the Cracow Institute of Nuclear Physics of the Polish Academy of Sciences (IFJ PAN). (eurekalert.org)
  • The National Drug Code, Lot Number, Expiration Date and other details of these products can be found in Pfizer's press release publicizing the recall. (lorphicweb.com)
  • Another is one seen in breast and many other cancers, called breast cancer resistance protein, BCRP. (smu.edu)
  • Another paper in the journal Nature Communications reported SP141's ability to degrade MDM2 and delay breast cancer progression and reduce its metastasis. (rosalindfranklin.edu)
  • And I'm fortunate enough to have Legina Deaver with me today, who is a patient with breast cancer, who's going to help with this conversation. (medscape.com)
  • The second component uses a protodrug of doxorubicin (a popular chemotherapy medication used in the treatment of breast cancer, bladder cancer, certain types of sarcoma, lymphoma and leukemia), modified with TCO. (albany.edu)
  • The study shows modifying the standard of care for late-stage neuroendocrine tumours (NETs) with Evans blue dye makes the treatment more effective and potentially less toxic. (europeanpharmaceuticalreview.com)
  • The results of the study are good news for chronic hepatitis B and C sufferers who now often undergo repeated and potentially painful liver biopsies as part of their disease management.The focus of the research was the French-made FibroScan, which was being used in more than 70 countries worldwide when it received approval by the U.S. Food and Drug Administration in April. (medindia.net)
  • Unlike conventional antiretroviral drugs, treatment with broadly neutralizing antibodies does not rely on vigilant daily dosing and could potentially reduce the body's reservoir of latent viruses. (rockefeller.edu)
  • Their work , published on Sept. 10 in Science Magazine, suggests a potentially more efficient and sustainable way to obtain the drug, and their methodology - pinpointing the mechanism by which the endangered plant produces the precursor - may prove useful in the study of other plant-derived drugs. (stanforddaily.com)
  • These risk factors may cause loss of efficacy and quality of the protein drug, potentially leading to patient safety concerns. (lu.se)
  • The FDA recently released a guidance on INDs, or Investigational New Drug (IND) applications-the starting point for all FDA-approved drugs. (anh-usa.org)
  • Cancer-fighting drugs used on humans can help plants fight disease as well. (frontiersin.org)
  • It also makes you wonder if there are other fields where AI techniques could cull out alternatives quickly, allowing humans to focus on the more promising candidates. (hackaday.com)
  • The lack of compassion for the suffering of their fellow humans by politicians created the problem. (cannabisnews.com)
  • NRPs are one of the last bastions of pharmacologically important biological compounds that remain virtually untouched by computational research. (scienceblog.com)
  • Together with the Netherlands Cancer Institute (NKI) and Leiden University Medical Center Oncode makes this library available for screening by research groups within and outside their institutes. (nki.nl)
  • Five European research institutes collaborated with the company SPECS, a supplier of research compounds to the life sciences industry, to generate a collection of more than 5.000 drugs. (nki.nl)
  • "One of the reasons why I think this library is of immense added value, is that it could support our goal of making healthcare and drug development more affordable", says NKI group leader René Bernards , who is also closely involved in the drug repurposing research. (nki.nl)
  • We focus on many different types of research and cancers and the library caters for this. (nki.nl)
  • The Netherlands Cancer Institute is among the world's best comprehensive cancer centers, combining innovative fundamental, translational, and clinical research with dedicated patient care. (nki.nl)
  • Our research institute gratefully acknowledges funding from the Dutch Ministry of Health, Welfare and Sport, the Dutch Cancer Society, and individual donors. (nki.nl)
  • This research didn't start with the goal of seeing what happened when you applied anticancer drugs to plants. (frontiersin.org)
  • The research team tapped the mechanism to incorporate fluorine-18 in CF 3 compounds they created. (techbriefs.com)
  • Several research groups have shown it's possible to get them to make immune proteins like antibodies and cytokines. (worldhealth.net)
  • The FDA in most cases over the past two decades, has taken at least several years to update the list of withdrawn drugs after the agency determined that a drug was removed from the market because it was unsafe or effective," Dr. Michael Carome, director of Public Citizen's Health Research Group, said in the press release. (aboutlawsuits.com)
  • 1. Warwick Ventures was created in April 2000 to build on the research successes of the University of Warwick. (warwick.ac.uk)
  • But Ruth's first year of life marked a turning point in the nascent field of cancer research. (popsci.com)
  • Former Vice President Joe Biden, champion of the $1.8 billion cancer "moonshot" named for his late son, told members of the American Association of Cancer Research in Washington, D.C., last spring that in the fight against cancer, a disease that "never surrenders," the nation must be "unwilling to postpone, even for a second, to do all we can, for as long as it takes. (rosalindfranklin.edu)
  • I tell graduate students working on research projects, 'If you make a new compound today, no one has ever made that compound before. (rosalindfranklin.edu)
  • Even if that research succeeds - no sure thing, given that just 12% of drugs that start clinical trials reach the market, according to the Congressional Budget Office - the potential return would be limited by the government. (pacificresearch.org)
  • Harvard had not taken up this kind of drug research since that time. (maps.org)
  • Halpern, 39, has been at McLean since 1998 and made a name for himself in 2005 with a groundbreaking research project studying peyote use within the Native American Church. (maps.org)
  • An active area of research in our lab is investigating the potential applications of metal oxidenanomaterials on the immune response and treatment of human diseases including cancer and autoimmunity. (boisestate.edu)
  • There are also research institutes with their own 10's of thousands of compound libraries that, with grant money, will run your protocol /assay and report back results. (hackaday.com)
  • Or more profitable research into fat loss drugs and hair growing for bald people. (hackaday.com)
  • This is one of the fastest-growing fields in biomedical research, and an increasingly important segment of the pharmaceutical market - last year, seven of the top 10 best-selling drugs were monoclonal antibodies . (iavi.org)
  • Stanford Vice Provost and Dean of Research Ann Arvin said that Takeda makes an ideal partner. (stanford.edu)
  • The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on some aromatic amines and related compounds is now available online. (who.int)
  • We must make sure the board keeps organic foods truly organic. (anh-usa.org)
  • Mass spectrometry is particularly useful for identifying organic compounds - the building blocks of life. (nist.gov)
  • Part of Mak's role in this project was to decide, of the countless organic compounds out there, which ones to include in the library. (nist.gov)
  • Organic compounds are like Tinkertoys made mostly of carbon, hydrogen, oxygen and nitrogen atoms. (nist.gov)
  • UNC3810A was used as an in vivo tool compound to understand the biological roles of Tyro3 in primary effusion lymphoma in this study," Wang said. (technologynetworks.com)
  • if enough of the pumps are present, the cancer isn't treatable anymore," said Wise, associate professor in the SMU Department of Biological Sciences. (smu.edu)
  • In testing the biological uptake of drugs that incorporate these compounds, it's useful to incorporate fluorine-18 ( 18 F), a radioactive isotope of fluorine, in the CF 3 compound as a sort of label or "tracer" that can be detected by PET scanners. (techbriefs.com)
  • They also can produce detailed images of the brain and other organs and help drug developers trace the biological pathways, concentration, and dispersal of new drugs. (techbriefs.com)
  • Fluorine-18 is a popular tracer for revealing cancers and other biological targets in PET scans. (techbriefs.com)
  • There is a concern with chemotherapy for pancreatic cancer that incorporation of additional drugs will make the treatment even less tolerable. (wustl.edu)
  • These results, published in the Journal of Nutrition & Intermediary Metabolism , suggest that saffron may be used as an alternative treatment for cancer. (naturalnews.com)
  • They manipulated this mechanism to derive drug compounds including leflunomide, a drug that is used to reduce swelling and inflammation in the treatment of rheumatoid arthritis, for example, and also a painkiller known as BAY 59-3074. (techbriefs.com)
  • The petition comes as a growing number of Belviq lawsuits continue to be filed against Eisai Inc. And Arena Pharmaceuticals in courts nationwide, each involving allegations that former users of the weight loss medication developed cancer, which could have been avoided if the drug makers had properly researched their weight loss treatment and warned consumers about the risks. (aboutlawsuits.com)
  • Dr. Buolamwini's lab also makes, modifies and tests compounds for the potential treatment of Alzheimer's, heart disease and HIV/AIDS. (rosalindfranklin.edu)
  • The compound, DIDOX, belongs to a family of drugs called anthracyclines that are commonly prescribed for the treatment of cancer. (boisestate.edu)
  • Only then do drug companies begin the work of optimizing a compound's treatment potential, safety and manufacturing efficiency - work that in the end may or may not yield a useful drug. (stanford.edu)
  • It has been used in compounding for more than 30 years and is used worldwide for treatment of these conditions. (medscape.com)
  • The There have been many developments in the drugs of choices are sodium stibogluconate use of light for the treatment of a wide varif and meglumine antimonite (both pentavaf ety of skin conditions from nonfmelanoma lent antimony derivatives). (who.int)
  • The pharmaceutical field and the diagnostic medicine field have been very limited in getting compounds that have been labeled with radioactive CF 3 and yet there are a lot of drugs that have these CF 3 groups in them. (techbriefs.com)
  • Kaplan's suggestion involved a drug named thalidomide, a name that rekindled dreadful memories for those within and without the pharmaceutical industry. (encyclopedia.com)
  • The update also included pesticides and environmental contaminants, chemicals used in manufacturing such as lubricants and surfactants, pharmaceutical drugs and illicit drugs such as new varieties of fentanyl , the drug that is driving a nationwide overdose epidemic. (nist.gov)
  • China has grown into the world's largest supplier of active pharmaceutical ingredients (APIs)--useful drug-making compounds supplied to drugmakers. (safehaven.com)
  • Exposure to these chemicals may occur variously through cigarette smoking, in industrial settings including manufacture of plastics, rubber, pharmaceutical drugs, and dyes and pigments used in consumer products such as paper and textiles, and via tattoo inks. (who.int)
  • They are based on natural antibodies - which are proteins that the body produces to defend itself against disease - but are created in the lab and mass-produced in factories. (iavi.org)
  • Fusion proteins are compounds that are produced in the laboratory and combine or "fuse" two different proteins with desirable immune-modifying and disease-fighting traits to form a single drug. (msdmanuals.com)
  • You might also benefit from a drug known as low dose naltrexone (LDN) as an immune system optimizer. (vitalitymagazine.com)
  • Protein drugs, such as monoclonal antibodies, have proved successful in treating cancer and immune system diseases. (lu.se)
  • Cross analyses of both in vitro and in vivo studies concluded that saffron is a potent anti-cancer agent. (naturalnews.com)
  • Although anthracyclines have potent anti-proliferative effects that make them effective chemotherapeutic agents, a serious side effect of cardiotoxicity can develop 10-20 years later. (boisestate.edu)
  • We didn't expect anticancer drugs to help plants fight pathogens. (frontiersin.org)
  • And it's one of these drugs that is a chemotherapy compound attached to the antibody, which targets what we now call HER2-low disease. (medscape.com)
  • Further, saffron may even reduce the toxic effects of some radiation drugs. (naturalnews.com)
  • Molecular cages are polyhedra made up of smaller 'bricks', usually protein molecules. (eurekalert.org)
  • Relevant protein drugs are chosen based on sales statistics within the hospital and the corresponding wards were observed. (lu.se)
  • In this study, a simulation is also performed to list measures that theoretically should be in place to ensure the quality of the protein drug, for example validated and protocol-based compounding in cleanroom, training and validated transports. (lu.se)
  • An example of a fusion protein is the drug etanercept , which fuses a cytokine receptor with an antibody. (msdmanuals.com)
  • For example, one currently prescribed drug combination for leukemia -- doxorubicin and cytarabine -- has a synergy coefficient of 13, Kirienko said. (sciencedaily.com)
  • The team's experiments showed several mitophagy-inducing compounds were significantly more synergistic with doxorubicin. (sciencedaily.com)
  • A drug that can reduce the risk of cardiometabolic diseases such as heart attack and stroke, and also reduce the incidence of liver cancer, which can follow fatty liver disease, will make a huge impact. (sciencedaily.com)
  • The study also noted that the device "exhibits excellent reproducibility," which makes it a "reasonable alternative" to liver biopsy. (medindia.net)
  • Stone Breaker Compound may be used as liver tonic to protect the liver. (herbspro.com)
  • In that newsletter, I also mentioned the use of the far infrared sauna which can detoxify the human body (at a comfortable heat level) of toxic heavy metals, drugs, and almost all chemicals by sweating them out through the skin. (vitalitymagazine.com)
  • PET scans are commonly used to detect, map, and monitor internal cancers. (techbriefs.com)
  • The new drug collection is based on the Broad Repurposing library and contains 5632 existing drugs in various stages of clinical development, including abandoned, off-patent and launched. (nki.nl)
  • Results: While issues such as SCD, SIDS or doping control are investigated mainly in forensic laboratories, others such as prenatal exposure to drugs or FAS are mainly treated in clinical laboratories. (benthamscience.com)
  • Conclusion: Many areas of common interest between clinical and forensic laboratories are building bridges between them. (benthamscience.com)
  • Ninety percent of new drugs fail in the clinical trial phase, evidence, Dr. Buolamwini says, that "there's still too much trial and error" in drug development. (rosalindfranklin.edu)
  • All of us in the Royzen Lab are really excited to be a part of this process, as few compounds developed in academic labs get a chance to be tested in human clinical trials," said Royzen, who is also an affiliate faculty member at the RNA Institute . (albany.edu)
  • When we give this drug to the mice for a short time, they start losing weight. (sciencedaily.com)
  • A still more recent paper reports that a series of compounds, including SP141, also works against breast and colon cancer. (rosalindfranklin.edu)
  • The collaboration also 'de-risks' projects born at Stanford, making it much easier to license them out for further development. (stanford.edu)
  • An additional source of quantita- erations for compounds that cause of tumour-free animals by 50% (Gold tive data on cancer risks is the group cancer in experimental animals. (who.int)
  • The immunization coverage rate of 95% before the crisis has been drastically reduced to 65%.1 Specifically, in the past six months some 500 000 children in parts of the West Bank have not been immunized,2,3 thereby creating a cohort of highly susceptible and vulnerable children for whom the risks of epidemics such as measles are tremendous. (who.int)
  • MSC are considered one of the most promising among the potential drug delivery platforms because they are relatively easy to obtain and grow in a lab. (news-medical.net)
  • This overreaching guidance requires companies to start a burdensome and expensive drug approval process if a nutrient is to be studied for potential health claims-even if the supplement won't be marketed as a drug. (anh-usa.org)
  • There's no point in investing in a biosimilar if the government will set an artificially low price for the name-brand drug against which it competes - and effectively eliminate its potential market overnight. (pacificresearch.org)
  • Yet, another oft-ignored risk is Beijing's potential disruption of vital drug supplies to the U.S. or, worse still, willfully contaminating the drugs with harmful compounds. (safehaven.com)
  • And our data indicated the molecules aren't cancer specific. (smu.edu)
  • Sattely added that the science has become sufficiently mature to enable rigorous investigations into how plants make molecules of interest. (stanforddaily.com)
  • The structural complexity of these molecules requires careful handling to ensure integrity and stability of the drug. (lu.se)
  • Quinoline is used to produce various drugs and dyes. (cdc.gov)