Modality TherapyCarcinomaCisplatinCarboplatinSquamous CellInduction chemotherapyRadiotherapy and chemotherapyAdultAdjuvant chemotherapyTherapyGenesRegimensColorectal cancerTherapeuticSurvivalCytotoxic chemotherapyOutcomeLeucovorinOvarian cancerDoxorubicinMetastasisEfficacyTumourClinicalMethodsFluorouracil-basedNeutropeniaGemcitabineAcute nonlymphMucositisSystemicAdenocarcinomaTreatment2020IntravenousOncolMetastatic diseaseSymptomsRecurrenceBreast cancerLung CancerTumorCervical
Modality Therapy2
- The authors conclude that combined radiotherapy and chemotherapy, although significantly more effective in reducing recurrence than no therapy, is significantly more toxic than single-modality therapy in many parameters, although most of the toxicity is transient and therefore not limiting. (emmes.com)
- This schedule of combined modality therapy is not only effective but appears to have tolerable toxicity, because of the relative lack of late effects. (emmes.com)
Carcinoma2
- Metastatic non-small cell bronchogenic carcinoma: a randomized trial of sequential vs combination chemotherapy. (uchicago.edu)
- A 57-year-old woman diagnosed with intestinal spinocellular carcinoma, showed OM score 3 (WHO) after 5-fluorouracil and cisplatin chemotherapy. (bvsalud.org)
Cisplatin5
- The majority of the patients had combined cisplatin-based chemoradiation. (bepress.com)
- FoxM1 inhibitor, thiostrepton, induces apoptosis in cancer cell lines and enhances sensitivity to cisplatin in these cells. (unm.edu)
- Vinorelbine, ifosfamide and cisplatin as first-line treatment in patients with inoperable non-small cell lung cancer. (ox.ac.uk)
- Reduction of cisplatin-induced anemia by the pineal indole 5-methoxytryptamine in metastatic lung cancer patients. (nel.edu)
- Lissoni P, Malugani F, Bukovec R, Bordin V, Perego M, Mengo S, Ardizzoia A, Tancini G. Reduction of cisplatin-induced anemia by the pineal indole 5-methoxytryptamine in metastatic lung cancer patients. (nel.edu)
Carboplatin8
- Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. (unm.edu)
- Thiostrepton downregulates FoxM1 expression in several cancer cell lines and enhances sensitivity to carboplatin in vivo. (unm.edu)
- Compared with AUC5, carboplatin at AUC6 would associate with a 2.7-fold increased risk of grade 3 or 4 chemotherapy-induced anaemia. (yonsei.ac.kr)
- Carboplatin AUC5 has comparable cytotoxic effects to carboplatin AUC6 in patients with HER2+ breast cancer treated with six cycles of neoadjuvant TCHP, with fewer complications associated with clinically meaningful anaemia. (yonsei.ac.kr)
- AUC5 may be the optimal carboplatin dose to reduce TCHP-induced anaemia in patients with HER2+ breast cancer treated with TCHP. (yonsei.ac.kr)
- Scholars@Duke publication: Trilaciclib prior to gemcitabine plus carboplatin for metastatic triple-negative breast cancer: phase III PRESERVE 2. (duke.edu)
- Concurrent paclitaxel, carboplatin, and radiotherapy in advanced head and neck cancers: a phase II study--preliminary results. (rush.edu)
- following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
Squamous Cell2
- Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy. (ox.ac.uk)
- It is concluded that thymidine phosphorylase is associated with angiogenesis, with resistance to radiotherapy and cytotoxic therapy, and with poorer survival in squamous cell head and neck cancer. (ox.ac.uk)
Induction chemotherapy8
- Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC). (nih.gov)
- We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy. (nih.gov)
- Selected patients with histologic or cytologic proven stage IIIA-N2 NSCLC were given three cycles of platinum-based induction chemotherapy. (nih.gov)
- Induction chemotherapy resulted in a response rate of 61% (95% confidence interval [CI] = 57% to 65%) among the 579 eligible patients. (nih.gov)
- In selected patients with pathologically proven stage IIIA-N2 NSCLC and a response to induction chemotherapy, surgical resection did not improve overall or progression-free survival compared with radiotherapy. (nih.gov)
- A low percentage of cancer cells with nuclear TP expression in pretreatment biopsies was associated with a high rate of CR after combined chemoradiotherapy (P = 0.006) and induction chemotherapy (0.01). (ox.ac.uk)
- This study was designed to assess the effect of methylation status on the outcome of conventional induction chemotherapy. (ox.ac.uk)
- Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
Radiotherapy and chemotherapy2
- A strong rationale is provided for subsequent clinical trials of concurrent radiotherapy and chemotherapy with antiangiogenic agents or with specific TP inhibitors. (ox.ac.uk)
- Compliance was good with 93 and 89% of patients completing radiotherapy and chemotherapy, respectively. (ox.ac.uk)
Adult1
- DESIGN, SETTING, AND PARTICIPANTS: The I-SPY2 is a multicenter, platform adaptive, randomized clinical trial in the US that compares, by subtype, investigational agents in combination with chemotherapy vs chemotherapy alone in adult women with stage 2/3 breast cancer at high risk of early recurrence. (providence.org)
Adjuvant chemotherapy4
- The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. (ox.ac.uk)
- 862 TNM I-III CRC validation cohort, and 2912 TNM II-III CRC adjuvant chemotherapy cohort (TransSCOT). (ox.ac.uk)
- Exploratory endpoint was adjuvant chemotherapy interaction.ResultsGMS independently associated with DFS (p = 0.001) and RFS (p interaction = 0.013), but not duration (p = 0.64) was dependent on GMS. (ox.ac.uk)
- 21-gene recurrence score and adjuvant chemotherapy decisions in patients with invasive lobular breast cancer. (cdc.gov)
Therapy13
- The primary objective was to compare the number of patients who achieved a pathological complete response (ypT0/is, ypN0), between groups in the intention-to-treat population (two-sided assessment), based on local evaluation of tumour samples taken at breast cancer surgery done between 14 days and 6 weeks after completion of neoadjuvant therapy. (nih.gov)
- Purpose: To assess the efficacy and exploratory biomarkers of continuing palbociclib plus endocrine therapy (ET) beyond progression on prior palbociclib-based regimen in patients with hormone receptor-positive/HER2-negative (HR+/HER2−) advanced breast cancer (ABC). (gencat.cat)
- Improved therapeutic efficacy has been reported using biochemical modulation of 5-FU by leucovorin (LV) or interferon alpha (IFN), the combination of 5-FU/LV frequently considered as standard therapy in metastatic colorectal cancer. (kl.ac.at)
- The results of this study are published elsewhere and show a significantly reduced recurrence rate and prolonged disease-free survival time for the combined modality arm compared with the no therapy arm. (emmes.com)
- Severe toxicity in the combined therapy arm was significantly worse (P less than 0.001) than in either single modality arm. (emmes.com)
- Exploiting the genetic basis of these tumours enables us to develop a more tailored approach to therapy for patients with BRCA mutated cancers. (ox.ac.uk)
- Oral mucositis (OM) is a debilitating acute inflammation of patients undergoing cancer therapy including high doses of chemotherapy or head and neck radiotherapy. (bvsalud.org)
- The percent of patients who had PD in response to chemotherapy was significantly high in patients with pre-treatment hyperprolactinemia than in those with normal blood levels of PRL before therapy. (nel.edu)
- The remaining patients had only minor deviations from protocol therapy. (ox.ac.uk)
- According to National Comprehensive Cancer Network (NCCN) guidelines, pelvic radiation therapy is currently a category 1 recommendation for women with stage IA disease and negative lymph nodes after surgery who have high-risk factors (eg, a large primary tumor, deep stromal invasion, or lymphovascular space invasion). (medscape.com)
- For purposes of this discussion, which involves therapy for oral erythematous lesions, the presented conditions are arbitrarily divided into the following categories: local infection, contact allergy, oral cancer, and localized vesiculoerosive and ulcerative disease. (medscape.com)
- 2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)
- AML also may occur as a secondary cancer after chemotherapy or radiation therapy for a different type of cancer. (msdmanuals.com)
Genes4
- BACKGROUND: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. (ox.ac.uk)
- Standard prognostic variables and methylation status of the P15(ink4b) (P15), E-cadherin (CDH), and hypermethylated in cancer 1 (HIC) genes were analyzed before treatment. (ox.ac.uk)
- Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: A Gynecologic Oncology Group study. (gwu.edu)
- However, the prevalence and role of fusion genes in female cancers remain largely unexplored. (broadinstitute.org)
Regimens3
- These results suggest that DFS after 3 years of median follow-up is an appropriate end point for adjuvant colon cancer clinical trials of fluorouracil-based regimens, although marginally significant DFS improvements may not translate into significant OS benefits. (ox.ac.uk)
- None of these treatment regimens have been proven to be safe or effective in human cancers but are occasionally tried on compassionate-use basis in patients who have exhausted all other options. (wikipedia.org)
- as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
Colorectal cancer11
- METHODS: In a multi-institutional study prospective databases of patients with peritoneal carcinomatosis (PC) from colorectal cancer and pseudomyxoma peritonei (PMP) treated according to the Dutch HIPEC protocol, a uniform approach for the CRS and HIPEC treatment, were reviewed. (lu.se)
- The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
- A total of 207 patients (Study Group n=54, Historical Group n=153) with metastatic colorectal cancer were enrolled. (medscimonit.com)
- TDM in colorectal cancer can reduce toxicity, improve efficacy and clinical outcome, and can be routinely used in 5-FU-based chemotherapy. (medscimonit.com)
- 5-Fluorouracil (5-FU) is widely applied in the treatment of various cancers, including colorectal cancer (CRC) [1,2]. (medscimonit.com)
- Colorectal cancer is the fifth most prevalent cancer in China, after lung, gastric, esophageal, and liver cancers [2]. (medscimonit.com)
- Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal cancer (mCRC).Initial analyses identified marker-defined subsets of PC, including cells expressing PDGFR-β or α-SMA or both markers. (lu.se)
- In conclusion, the addition of IFN to 5-FU/LV in the schedules and doses used in the study did not provide any clinical benefit over 5-FU/LV alone and cannot be recommended for routine use in the treatment of advanced colorectal cancer. (kl.ac.at)
- Furthermore, GMS 0 significantly associated with improved DFS in patients receiving FOLFOX compared with CAPOX (HR 2.23 95% CI 1.19-4.16, p = 0.012).ConclusionsThis study validates the GMS as a prognostic tool for patients with stage I-III colorectal cancer, independent of TNM, with the ability to stratify both low- and high-risk disease. (ox.ac.uk)
- BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) intracellular signalling pathways predict non-response to cetuximab in the treatment of advanced colorectal cancer (aCRC). (ox.ac.uk)
- colorectal cancer occurs in the colon or rectum. (medscape.com)
Therapeutic1
- In summary, the present study provides novel evidence that both amorphic and neomorphic mutations in TP53 contribute to FoxM1 overexpression and that FoxM1 may be targeted for therapeutic benefits in cancers. (unm.edu)
Survival8
- Assessment of Residual Cancer Burden and Event-Free Survival in Neoadj" by W Fraser Symmans, Christina Yau et al. (providence.org)
- Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial. (providence.org)
- OBJECTIVE: To compare RCB distributions between randomized control and investigational treatments within subtypes of breast cancer and explore the relationship with survival. (providence.org)
- MAIN OUTCOMES AND MEASURES: Residual cancer burden (pathological measure of residual disease) and event-free survival (EFS). (providence.org)
- Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials. (ox.ac.uk)
- Among local non-responders, a subset of patients (21·3 per cent) derived benefit from neoadjuvant chemotherapy by lymph node downstaging and their survival mirrored that of local responders. (ox.ac.uk)
- It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. (lookformedical.com)
- CUSP9 [Coordinated Undermining of Survival Paths] is one of several cancer treatment protocols using re-purposed older drugs to interfere with cancer cell's growth signaling rather than directly killing them with cytotoxic drugs. (wikipedia.org)
Cytotoxic chemotherapy2
- Triple-negative breast cancer (TNBC) is an aggressive malignancy for which cytotoxic chemotherapy remains the backbone of treatment. (duke.edu)
- BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
Outcome8
- Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome. (ox.ac.uk)
- CONCLUSIONS: We show for the first time a significant effect of methylation status on the outcome of conventional chemotherapy in high-risk MDS and acute myelogenous leukemia following MDS. (ox.ac.uk)
- Does chemotherapy affect the visual outcome in children with optic pathway glioma? (prinsesmaximacentrum.nl)
- Little is known, however, about the effect of chemotherapy on visual outcome of these patients. (prinsesmaximacentrum.nl)
- MATERIAL AND METHODS: A systematic review of the literature was carried out to identify all studies published in PubMed, EMBASE and Cochrane Library between 1990 and 2008 reporting visual outcome in children with OPG after chemotherapy. (prinsesmaximacentrum.nl)
- Studies were included when they included 10 or more children with OPG, main treatment was chemotherapy and visual outcome was described. (prinsesmaximacentrum.nl)
- DISCUSSION: Published studies on childhood low grade gliomas have not shown satisfactorily whether chemotherapy improves outcome of vision in children with OPG. (prinsesmaximacentrum.nl)
- A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane: Results From a Prospective Study. (cdc.gov)
Leucovorin2
- A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study. (ox.ac.uk)
- The objective of this study was to evaluate the maximum tolerated dose (MTD) and recommended dose of irinotecan administered as a 5-day schedule synchronously with 5-fluorouracil (5FU), leucovorin (LV) and preoperative pelvic radiation (45 Gy) for primary borderline/unresectable, locally advanced rectal cancer. (ox.ac.uk)
Ovarian cancer7
- FoxM1 is an oncogenic Forkhead transcription factor that is overexpressed in ovarian cancer. (unm.edu)
- However, the mechanisms by which FoxM1 is deregulated in ovarian cancer and the extent to which FoxM1 can be targeted in ovarian cancer have not been reported previously. (unm.edu)
- Finally, FoxM1 expression is elevated in nearly all (48/49) ovarian tumors, indicating that thiostrepton target gene is highly expressed in ovarian cancer. (unm.edu)
- METHODS: This multi-centre phase II single arm trial was designed to investigate the activity and safety of 6-mercaptopurine (6MP) 55 mg/m² per day, and methotrexate 15 mg/m² per week in patients with advanced breast or ovarian cancer, ECOG PS 0-2, progressing after ≥ one prior regimen and known to bear a BRCA1/2 germ line mutation. (ox.ac.uk)
- Here, we investigate the fusion gene landscape in triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC), two subtypes of female cancers with high molecular similarity but limited treatment options at present. (broadinstitute.org)
- Development and validation of an immune gene-set based Prognostic signature in ovarian cancer. (cdc.gov)
- Communication about genetic testing with breast and ovarian cancer patients: a scoping review. (cdc.gov)
Doxorubicin1
- INTERVENTIONS: Neoadjuvant paclitaxel plus/minus 1 of several investigational agents for 12 weeks, then 12 weeks of cyclophosphamide/doxorubicin chemotherapy followed by surgery. (providence.org)
Metastasis1
- PURPOSE: This nationwide study evaluated results of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastasis of colorectal origin in the Netherlands following a national protocol. (lu.se)
Efficacy8
- The combined treatment using wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug. (medscimonit.com)
- IMPORTANCE: Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast cancer trials. (providence.org)
- Efficacy of monochemotherapy with docetaxel (taxotere) in relation to prolactin secretion in heavily pretreated metastatic breast cancer. (nel.edu)
- Recent data have suggested that the efficacy of cancer chemotherapy does not depend only on tumor-related characteristics, but. (nel.edu)
- Lissoni P, Vaghi M, Ardizzoia A, Fumagalli E, Tancini G, Gardani G, Conti A, Maestroni G. Efficacy of monochemotherapy with docetaxel (taxotere) in relation to prolactin secretion in heavily pretreated metastatic breast cancer. (nel.edu)
- Recent data have suggested that the efficacy of cancer chemotherapy does not depend only on tumor-related characteristics, but also on patient biological status, namely immune and endocrine functions. (nel.edu)
- The present study was performed to evaluate the efficacy of chemotherapy with taxanes in relation to PRL blood levels in metastatic breast cancer. (nel.edu)
- Therefore, a concomitant administration of anti-prolactinemic agents, such as bromocriptine, could enhance the efficacy of chemotherapy itself. (nel.edu)
Tumour4
- BackgroundThe Glasgow Microenvironment Score (GMS) combines peritumoural inflammation and tumour stroma percentage to assess interactions between tumour and microenvironment. (ox.ac.uk)
- Pathological response to neoadjuvant chemotherapy was assessed using the Mandard Tumour Regression Grade (TRG) and lymph node downstaging.TRG (8 of 11 centres) was the most widely used system to assess response to neoadjuvant chemotherapy, but there was discordance on how it was used in practice. (ox.ac.uk)
- The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. (ox.ac.uk)
- BACKGROUND: Pre-clinical studies have demonstrated synergistic anti-tumour effects of chemotherapy (CT) and zoledronic acid (ZOL). (ox.ac.uk)
Clinical4
- Randomized trial of interferon maintenance in multiple myeloma: a study of the National Cancer Institute of Canada Clinical Trials Group. (mcmaster.ca)
- METHODS: Individual patient data were pooled from 18 randomized phase III colon cancer adjuvant clinical trials. (ox.ac.uk)
- A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol. (ox.ac.uk)
- Clinical protocols used to inhibit the growth or spread of NEOPLASMS. (bvsalud.org)
Methods3
- METHODS AND MATERIALS: One of 3 case presentations of different stages of cervical esophageal cancer was randomly assigned and sent to participating radiation oncologists by mail. (bepress.com)
- Materials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. (uandes.cl)
- METHODS: We analysed 54 potentially functional, common, inherited EGFR pathway variants in 815 patients with aCRC treated with oxaliplatin-fluoropyrimidine chemotherapy plus cetuximab. (ox.ac.uk)
Fluorouracil-based1
- All patients were treated with conventionally fractionated radiotherapy combined with induction (platinum- and 5-fluorouracil-based) or concurrent platinum chemotherapy. (ox.ac.uk)
Neutropenia2
- Predicting risk of chemotherapy-induced severe neutropenia: A pooled analysis in individual patients data with advanced lung cancer. (unc.edu)
- Adjusted on the other haematological toxicities as a multivariate analysis, neutropenia was significantly associated to non-adherence to chemotherapy (OR: 0.43). (bvsalud.org)
Gemcitabine1
- Background: the APICE study evaluates the cost-effectiveness of nanoparticle albumin-bound paclitaxel (nab-paclitaxel-Nab-P) + gemcitabine (G) vs G alone in metastatic pancreatic cancer (MPC) from the Italian National Health Service (INHS) standpoint. (unisr.it)
Acute nonlymph1
Mucositis2
- The oral mucositis (OM) represents a frequent inflammatory condition in cancer patients, and poor oral hygiene has been related as a predisposing factor for its onset. (bvsalud.org)
- La mucositis oral (MO) representa una afección inflamatoria frequente em pacientes oncológicos e uma higiene oral insatisfatória tem frecuente en pacientes con cáncer, y la mala higiene bucal se ha relacionado sido relacionada como fator predisponente para o seu surgimento. (bvsalud.org)
Systemic3
- We did a phase 3 trial to assess a neoadjuvant regimen for HER2-positive breast cancer that replaces traditional systemic chemotherapy with targeted treatment. (nih.gov)
- The systemic treatment of non-small-cell lung cancer. (ox.ac.uk)
- Many conditions can cause oral erythema, including localized trauma, infection, contact allergy, cancer, and other causes of inflammatory changes, as well as systemic diseases such as those that produce vesiculoerosive lesions or oral ulceration. (medscape.com)
Adenocarcinoma1
- This multicentre cohort study sought to define a robust pathological indicator of clinically meaningful response to neoadjuvant chemotherapy in oesophageal adenocarcinoma.A questionnaire was distributed to 11 UK upper gastrointestinal cancer centres to determine the use of assessment of response to neoadjuvant chemotherapy. (ox.ac.uk)
Treatment17
- This study thus investigated the potential effect of paclitaxel combined with wilfortrine on cultured liver cancer cells and related mechanisms, in order to provide evidence for pathogenesis and treatment of liver cancer. (medscimonit.com)
- Liver cancer cell line HpeG2 was divided into control, paclitaxel, wilfortrine, and combined treatment groups. (medscimonit.com)
- The two enteritis fatalities occurred late at 605 and 1000 days after start of combined modality treatment, respectively. (emmes.com)
- Treatment of metastatic urothelial cancer in the post-MVAC era. (uchicago.edu)
- Based on our systematic review it appears that treatment with chemotherapy does not improve resulting vision in the majority of children with OPG. (prinsesmaximacentrum.nl)
- The increasing success of intensive consolidation chemotherapy (CCT) as an alternative to bone marrow transplant (BMT) in acute myeloid leukaemia (AML) necessitates comparison of the impact on quality of life (QoL) of these two treatment modalities. (ox.ac.uk)
- All adults having received six treatment sessions as fi rst-line chemotherapy were taken into account. (bvsalud.org)
- The ReDO project and many others also follow this line of thought as in CUSP9, repurposing older drugs for their anti-cancer effect with simultaneous use of several of them, in cancer treatment. (wikipedia.org)
- The treatment of cervical cancer varies with the stage of the disease (see Cervical Cancer Staging ). (medscape.com)
- For early invasive cancer, surgery is the treatment of choice. (medscape.com)
- See also Cervical Cancer Treatment Protocols . (medscape.com)
- The treatment of cervical cancer frequently requires a multidisciplinary approach. (medscape.com)
- Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
- A multidisciplinary approach that includes colorectal surgery, medical oncology, and radiation oncology is required for optimal treatment of patients with rectal cancer. (medscape.com)
- Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
- Cost Effectiveness of the Oncotype DX Genomic Prostate Score for Guiding Treatment Decisions in Patients With Early Stage Prostate Cancer. (cdc.gov)
- Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment. (cdc.gov)
20201
- Lung Cancer 141 (2020): 14-20. (unc.edu)
Intravenous1
- Trilaciclib is an intravenous cyclin-dependent kinase 4/6 inhibitor that induces transient cell cycle arrest of hematopoietic stem and progenitor cells and immune cells during chemotherapy exposure, protecting them from chemotherapy-induced damage and enhancing immune activity. (duke.edu)
Oncol1
- Eur J Cancer Clin Oncol. (uchicago.edu)
Metastatic disease1
- Of these, a total of 98 patients received chemotherapy for metastatic disease. (ox.ac.uk)
Symptoms1
- However, many rectal cancers produce no symptoms and are discovered during digital or proctoscopic screening examinations. (medscape.com)
Recurrence1
- The first step involves achievement of cure, because the risk of pelvic recurrence is high in patients with rectal cancer, and locally recurrent rectal cancer has a poor prognosis. (medscape.com)
Breast cancer7
- Risk or protective factors for breast cancer? (uniroma1.it)
- Breast cancer risk of hormonal contraception. (uniroma1.it)
- How reliable is MRI for predicting extent of residual breast cancer with different primary medical therapies? (ox.ac.uk)
- In particular, it has been shown that prolactin (PRL) is a growth factor for breast cancer, and abnormally high blood levels of PRL have been described in metastatic breast cancer patients. (nel.edu)
- The study included 20 metastatic breast cancer patients, who were treated with taxotere (100 mg/mq I.V. every 21 days) for at least 3 consecutive cycles. (nel.edu)
- This study shows that the evidence of abnormally high serum levels of PRL correlates with resistance to chemotherapy with taxanes in metastatic breast cancer. (nel.edu)
- TP53 p.Arg337His germline mutation prevalence in Southern Brazil: Further evidence for mutation testing in young breast cancer patients. (cdc.gov)
Lung Cancer1
- Detecting EGFR mutations and ALK/ROS1 rearrangements in non-small cell lung cancer using malignant pleural effusion samples. (cdc.gov)
Tumor3
- Liver cancer is a common malignant tumor with high mortality. (medscimonit.com)
- Paclitaxel is a wide-spectrum anti-tumor agent, while wilfortrine has been shown to have an inhibitory effect on the proliferation of liver cancer cells. (medscimonit.com)
- Both TP expression and tumor vascularization are putative postoperative prognostic markers of cancer. (ox.ac.uk)
Cervical2
- We provided a comprehensive analysis of rate, pattern, and severity of early and late postoperative complications in a very large, single-institution series of locally advanced cervical cancer (LACC) patients administered CT/RT plus radical surgery (RS). (unicatt.it)
- Current surgical guidelines for stage IA2 to IIA cervical cancers allow for minimally invasive techniques, such as traditional laparoscopic and robotically assisted laparoscopic techniques, in the surgical management of these tumors. (medscape.com)