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Tuberculosis, BovineMycobacterium bovisTuberculosisTuberculosis, PulmonaryMustelidaeMycobacterium tuberculosisTuberculin TestTuberculosis VaccinesCattleAntigens, BacterialTuberculosis, Multidrug-ResistantAnimals, WildCarnivoraTrichosurusBCG VaccineDeerPopulation ControlTuberculosis, MiliaryDisease ReservoirsIsoniazidBuffaloesLatent TuberculosisTuberculosis, Lymph NodeTuberculosis, OsteoarticularTuberculosis, GastrointestinalTuberculosis, SpinalEthiopiaBacterial ProteinsLivestockMycobacteriumTuberculosis, CutaneousTuberculinVeterinary MedicineRifampinInterferon-gammaAntelopesSputumTuberculosis, PleuralExtensively Drug-Resistant TuberculosisTuberculosis, UrogenitalPyrazinamideAntibiotics, AntitubercularSensitivity and SpecificityCattle DiseasesLiechtensteinTuberculosis, MeningealAnimal HusbandryBisonSus scrofaIntradermal TestsDNA, BacterialTuberculosis, OcularAbattoirsTuberculosis, SplenicDairyingTuberculosis, HepaticZoonosesTuberculosis, Female GenitalEthambutolMycobacterium smegmatisCoyotesPest ControlAntibodies, BacterialSerum Albumin, BovinePolymerase Chain ReactionHerpesvirus 1, BovineDirectly Observed TherapyTuberculosis, EndocrineTuberculosis, Central Nervous SystemTuberculosis, LaryngealMycobacterium avium subsp. paratuberculosisMilkTuberculosis, RenalLungBacterial Typing TechniquesAnimals, DomesticReagent Kits, DiagnosticParatuberculosisMolecular Sequence DataGreat BritainDisease OutbreaksPrevalenceSkin TestsEnzyme-Linked Immunosorbent AssayLeukemia Virus, BovineTuberculosis, OralLymph NodesBacteriological TechniquesMicrobial Sensitivity TestsVaccinationDrug Resistance, BacterialSpecies SpecificityTime FactorsContact TracingDNA FingerprintingAIDS-Related Opportunistic InfectionsDiarrhea Viruses, Bovine ViralAmino Acid SequenceMastitis, BovinePolymorphism, Restriction Fragment Length
MycobacteriumInfectionVaccine against tuberculosisProtection against tuberculosisBacteriaPulmonaryVaccinationBovisBacilleCases of bovineAlbert CalmetteAnti-tuberculosis drugsBacterialPrevent tuberculosisLungsMiliary tuberculosisExtrapulmonary tuberculosisDiphtheriaSpecificityEtiologyForm of tuberculosisAvianAntigenRespiratoryInfectionsPhthisisGuinea pigsActive tuberculosisCattle2021AffectsRecombinantWidelyDiseasesTetanusWorld Health OrganEffective vaccine1998StrainTransmissionImmuneStrainsLeprosySymptomsTumorCommonlyEndogenousTuberculinBacilliMeningitisPrimarilyInhalation of airborneDisease
Mycobacterium31
Infection22
  • TB disease is a nationally notifiable disease, however latent tuberculosis infection is not reported to CDC. (cdc.gov)
  • Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. (encyclopedia.com)
  • Scientists know it as an infection caused by M. tuberculosis . (encyclopedia.com)
  • When streptomycin, the first antibiotic effective against M. tuberculosis , was discovered in the early 1940s, the infection began to come under control. (encyclopedia.com)
  • Researchers at the Max Planck Institute for Infection Biology in Berlin have genetically modified the tuberculosis vaccine BCG in a way that it stimulates the immune system more specifically. (oullins-patriote.com)
  • Improved protection against infection with tuberculosis bacteria has already been proven using VPM1002. (oullins-patriote.com)
  • If a tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). (goto95.com)
  • Notable extrapulmonary infection sites include the pleura (in tuberculous pleurisy), the central nervous system (in tuberculous meningitis ), the lymphatic system (in scrofula of the neck), the genitourinary system (in urogenital tuberculosis ), and the bone s and joints (in Pott disease of the spine), among others. (goto95.com)
  • Rates of protection against tuberculosis infection vary widely and protection lasts up to 20 years. (wikipedia.org)
  • Exposure to M.tuberculosis may lead to infection, but most infections do not lead to disease. (myhealth.gov.my)
  • Tests for diagnosing latent infection with tuberculosis include a positive TST or a blood assay. (unboundmedicine.com)
  • We propose that the bovine model of RSV infection is a valuable alternative for assessing the translational potential of interventions aimed at the human population. (bvsalud.org)
  • BCG administration could induce innate training, identify the cell type involved, and determine whether innate training promoted resistance to bovine respiratory syncytial virus (BRSV) infection, a major cause of bovine respiratory disease in preweaned calves. (bvsalud.org)
  • Having progressively perceived the infection and the disease of tuberculosis , the physicians of the Colonial Health Service study the geographical extent of the disease and analyse its epidemiology . (asnom.org)
  • Tuberculosis is a chronic, progressive mycobacterial infection, often with an asymptomatic latent period following initial infection. (merckmanuals.com)
  • IL-22-producing helper T cells (Th22 cells) have been reported to be involved in tuberculosis infection. (atsjournals.org)
  • acr was able to efficiently boost the BCG induced protection against M. tuberculosis infection in guinea pigs by significantly reducing the pulmonary bacillary load (1.27 log 10 fewer bacilli) in comparison to BCG vaccination alone. (nature.com)
  • HspX or α-crystallin, a 16 kDa protein, is one of the dominant antigens expressed during the latent stages of M. tuberculosis infection and under various other conditions like low oxygen tension, nutrient starvation or hypoxia 7 , 8 . (nature.com)
  • In one of the study from our laboratory, we have shown that a DNA vaccine expressing α-crystallin provides considerable protection to guinea pigs against M. tuberculosis infection 12 . (nature.com)
  • Patients should be tested for latent tuberculosis before RENFLEXIS use and during therapy.1,2 Treatment for latent infection should be initiated prior to RENFLEXIS use. (rxlist.com)
  • Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with RENFLEXIS, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy. (rxlist.com)
  • When differentiated human THP-1 cells were infected with MAP, the expression of various genes associated with stress responses and metabolism was altered in both host and MAP at 3 h post-infection. (biomedcentral.com)
Vaccine against tuberculosis2
  • Bacillus Calmette-Guérin (BCG) is widely used as a vaccine against tuberculosis but has a variable protection against neonatal and adult pulmonary TB. (technologynetworks.com)
  • acr ) was generated which was further evaluated for its ability to impart protection as a booster vaccine against tuberculosis in a heterologous prime boost approach. (nature.com)
Protection against tuberculosis3
  • Consequently, the new vaccine offers much greater protection against tuberculosis. (oullins-patriote.com)
  • Therefore, this study provides evidence of improved protection against tuberculosis by viral booster vaccination in a natural target species and has prioritized potential correlates of vaccine efficacy for further evaluation. (ox.ac.uk)
  • A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice. (technologynetworks.com)
Bacteria2
  • The researchers modified the weakened tuberculosis bacteria in a way that it can be recognized better by the immune system. (oullins-patriote.com)
  • The new vaccine VPM1002 is absorbed like BCG by the immune system's phagocytes, that can then subsequently identify their targets-tuberculosis bacteria and cancer cells-much better," explains Kaufmann. (oullins-patriote.com)
Pulmonary7
  • Tuberculosis may infect any part of the body, but most commonly occurs in the lungs (known as pulmonary tuberculosis). (goto95.com)
  • Extrapulmonary TB occurs when tuberculosis develops outside of the lungs, although extrapulmonary TB may coexist with pulmonary TB. (goto95.com)
  • BCG seems to have its greatest effect in preventing miliary tuberculosis or tuberculosis meningitis, so it is still extensively used even in countries where efficacy against pulmonary tuberculosis is negligible. (wikipedia.org)
  • Tuberculosis elimination is a goal of the World Health Organization (WHO), although the development of new vaccines with greater efficacy against adult pulmonary tuberculosis may be needed to make substantial progress. (wikipedia.org)
  • He also identified that M. tuberculosis can infect the gastrointestinal tract, bones, joints, nervous systems, lymph nodes, genital and urinary tracts, and skin (extra-pulmonary tuberculosis), in addition to the respiratory tract (pulmonary tuberculosis). (news-medical.net)
  • Diagnosis of TB disease is further confirmed by culturing M. tuberculosis from sputum or other respiratory specimens for pulmonary TB and from other affected body tissues or fluids for extrapulmonary TB. (myhealth.gov.my)
  • However, the unsatisfactory performance of BCG in controlling the adult pulmonary tuberculosis has made the development of an effective vaccine against M. tuberculosis a prime objective of the TB research. (nature.com)
Vaccination6
Bovis3
  • People can acquire bovine TB (caused by M. bovis ) by consuming unpasteurized dairy products from infected cattle. (cdc.gov)
  • M. bovis risk in some African countries has been postulated, but human M. bovis statistics are unavailable for those countries. (cdc.gov)
  • The BCG vaccine is a live, attenuated vaccine derived from M. bovis that is used to protect humans from tuberculosis. (whatfuture.net)
Bacille3
  • The tuberculosis vaccine Bacille Calmette-Guérin (BCG) that was introduced back in the 1920s contains weakened pathogens of bovine tuberculosis, which can also be transmitted to humans. (oullins-patriote.com)
  • IL-17 KO mice did display attenuated delayed-type hypersensitivity (DTH) against bovine serum albumin and bacille Calmette-Guérin (BCG). (medscape.com)
  • Currently the only vaccine available to prevent tuberculosis is the bacille Calmette-Guérin (BCG) vaccine. (unboundmedicine.com)
Cases of bovine2
  • anda reduction in the number of human cases of bovine TB in people under age of 35 years born in the UK. (parliament.uk)
  • twelve cases of bovine tuberculosis in man were reported in 1974 and 1975. (liverpool.ac.uk)
Albert Calmette1
  • [8] It is named after its inventors Albert Calmette and Camille Guérin . (wikipedia.org)
Anti-tuberculosis drugs2
  • Although other more effective anti-tuberculosis drugs were developed in the following decades, the number of cases of TB in the United States began to rise again in the mid-1980s. (encyclopedia.com)
  • Patients who need desensitization to anti-tuberculosis drugs. (myhealth.gov.my)
Bacterial1
  • A series of works exploring how our bacterial flora might be enhanced to create human super-organisms. (annadumitriu.co.uk)
Prevent tuberculosis1
  • The bacillus Calmette-Guérin (BCG) vaccine, administered to prevent tuberculosis, is a well-studied inducer of trained immunity in human and mouse monocytes. (bvsalud.org)
Lungs6
  • Tuberculosis is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze . (goto95.com)
  • Tuberculosis may become a chronic illness and cause extensive scarring in the upper lobes of the lungs. (goto95.com)
  • In 1843, Philipp Friedrich Hermann Klencke, a German physician, experimentally produced the human and bovine forms of tuberculosis for the first time by inoculating extracts from a miliary tubercle into the liver and lungs. (news-medical.net)
  • Because of the absence of immunity, the disease is going to break out violently, a phenomenon which some have chosen to call 'tuberculosis of the virgin races' ('la tuberculoses des races vierges') where the disease is located in other organs than the lungs and manifest extremely acute developments. (asnom.org)
  • Tuberculosis most commonly affects the lungs. (merckmanuals.com)
  • Tuberculosis (TB) is a chronic infectious disease caused by myco- bacterium tuberculosis (Mtb), usually the bacillus invades human lungs (about 85 % of cases) (Van Zyl et al. (azd8931inhibitor.com)
Miliary tuberculosis1
  • A potentially more serious, widespread form of TB is called "disseminated tuberculosis", it is also known as miliary tuberculosis . (goto95.com)
Extrapulmonary tuberculosis2
Diphtheria4
  • Montagnier and Barré-Sinoussi were honored by the 2008 Nobel Prize A new age of preventive medicine in France was made possible by the Institut Pasteur's (early 20th century) development of vaccines for tuberculosis, diphtheria, tetanus, yellow fever and poliomyelitis. (wikipedia.org)
  • Two Manuscript Books of Laboratory Notes by student of bacteriology and later publisher of "The Causes of Tuberculosis", Louis Cobbett (1863 - 1947), dealing in these lab notes with the discovery of remedies for Tuberculosis and Diphtheria. (inannararebooks.com)
  • Original, two-volume Manuscript-Compendium of research-notes regarding all the important discoveries in Bacteriology (Diphtheria and Tuberculosis) by contemporaries of Louis Cobbett during the years 1885 - 1908 (Behring, Koch, Metchnikoff etc. (inannararebooks.com)
  • The stunning documents are not only reading like a first-hand-journal of discoveries, citing and reflecting on all the important developments and medical advancements of the outgoing 19th and beginning 20th century, but these notes were written parallel to Robert Koch, Emil von Behring and others making their breakthrough discoveries for mankind's desperately needed cures against Tuberculosis and Diphtheria. (inannararebooks.com)
Specificity2
Etiology1
Form of tuberculosis2
Avian2
  • Three types of the tubercle bacillus exist: human, bovine, and avian. (unboundmedicine.com)
  • TWiV 1047: Long COVID and avian flu in ferrets September 24, 2023 TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and airborne transmission of human-isolated avian H3N8 influenza virus between ferrets. (microbe.tv)
Antigen2
  • Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
  • Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
Respiratory3
  • Bovine respiratory disease (BRD) causes morbidity and mortality in cattle of all ages. (bvsalud.org)
  • The objective of this study was to determine effects of SCFP supplementation on the transcriptional response to coinfection with bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) in the lung using RNA seq. (bvsalud.org)
  • The human orthopneumovirus (human respiratory syncytial virus [RSV]) is a leading cause of respiratory disease in children worldwide and a significant cause of infant mortality in low- and middle-income countries. (bvsalud.org)
Infections2
  • Most infections show no symptoms, in which case it is known as latent tuberculosis . (goto95.com)
  • As only feral cats were infected it is most likely that infections in cats were initiated by mink, not by humans. (authorea.com)
Phthisis2
  • Tuberculosis (TB) was called "phthisis" in ancient Greece, "tabes" in ancient Rome, and "schachepheth" in ancient Hebrew. (cdc.gov)
  • In the 17th and 18th centuries, the terms 'Consumption' and 'phthisis' were used to describe tuberculosis. (news-medical.net)
Guinea pigs2
  • These microbes induce tuberculosis in those used as guinea-pigs. (asnom.org)
  • In addition, a previous study from our laboratory based on BCG priming followed by boosting with the DNA vaccine expressing α-crystallin imparted markedly better protection against M. tuberculosis in comparison to BCG in both guinea pigs and mice 13 . (nature.com)
Active tuberculosis2
Cattle6
  • Vaccines have been developed to control the spread of bovine TB, but they are not widely used in cattle. (whatfuture.net)
  • The BCG vaccine is not used in cattle at present, due to its variable efficacy and because it interferes with the standard diagnostic test for bovine TB, the PPD test. (whatfuture.net)
  • the matching of these two tuberculins for potency in naturally infected cattle had already been established, the bovine ppd being approximately one-and-a-half times more potent than the human ppd per unit of weight. (liverpool.ac.uk)
  • cattle tuberculosis was totally eradicated in sweden 20 years ago. (liverpool.ac.uk)
  • all cases lived for many years in areas where cattle tuberculosis had previously been common. (liverpool.ac.uk)
  • In the majority of cases of tuberculosis in cattle and swine, symptoms are either entirely lacking or so vague and obscure as to be of no material assistance in the recognition of the disease. (kerala.gov.in)
20211
Affects1
  • Tuberculosis generally affects the lung s, but it can also affect other parts of the body. (goto95.com)
Recombinant2
  • In this study, a genetically stable, marker-free recombinant MVA expressing α-crystallin of M. tuberculosis (rMVA. (nature.com)
  • Recombinant human NOD2 protein corresponding to residues 28-301. (novusbio.com)
Widely1
  • Tuberculosis spread much more widely in Europe when the industrial revolution began in the late nineteenth century. (encyclopedia.com)
Diseases2
  • There are several meanings for "white plague", but the only one I've found that makes sense in this context is as a synonym for Tuberculosis (and some similar diseases that make the afflicted pale). (stackexchange.com)
  • for Taiwan, Statistics of Communicable Diseases and Surveillance Report 2019, Centers for Disease Control, Ministry of Health and Welfare, R.O.C. (Taiwan), November 2020 ( www.cdc.gov.tw/En/File/Get/0nnMQjC37VAuhzVY3Vuq-A ). (cdc.gov)
Tetanus2
  • other commonly used Ags for DTH responses in humans include tetanus , Candida and Trichophyton species, and mumps . (medscape.com)
  • It is also theoretically possible to 'eliminate' a disease in humans while the microbe remains at large, as in the case of neonatal tetanus, for which the World Health Organization (WHO) in 1989 declared a goal of global elimination by 1995. (cdc.gov)
World Health Organ1
  • Although the recommendations pertain to the United States, they might be adaptable for use in other countries that adhere to guidelines issued by the World Health Organization, the International Union against Tuberculosis and Lung Disease, and national TB control programs. (cdc.gov)
Effective vaccine1
  • The bacilli have retained enough strong antigenicity to become a somewhat effective vaccine for the prevention of human tuberculosis. (curezone.org)
19981
Strain1
  • This is par-ticularly true in relation to the bovine strain. (kerala.gov.in)
Transmission5
  • The risk for M. tuberculosis transmission on an airplane is low, but instances of in-flight TB transmission have occurred. (cdc.gov)
  • Risk of tuberculosis transmission on airplane is similar to any other enclosed space. (myhealth.gov.my)
  • Barlow N.D., Non-linear transmission and simple models for bovine tuberculosis, J. Anim. (vetres.org)
  • Caley P., Spencer N., Cole R., Efford M., The effect of manipulating population density on the probability of den-sharing among common brushtail possums, and the implications for transmission of bovine tuberculosis, Wildl. (vetres.org)
  • This study presents one of the first reports of interspecies transmission of SARS-CoV-2 that does not involve humans, namely mink-to-cat transmission, which should also be considered as a potential risk for spread of SARS-CoV-2. (authorea.com)
Immune6
  • AIDS patients are much more likely to develop tuberculosis because of their weakened immune systems. (encyclopedia.com)
  • The human immune system can recognize and eliminate not only germs but also cancer cells. (oullins-patriote.com)
  • These adverse reactions to the BCG vaccine are a particular risk for children infected with the Human Immunodeficiency Virus (HIV), where the condition is known as BCG immune reconstitution inflammatory syndrome (BCG-IRIS). (evidence4health.org)
  • Chinnaswamy Jagannath, professor of pathology and genomic medicine at the Houston Methodist Research Institute, which is an affiliate of Weill Cornell Medical College, showed that the novel formulation improves the development of tuberculosis-specific immune responses. (technologynetworks.com)
  • The development of preventive interventions against human RSV has been difficult partly due to the need to use animal models that only partially recapitulate the immune response as well as the disease progression seen in human infants. (bvsalud.org)
  • Granuloma is a pathological feature of tuberculosis and is a tight immune cell aggregation caused by Mtb. (azd8931inhibitor.com)
Strains3
  • A growing pool of evidence suggests that the current strains of M. tuberculosis is originated from a common ancestor around 20,000 - 15,000 years ago. (news-medical.net)
  • Bovine strains grow best in acid medium, human strains in alkaline medium. (kerala.gov.in)
  • Slightly acidified, glycerin bouillon is rendered more acid in reaction by the growth of human strains while growth is inhibited in bovine strains. (kerala.gov.in)
Leprosy1
  • [9] [10] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. (wikipedia.org)
Symptoms1
  • A Greek physician, Clarissimus Galen, who became the physician of the Roman Emperor Marcus Aurelius in 174 AD, described the symptoms of tuberculosis as fever, sweating, coughing and blood-stained sputum. (news-medical.net)
Tumor1
  • Infliximab-abda, the active ingredient in RENFLEXIS, is a chimeric IgG1τ monoclonal antibody (composed of human constant and murine variable regions) specific for human tumor necrosis factor -alpha (TNFα). (rxlist.com)
Commonly1
  • TB was commonly called "consumption" in the 1800s even after Schonlein named it tuberculosis. (cdc.gov)
Endogenous2
  • bovine tuberculosis in man--reinfection or endogenous exacerbation. (liverpool.ac.uk)
  • In WB, this antibody has been tested with NOD2 transfected 293T lysates and HT29 human colorectal adenocarcinoma lysates (endogenous detection has some background) where a band is seen at ~110 kDa. (novusbio.com)
Tuberculin1
Bacilli1
  • In the 1960s, in Dakar, Boiron*, studying colonies of isolated BK in patients systematically, notices in more than half of them original characteristics, intermediary between human and bovine tuberculosis bacilli. (asnom.org)
Meningitis1
Primarily1
Inhalation of airborne1
Disease12
  • TB is not just a disease found in humans. (cdc.gov)
  • TB is a disease that infects animals as well as humans. (cdc.gov)
  • Bovine tuberculosis is a serious infectious disease that can affect both animals and humans. (whatfuture.net)
  • In the Andean states, the first pre-Columbian evidence of tuberculosis was observed in Peruvian mummies, indicating the presence of the disease before the European colonization in South America. (news-medical.net)
  • After the decline of the Roman Empire in the 5th century, a vast pool of archeologic evidence of tuberculosis was found throughout Europe, indicating that the disease was widespread in Europe during this time. (news-medical.net)
  • Universal and very ancient, a social disease par excellence, Tuberculosis is infectious, contagious and due to Koch's bacillus (BK) . (asnom.org)
  • Tuberculosis is a chronic, infectious disease of mammals caused by Mycobac-terium tuberculosis and characterized by the development of tubercles and by abscess formation, with resulting caseation and calcification. (kerala.gov.in)
  • In 1962, isoniazid (INH) was demonstrated to be effective in preventing tuberculosis (TB) among household contacts of persons with TB disease ( 1 ). (cdc.gov)
  • One third of the world's population is infected latently with M. tuberculosis and is potentially at the risk of developing an active disease 1 , 2 . (nature.com)
  • Patients with tuberculosis have frequently presented with disseminated or extrapulmonary disease. (rxlist.com)
  • 2015). In addition, tuberculosis is a complex disease and more than 90 % of people infected could spon- taneously control. (azd8931inhibitor.com)
  • MAP is also considered to be a potential cause of human Crohn's disease (CD) because MAP is associated with CD [ 1 , 2 ]. (biomedcentral.com)