Calcium regulate lymphocytes cell proliferation. Medical search. Frequent questions

MSCs have multilineage differentiation potential, allowing them to differentiate, for example, into chondrocytes and osteoblasts, the key cells from the two tissues that constitute the osteochondral unit. (hindawi.com)
CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. (thermofisher.com)
CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation. (thermofisher.com)
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)
Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
Biologically, the canonical WNT/-catenin signaling pathway usually plays crucial functions in regulating cell fate, proliferation and survival, while the non-canonical WNT signaling is usually more associated with differentiation, cell polarity and migration 25-27. (icsv20.org)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)
This review will discuss the metabolic adaptations necessary for T cells to meet changing biochemical needs throughout different stages of differentiation. (elifesciences.org)
Launch Proteins kinase C (EC 2.7.11.13), known as PKC also, is a family group of serine/threonine kinases that play an integral function in the legislation of varied cellular procedures, including cell proliferation, apoptosis, and differentiation.1,2 In individuals, at least 11 different PKC polypeptides have already been identified. (nibbp2p.org)
Cyclic GMP is important for normal cell proliferation and differentiation. (livonlabs.com)
This study also demonstrates that the inhibition of Treg cell differentiation in MNCs by CD38+ NK cells is a potential cause of the immune imbalance in RA and CIA. (biomedcentral.com)
details] Effects of Low-Intensity Electromagnetic Fields on the Proliferation and Differentiation of Cultured Mouse Bone Marrow Stromal Stem Cells [med. (emf-portal.org)

Cytokines are cell signaling molecules that can enhance the immune response. (wikipedia.org)
The disturbance of the function of Kv1.3-channels, for example due to inhibition of these channels, will lower the cytokines production and lymphocyte proliferation in vitro. (wikipedia.org)
If they can't handle the infection they release messengers called cytokines that call backup cells (lymphocytes) to join the battle. (iherb.com)
Cytokines are communication proteins released by certain white blood cells that transmit information to other cells, promoting the immune response. (livonlabs.com)
General regulation of B cell homeostasis is mastered by BLyS (B Lymphocyte Stimulator) and several other BLyS family cytokines, which serve as a crucial survival factor for which transitional and mature B cells compete. (uab.edu)
DNA damage assessment and cell cycle analysis revealed differences in the modes of cell death between asbestos and respective CF. There was an increase in chemokines, but not pro-inflammatory cytokines after all EMP treatments. (cdc.gov)

Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
thus, those cells that fail to receive a signal (ie, do not recognize self) die by apoptosis or become inactive. (medscape.com)
Immune escape is mainly caused by histocompatibility complex (MHC) class I, abnormal antigen signaling mechanism, immunosuppressive components (such as HLA-G), Fas and its ligands to activate apoptosis and overexpression of other immunosuppressive molecules, such as lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3) ( Steven and Seliger, 2018 ). (techscience.com)
Treating HeLa cells with different concentrations of kelp sulfate polysaccharides found that it not only inhibits the growth of human cervical cancer cell lines, but also regulates the expression of bc-l2 protein and NF-JBp65 to affect the apoptosis of cervical cancer cells. (pure-plantextract.com)
In summary, homozygous mutation leads to B-cell hyperproliferation and faulty apoptosis with consequent lymphocyte autoantibody and deposition creation in human beings, and disrupts organic killer cell function. (nibbp2p.org)
This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. (nih.gov)
Additionally, C3G significantly increased RASF apoptosis and decreased RASF proliferation and IL-6 production in the culture medium. (biomedcentral.com)

Ion channels play a key role in lymphocyte signal transduction. (wikipedia.org)
It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. (southernbiotech.com)
CD38 participates in cell adhesion, signal transduction and calcium signaling. (thermofisher.com)

Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. (hindawi.com)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. (thermofisher.com)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
A fuller picture of the WNT signaling pathway surfaced when T-cell aspect/lymphocyte enhancer aspect (TCF/LEF) transcription elements had been defined as WNT nuclear effectors 9, 10 and Frizzleds (FZDs) had been defined as WNT obligate receptors 11, working as well as co-receptors, such as for example low-density lipoprotein-receptor-related proteins (LRPs)/Arrow 12. (icsv20.org)
Non-canonical WNT signaling can be initiated by WNT conversation with Frizzled receptors, or RYK and ROR receptor tyrosine kinases, and regulates small GTPases (such as RhoA, Rac and Cdc42) in DVL-dependent manner. (icsv20.org)
The antibody LT20 reacts with an extracellular epitope of CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes. (exbio.cz)
It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. (exbio.cz)
After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. (exbio.cz)
Petrie RJ, Deans JP: Colocalization of the B cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts. (exbio.cz)
Studies have shown that the enzyme 1a- hydroxylase, which catalyzes the last and rate limiting step in the synthesis of active 1,25- dihydroxyvitamin D3 (1,25D), and the vitamin D receptor (VDR), which mediates the actions of vitamin D, are expressed widely in the body, including the lungs and cells of the immune system. (vitamindwiki.com)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
Likewise, lysophosphatidic acid receptor 1 (LPA 1 ) is implicated in cancer cell proliferation and migration. (biomedcentral.com)
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism. (umassmed.edu)
Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1 [med. (emf-portal.org)
details] Weak power frequency magnetic fields induce microtubule cytoskeleton reorganization depending on the epidermal growth factor receptor and the calcium related signaling [med. (emf-portal.org)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Kv1.3-channels can be found in various cells, including T-lymphocytes and macrophages. (wikipedia.org)
Kv1.3-channels are important for the activation of T-lymphocytes, and thus for the activation of macrophages. (wikipedia.org)
Kv channels are regulated during proliferation and regulation of macrophages and their activity is important during cell responses. (wikipedia.org)
These heterotetramers plays a role in regulating the membrane potential of macrophages on different stages of macrophage activation by lymphocytes. (wikipedia.org)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
The active vitamin D generating enzyme, 1a-hydroxylase, is expressed by the airway epithelium, alveolar macrophages, dendritic cells and lymphocytes indicating that active vitamin D can be produced locally within the lungs. (vitamindwiki.com)
The main players in innate immunity in the lungs include the airway epithelium itself, alveolar macrophages and dendritic cells. (vitamindwiki.com)
The innate immune system is the first line of defence, and consists of the skin, mucosal barriers, enzymes such as those in saliva and stomach acid, and generalized immune cells such as macrophages, leukocytes, natural killer cells (NK cells), and dendritic cells. (loonscallwellness.ca)
6.Immune regulation: Laminaria fucoidan sulfate has good immune activity, has a direct effect on T cells and macrophages, and can perform better immune regulation on mice with low immunity. (pure-plantextract.com)
Cell-mediated response refers to the activation of macrophages, natural killer cells, and antigen-specific T-lymphocytes that attack anything perceived as a foreign agent. (livonlabs.com)
Alveolar macrophages (AM) are the first responders to inhaled particulates, participating in clearance and activating other resident and recruited immunocompetent cells, impacting the long-term outcomes. (cdc.gov)

Kv1.2 channel regulates neurotransmitter release associated with heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, immunological response and cell volume. (wikipedia.org)
Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. (southernbiotech.com)
Vitamin D generated in tissues is responsible for many of the immunomodulatory actions of vitamin D. The effects of vitamin D within the lungs include increased secretion of the antimicrobial peptide cathelicidin, decreased chemokine production, inhibition of dendritic cell activation and alteration of T cell activation. (vitamindwiki.com)
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
C3G decreased the proportion of CD38+ cells, RASF proliferation, and proinflammatory cytokine secretion, and it increased the Treg cell proportion. (biomedcentral.com)
C3G also elevated Sirt6 expression to suppress NKG2D expression, increase TNF-α secretion, and decrease IFN-γ secretion in CD38+ NK cells, which stimulates MNCs to differentiate into Treg cells. (biomedcentral.com)

Phenotypic and functional alterations in lupus T cells including expansion of the Th17 population, perturbations of the physiology of T-cell receptors (TCRs) and postreceptor downstream signalling, oxidative stress, and epigenetic changes result in exaggeration of TCR response to stimuli and the propensity of lupus T cells to get activated [ 6 ]. (hindawi.com)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)
Hormones are recognised by either cell surface receptors (modified amino acids, peptides, proteins) or cytoplasmic/nuclear receptors (steroids). (edu.au)
Specificity-based control is achieved via B cell antigen receptors (BCRs), which serve as a determinant of whether an antigen-specific B cell will survive negative and positive selection and successfully mature. (uab.edu)
In this work, we uncovered two new mechanisms that contribute to B cell regulation: Fcγ receptors boosting soluble BLyS levels, and enhancing BCR signaling. (uab.edu)
This get the job done demonstrates a novel complicated concerning FE65, VLDLR, and APP, which assists elucidate the part of FE65 in regulating transmem brane proteins like ApoE receptors and APP while in the CNS. (mirnasynthesis.com)

The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. (exbio.cz)
LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)

Margatoxin irreversibly inhibits the proliferation of human T-cells in a concentration of 20 μM. (wikipedia.org)
Defective proximal TCR signaling inhibits CD8 + tumor-infiltrating lymphocyte lytic function. (southernbiotech.com)
Vitamin C inhibits various forms of T-lymphocyte death. (livonlabs.com)

Breakdown of immune tolerance is believed to be one of the major mechanisms which triggers the production of autoantibodies by B cells and antibody forming cells, leading to inflammation upon binding to autoantigens and consequent tissue damage [ 2 ]. (hindawi.com)

CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). (exbio.cz)
High inductive magnetic stimuli and their effects on mesenchymal stromal cells, dendritic cells, and fibroblasts [med. (emf-portal.org)

1 V(D)J recombination and the activity of genes of interest (using GFP as a reporter of gene expression) can be detected as intracellular fluorescence and are measured simultaneously in the same cell population, at the single cell level. (umassmed.edu)
details] A 60 Hz uniform electromagnetic field promotes human cell proliferation by decreasing intracellular reactive oxygen species levels [med. (emf-portal.org)
Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. (cdc.gov)

Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. (thermofisher.com)
Correction: Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells. (umassmed.edu)

Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. (thermofisher.com)

Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)
To find out if oncolytic viruses could infect and destroy the BIN 67 cells in vitro, the 4 cell lines had been plated as described above. (mirnasynthesis.com)

Due to its role in proliferation and maturation of keratinocytes, vitamin D has become an important local therapeutic option in the treatment of psoriasis. (springer.com)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
B cell development, maturation and proliferation are all strictly regulated processes. (uab.edu)

Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. (hindawi.com)
Mesenchymal stem cells (MSCs) play a key role in articular cartilage repair. (hindawi.com)
She is known for her work on neuronal and mesenchymal stem and precursor cells and how they can promote tissue repair and regeneration. (nature.com)
Lai, R. C., Chen, T. S. & Lim, S. K. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. (nature.com)
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. (nature.com)
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (nature.com)

Vitamin C enhances cytokine production by white blood cells. (livonlabs.com)

CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. (southernbiotech.com)
In the normal thymus, bone marrow-derived precursor cells destined to become thymocytes (or T lymphocytes) enter the thymus at the corticomedullary junction and differentiate as they pass through the thymus. (medscape.com)

A total of 243 proteins were dys-expressed under E2 condition, 123 were up-regulated and 120 were down-regulated thereinto. (bvsalud.org)
Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
Our results create PKC as an integral proteins regulating B-cell proliferation and tolerance aswell as NK function in human beings. (nibbp2p.org)
Biotin labeled cell surface proteins COS7 cells were transiently transfected with VLDLR and vector or VLDLR and FE65 in Fugene six and cultured 24 hrs in DMEM containing 10% FBS. (mirnasynthesis.com)

Vitamin D, also known as the sunshine vitamin, has long been known to be a hormone that regulates calcium-phosphorous homeostasis and safeguards the integrity of the skeletal system [ 7 ]. (springer.com)
Emerging information on vitamin D physiology has revealed that Vitamin D is not merely a micronutrient that plays a role in calcium homeostasis but a pluripotent hormone with extensive immunomodulatory functions. (vitamindwiki.com)
Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. (uc.edu)
The regulatory system of B cells can be considered as two layers: a general homeostasis regulation system and a specificity-based control system. (uab.edu)
CD38 catalyzes the conversion of nicotinamide adenine dinucleotide (Coenzyme I, NAD+) to cyclic ADP-ribose (cADPR) to regulate calcium ion (Ca 2+ ) homeostasis. (biomedcentral.com)

Note: When using high concentrations of antibody, background binding of this dye to erythroid cell subsets (mature erythrocytes and precursors) has been observed. (bdbiosciences.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment. (exbio.cz)
The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism. (exbio.cz)
There are 2 major ways the body can respond to a pathogen: antibody-mediated immunity and cell-mediated immunity. (livonlabs.com)
These white blood cells make antibodies as part of the antibody-mediated immune response. (livonlabs.com)
When MNCs were cocultured with C3G-pretreated CD38+ NK cells in the presence of TNF-α and an anti-IFN-γ antibody, the IL-10+ Treg cell proportion significantly increased. (biomedcentral.com)
My lab is interested in what controls the initiation of antibody gene rearrangement during B cell development. (umassmed.edu)

It is expressed on mantle zone B cells, but weakly on germinal center B cells. (bdbiosciences.com)

Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
The shed BLyS promotes long-term (days) B cell survival. (uab.edu)

When fluorochrome conjugated antibodies are bound to BD CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. (thermofisher.com)
Your body makes several types of cells and antibodies that fight infections while you're sleeping. (iherb.com)

Rapid proliferation and acquisition of effector function are demanding processes that require precise metabolic re-wiring. (elifesciences.org)
GPCRs have been extensively studied as drug targets because they are involved in essential physiological processes and pathological conditions and have drug-accessible sites at the cell surface [ 3 ]. (biomedcentral.com)
Prostaglandins are hormone-like compounds that control many physiologic processes, including regulating T-lymphocyte function. (livonlabs.com)
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. (nature.com)
When their protective barriers are missing, hormones and cells that are present during inflammatory processes induce activation of clasts which, when unbalanced, no longer perform physiological bone remodeling and begin to provoke an immunopathological response that causes dental resorption. (bvsalud.org)

From the corticomedullary junction, the cells enter the medulla or circulate in the periphery to other lymphoid structures (ie, lymph nodes). (medscape.com)
Normal human lymphocytes from lymph node. (exbio.cz)

As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)

Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers of inflammation and predict mortality in patients with different inflammatory diseases. (biomedcentral.com)
We aimed to investigate the correlation between levels of these three biomarkers and neutrophil granulocyte and lymphocyte count in patients with moderate to very severe COPD stratified by use of systemic glucocorticoids. (biomedcentral.com)
Recently, neutrophil-to-lymphocyte ratio (NLR) has attracted attention as an inflammatory biomarker. (biomedcentral.com)

The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. (ersjournals.com)
They span the membrane of cells, allowing the selective permeation of K + ions from one side of the membrane to the other, usually from the inside of the cell to the outside. (ersjournals.com)
They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. (uc.edu)
1) Both IgG and CRP, immune system opsonins, induced rapid and significant shedding of membrane-bound BLyS on human myeloid cells. (uab.edu)
CD38 is a glycoprotein on the cell membrane that functions as a cyclic ADP-ribose hydrolase (cADPRH). (biomedcentral.com)

Figure 1: Biogenesis of extracellular vesicles and their interactions with recipient cells. (nature.com)
Small and large extracellular vesicles derived from pleural mesothelioma cell lines offer biomarker potential. (otago.ac.nz)

Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
In this study, we aimed to assess the neoplastic-like transformation potential of two forms of CNC derived from wood (powder and gel) in human pulmonary epithelial cells (BEAS-2B) in comparison to fibrous tremolite (TF), known to induce lung cancer. (cdc.gov)

Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
In comparison with healthy subjects, a number of studies have demonstrated that T cells isolated from patients with SLE are abnormal, with regard to their phenotypes and functions [ 4 , 5 ]. (hindawi.com)
Patients with thymoma may experience dysregulation of the lymphocyte negative and positive selection process leading to abnormal proliferation, autoimmunity, and/or immunodeficiency. (medscape.com)

Non-canonical WNT signaling can also activate calcium flux and kinase cascades, including protein kinase C (PKC), calcium/calmodulin-dependent protein kinase II (CaMKII) and JUN N-terminal kinase (JNK), leading to the activation of AP1- and NFAT-regulated gene expression 25-27. (icsv20.org)
This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)

The term lymphoepithelioma has been used in cases in which the thymoma contains a large number of lymphoid cells. (medscape.com)
Chemokines regulate the transport activation and sometimes proliferation of several cell types including myeloid lymphoid GW788388 endothelial and epithelial cells1 2 There are four chemokine subfamilies - CXC C CX3C and CC - based on the positions of conserved cysteine residues near the amino terminus of the proteins1 (TABLE 1). (cancerrealitycheck.com)

Potassium channels are involved in leukocyte activation by calcium. (wikipedia.org)
Potassium channels are required for the activation of T-cells. (wikipedia.org)
Human CD38, a surface molecule expressed by immature and activated T and B lymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31. (nih.gov)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. (uc.edu)
nPKCs need diacylglycerol (DAG) however, not calcium mineral (Ca2+) for activation. (nibbp2p.org)
In transduced cells, co-ligation of FcγRIIC and BCR led to FcγRIIC tyrosine phosphorylation, as well as enhanced B cell activation, reflected by amplified global tyrosine phosphorylation and increased phosphorylation of a series of key molecules in the BCR signaling cascade, and enhanced calcium flux. (uab.edu)
Therefore, in carriers of the open reading frame allele, FcγRIIC is expressed on B cells and would set up a new activation threshold, potentially slanting B cells towards hyper-activation. (uab.edu)
In part the endogenous transcription of chemokine genes in melanoma cells is due to altered NF-κB activation. (cancerrealitycheck.com)

PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)
Vitamin C enhances T-lymphocyte production. (livonlabs.com)
Vitamin C enhances cyclic GMP levels in lymphocytes. (livonlabs.com)

Calcium absorption is higher in physiologic states in which there is an increased demand for calcium, such as pregnancy and lactation, suggesting that strontium absorption may also be higher as well. (cdc.gov)

Stimulation of TCRs upon antigen binding triggers downstream signalling pathways which enables various physiological functions of the T cells. (hindawi.com)
Cell proliferation is a very important physiological effect for low power laser irradiation (LPLI) used in clinical practice. (biomedcentral.com)

It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD CompBead to ensure that BD CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. (springer.com)
They facilitate the ability of cells to launch protective cellular defenses. (livonlabs.com)
This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. (420magazine.com)
As described below, these diverse situations range from the complications of diabetes and cellular perturbation in amyloidoses to immune and inflammatory responses and tumor cell behavior. (jci.org)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

Additionally, the failure of the regulatory CD4+ and CD8+ T lymphocytes in alleviating the proinflammatory milieu occurring in SLE is contributory to the pathogenicity of the condition [ 7 , 8 ]. (hindawi.com)
In this brief review, a detailed account of the putative mechanisms by which the normal physiology of T cells are disturbed and why regulatory T cells fail to alleviate proinflammatory response in SLE will be discussed. (hindawi.com)
Proinflammatory mediators as modulators of decidual calcium channel expression and function. (nottingham.ac.uk)

Like an army with many units, your immune system is a complicated defense complex made up of various cells, chemicals, tissues, and organs. (iherb.com)
Vitamin C supports the cell-mediated immune system response. (livonlabs.com)
Some of the primary cells in the immune system concentrate Vitamin C as much as 80 times higher than the level in plasma. (livonlabs.com)
As one would expect, mechanisms that can regulate either BLyS levels or BCR signaling strength can impact B cell destiny and the shape of adaptive immune system. (uab.edu)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

An early on identified take a flight Wingless (Wg) gene, which regulates portion polarity during larval advancement 3, was discovered to be always a WNT1 homolog 4. (icsv20.org)
OMIM 601859),7 including autoimmunity, Chelidonin neutropenia, and elevated B-cell proliferation and quantities, 3 building an attractive applicant gene for human beings Chelidonin with ALPS-like disease PKC. (nibbp2p.org)

We will then examine how tumor cells create a toxic milieu for T cells that enter the TME. (elifesciences.org)
Natural killer cells are lymphocytes that can directly attack cells, like tumor cells, and kill them. (livonlabs.com)

Background: HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. (uni-frankfurt.de)

T cells have been recognized to be crucial in the pathogenicity of SLE through their capabilities to communicate with and offer enormous help to B cells for driving autoantibody production. (hindawi.com)

Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
Human MC were initially divided into three subsets based on the cell surface expression of CD14 and CD16, and recently classified based on CD40 expression ( 2 - 5 ). (frontiersin.org)
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD20 (LT20) APC. (exbio.cz)
Hultin LE, Hausner MA, Hultin PM, Giorgi JV: CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. (exbio.cz)
We observed that CXCR4 forms heteromers with LPA 1 in recombinant HEK293A cells and the human breast cancer cell line MDA-MB-231. (biomedcentral.com)
2) We identified FcγRIIC as a second FcγR on human B cells besides FcγRIIB. (uab.edu)

Histologically, the dermatosis is characterized by hyperproliferation of keratinocytes, impaired epidermal barrier function at the sites of skin lesions, and skin infiltration by activated inflammatory cells [ 5 ]. (springer.com)
Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
The rising evidence signifies that WNT signaling performs an essential function in regulating many natural procedures, including embryonic advancement, tissues maintenance and homoeostasis of stem cells. (icsv20.org)
kelp polysaccharide has an effect on diabetes Mice have the function of lowering blood sugar and protecting islet cells. (pure-plantextract.com)

In addition, my lab studies the process of developmental committment to the B cell lineages, using 7-color flow cytometry on a state-of-the-art 3 laser FACS. (umassmed.edu)

Together with Dr Cath Drummond, I am investigating the ability of cancer cells to shift to drug-tolerant states, allowing their initial survival - and eventual resistance - following treatment with targeted therapies. (otago.ac.nz)

HHcy in Cbs -/- mice reinforced inflammatory features in Ly6C high MC by upregulating inflammatory TFs ( Ets1 and Tbx21 ) and strengthened lymphocytes functional adaptation in Ly6C low MC by increased expression of CD3, DR3, ICOS, and Fos . (frontiersin.org)
HHcy reinforced inflammatory feature in Ly6C high MC and strengthened lymphocytes functional adaptation in Ly6C low MC. (frontiersin.org)
Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)

C3G also significantly increased the level of interleukin (IL)-10 and the regulatory T (Treg) cell proportion, and it decreased the interleukin (IL)-6 and interferon (IFN)-γ levels and CD38+ NK cell proportion in rat peripheral blood and synovial fluid. (biomedcentral.com)

The frequency of CD5 + B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5 + B cells suggest that they may represent a distinct lineage, known as B-1 cells. (southernbiotech.com)
Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed difficult for the "helpless" B cells to become functional enough to trigger SLE-related inflammation. (hindawi.com)
Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells. (hindawi.com)
specifically, evidence showing that cannabinoids inhibit neuroinflammation and that immune cells express the entire machinery that constitutes a functional cannabinoid signaling system. (420magazine.com)

Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)
Its expression on B cells is synchronous with the expression of surface IgM. (exbio.cz)
Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype. (uc.edu)
Understanding how how NF-kappaB regulates expression and repression of the Galphas GTPbinding protein in the myometrium. (nottingham.ac.uk)
In CD38+ NK cells, C3G significantly increased Sirtuin 6 (Sirt6) expression and the tumor necrosis factor (TNF)-α level, and it decreased natural killer group 2D (NKG2D) expression and the IFN-γ level. (biomedcentral.com)
However, when CD38+ NK cells were treated with Sirt6 siRNA, C3G did not change the NKG2D expression, the TNF-α level sharply decreased, and the IFN-γ level increased. (biomedcentral.com)

1993), expressed primarily by immune cells. (420magazine.com)

Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. (uc.edu)

Cell lines and lifestyle EBV-transformed B-cell lines produced from sufferers and regular donors were preserved in RPMI 1640 with 20% fetal leg serum (Gibco), 2mM L-glutamine, penicillin 100 U/mL, and 100 g/mL streptomycin (Gibco) at 37C within a humidified 5% CO2 incubator. (nibbp2p.org)
Cell lines and culture problems COS7 was maintained in Opti MEM with 10% fetal bovine serum in a 5% CO2 incubator. (mirnasynthesis.com)
Mammals start generating B lymphocytes during fetal development and continue to do so throughout life. (umassmed.edu)

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)
Stem Cell Res. (nature.com)

The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
However, the mechanisms of cell proliferation induced by LPLI are poorly understood. (biomedcentral.com)
then we review the studies on the molecular mechanisms of LPLI-induced proliferation since January 1999, which will serve as a reference for the researchers in this field. (biomedcentral.com)

The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line Cancer Cell International. (nottingham.ac.uk)
In hanging drop cultures, BIN 67 cells are capable of forming densely packed spheroids with an irregular but compact margin, that is a feature exhibited by some epithelial ovarian cancer cell lines that happen to be capable of forming tumours in mouse xeno graft selleckchem versions. (mirnasynthesis.com)

Generally in most cell/tissues contexts, WNTs become short-range signaling 23. (icsv20.org)
The light must be absorbed by the endogenous chromophores of cells or tissues for actions. (biomedcentral.com)

In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
In contrast to the cost- and labor-intensive cultivation and propagation of cells such as MSCs or articular chondrocytes, the clinical use of "minimally processed" autologous BMA that can be prepared in the operation room as a single-step procedure appears straightforward. (hindawi.com)

Anatomy45

Organisms16

Diseases9

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Differentiation13

Cytokines6

Apoptosis8

Signal transduction3

Receptor18

Macrophages11

Secretion6

Receptors6

Progression3

Inhibits3

Binding to autoant1

Dendritic cells2

Intracellular3

Induces2

Reported on a subpopulation1

Vitro2

Maturation3

Mesenchymal6

Cytokine1

Thymocytes2

Proteins5

Homeostasis5

Antibody8

Germinal center1

Promotes2

Antibodies3

Processes5

Lymph2

Immunity2

Neutrophil3

Membrane8

Extracellular2

Epithelial cells2

Abnormal3

Protein kinase2

Lymphoid2

Activation9

Enhances3

Physiologic1

Physiological2

Cellular6

Proinflammatory3

Immune system5

Gene2

Tumor cells2

Kinase1

Autoantibody1

Human7

Function4

Cytometry1

Survival1

Inflammatory3

Peripheral blood1

Functional4

Expression6

19931

Systemic Lupus Erythem1

Fetal3

Stem2

Mechanisms4

Ovarian cancer cell2

Tissues2

MSCs2