• The cause of the rare condition of tumoral calcinosis is not entirely understood. (wikipedia.org)
  • Hyperphosphatemic familial tumoral calcinosis (HFTC) is a condition characterized by an increase in the levels of phosphate in the blood (hyperphosphatemia) and abnormal deposits of phosphate and calcium (calcinosis) in the body's tissues. (medlineplus.gov)
  • These include calcinosis cutis circumscripta, calcinosis cutis universalis, tumoral calcinosis, and transplant-associated calcinosis cutis. (medscape.com)
  • Uremic tumoral calcinosis (UTC) is a form of metastatic tissue calcification unique to dialysis patients, manifesting with amorphous and cystic masses containing calcium phosphate deposits in periarticular soft tissue. (springer.com)
  • Surgical removal of the destructive cervical spine lesion, showing typical tumoral calcinosis on histology, completely resolved the clinical symptoms. (springer.com)
  • Cofan F, Garcia S, Combalia A et al (1999) Uremic tumoral calcinosis in patients receiving longterm hemodialysis therapy. (springer.com)
  • Hamada J, Tamai K, Saotome K et al (2006) Uremic tumoral calcinosis in hemodialysis patients: clinicopathological findings and identification of calcific deposits. (springer.com)
  • Chu HY, Chu P, Lin SH et al (2011) Uremic tumoral calcinosis in patients on peritoneal dialysis: clinical, radiographic, and laboratory features. (springer.com)
  • Möckel G, Buttgereit F, Perka C et al (2005) Tumoral calcinosis revisited: pathophysiology and treatment. (springer.com)
  • Fernández E, Amoedo ML, Montoliu J et al (1993) Tumoral calcinosis in haemodialysis patients without severe hyperparathyroidism. (springer.com)
  • Matsukado K, Amano T, Nagata S et al (2001) Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy-case report. (springer.com)
  • Carlson AP, Yonas HM, Turner PT (2007) Disorder of tumoral calcinosis of the spine: illustrative case study and review of literature. (springer.com)
  • Remy-Leroux V, Reguiaï Z, Bernard P et al (2009) Tumoral calcinosis at an unusual site in a haemodialysis patient. (springer.com)
  • Hematoxylin-eosin (H&E)-stained sections may not allow proper evaluation of birefringence properties of the crystals in the lesions of pseudogout, gout, and tumoral calcinosis. (nih.gov)
  • None of the three sections from two cases of tumoral calcinosis showed birefringence with either stain. (nih.gov)
  • However, polarizing microscopy of sections stained with NAES method allowed demonstration of CPPD crystals with positive birefringence in pseudogout, MSU crystals with negative birefringence in gout, and calcium hydroxyapatite crystals without birefringence in tumoral calcinosis. (nih.gov)
  • Tumoral Calcinosis is a condition consisting of massive subcutaneous deposits of calcium salts often overlying large joints in otherwise healthy patients. (ajol.info)
  • To describe the characteristics of a series of patients with Tumoral Calcinosis in the Gurage Zone of Central Ethiopia. (ajol.info)
  • Tumoral calcinosis is more common in blacks of South African heritage. (medscape.com)
  • Tumoral calcinosis usually arises in the first or second decade of life. (medscape.com)
  • In this episode, we review the high-yield topic of Tumoral Calcinosis from the Pathology section. (orthohub.xyz)
  • Familial tumoral calcinosis (FTC) is a severe metabolic disorder characterised by the progressive deposition of calcified masses in cutaneous and subcutaneous tissues, which results in painful ulcerative lesions with severe skin and bone infections. (exeterlaboratory.com)
  • In this article, the CT, three-dimensional CT, and MR findings are reviewed in a 59-year-old woman with tumoral calcinosis involving the temporomandibular joint. (elsevierpure.com)
  • Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and aKlotho). (childrensmercy.org)
  • Biopsy showed features suggestive of tumoral calcinosis. (msjonline.org)
  • Tumoral calcinosis is a distinct clinico-radiopathological entity characterised by soft tissue periarticular calcinosis which mimics a true neoplasm, associated with elevated levels of serum phosphate. (msjonline.org)
  • Tumoral Calcinosis-un recongnized disease. (msjonline.org)
  • Inclan A, Leon P, Camejo MG. Tumoral calcinosis. (msjonline.org)
  • Tumoral calcinosis: pearls, polemics, and alternative possibilities. (msjonline.org)
  • Slavin RE, Wen J, Barmada A. Tumoral calcinosis -a pathogenetic overview: a histological and ultrastructural study with a report of two new cases, one in infancy. (msjonline.org)
  • Narchi H. Hyperostosis with hyperphosphatemia: evidence of familial occurrence and association with tumoral calcinosis. (msjonline.org)
  • Genetic transmission of tumoral calcinosis: autosomal dominant with variable clinical expressivity. (msjonline.org)
  • Tumoral calcinosis: Evidence for concurrent defects in renal tubular phosphorus transport and in 1α, 25-dihydroxycholecalciferol synthesis. (msjonline.org)
  • Phosphorus excretion in tumoral calcinosis: response to parathyroid hormone and acetazolamide. (msjonline.org)
  • Fathi I, Sakr M. Review of tumoral calcinosis: a rare clinico-pathological entity. (msjonline.org)
  • Calcinosis cutis is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. (medscape.com)
  • Solitary milialike idiopathic calcinosis cutis: a case unassociated with Down syndrome. (medscape.com)
  • Sais G, Jucglà A, Moreno A, Peyrí J. Milia-like idiopathic calcinosis cutis and multiple connective tissue nevi in a patient with Down syndrome. (medscape.com)
  • Idiopathic scrotal calcinosis is a rare, benign entity seen in the scrotum, comprised of calcified nodules, and some areas show foreign body-type granulomatous reaction. (utoronto.ca)
  • Some believe that calcinosis seen in this lesion is not idiopathic calcification, but rather dystrophic calcification, perhaps related to an epidermal cyst that preceded the lesion. (utoronto.ca)
  • The most common type of calcinosis is dystrophic calcification. (wikipedia.org)
  • In secondary scrotal calcinosis, the causes are identified as calcification of epidermal cysts, calcific degeneration of the dartos muscle, and dystrophic calcification of subcutaneous soft tissue secondary to chronic inflammation or infection. (patientcareonline.com)
  • DYSTROPHIC CALCINOSIS CUTIS - Dystrophic calcinosis cutis, the most common form of calcinosis cutis, results from local tissue injury. (medilib.ir)
  • Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
  • Although early reports documenting poor wound healing and sinus track formation led to the historical avoidance of surgical procedures for dystrophic calcinosis cutis, subsequent reports suggest that surgery can be effective for some patients. (medilib.ir)
  • Dystrophic calcinosis cutis is most common. (medscape.com)
  • Marzano AV, Kolesnikova LV, Gasparini G, Alessi E. Dystrophic calcinosis cutis in subacute lupus. (medscape.com)
  • Dystrophic calcinosis cutis has also been reported. (wikipedia.org)
  • The pathogenesis of scrotal calcinosis largely remains unknown. (patientcareonline.com)
  • Santos and Sarma 2 proposed primary and secondary classifications of scrotal calcinosis. (patientcareonline.com)
  • In primary scrotal calcinosis, there is no definite cause. (patientcareonline.com)
  • Shah and Shet 3 summarized the events leading to the formation of scrotal calcinosis. (patientcareonline.com)
  • They examined 14 cases and concluded that scrotal calcinosis results from calcification of hair follicles and epidermal cysts. (patientcareonline.com)
  • Most patients with scrotal calcinosis are asymptomatic. (patientcareonline.com)
  • Surgical excision of the lesions helps confirm the diagnosis of scrotal calcinosis and is the mainstay of treatment for cosmesis. (patientcareonline.com)
  • Saladi RN, Persaud AN, Phelps RG, Cohen SR. Scrotal calcinosis: is the cause still unknown? (patientcareonline.com)
  • Scrotal calcinosis: primary and secondary. (patientcareonline.com)
  • Shah V, Shet T. Scrotal calcinosis results from calcification of cysts derived from hair follicles: a series of 20 cases evaluating the spectrum of changes resulting in scrotal calcinosis. (patientcareonline.com)
  • Scleroderma / CREST syndrome (calcinosis cutis, Raynaud phenomena, esophageal dysfunction, sclerodactyly, and telangiectasia) is the most common overlap syndrome resulting in sclerodermatomyositis. (medpagetoday.com)
  • Calcinosis cutis universalis occurs in the second decade of life. (medscape.com)
  • Calcinosis cutis universalis with joint contractures complicating juvenile dermatomyositis. (medscape.com)
  • Tristano AG, Villarroel JL, Rodriguez MA, Millan A. Calcinosis cutis universalis in a patient with systemic lupus erythematosus. (medscape.com)
  • Data was collected from 59 patients who presented with clinical diagnosis of calcinosis cutis around hip region between January 2005 and January 2009. (ajol.info)
  • The diagnosis and evaluation of patients with calcinosis cutis is discussed separately. (medilib.ir)
  • To further complicate the terminology, some people with diffuse disease will go on to develop calcinosis and telangiectasias so that they also have the features of CREST. (scleroderma.org)
  • Calcinosis cutis circumscripta tends to arise in the second half of life. (medscape.com)
  • Calcinosis circumscripta, a more localized form of calcium deposition in the skin, can occur on pressure points such as the paws and elbows, at suture sites, and on the tongue, but has different underlying causes than calcinosis cutis. (dermvetolympia.com)
  • Additionally, dogs that are suffering from Cushing's Disease can develop calcinosis cutis if their disease is not well controlled. (dermvetolympia.com)
  • Calcinosis is the formation of calcium deposits in any soft tissue. (wikipedia.org)
  • Calcinosis typically develops in early childhood to early adulthood, although in some people the deposits first appear in infancy or in late adulthood. (medlineplus.gov)
  • Calcinosis cutis is a term used to describe a group of disorders in which calcium deposits form in the skin. (medscape.com)
  • Clinical follow-up without intervention to reduce calcium deposits is a reasonable option for calcinosis cutis that is asymptomatic, nonprogressive, unassociated with internal involvement, and of minimal concern to the patient. (medilib.ir)
  • Tumour calcinosis is a rare clinical and histopathological syndrome characterised by deposition of calcium deposits in different periarticular soft tissue regions of the body. (msjonline.org)
  • INTRODUCTION - The term "calcinosis cutis" describes the deposition of insoluble calcium salts in the skin and subcutaneous tissue. (medilib.ir)
  • A radiograph of the elbow showed no fracture, but calcifications overlying the extensor surfaces of the articulation and the forearm, related to a subcutaneous calcinosis. (panafrican-med-journal.com)
  • Subcutaneous calcinosis results from the deposition of calcium hydroxyapatite crystals and other calcium salts. (panafrican-med-journal.com)
  • Calcinosis cutis occurs when calcium crystals are abnormally deposited in the skin. (dermvetolympia.com)
  • Calcinosis cutis is an uncommon disorder characterized deposition of crystals of calsium phosphate (hydroxyapatite) in the skin in various areas of the body. (biomedcentral.com)
  • Calcinosis cutis is an uncommon disorder which results in progressive deposition of insoluble calsium salts (crystals of calcium phosphate, hydroxyapatite) in the skin. (biomedcentral.com)
  • Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
  • See "Calcinosis cutis: Etiology and patient evaluation" . (medilib.ir)
  • Bivariate analysis was used to test for associations of 94 clinical, demographic, and laboratory factors with two long-term outcomes: a higher Myositis Damage Index (MDI) and the presence of calcinosis on last evaluation. (acrabstracts.org)
  • Juvenile myositis (JDM) diagnosed >5 years from screening or juvenile myositis with extensive calcinosis or severe calcinosis. (who.int)
  • The pathogenesis of calcinosis cutis is not completely understood and a variety of factors allow for different clinical scenarios to occur. (medscape.com)
  • Calcinosis usually occurs in and just under skin tissue around the joints, most often the hips, shoulders, and elbows. (medlineplus.gov)
  • Rarely, calcinosis occurs in blood vessels or in the brain and can cause serious health problems. (medlineplus.gov)
  • Tumoural calcinosis (TC) is a rare disorder characterized by nonneoplastic amorphous calcium deposition that tends to occur in soft tissues around the large joint. (biomedcentral.com)
  • Surgery - Surgical removal of calcinosis may be useful for patients with discrete, symptomatic areas of calcinosis cutis as the primary treatment or as an adjunct to medical therapy. (medilib.ir)
  • Duration of therapy - Patients who respond to systemic pharmacologic therapies for calcinosis cutis are often maintained on continuous or intermittent treatment for months to years in an attempt to reduce risk for recurrence of disease. (medilib.ir)
  • Calcinosis was present in 55% of patients. (acrabstracts.org)
  • We were able to identify multiple clinical factors associated with long-term damage and calcinosis when JIIM patients become of adult age, which included specific cutaneous and musculoskeletal features. (acrabstracts.org)
  • Miteva L, Pramatarov K, Vassileva S. Calcinosis cutis in childhood systemic lupus erythematosus. (medscape.com)
  • Extensive calcinosis cutis with systemic lupus erythematosus. (medscape.com)
  • Bullous systemic lupus erythematosus with milia and calcinosis. (medscape.com)
  • Calcinosis may also develop in the soft tissue of the feet, legs, and hands. (medlineplus.gov)
  • Calcinosis cutis is definitively diagnosed using a biopsy (a sample of tissue taken and submitted to a pathologist for analysis). (dermvetolympia.com)
  • In all cases of calcinosis cutis, insoluble compounds of calcium are deposited within the skin due to local and/or systemic factors. (medscape.com)
  • AJOU Open Repository: Obesity and calcinosis cutis: characteristic early signs of infantile pseudohypoparathyroidism. (ajou.ac.kr)
  • Juvenile dermatomyocitis with calcinosis received an Award of Excellence in the Biomedical catagory in BioImages 2021. (bca.org)
  • Calcinosis cutis lesions commonly appear on the skin as bumps or flat raised areas (papules or plaques) with gritty yellow, white, or grey granules. (dermvetolympia.com)
  • The lesions are commonly surrounded by reddened skin, because calcinosis cutis often causes inflammation. (dermvetolympia.com)
  • Because calcinosis cutis are not always well defined, a recurrence of the lesions may occur. (biomedcentral.com)
  • A better understanding of the process of calcinosis cutis will lead to therapies to improve patient morbidity. (biomedcentral.com)
  • lipodystrophy and, as in the example here, calcinosis - hard calcium lumps under the skin or muscle. (bca.org)
  • Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease. (nih.gov)
  • Tumoural calcinosis (TC) is a rare benign disease that was first named by Inclan and Leon in 1943 [ 1 ]. (biomedcentral.com)
  • Do the signs and symptoms of calcinosis cutis warrant treatment? (medilib.ir)
  • Decision to treat - Consideration of the severity of the signs and symptoms of calcinosis cutis is important because the response to treatment is variable and unpredictable, and there is risk for treatment-related adverse effects. (medilib.ir)