DiseasesChemicals and Drugs
MexiletineCaffeinePropylaminesAnti-Arrhythmia AgentsMyotoniaDisopyramideSodium Channel BlockersTocainideVoltage-Gated Sodium Channel BlockersPropafenoneMedigoxinSodium ChannelsCentral Nervous System Stimulants
TheophyllineQuinidineDosesHepaticAspirinMetabolitesAcetaminophenAnalgesicGastrointestinal tractPropylene glycolGuaranaCardiacBitter tasteInsomniaToxicityMetabolismConsumingOralMonographCiprofloxacinWorsenMedicinal productsEffectBeveragesCombination ProductsFoodClearanceDurationSmallPatientsBloodSupplementsHighCentral nervouMedicinesHoursAffectEffectsPreparationMonitorSubstituteSimilarLevelsTreatmentDrugCurrent
Theophylline2
  • Guarana also contains theophylline and theobromine, which are chemicals similar to caffeine. (medlineplus.gov)
  • CYP1A2 inhibition can cause alteration of the metabolism of many important drugs like theophylline, clozapine, olanzapine, and caffeine [27]. (researchgate.net)
Quinidine2
  • Mexiletine is a Class 1B antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide. (nih.gov)
  • The antiarrhythmic effect of mexiletine has been established in controlled comparative trials against placebo, quinidine, procainamide and disopyramide. (nih.gov)
Doses4
  • Doses containing more than 400 mg of caffeine daily have been linked to side effects. (medlineplus.gov)
  • There is a concern that high doses of caffeine might cause seizures or decrease the effects of drugs used to prevent seizures. (medlineplus.gov)
  • Mexiletine hydrochloride, at doses of 200-400 mg q8h, produced a significant reduction of ventricular premature beats, paired beats, and episodes of non- sustained ventricular tachycardia compared to placebo and was similar in effectiveness to the active agents. (nih.gov)
  • Symptomatic GI disturbances occur in 2-10% of healthy individuals receiving normal doses of aspirin-containing products for analgesia or fever and 30-90% of patients with preexisting peptic ulcer gastritis or duodenitis. (wellrx.com)
Hepatic1
  • Since approximately 90% of mexiletine hydrochloride is metabolized in the liver into inactive metabolites, pathological changes in the liver can restrict hepatic clearance of mexiletine hydrochloride and its metabolites. (nih.gov)
Aspirin2
Metabolites1
  • Caffeine and its metabolites especially paraxanthine readily cross the blood-brain barrier to sit on adenosine receptors to inhibit adenosine from functioning, which leads to enhanced mental alertness, diminished fatigue and improved motor coordination. (caasn.com)
Acetaminophen1
Analgesic4
  • Another interesting effect of caffeine on the brain is its analgesic effect . (caasn.com)
  • Although the analgesic effect of caffeine is not significant, it may help athletes reduce the perception of effort during exercise. (caasn.com)
  • Caffeine is included in many nonprescription products to enhance analgesic efficacy. (wellrx.com)
  • Although some data indicate that caffeine may increase bioavailability of certain analgesics, caffeine does not have intrinsic analgesic properties. (wellrx.com)
Gastrointestinal tract2
  • Caffeine is rapidly absorbed from the gastrointestinal tract. (caasn.com)
  • Mexiletine is well absorbed (~90%) from the gastrointestinal tract. (nih.gov)
Propylene glycol1
  • Propylene Glycol is, therefore, a good ingredient in any cosmetic or personal care product for hydrating your skin and resolving your dryness and dullness issues with the skin. (shreejipharmainternational.com)
Guarana11
Cardiac3
  • In patients with normal conduction systems, mexiletine has a minimal effect on cardiac impulse generation and propagation. (nih.gov)
  • Hemodynamic studies in a limited number of patients, with normal or abnormal myocardial function, following oral administration of mexiletine hydrochloride, have shown small, usually not statistically significant, decreases in cardiac output and increases in systemic vascular resistance, but no significant negative inotropic effect. (nih.gov)
  • Mild depression of myocardial function, similar to that produced by lidocaine, has occasionally been observed following intravenous mexiletine therapy in patients with cardiac disease. (nih.gov)
Bitter taste1
  • Having a bitter taste, caffeine is mainly extracted from the plant Caffea Arabica (coffee bean). (caasn.com)
Insomnia1
Toxicity1
  • In animal studies, mexiletine has been shown to be effective in the suppression of induced ventricular arrhythmias, including those induced by glycoside toxicity and coronary artery ligation. (nih.gov)
Metabolism2
  • Since caffeine is metabolized by the enzyme complex of Cytochrome P450 isoenzyme CYP1A2 in the liver, any factors that affect activity of Cytochrome P450 will impact the metabolism of caffeine. (caasn.com)
  • Mexiletine is mainly metabolized in the liver, the primary pathway being CYP2D6 metabolism, although it is also a substrate for CYP1A2. (nih.gov)
Consuming2
  • Consuming more than 300 mg of caffeine daily has been linked to an increased risk of miscarriage and other negative effects. (medlineplus.gov)
  • Consuming caffeine used to be banned in sports and if the concentration of caffeine metabolite in urine was more than 12 mcg/ml, the athlete was accused of doping! (caasn.com)
Oral2
  • Acceptable dosage forms for oral use are indicated in the dosage form drop-down list of the web-based Product Licence Application form for Compendial applications. (gc.ca)
  • caffeine is an oral combination preparation used for the temporary relief of pain of headache (including migraine), sinusitis (e.g., sinus congestion), common cold (e.g., nasal congestion), myalgia, dysmenorrhea, dental pain (e.g., toothache), and minor arthritis pain. (wellrx.com)
Monograph2
  • This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. (gc.ca)
  • This monograph does not apply to caffeine added to food. (gc.ca)
Ciprofloxacin1
  • Although ciprofloxacin can be taken with meals that include milk, you should not take ciprofloxacin with dairy products alone or with calcium-fortified products. (medbroadcast.com)
Worsen1
  • Some research suggests that caffeine may affect the way the body uses sugar and might worsen diabetes. (medlineplus.gov)
Medicinal products1
  • Veterinary medicinal products containing clorsulon are currently marketed in the EU for the treatment of cattle. (shreejipharma.net)
Effect3
  • However, this effect might be less in people who consume caffeine regularly. (medlineplus.gov)
  • Decreased fatigue and drowsiness and enhanced alertness and wakefulness come from the stimulating effect of caffeine on the brain. (caasn.com)
  • Effect of mexiletine on the mutated constructs. (bioz.com)
Beverages1
  • Caffeine is regulated as a food additive when it is added to foods, including beverages, chewing gum, and bars. (gc.ca)
Combination Products1
Food6
Clearance2
  • When the activity of this enzyme complex is diminished, the clearance rate of caffeine is also decreased, causing " caffeine high " to last longer. (caasn.com)
  • On the other hand, when the activity of the enzyme complex is increased, the clearance rate of caffeine is also increased, causing " caffeine high " to last for a short period. (caasn.com)
Duration1
  • Mexiletine did not prolong ventricular depolarization (QRS duration) or repolarization (QT intervals) as measured by electrocardiography. (nih.gov)
Small1
  • Even though caffeine can enter into the blood stream through mucosal membranes of the mouth and stomach, most of the absorption takes place in the small intestine. (caasn.com)
Patients2
  • Caffeine containing herb: should not be taken by patients on Monoamine oxidase inhibitors such as isocarboxazid, phenelzine, tranylcypromine as it may cause hypertensive reactions. (naturaloptions.co.za)
  • Follow-up of patients from the controlled trials has demonstrated continued effectiveness of mexiletine in long-term use. (nih.gov)
Blood3
  • Caffeine has been shown to reduce blood flow to the heart muscle during exercise which might lead to cardiovascular complications such as chest pain, and irregular heartbeat even in healthy individuals. (gc.ca)
  • Interestingly, 99% of caffeine is absorbed into the body and reaches to maximum concentration in the blood within 1 hour. (caasn.com)
  • Depending on factors such as obesity, pregnancy, use of birth control pills, smoking, altitude etc, the half life of caffeine is between 2 and 8 hours, which means it takes about 2 to 8 hours for caffeine to decease by 50% in the blood. (caasn.com)
Supplements1
  • These products were copied to the dietary supplements section. (cdc.gov)
High1
  • High intake of caffeine can cause sleep problems, irritability, and increased bowel activity in breastfed infants. (medlineplus.gov)
Central nervou1
  • Caffeine works by stimulating the central nervous system, heart, and muscles. (medlineplus.gov)
Medicines1
  • The NCHS staff created product codes for these medicines. (cdc.gov)
Hours1
  • In normal subjects, the plasma elimination half-life of mexiletine is approximately 10-12 hours. (nih.gov)
Affect2
  • Caffeine passes into breast milk and can affect a nursing infant. (medlineplus.gov)
  • Contrary to public beliefs, caffeine does not affect the brain directly. (caasn.com)
Effects3
  • Sedative effects of benzodiazepines, zopiclone, barbiturate pentobarbital are reduced by caffeine. (naturaloptions.co.za)
  • Caffeine demonstrates ergogenic effects and alertness enhancing activities―the two properties sought by public and athletes. (caasn.com)
  • The potential ergogenic effects of caffeine have always interested athletes and sports nutritionists. (caasn.com)
Preparation1
  • Depending on preparation, one cup of brewed coffee has about 80 to 140 mg of caffeine, brewed tea about 60 to 80 mg and caffeinated soft drinks about 40 to 60 mg. (caasn.com)
Monitor2
  • If you are nursing, closely monitor caffeine intake to make sure it is on the low side. (medlineplus.gov)
  • As of January 01, 2018, one of the two major changes in the prohibited list of substances in sports is that WADA (World Anti-Doping Agency) has placed caffeine in the " watch list ", which means they will monitor the pattern of its misuse in sports. (caasn.com)
Substitute2
  • This product is not intended as a substitute for sleep (Berardi et al. (gc.ca)
  • The information in LiverTox is not meant as a substitute for FDA approved product labeling and professional judgment in the diagnosis and treatment of drug induced liver injury. (nih.gov)
Similar1
  • Mexiletine hydrochloride is a local anesthetic, antiarrhythmic agent, structurally similar to lidocaine, but orally active. (nih.gov)
Levels3
Treatment3
  • Theoretically, therefore, mexiletine may be useful in the treatment of ventricular arrhythmias associated with a prolonged QT interval. (nih.gov)
  • Tolsura (itraconazole) is not indicated for the treatment of onychomycosis and is not interchangeable or substitutable with other itraconazole products. (dokumen.tips)
  • Excedrin(R) Extra Strength was the first OTC product to be FDA approved for the treatment of migraines. (wellrx.com)
Drug1
  • When using the search box, include the name of the drug substance rather than the name of the drug product or the proprietary name. (fda.gov)
Current3
  • Mexiletine, like lidocaine, inhibits the inward sodium current, thus reducing the rate of rise of the action potential, Phase 0. (nih.gov)
  • A ) Representative current traces of mutated channels recorded after mexiletine incubation in response to a depolarizing stimulus at −20 mV in HEK293 cells expressing the constructs as indicated: WT in black (for reference), p.A344S in blue, p.N347K in green, and p.D349N in red. (bioz.com)
  • B ). Scattered plot showing the distribution of the current density values obtained in absence (filled symbols) and in presence (empty symbols) of mexiletine. (bioz.com)