• APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F: Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
  • BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
  • The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MGSA-α). (wikidoc.org)
  • The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
  • Astrocyte-derived chemokine C-C motif ligand 20 (CCL20) was identified using cytokine arrays, and its role in glioblastoma development was evaluated in orthotopic xenografts. (cancerindex.org)
  • Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikidoc.org)
  • CXCL12 (over-)expressing cancers might not sense the CXCL12 gradient released from the metastasis target tissues since the receptor, CXCR4, is saturated with the ligand produced in an autocrine manner. (wikidoc.org)
  • According to a gene enrichment study, XCR1 enhanced immune system performance by promoting T-cell infiltration through the C-X-C Motif Chemokine Ligand 9 (CXCL9)- C-X-C Motif Chemokine Receptor 3 (CXCR3) axis. (bvsalud.org)
  • The receptors are members of the seven-transmembrane G protein-coupled receptor family. (lookformedical.com)
  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
  • Over the past thirty years, the importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs) has been increasingly recognized. (bvsalud.org)
  • In the results of microarray using back skin obtained from animals, we found that S. lappa 's properties are closely associated with cytokine-cytokine receptor interaction and the JAK-STAT signaling pathway. (molcells.org)
  • They are grouped into one family because the receptor complex of each cytokine contains two (IL-6 and IL-11) or one molecule (all others cytokines) of the signaling receptor subunit gp130. (antibodies-online.cn)
  • Our findings revealed that 170 genes were correlated with cytokine production and inflammatory cell activation, as determined by GO and KEGG analyses. (bvsalud.org)
  • Interleukin-23 receptor is a type I cytokine receptor . (wikidoc.org)
  • Mechanistically, the CCL20/CCR6 signaling pathway upregulates HIF-1α by stimulating nuclear factor kappa B-driven transactivation of the HIF1A gene. (cancerindex.org)
  • Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes, including host homeostasis and responses to disease. (bvsalud.org)
  • The protein encoded by this gene is a subunit of the receptor for IL-23 . (wikidoc.org)
  • S. lappa decreased the immunoglobulin E, cytokines and chemokines with the reduction in histopatholgical features of atopic dermatitis (AD) lesion. (molcells.org)
  • In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. (antibodies-online.cn)
  • It has specificity for CCR2 RECEPTORS. (lookformedical.com)
  • These findings suggest that differentially expressed genes, including Ptgs2, Tlr4, and Ccr2 may play crucial roles in the neuroinflammation of IS, and their expression may be negatively regulated by miR-202-3p. (bvsalud.org)
  • Chemokines and their receptors play an important role in immune monitoring and immune defense during tumor growth and metastasis. (bvsalud.org)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • In this work, we screened all chemokine receptors in pan-cancer and discovered X-C Motif Chemokine Receptor 1 (XCR1) as a reliable immunological and prognostic biomarker in pan-cancer using bioinformation. (bvsalud.org)
  • Therefore, candidate for treating AD need to identify target molecule exerting its curative effects throughout a gene analysis. (molcells.org)
  • CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
  • The targeted genes and miRNA molecule were clarified using the mice middle cerebral artery occlusion-reperfusion (MCAO/R) model. (bvsalud.org)
  • This protein pairs with the receptor molecule IL-12Rβ1 ( IL12RB1 ), together forming the IL-23 receptor complex, and both are required for IL-23 signaling. (wikidoc.org)
  • ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
  • In 1995, HIV- interactions with other host genes. (cdc.gov)
  • One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. (cdc.gov)
  • Pre- hematopoietic and other cells, but the Duffy sence of one copy of the deleted CCR5 gene also antigen of erythrocytes (DARC) is the only influences the course of disease as the onset of member expressed on cells of erythroid lineage. (cdc.gov)
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
  • The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
  • CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells . (wikidoc.org)
  • Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells . (wikidoc.org)
  • Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikidoc.org)
  • We screened differentially expressed genes (DEGs) using GEO2R and analyzed 170 differentially expressed intersection genes for Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and Gene Ontology (GO) analysis. (bvsalud.org)
  • Alternatively spliced transcript variants that encode the same protein have been described for this gene. (cancerindex.org)
  • Three variants in the IL23R gene have been shown to protect against Crohn's disease and ulcerative colitis . (wikidoc.org)
  • TGF-α is related to EGF and binds to the EGF receptor, whereas TGF-β is structurally distinct from TGF-α. (antibodies-online.cn)
  • The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
  • The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states, including, among others, coronavirus disease 2019 (COVID-19). (bvsalud.org)
  • In this study, we have confirmed the S. lappa 's anti-atopic properties in Nc/Nga mice and investigated the candidate gene related with its properties using microarray. (molcells.org)
  • We found that of S. lappa extract reduced the expression of genes related to allergy metabolism in Nc/Nga mice. (molcells.org)
  • In humans, this protein is encoded by the Cxcl1. (wikidoc.org)
  • C-X-C chemokine receptor type 4 ( CXCR-4 ) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene . (wikidoc.org)
  • [8] The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. (wikidoc.org)
  • Human CXCL1 genome location and CXCL1 gene details page in the UCSC Genome Browser . (wikidoc.org)
  • Microarray analysis is a molecular technique that enables the parallel analysis of expression by a very large number of genes encompassing a significant fraction of the human genome. (molcells.org)
  • The role of genes ceptibility to HIV infection and the course of HIV of the human leukocyte antigen (HLA) system in disease. (cdc.gov)
  • Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
  • CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst , a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation . (wikidoc.org)
  • IL23R is the name of its human gene . (wikidoc.org)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity. (bvsalud.org)
  • A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. (lookformedical.com)
  • We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. (cdc.gov)
  • Studies of the effect of host genes on sus- million people, including 300,000 children under ceptibility to HIV infection were facilitated by the 5 years of age. (cdc.gov)
  • Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
  • Before the discovery of the role of chemokine disease is expected to increase. (cdc.gov)
  • Plerixafor (AMD3100) is a drug, approved for routine clinical use, [7] which directly blocks the CXCR4 receptor. (wikidoc.org)
  • To address this knowledge gap, conducted a study using Gene Set Enrichment Analysis (GSEA) on two gene expression profiles, GSE58720 and GSE202659, downloaded from the GEO database. (bvsalud.org)
  • In addition, STARD12/14 could regulate the ferroptosis related genes. (medsci.org)
  • The levels of the receptor decrease as neurons mature. (wikidoc.org)
  • We determined the target gene using real time PCR in in vitro experiment. (molcells.org)