Coup transcription factor ii. Medical search. Frequent questions

Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS. (nih.gov)
Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. (nih.gov)
2. COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. (nih.gov)
12. COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1. (nih.gov)
13. Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus. (nih.gov)
16. Orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) protein negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation through suppressing runt-related gene 2 (Runx2) activity. (nih.gov)
20. Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse cerebellum. (nih.gov)
A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. (nih.gov)
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) regulates adult RT function and is expressed in the mesenchyme of the embryonic gonad and mesonephros. (nih.gov)
Transcription factor Sp1 regulates mitotic chromosome assembly and segregation. (nih.gov)
Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (umassmed.edu)

Translational importance is suggested by Cancer Methylome System (CMS) analysis revealing that breast tumors have increased COUP-TFII (NR2F2) promoter and gene methylation versus normal breast. (nih.gov)
The Shh/VEGF/Notch pathway is critical for arterial specification, while the orphan receptor nr2f2 (COUP-TFII) has been implicated in venous specification. (nih.gov)
Mechanistically, we demonstrate that BCL11A may mediate Schwann cell activity through binding to the promoter of nuclear receptor subfamily 2 group F member 2 (Nr2f2) and regulating Nr2f2 expression. (bvsalud.org)

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. (wikipedia.org)
Percent identity values were calculated for the principal insulin promoter (-300 to + 1) and 50-bp windows further upstream to -600 bp from the start of transcription. (medscape.com)
8. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. (nih.gov)
9. Chicken ovalbumin upstream promoter transcription factor II in human breast carcinoma: possible regulator of lymphangiogenesis via vascular endothelial growth factor-C expression. (nih.gov)
14. Decreased chicken ovalbumin upstream promoter transcription factor II expression in tamoxifen-resistant breast cancer cells. (nih.gov)
15. Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury. (nih.gov)
COUP-TFII represses the expression of a number of proadipogenic factors in adipocytes, with direct action noted at the CAAT enhancer-binding protein α promoter. (elsevierpure.com)
COUP-TFs have been shown to inhibit the transactivation of HNF4 due to mutually exclusive binding to the promoter of many genes. (guidetopharmacology.org)
In addition, COUP-TF activates transcription through protein-protein interaction with DNA-bound factor, such as with HNF-4 in the HNF-1a gene promoter. (guidetopharmacology.org)
COUP-TFs directly inhibits MHC Class I expression via interaction with the R2 promoter element and recruitment of the NCoR and HDACs. (guidetopharmacology.org)
COUP-TFII stimulates the transcriptional activity of the rat cholesterol 7a-hydroxylase (CYP7A) promoter by binding to the nucleotide sequence located between 74 and 54 (relative to the transcription start site), which contains a direct repeat of two hormone response element half-sites separated by 4 nucleotides. (guidetopharmacology.org)
Your body, from protein chief, Drug and activity of chicken ovalbumin upstream promoter transcription factor I (COUP-TF1), which itself is coactivated by the small ubiquitin-related modifier-1 (SUMO-1) conjugase and ligase Ubc9 and PIAS1 (79). (sideload.com)
Drosophila protein ultraspiracle (usp) (or chorion factor 1), which binds to the promoter region of s15 chorion gene. (expasy.org)
A COUP transcription factor that was originally identified as a homodimer that binds to a direct repeat regulatory element in the chicken albumin promoter. (lookformedical.com)
Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) and steroidogenic factor-1 (SF-1) play key roles in the transcriptional regulation of steroidogenic P450 genes. (elsevierpure.com)
Transfection studies showed that SF-1 activated bovine CYP17 promoter activity, whereas COUP-TFs repressed it from the CRS2 element in a mutually exclusive manner in mouse adrenocortical Y-1 cells. (elsevierpure.com)
COUP-TFI and SF-1 competitively bind to the Ad5 element of the human CYP11B2 gene promoter. (elsevierpure.com)
Unexpectedly, overexpression of COUP-TFI increased the CYP11B2 promoter activity, whereas overexpression of SF-1 repressed it in human adrenocortical H295R cells. (elsevierpure.com)
19112178 . RA Zhang L. J., Liu X., Gafken P. R., Kioussi C., Leid M. RT A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8). (genexplain.com)
This transcription activity did not occur without the hormone progesterone, and occurred concurrently with specific progesterone response elements (PRE) binding to the progesterone receptor, thus forming a PRE-driven promoter. (readabstracts.com)
Guti?rrez J, Sierra J, Medina R, Puchi M, Imschenetzky M, van Wijnen A, Lian J, Stein G, Stein J, Montecino M. Interaction of CBF alpha/AML/PEBP2 alpha transcription factors with nucleosomes containing promoter sequences requires flexibility in the translational positioning of the histone octamer and exposure of the CBF alpha site. (umassmed.edu)

It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL . (nih.gov)
The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. (nih.gov)
It has been demonstrated that COUP-TFs repress the hormonal induction of target genes by PPAR, VDR, TR, and RAR in transient transfection assays through direct competition with VDR, TR, and RAR for the available binding sites. (guidetopharmacology.org)
Hepatocyte nuclear factor 4 (HNF-4), which binds to DNA sites required for the transcription of the genes for alpha-1-antitrypsin, apolipoprotein CIII and transthyretin. (expasy.org)
Human estrogen receptor related genes 1 and 2 (err1 and err2). (expasy.org)
To identify host factors that support the HBV life cycle, we previously established the HC1 cell line that maintains HBV infection and identified host genes required for HBV persistence. (inrae.fr)

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. (wikipedia.org)
Kruppel-like factor 1-GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo. (nih.gov)
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. (nih.gov)
Apolipoprotein AI regulatory protein-1 (ARP-1), required for the transcription of apolipoprotein AI. (expasy.org)
1] Gronemeyer H., Laudet V. Protein Prof. 2:1173-1308(1995). (expasy.org)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
LIPG was shown to be involved in HBV attachment to the cell surface by using 2 sodium taurocholate cotransporting peptide (NTCP)-expressing cell lines, and the direct interaction of LIPG and HBV large surface protein was revealed. (inrae.fr)
H Tubers escape from tarkov wallhack undetected free under liquid N 2 for protein or RNA extraction, or analysis of starch self-processing ability. (mhrburgers.com)

COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. (wikipedia.org)

COUP-TFII interacts with SMAD4 to modulate TGF-β signaling mediating prostate tumorigenesis. (guidetopharmacology.org)
These findings indicate that Ubc9 and PIAS1 can function as transcriptional co-regulators of COUP-TFI to modulate adrenal cortical steroidogenesis in a SUMOylation-independent manner. (elsevierpure.com)
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1). (omeka.net)

On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha. (omeka.net)

2] Evans R.M. "The steroid and thyroid hormone receptor superfamily. (expasy.org)
The recently identified steroid receptor coactivator (SRC) family contains three homologous members that can enhance transcriptional activities of NRs and certain non-NR transcription factors. (jneurosci.org)

In particular, the temporal progression of granule cell differentiation is affected resulting ultimately in decreased adult neurogenesis in adult COUP-TFI mutant mice. (unina.it)
RT development depends on the regression and differentiation of two primitive mesonephric ducts into a single RT. (nih.gov)
Overexpression of COUP-TFII prevents adipogenesis, whereas shRNA-mediated reduction of COUP-TFII promotes differentiation, as shown by increased lipid accumulation and elevated expression of fat cell marker proteins. (elsevierpure.com)
Regulation of follicular development and differentiation by intra-ovarian factors and endocrine hormones. (docslib.org)
We discuss factors that influence CD8 T cell differentiation and function in cancer through a framework that incorporates the classic three-signal model and a fourth signal-metabolism-and also consider the impact of the tumor microenvironment from a T cell perspective. (salk.edu)

These in vitro (in the laboratory) experiments show activity similar to that observed in vivo (in the body), and affirm that there is a two-step complex-mediated (or ligand-induced) activation of the progesterone receptor's activation of genetic transcription. (readabstracts.com)

The carboxyl terminus of the COUP-TF proteins interacts with multiple FOG2 zinc finger and FOG-2 serves as a co-repressor for COUP-TFII. (guidetopharmacology.org)
We therefore screened for COUP-TFI-interacting proteins using a yeast two-hybrid system and have identified Ubc9 and PIAS1, SUMO-1 conjugating enzyme and ligase, respectively. (elsevierpure.com)
The SUMOylation-defective mutants of these proteins continued to function as co-regulators of COUP-TFI. (elsevierpure.com)
To identify the proteins that regulate the female reproductive tract during these processes, group members use genetically engineered mice, human cells, and transcription factor analysis. (nih.gov)

NUCLEAR_REC_DBD_2} {BEGIN} ********************************************************************** * Nuclear hormone receptors DNA-binding domain signature and profile * ********************************************************************** Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes. (expasy.org)

COUP-TFII is reduced in endocrine-resistant breast cancer cells and is negatively associated with tumor grade. (nih.gov)

18. COUP-TFII in pancreatic adenocarcinoma: clinical implication for patient survival and tumor progression. (nih.gov)
Vaccines or, alternatively, the utilization of genetically engineered memory T cells could be methods of engaging and creating cancer-specific T cells with superb memory, lenient activation requirements, potent antitumor cytotoxicity, tumor surveillance, and resilience against immunosuppressive factors in the tumor microenvironment. (salk.edu)

Transcription factors regulate cell reprogramming and thus may be critical for Schwann cell phenotype switch during peripheral nerve regeneration. (bvsalud.org)

Classical nuclear hormone receptors contain two conserved regions, the hormone binding domain and a DNA-binding domain (DBD) that is composed of two C4-type zinc fingers. (expasy.org)
Peroxisome proliferator activated receptors (PPAR), transcription factors specifically activated by peroxisome proliferators. (expasy.org)
In the brain, most hormonal actions are mediated by their cognate nuclear receptors (NRs), which are ligand-regulated transcription factors ( Tsai and O'Malley, 1994 ). (jneurosci.org)
In cortisol-producing adrenal cortical adenomas, down-regulation of nuclear receptors, including COUP-TFs was found. (elsevierpure.com)
Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. (cusabio.com)

Regulation of the apolipoprotein A-I gene transcription. (nih.gov)
COUP-TFs repressed the apolipoprotein A1 gene expression by interacting with RXR and HNF4. (guidetopharmacology.org)

Taken together, our data demonstrate that COUP-TFII represents an endogenous suppressor of adipogenesis, linking antiadipogenic extracellular signals to the core transcriptional cascade. (elsevierpure.com)

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It is calculated in accordance with section two of fake lags overwatch 2 terms and conditions for your account. (mhrburgers.com)

The nuclear receptor COUP-TFI is involved in many aspects of cortical neurogenesis, from arealization to cell-type specification and axon formation. (unina.it)
5. The role of the orphan nuclear receptor COUP-TFII in tumorigenesis. (nih.gov)
11. The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells. (nih.gov)
19. The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells. (nih.gov)
Two of these sites, FP3 (bases −7738 to −7715) and FP4 (bases −7698 to −7682), overlapped binding motifs for the orphan human pregnane X receptor (hPXR). (aspetjournals.org)
The study shows that COUP-TFII, a member of the orphan nuclear receptor superfamily, is specifically expressed in venous. (readabstracts.com)

COUP-TFI is able to heterodimerize with COUP-TFII. (guidetopharmacology.org)

Transient re-expression of COUP-TFII restores antiestrogen sensitivity in resistant LCC2 and LCC9 cells and repression of COUP-TFII results in antiestrogen-resistance in MCF-7 endocrine-sensitive cells. (nih.gov)
During early mesoderm induction, the mesoderm-associated transcription factors MESP1 and EOMES showed a transient up-regulation, which decreased later in the cardiac induction stage. (nih.gov)
Known as silent injuries, mTBIs produce transient behavioral deficits lasting 1-2 weeks, but do not produce skull fractures or brain bleeds [ 3 ]. (biomedcentral.com)

Initial embryonic determination of artery or vein identity is regulated by genetic factors that work in concert to specify the endothelial cell׳s (EC) fate, giving rise to two structurally unique components of the circulatory loop. (nih.gov)
It discusses that COUP-TFII has a critical role in repressing notch signaling to maintain vein identity, which suggest that vein identity is under genetic control and is not derived by a default pathway. (readabstracts.com)

10. Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis. (nih.gov)

We addressed the hypothesis that reduced COUP-TFII expression in endocrine-resistant breast cancer cells results from epigenetic modification. (nih.gov)
17. COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells. (nih.gov)

Rifampicin-inducible transcription of the reporter gene was observed only with the longest construct, which encompassed bases −13000 to +53 of CYP3A4 (3-fold induction). (aspetjournals.org)
Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s. (omeka.net)
We have studied the immunochemical properties of two major 3-methylcholanthrene inducible hamster liver cytochrome P450 isozymes, P450 MC1 and P450 MC4. (omeka.net)

Ligand-activated transcription factor. (nih.gov)
The specific of the two such kinds living the above three, he recognizes, would greatly create a US military online Trade and that in all injury would be to an science and a turnover that would plunge the latest Iraq War illustrate like a British ligand. (choyleefutchile.cl)

2019 Feb 15;446(2):168-179. (docslib.org)
2019 Jan 15;445(2):145-155. (docslib.org)

However, COUP-TFs readily form DNA-binding heterodimers with RXR. (guidetopharmacology.org)
Core Binding Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. (umassmed.edu)
This graph shows the total number of publications written about "Core Binding Factors" by people in this website by year, and whether "Core Binding Factors" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Core Binding Factors" by people in Profiles. (umassmed.edu)

This process is controlled by two hormones: androgens and anti-Müllerian hormone (AMH). (nih.gov)

COUP-TFII and GATA2 are physically associated and repress target gene expression in an additive manner. (elsevierpure.com)

Together, these data indicate that COUP-TFII mediates ductal regression by a mechanism other than gonadal hormone production and suggests that mesonephric mesenchymal COUP-TFII signals ductal epithelial cell regression. (nih.gov)
Similar mechanism are observed for other transcription factor (Sp1). (guidetopharmacology.org)

COUP-TF interact both functionally and physically with the NRs HNF4. (guidetopharmacology.org)

COUP-TFII physically interacts with Prox1 to specify lymphatic endothelial cell fate. (guidetopharmacology.org)

Our results provide evidence for the existence of a potent enhancer module, 8 kb distal to the transcription start point, which mediates the transcriptional induction of CYP3A4 by activators of hPXR. (aspetjournals.org)

To assess its role in hippocampal development, two independent conditional lines, in which COUP-TFI is either inactivated in all cortical progenitors or exclusively in post-mitotic neurons, were used. (unina.it)
While absence of COUP-TFI function in post-mitotic neurons has a minor effect on the overall hippocampal development, loss-of-function of COUP-TFI in cortical progenitors leads to dramatic malformations in the growth and maturation of the hippocampus and dentate gyrus. (unina.it)

1. Multiple roles of COUP-TFII in cancer initiation and progression. (nih.gov)

COUP-TFII interacts with Runx2 to repress Runx2 transcriptional activity in mesenchymal cell. (guidetopharmacology.org)
In this study, we investigated the effects of recombinant adeno-associated virus (AAV) of mesencephalic astrocyte-derived neurotrophic factor (AAV-MANF) or placental growth factor (AAV-PlGF) transduced into mesenchymal stem cells (hMSC-MANF and hMSC-PlGF), which were then transplanted using human decellularized nerves (HDN) into sciatic nerve injury model. (bvsalud.org)

Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin. (lookformedical.com)

Human erbA related gene 2 (ear-2). (expasy.org)
Interestingly, Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology in Leipzig, working in cooperation with Fisher in 2002, discovered that two of these amino acid differences happened in human evolution after our lineage separated from that of chimpanzees. (mpg.de)
The characterization of three types of partially processed mRNA and two pseudogenes for human liver cytochrome b5. (omeka.net)

deoxycytidine (AZA), a DNA methyltransferase (DNMT) inhibitor, +/- trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, increased COUP-TFII suggesting that the decrease in COUP-TFII is mediated by epigenetic changes. (nih.gov)

To determine its role in RT development, COUP-TFII was ablated in the embryonic gonad and mesonephros. (nih.gov)
It is a transcription factor that plays an important role in EMBRYONIC DEVELOPMENT of the CENTRAL NERVOUS SYSTEM. (lookformedical.com)

In the adult cerebellum, Purkinje cells (PCs) preferentially express SRC-1 over SRC-2, but SRC-2 mRNA is slightly elevated in the SRC-1 − / − PCs. (jneurosci.org)

6. Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway. (nih.gov)
We show that COUP-TFII acts downstream of hedgehog signaling and is required for the full antiadipogenic effect of this pathway. (elsevierpure.com)

Anatomy1

Diseases2

Chemicals and Drugs6

Phenomena and Processes3

Information Science2

Regulates11

NR2F23

Promoter21

Genes6

Protein8

Binds1

Modulate3

Hepatocyte1

Steroid2

Differentiation5

GENETIC TRANSCRIPTION1

PROTEINS4

Upstream1

Negatively1

Tumor2

Regulate1

RECEPTORS5

Apolipoprotein2

Endogenous1

Overwatch4

Receptor6

Heterodimerize1

Transient3

Vein identity2

Suppression1

Endocrine-resistant breast cancer cells2

Inducible3

Ligand2

20192

Binding5

Hormones1

Gene expression1

Mechanism2

HNF41

Endothelial cell1

Mediates1

Cortical2

Initiation1

Mesenchymal2

Chromatin1

Human3

Epigenetic1

Embryonic2

MRNA1

Pathway2