LipoproteinAPOC3Single-nucleotide poAtherosclerosisApoa1Coronary heart dLipoproteinsPolyclonalApoBParticlesHumanMajorLevelsApoCIIICholesterolApoC-IIILipidQuantificationLipidsGenesSubclassesProteinTriglyceride richMarkersSpecificityPromoter regionLiverHepaticBiomarkersRegulatoryHuman plasmaOverviewResearchComponentAnalysis
Lipoprotein12
- Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as chylomicrons, very low density lipoprotein (VLDL), and remnant cholesterol. (wikipedia.org)
- ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. (portlandpress.com)
- Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. (biomedcentral.com)
- Many people with this condition have low levels of triglycerides, lipoprotein(a), apolipoproteins AII and CIII. (wikipedia.org)
- Apo-CIII is a component of very low density lipoprotein (VLDL). (nsjbio.com)
- Apolipoprotein C2 is secreted in plasma where it is a component of very low density lipoprotein. (abebio.cn)
- Apolipoprotein C-II (apoC-II) is a necessary cofactor for the activation of lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues.The APOC2 cDNA sequence encodes a deduced 79-amino acid protein. (abebio.cn)
- Apolipoprotein A1 (apoA1) is the major apolipoprotein constituent of the high-density lipoprotein (HDL) and is involved in reverse cholesterol transport [ 15 ]. (biomedcentral.com)
- Apolipoprotein B (apoB ) is a major component of atherogenic lipoprotein particles such as LDL, VLDL and Lp(a). (docsopinion.com)
- Apolipoprotein E (APOE) is a lipoprotein found primarily in chylomicrons and intermediate-density lipoprotein (IDL). (docsopinion.com)
- Apolipoprotein A-I (Apo A-I) is the major protein carried on high density lipoprotein cholesterol (HDL-C) particles. (biorexdiagnostics.com)
- Apolipoprotein C-III (Apo C-III) is an inhibitor of lipoprotein lipase (LPL) activity, a key regulator of triglyceride-rich lipoproteins (TRLs) and contributes to the atherogenicity of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. (biorexdiagnostics.com)
APOC32
- Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. (wikipedia.org)
- Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. (biomedcentral.com)
Single-nucleotide po1
- Elevations of Apo-CIII associated with single-nucleotide polymorphisms found in genetic variation studies may predispose patients to non-alcoholic fatty liver disease, although the association has been questioned and may be specific to certain ethnicities or to people without central obesity. (wikipedia.org)
Atherosclerosis3
- Overexpression of Apo-CIII in humans contributes to atherosclerosis. (wikipedia.org)
- In persons with type 2 diabetes, elevated plasma Apo-CIII is associated with higher plasma triglycerides and greater coronary artery calcification (a measure of subclinical atherosclerosis). (wikipedia.org)
- Apolipoprotein E (Apo E) is recognised for its exceptional ability to suppress atherosclerosis through the prevention of foam cell formations in the vessel wall. (biorexdiagnostics.com)
Apoa11
- Variants in the apolipoprotein A1 ( APOA1 ) gene play an important role in the regulation of lipids. (biomedcentral.com)
Coronary heart d1
- HDL cholesterol particles that bear Apo-CIII are associated with increased, rather than decreased, risk for coronary heart disease. (wikipedia.org)
Lipoproteins2
- Apolipoprotein C-III (apo C-III) is found on the surface of triglyceride-rich lipoproteins ( 6 ). (docsopinion.com)
- Apolipoprotein B (Apo B)-containing lipoproteins that are cholesterol-rich are widely accepted as one of the most causal agents of atherosclerotic cardiovascular disease (ASCVD) 7 . (biorexdiagnostics.com)
Polyclonal1
- Can be paired for ELISA with Rabbit polyclonal to Apolipoprotein CIII (ab21032) . (abcam.co.jp)
ApoB1
- This CETP inhibition, which exchanges a triglyceride molecule for a cholesteryl ester molecule between HDL-C-containing and apolipoprotein B (ApoB)-containing particles, also this particular therapeutic has been shown in prior studies to decrease ApoB significantly and, actually, to even decrease Lp(a), which is interesting. (medscape.com)
Particles3
- Recent evidences suggest an intracellular role for Apo-CIII in promoting the assembly and secretion of triglyceride-rich VLDL particles from hepatic cells under lipid-rich conditions. (wikipedia.org)
- Apo-CIII delays the catabolism of triglyceride rich particles. (wikipedia.org)
- Apolipoprotein CIII is also found on HDL particles. (wikipedia.org)
Human2
- Purified human Apolipoprotein CIII. (abcam.co.jp)
- Human Apo CIII-Sepharose affinity column and labeled with Biotin. (abcam.co.jp)
Major1
- Major lipids, apolipoproteins, and risk of vascular disease. (thieme-connect.com)
Levels1
- Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy. (umassmed.edu)
ApoCIII3
- Apolipoprotein CIII (apoCIII) is of particular interest because increasing the synthesis of this protein in transgenic mice markedly increases plasma TG levels [ 14 ] and the absence of functional apoCIII produces a dramatic reduction in TGs associated with enhanced clearance in both mice [ 15 ] and humans. (medscape.com)
- The Apolipoprotein CIII ELISA Assay Kit is intended for the quantification of human Apolipoprotein CIII (ApoCIII) in human plasma, serum and biological fluids. (eaglebio.com)
- 3. Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. (nih.gov)
Cholesterol6
- HDL cholesterol particles that bear Apo-CIII are associated with increased, rather than decreased, risk for coronary heart disease. (wikipedia.org)
- While cholesterol levels are still used to measure cardiovascular risk, apolipoproteins have emerged as relevant biomarkers for assessing the risk of various CVD and initiating prophylactic and therapeutic strategies. (bioradiations.com)
- Compared to hypercholesterolemic Ldlr-/- mice treated with vehicle or 4-HOBA, a nonreactive analogue, 2-HOBA decreases atherosclerosis by 60% in en face aortas, without changing plasma cholesterol. (bvsalud.org)
- Karela reduces apolipoprotein C-III, the protein found in low-density cholesterolwhich turns into LDL cholesterol. (zenpharmacy.com.my)
- Karela increases apolipoprotein A-1, the major protein component of high-density or 'good' cholesterol. (zenpharmacy.com.my)
- CONCLUSIONS: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the incidence of cardiovascular events was not lower among those who received pemafibrate than among those who received placebo, although pemafibrate lowered triglyceride, VLDL cholesterol, remnant cholesterol, and apolipoprotein C-III levels. (bvsalud.org)
ApoC-III1
- Described here is the development of a multiplex mass spectrometric immunoassay (MSIA) for quantification of apolipoprotein C-I (apoC-I), apolipoprotein C-II (apoC-II), apolipoprotein C-III (apoC-III) and their proteoforms. (elsevierpure.com)
Lipid3
- Recent evidences suggest an intracellular role for Apo-CIII in promoting the assembly and secretion of triglyceride-rich VLDL particles from hepatic cells under lipid-rich conditions. (wikipedia.org)
- Apolipoproteins are lipid transport proteins, helping to move lipids (and fat-soluble vitamins) in the body. (meridianbioscience.com)
- They are produced in the small intestine and the liver and each apolipoprotein have a specific function in lipid transport and metabolism. (meridianbioscience.com)
Quantification1
- This multiplex assay kit manufactured by Linco Research is to be used for the simultaneous quantification of the following six apolipoproteins in any combinations: Apo AI, Apo AII, Apo B, Apo CII, Apo CIII, and Apo E. This kit may be used for the analysis of the above apolipoproteins in serum, plasma, tissue extract, other biological fluids, or tissue culture supernatant samples. (lincoresearch.com)
Lipids1
- Disialylated apolipoprotein C-III proteoform is associated with improved lipids in prediabetes and type 2 diabetes. (nih.gov)
Genes3
- This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. (nih.gov)
- The hyperlipidemic models of mice have been generated by the targeting of genes, such as apolipoprotein (apo) E and LDL receptor (LDLR) [ 6 ] [ 7 ] . (encyclopedia.pub)
- Hepatocyte nuclear factor 4 (HNF-4), which binds to DNA sites required for the transcription of the genes for alpha-1-antitrypsin, apolipoprotein CIII and transthyretin. (expasy.org)
Subclasses1
- There are eight classes of apolipoproteins with many subclasses, and each has a unique function in maintaining health or driving disease (Table 1). (bioradiations.com)
Protein4
- 6. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. (nih.gov)
- Abe Y, Kawakami A, Osaka M, Uematsu S, Akira S, Shimokado K, Sacks FM, Yoshida M. Apolipoprotein CIII induces monocyte chemoattractant protein-1 and interleukin 6 expression via toll-like receptor 2 pathway in mouse adipocytes. (cardiobrief.org)
- Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort. (musc.edu)
- Apolipoprotein AI regulatory protein-1 (ARP-1), required for the transcription of apolipoprotein AI. (expasy.org)
Triglyceride rich1
- Apo-CIII delays the catabolism of triglyceride rich particles. (wikipedia.org)
Markers1
- Specific apolipoproteins have been identified as key markers of cardiovascular risk. (bioradiations.com)
Specificity1
- 15. A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. (nih.gov)
Promoter region1
- 8. Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene. (nih.gov)
Liver1
- Elevations of Apo-CIII associated with single-nucleotide polymorphisms found in genetic variation studies may predispose patients to non-alcoholic fatty liver disease, although the association has been questioned and may be specific to certain ethnicities or to people without central obesity. (wikipedia.org)
Hepatic1
- 4. Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids. (nih.gov)
Biomarkers1
- However, recent studies indicate that apolipoproteins are critical biomarkers in many other diseases, from autoimmunity to cancer (Table 2). (bioradiations.com)
Regulatory1
- 16. Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. (nih.gov)
Human plasma1
- The assay was applied to a small cohort of human plasma samples, revealing the existence of multiple proteoforms for each apolipoprotein C. The quantitative aspect of the assay enabled determination of the concentration for each proteoform individually. (elsevierpure.com)
Overview1
- An overview of apolipoproteins. (bioradiations.com)
Research1
- The Eagle Biosciences Apolipoprotein CIII ELISA Assay Kit is for research use only and should not be used for diagnostic procedures. (eaglebio.com)
Component1
- A component of HDL that has no marked similarity to other apolipoprotein sequences. (bioradiations.com)
Analysis1
- The multiplex analysis of the three apolipoproteins C and their proteoforms using quantitative MSIA represents a significant step forward toward better understanding of their physiological roles in health and disease. (elsevierpure.com)