AntigenLymphomasCD30LLigandAnti-CD30 antibodyTNFRSF8Lymphoproliferative disordersHodgkin'sCD15Transmembrane glycoproteinMonoclonalHodgkinLymphomaMolecule in thymic negative selectionProteinBrentuximab VedotinSerumLPDsPositivitySolubleSubset of T cellsExpressionLymphoidSequencePatientsCellsHumanRoleStudy
Antigen5
- In Hodgkin's disease, the CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. (biogenex.com)
- CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using the monoclonal antibody Ki-1. (rndsystems.com)
- A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
- TT11 is an autologous CD30 chimeric antigen receptor T-cell (CAR-T) therapy that harvests the patient's own T-cells and modifies them to target cancer cells expressing the CD30 protein, a well-validated lymphoma target. (newsasiatoday.com)
- Recently, it has been shown that CD30 antigen expression is associated with a relatively favorable prognosis in primary cutaneous large-cell lymphomas (CLCLs). (unipv.it)
Lymphomas6
- Anti-CD30 distinguishes large cell lymphomas derived from activated lymphoid cells from histocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. (biogenex.com)
- CD30 is also expressed on different non-Hodgkin's lymphomas, virus-infected T and B cells, and on normal T and B cells after activation. (rndsystems.com)
- CD30 can act as a co-stimulatory molecule in thymic negative selection and may also play a critical role in the pathophysiology of Hodgkin's disease and other CD30 + lymphomas. (rndsystems.com)
- CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. (exbio.cz)
- In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. (exbio.cz)
- Primary cutaneous CD30(+) lymphoproliferative disorders (CD30(+) LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (qxmd.com)
CD30L8
- In reactive conditions, CD30 receptor and ligand (CD30L, CD153) expression is normally seen on activated T-immunoblasts and B-immunoblasts. (aad.org)
- CD30 functions as a receptor for TNFSF8/CD30L and may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. (biogenex.com)
- CD30 ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. (rndsystems.com)
- The specific receptor for CD30L is CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. (rndsystems.com)
- CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. (rndsystems.com)
- The ligand for CD30 is CD30L (CD153). (exbio.cz)
- The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. (exbio.cz)
- CD30 is the receptor for TNFSF8/CD30L. (transcriptionfactor.org)
Ligand9
- Detects human CD30 ligand/TNFSF8 in direct ELISAs. (rndsystems.com)
- Mouse myeloma cell line NS0-derived human CD30 Ligand/TNFSF8. (rndsystems.com)
- Human and mouse CD30 ligand cDNAs share 70% sequence homology. (rndsystems.com)
- CD30 Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- This graph shows the total number of publications written about "CD30 Ligand" by people in this website by year, and whether "CD30 Ligand" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "CD30 Ligand" by people in Profiles. (wakehealth.edu)
- Measured by its ability to block CD30 Ligand-induced IL-6 secretion by HDLM human Hodgkin's lymphoma cells. (transcriptionfactor.org)
- The ED50 for this effect is typically 0.5 - 2.5 µg/ml in the presence of 50 ng/ml of Recombinant Human CD30 Ligand. (transcriptionfactor.org)
- The ligand for CD30 is CD30 Ligand/TNFSF8 (CD153), a member of the TNF superfamily. (bio-techne.com)
Anti-CD30 antibody1
- Patients who have had previous treatment with any anti-CD30 antibody. (stanford.edu)
TNFRSF83
- CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker. (wikipedia.org)
- CD30 is a transmembrane glycoprotein receptor of the tumor necrosis factor receptor super family 8 (TNFRSF8), mediating its effects through a number of signaling pathways that produce a survival advantage to the cells on which the protein is overexpressed. (aad.org)
- CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B. TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts. (transcriptionfactor.org)
Lymphoproliferative disorders5
- A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders. (bvsalud.org)
- The spectrum of cutaneous CD30-positive lymphoproliferative disorders (LPDs) includes lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma . (bvsalud.org)
- CD30/Ki-1-positive lymphoproliferative disorders of the skin--clinicopathologic correlation and statistical analysis of 86 cases: a multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group. (unipv.it)
- EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (qxmd.com)
- Genomic Analysis of Cutaneous CD30-Positive Lymphoproliferative Disorders. (cdc.gov)
Hodgkin's1
- CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma. (wikipedia.org)
CD152
- Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15. (transcriptionfactor.org)
- The Reed Sterberg cells also have with a specific protein called CD15 or CD30 on them. (lymphoma.org.au)
Transmembrane glycoprotein1
- CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. (exbio.cz)
Monoclonal1
- SGN-30, a chimeric anti-CD30 monoclonal antibody, has demonstrated potent preclinical antitumour activity in both Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). (qxmd.com)
Hodgkin2
Lymphoma2
- CD30 is associated with anaplastic large cell lymphoma. (wikipedia.org)
- Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. (exbio.cz)
Molecule in thymic negative selection1
- CD30 acts as a costimulatory molecule in thymic negative selection. (exbio.cz)
Protein2
- Stimulation of CD30 leads signal mediation through tumor necrosis factor receptor-associated proteins (TRAF), thereby stimulating the nuclear factor-kappa B (NFkB) pathway and the mitogen-activated protein kinase (MAPK) pathways. (aad.org)
- CD30 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. (angioproteomie.com)
Brentuximab Vedotin1
- CD30 is the target of the FDA approved therapeutic brentuximab vedotin (Adcetris). (wikipedia.org)
Serum2
- We used this kit for the quantification of CD30 in human serum and plasma. (bio-techne.com)
- CD30 cell expression and abnormal soluble CD30 serum accumulation in Omenn's syndrome: evidence for a T helper 2-mediated condition. (lu.se)
LPDs6
- Chromosomal translocations targeting tyrosine kinases in CD30-positive LPDs have not been described. (bvsalud.org)
- Fluorescence in situ hybridization revealed NPM1-TYK2 fusions in 2 of 47 (4%) primary cases of CD30-positive LPDs and was absent in other mature T-cell neoplasms (n = 151). (bvsalud.org)
- This is the first report of recurrent translocations involving TYK2, and it highlights the novel therapeutic opportunities in the treatment of CD30-positive LPDs with TYK2 translocations. (bvsalud.org)
- Despite the anaplastic cytomorphology of tumor cells that suggest an aggressive course, CD30(+) LPDs are characterized by an excellent prognosis. (qxmd.com)
- Moreover, international guidelines for staging and treatment of CD30(+) LPDs have not yet been presented. (qxmd.com)
- The recommendations represent the state-of-the-art management of CD30(+) LPDs and include definitions for clinical endpoints as well as response criteria for future clinical trials in CD30(+) LPDs. (qxmd.com)
Positivity1
- Of all patients studied, CD5 and CD30 immunostains demonstrated positivity in less than 10% of all cases. (asianarchpath.com)
Soluble1
- Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. (exbio.cz)
Subset of T cells2
- Among T cells, CD30 is preferentially expressed on a subset of T cells producing Th2-type cytokines and on CD4 + /CD8 + thymocytes that co-express CD45RO and IL-4 receptor. (rndsystems.com)
- In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. (exbio.cz)
Expression2
- Xu et al state that "there is no standardized or validated form of performing the interpretation of CD30 expression. (aad.org)
- In conclusion, CD5 and CD30 expression were infrequently identified in DLBCL, NOS patients diagnosed in the Department of Pathology, Ramathibodi Hospital. (asianarchpath.com)
Lymphoid1
- In particular, the present invention concerns a third generation of CAR-CD30 T cells for treatment of CD30+ Tumors such as lymphoid malignancies, leukemia, solid tumors. (knowledge-share.eu)
Sequence1
- The present invention relates to a vector comprising the nucleotide sequence which encodes the sequence SFG.CAR.CD30(AC10)ΔCD34.CD8aTM.CD28cyto.OX40.ζ, wherein said vector is a DNA vector, an RNA vector, a plasmid, a lentiviral vector, an adenoviral vector, a retroviral or a non-viral vector. (knowledge-share.eu)
Patients2
- Patients with other CD30-positive malignancies (including ALCL) must be beyond first remission or refractory to front line chemotherapy. (stanford.edu)
- These results led to ALCANZA, a randomized, open-label, multicenter phase 3 trial of the efficacy and safety of BV vs physician's choice (PC) of MTX or Bex, in previously treated patients with CD30-expressing CTCL (NCT01578499). (ashpublications.org)
Cells2
- Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS: Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease. (exbio.cz)
- The present invention concerns CAR-CD30 T cells for treatment of CD30+ Tumors. (knowledge-share.eu)
Human1
- CD30 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 384 amino acids (19-379a.a.) and having a molecular mass of 40.8kDa. (angioproteomie.com)
Role1
- Polte T, Behrendt AK, Hansen G: Direct evidence for a critical role of CD30 in the development of allergic asthma. (exbio.cz)
Study2
- This study aimed to investigate the immunoexpression of CD5, CD30, and p53 in DLBCL, NOS and its impact to survival. (asianarchpath.com)
- cutánea maligna de células T. Luego se realizó el frotis de médula ósea, en el que se identificaron células «cerebriformes» study conception, manuscript que confirmaron el diagnóstico de síndrome de Sézary. (bvsalud.org)