• Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
  • The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
  • They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis (LCH). (wikipedia.org)
  • In the rare disease Langerhans cell histiocytosis (LCH), an excess of cells similar to these cells are produced. (wikipedia.org)
  • Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
  • We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
  • Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)
  • A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
  • We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. (thieme-connect.de)
  • Here, we outline the most likely diagnoses with this presentation and discuss a case of Langerhans cell histiocytosis (LCH) in a preterm neonate with severe multiorgan involvement. (thieme-connect.de)
  • Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
  • Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
  • OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
  • Langerhans cell histiocytosis is not only a disease of unknown cause but also there is still a lot of controversy about whether this is a malignant disease. (histio.org)
  • Pathology of the tissue biopsy demonstrated proliferation of macrophages or dendritic cells, and positive staining with CD1a confirmed a diagnosis of Langerhans' cell histiocytosis (See Figure 2) . (reviewofophthalmology.com)
  • Langerhans' cell histiocytosis (LCH), previously known as histiocytosis X, describes a rare spectrum of conditions with abnormal proliferation of histiocytes, occuring in various locations throughout the body. (reviewofophthalmology.com)
  • No consensus exists for the optimal therapy for Langerhans cell histiocytosis (LCH), particularly in the case of multisystem organ disease. (medscape.com)
  • Single-agent chemotherapy with cladribine (2-chlorodeoxyadenosine/2-CdA) may be a promising treatment for single-system pulmonary Langerhans cell histiocytosis. (medscape.com)
  • Lichtenstein proposed a common diagnosis, histiocytosis X , with the X indicating an uncertain cell of origin. (capsulehealth.one)
  • Histiocytosis X was renamed Langerhans-cell histiocytosis , reflecting the concept that LCH cells represented dysfunctional epidermal Langerhans cells. (capsulehealth.one)
  • Available at: http://www.cancernetwork.com/oncology-journal/langerhans-cell-histiocytosis-emerging-insights-and-clinical-implications [Accessed 1 Jul. (capsulehealth.one)
  • It has also proved useful for phenotyping Langerhans cell histiocytosis. (micro-shop.pl)
  • A pathological diagnosis of Langerhans cell histiocytosis was made. (bvsalud.org)
  • Since orbital Langerhans cell histiocytosis has a high risk for central nervous system involvement, chemotherapy was the treatment of choice for any residual lesion to prevent sequelae to the central nervous system. (bvsalud.org)
  • Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
  • Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
  • Pulmonary Langerhans cell histiocytosis is a disease in which monoclonal CD1a-positive Langerhans cells (a type of histiocyte) infiltrate the bronchioles and alveolar interstitium, accompanied by lymphocytes, plasma cells, neutrophils, and eosinophils. (msdmanuals.com)
  • Langerhans cell histiocytosis (LCH) is a rare haematological neoplasm characterized by the accumulation of CD1a + , CD207/Langerin + histiocytes within inflammatory lesions. (biomedcentral.com)
  • Sakata N, Toguchi N, Kimura M, Nakayama M, Kawa K, Takemura T. Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (mayabouchenaki.com)
  • Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
  • Erdem AP, Kasimoglu Y, Sepet E, Gencay K, Sahin S, Dervisoglu S. Oral manifestations may be the first sign of Langerhans cell histiocytosis. (mayabouchenaki.com)
  • Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. (elsevierpure.com)
  • Vassallo, R & Limper, AH 2002, ' Pulmonary Langerhans' cell histiocytosis ', Seminars in Respiratory and Critical Care Medicine , vol. 23, no. 2, pp. 93-101. (elsevierpure.com)
  • JXG does not carry BRAF V600E mutation, except in patients with both Langerhans' cells histiocytosis (LCH) and JXG (non-Langerhan cells histiocytosis) diseases and in the aggressive forms of JXG. (eyewiki.org)
  • Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis. (unil.ch)
  • These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. (medscape.com)
  • The cellular makeup of these monocytoid/histocytic cells is heterogeneous and ranges from cells of lymphoid, histiocytic, and dendritic origin. (medscape.com)
  • It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)
  • Histopathological examinations revealed a dense infiltrate of histiocytic cells. (bvsalud.org)
  • The tumour is composed of numerous histiocytic Langerhans cells displaying irregular nuclei with nuclear indentation and grooving, fine chromatin, inconspiciousto small nucleoli, and ample cytoplasm. (radiologycases.my)
  • Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
  • In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
  • Immunohistochemistry was used to identify activated T lymphocytes (CD45R0), monocyte-macrophages (Mac 387, CD68), DD (Factor XIIIa), and Langerhans cells (CD1a). (spandidos-publications.com)
  • Scattered T gamma-delta and B lymphocytes, macrophages and NK cells were observed among the cells of the dermal infiltrate of vulvar condylomata. (medicaljournals.se)
  • In the 1970s , Steinman and Cohn distinguished dendritic cells from macrophages on the basis of specific morphologic features of dendritic cells and their superior capacity to present antigens to and activate antigen-specific T cells. (capsulehealth.one)
  • LCH lesion also contains inflammatory cells and cytokines such as T lymphocytes, eosinophils, neutrophils, and macrophages. (capsulehealth.one)
  • Of these, tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) create an immunosuppressive microenvironment through various pathways. (iiarjournals.org)
  • Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (msdmanuals.com)
  • Double IHC showed that the distribution of FcεRI + cells was tryptase + mast cells (33%), CD68 + macrophages (36%), EG2 + eosinophils (20%), CD1a + Langerhans' cells (4%) and unidentified cells (7%), at the 24-hr allergen-challenged sites. (utmb.edu)
  • These observations suggest that the cutaneous late-phase reaction in man is associated with up-regulation of FcεRI on eosinophils, macrophages, mast cells and Langerhans' cells. (utmb.edu)
  • [16] One theory proposed the coexistence of LCH and JXG could be the result of chemotherapy-induced maturation of Langerhans' cells into macrophages, in particular foamy cells. (eyewiki.org)
  • Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
  • HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • Langerin is a protein found in Langerhans cells, and dendritic cells. (wikipedia.org)
  • Darüber hinaus ist Langerin (CD207) ein einzigartiger Marker, der von Langerhans-Zellen exprimiert wird und eine entscheidende Rolle für ihre Funktion spielt. (antikoerper-online.de)
  • Immunohistochemical staining of the tumors for CD1a and Langerin was positive. (bvsalud.org)
  • Histopathological analysis of a thick needle biopsy demonstrated, however, a dense infiltrate of S100, CD1a and CD207/Langerin positive histiocytes accompanied by many eosinophilic granulocytes (Fig. 2 A), compatible with a diagnosis of LCH. (biomedcentral.com)
  • Epidermal Langerhans cells (CD207/langerin(+)), dermal langerin(neg), and dermal langerin(+) dendritic cells (DC) have been described, the latter subset so far only in mouse skin. (cnrs.fr)
  • In human skin langerin(neg) dermal DC can be further classified based on their reciprocal expression of CD1a and CD14. (cnrs.fr)
  • Antigens targeted to DCs via the C-type lectin Langerin/CD207 are cross-presented to CD8(+) T cells in vivo. (cnrs.fr)
  • We investigated the relative roles of Langerhans cells (LCs) and Langerin(+) dermal DCs (dDCs) in different vaccination settings. (cnrs.fr)
  • In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
  • citation needed] Langerhans cells are named after Paul Langerhans, a German physician and anatomist, who discovered the cells at the age of 21 while he was a medical student. (wikipedia.org)
  • Langerhans cells are named after Paul Langerhans , a bright, young medical student who worked with the new technique of gold colloid staining in the mid-19th century. (capsulehealth.one)
  • A surgical biopsy showed an infiltrate of eosinophilic cells with oval, grooved and convoluted nucleus, associated with eosinophils, lymphocytes and plasma cells ( Figure 2 ). (scirp.org)
  • It consists of Langerhans cells with oval, grooved and convoluted nucleus and slightly eosinophilic cytoplasm, associated with eosinophils, lymphocytes and plasma cells (H & E × 400). (scirp.org)
  • Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)
  • The background shows reactive cellular infiltrates comprising eosinophils, neutrophils, histiocytes, lymphocytes and plasma cells. (radiologycases.my)
  • This Langerhans cell-targeted immune escape mechanism seems to be conserved among different HPV genotypes enabling these viruses to remain undetected in the absence of other inflammatory events. (wikipedia.org)
  • CD1a on Langerhans cells controls inflammatory skin disease. (harvard.edu)
  • In view of the absence of inflammatory cells in the epidermis, keratinocytes appeared responsible for their own destruction through CD95-mediated and/or calcium-dependent apoptotic pathways. (spandidos-publications.com)
  • This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process. (spandidos-publications.com)
  • LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)
  • Other inflammatory cells may be present to varying degrees. (eyewiki.org)
  • However, Langerhans cells can also take on a dendritic cell-like phenotype and migrate to lymph nodes to interact with naive T-cells. (wikipedia.org)
  • We have used in situ hybridization (ISH) and immunohistochemistry (IHC) to investigate the kinetics of the expression for FcεRI mRNA (α-, β- and γ-chains), the α-chain protein product, as well as the phenotype of the mRNA- or protein-positive cells in allergen-induced late-phase skin reactions in atopic subjects. (utmb.edu)
  • Furthermore, we established cutaneous models of GAS infection in a humanized CD1a transgenic mouse model and identified enhanced and prolonged local and systemic inflammation, with resolution through a psoriasis-like phenotype. (ox.ac.uk)
  • Immunohistochemistry: The Langerhans cells are positive for S100, CD68 and CD1a. (radiologycases.my)
  • [16] JXG cells stain positive for CD68, have variable reactivity for factor XIIIa and stain negative for CD1a, S100, CD20716. (eyewiki.org)
  • Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
  • Positive immunohistological staining with neuronal markers S100 and CD1a are specific for Langerhans' cells and help to confirm the diagnosis. (reviewofophthalmology.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • T6 (ref 6T-CD1.7) was used as a CD1a reference monoclonal antibody during HLDA 6. (beckman.com)
  • CD1a antibodies are useful in the definition of the thymic stage of T cells. (beckman.com)
  • Microscopic review of the tissue specimen revealed proliferation of histiocytes (left) with positive CD1a staining, a marker for Langerhans' cells (right). (reviewofophthalmology.com)
  • Idiopathic non-malignant disease characterized by idiopathic infiltration and accumulation of abnormal histiocytes (i.e. the Langerhans cells) within various tissues (bone marrow, skin, central nervous system, lung, liver, spleen, lymph nodes) causing focal or systemic effects. (capsulehealth.one)
  • [13] Histologically, the cutaneous infiltrate includes a mixture of foamy histiocytes, lymphocytes, fibroblasts and multinucleated giant cells, including Touton-type giant cells, with a moderate amount of collagen deposition (Figures 4-5). (eyewiki.org)
  • Figure 5: High-power view reveals a mixture of multinucleated giant cells, including Touton-type giant cells, foamy histiocytes, lymphocytes, and fibroblasts with a moderate amount of collagen deposition. (eyewiki.org)
  • 1 ] and was since classified in the 2008 World Health Organization classification of haematolymphoid neoplasms with tumours of histiocytes and dendritic cells, alongside other dendritic cell tumours including Langerhans cell tumours, interdigitating dendritic cell sarcoma and other rare tumours. (biomedcentral.com)
  • Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. (biomedcentral.com)
  • We describe a case of progressive follicular dendritic cell sarcoma of the lung and pleura, treated based on knowledge of the tumour's molecular aberrations. (biomedcentral.com)
  • Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm of mesenchymal stem cell origin whose clinical course displays much variability. (biomedcentral.com)
  • Sections of lymph node and skin were embedded using the acetone, methyl benzoate and xylene (AMeX) method and dendritic cells were immunostained with anti S-100 protein antibody (S-100, and OKT-6 (CD1a) using the restaining method. (fujita-hu.ac.jp)
  • The BL6 antibody recognizes the C epitope of the CD1a molecule. (beckman.com)
  • The majority of the dendritic cells that existed in the LN of dermatopathic lymphadenopathy were positive for OKT-6 (CD 1a) antibody. (fujita-hu.ac.jp)
  • human CD14(+) dermal DC can promote antibody production by B cells. (cnrs.fr)
  • Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
  • Although the epidermal Langerhans cell has been presumed to be the cell of origin in LCH, recent studies have called this belief into question. (medscape.com)
  • Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
  • [ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
  • At this point, Birbeck granules were thought to be exclusive to epidermal Langerhans cells, skin-restricted cells of the mononuclear phagocyte system. (capsulehealth.one)
  • We now know that epidermal Langerhans cells are not nerves but dendritic cells, a heterogeneous group of hematopoietic cells enriched in interface tissues and lymphoid organs. (capsulehealth.one)
  • Epidermal Langerhans cells are unique among dendritic cells in that they arise not from myeloid progenitor cells in bone marrow but rather from yolk-sac progenitors and fetal liver-derived monocytes that populate the skin before birth and are maintained locally under steady-state conditions. (capsulehealth.one)
  • Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy? (fujita-hu.ac.jp)
  • Dive into the research topics of 'Do epidermal Langerhans cells, migrating from skin lesions, induce the paracortical hyperplasia of dermatopathic lymphadenopathy? (fujita-hu.ac.jp)
  • The ultrastructural hallmark of the Langerhans cell, the Birbeck granule, was described a century later. (medscape.com)
  • These cells contain organelles called Birbeck granules. (wikipedia.org)
  • Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
  • [ 1 ] Antigen-presenting cells or histiocyte-like cells containing Birbeck granules have been identified within inflamed synovial tissues. (medscape.com)
  • These CD1a- leukocytes include (1) LC as evidenced by the presence of Birbeck granules (BG), (2) CD14+ monocytes, and (3) Birbeck granule-negative cells with a dendritic morphology. (ashpublications.org)
  • To evaluate the utility of immunoexpression of CD1a in the early diagnosis of psoriasis and to study the histopathology of skin biopsies from clinically diagnosed cases of psoriasis. (njlm.net)
  • [ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
  • Those condylomata with moderate to severe mononuclear infiltrate showed leucocyte function antigen 1 positive T cells forming small clusters in the lower epithelial half around the ICAM-1 positive keratinocytes. (medicaljournals.se)
  • T lymphocytes with a mean CD4/CD8 ratio of 0.25 and a mean density of 267 +/- 59 cells/mm2 of epithelial section were the main cellular infiltrate in vulvar papillomavirus infection. (medicaljournals.se)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • Psoriasis is a long-lasting autoimmune disease mediated by T-lymphocytes and dendritic cells. (njlm.net)
  • Follicular dendritic cells (FDC) form a tight meshwork in primary and secondary lymphoid follicles and interact with T and B lymphocytes through antigen presentation and generation and regulation of the germinal centre reaction [ 2 , 3 ]. (biomedcentral.com)
  • It is expressed by those cells related to dermal dendritic cells, derived from monocytes cultured for 6 days in the presence of GMCSF and IL-4. (beckman.com)
  • Our data from micro-dissected LC in both dermatopathic lymphadenopathy [12] and LCS [13] suggest that monocytes, precursor Langerhans cells, or Langerhans cells are one of the reservoir cells for MCPyV. (mayabouchenaki.com)
  • Addition of interleukin (IL)-4 to the cytokine cocktail interfered with the development of monocytes and led to a reduction in the overall yield but, on the other hand, resulted in an increased percentage of CD1a+ cells (mean: 24%) among all cells generated. (ashpublications.org)
  • The CD1 family: serving lipid antigens to T cells since the Mesozoic era. (hcdm.org)
  • CD1a, as other members of the CD1 family, is involved in the immune response by presenting self and non-self lipid and glycolipid antigens to T cells. (hcdm.org)
  • CD1a is expressed at constitutively high levels by Langerhans cells and presents lipid antigens to T cells, but the potential relevance to GAS infection has not been studied. (ox.ac.uk)
  • Histogenesis is still controversial- dermal dendritical cells? (eurocytology.eu)
  • However LCH cells stain positive to CD14 which is a monocyte marker and shows a different, hematopoietic origin for the disorder. (wikipedia.org)
  • Der bekannteste Marker für Langerhans-Zellen ist CD1a, ein Oberflächenmarker, der an der Antigenpräsentation beteiligt ist. (antikoerper-online.de)
  • Diese Marker erleichtern die Identifizierung und Untersuchung von Langerhans-Zellen in verschiedenen immunologischen und dermatologischen Forschungsarbeiten und geben Aufschluss über ihre Rolle bei Immunreaktionen und Hauterkrankungen. (antikoerper-online.de)
  • However, in LCH there is clearly a dividing clonal cell population, a feature widely considered to be characteristic of a malignant tumor. (histio.org)
  • Further evidence that a cell is a tumor cell is that it has genetic abnormalities. (histio.org)
  • For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)
  • In vitro stimulation of these cells with granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-alpha led to their vigorous proliferation and differentiation resulting in the emergence of CD45+/CD68+/CD3-/CD19- /CD56- leukocytes some of which (mean: 12%) express CD1a and exhibit anti-CD4 and anti-major histocompatibility complex (MHC) class II reactivity. (ashpublications.org)
  • abstract = "The present study shows that Langerhans cells can be differentiated from Interdigitating cells at the light microscopic level. (fujita-hu.ac.jp)
  • abstract = "In the present study, immunohistochemical and immunoelectron microscopic techniques were used to differentiate Langerhans cells (LC) from interdigitating cells (IDC) in the lymph nodes (LN) of dermatopathic lymphadenopathy. (fujita-hu.ac.jp)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • Using a more sensitive technique for detection of mutant BRAF alleles (droplet digital PCR) [ 9 ], BRAF V600E was not detected in DNA extracted from myeloid or lymphoid cells isolated by flowcytometric sorting from a peripheral blood sample collected at the time of the fourth bone sample. (biomedcentral.com)
  • The photoconjugation of psoralens with DNA produces an antiproliferative reaction in the skin, generates programmed cell death (apoptosis), and induces down-regulation of the cutaneous immune system. (medscape.com)
  • Healthy individuals had high frequencies of circulating and cutaneous GAS-responsive CD4+ and CD8+ T cells with rapid effector functions, including the production of interleukin-22 (IL-22). (ox.ac.uk)
  • A Touton giant cell is a multinucleated cell that contains a wreath of nuclei surrounding homogeneous cytoplasm, with a rim of foamy cytoplasm peripheral to the nuclei. (eyewiki.org)
  • In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
  • Like the other CD1 proteins (group 1: CD1a, CD1b, CD1c and group 2: CD1d, CD1e), CD1a is a transmembrane protein of 49 kDa, noncovalently associated with β2-microglobulin. (beckman.com)
  • For example, TAMs suppress effector T-cells through immune checkpoint molecules, such as those of the programmed cell death 1 (PD-1) ( 7 ) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) ( 8 , 9 ) pathways. (iiarjournals.org)
  • These neoplastic cells are the result of sporadic activating mutations in genes of the mitogen-activated protein kinase (MAPK) signaling pathway expressed by multipotent hematopoietic stem/progenitor cells or committed myeloid precursors [ 1 ]. (biomedcentral.com)
  • CD1a [O10] staining has been shown to be useful in the differentiation of Langerhans cells from interdigitating cells. (micro-shop.pl)
  • Langerhans cells are a unique population of dendritic cells found in the epidermis, where they can be identified by Cluster of Differentiation 1a (CD1a) positivity. (njlm.net)
  • During its natural life cycle, HPV16 infects the basal cells of the epithelium and interacts with Langerhans cells within the epithelial layer, which are responsible for initiating immune responses against epithelial invading pathogens. (wikipedia.org)
  • Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. (mayabouchenaki.com)
  • risk of basal and squamous cell skin cancer. (who.int)
  • CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. (biolegend.com)
  • I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
  • It was demonstrated that Langerhans cells in HPV-induced cervical lesions were spherical, lacked dendrites, and secreted the suppressive cytokine IL-10 in vivo. (wikipedia.org)
  • The authors further demonstrated that the number of IL-10 secreting immunosuppressive Langerhans cells, and the amount of IL-10 produced in lesions, corresponded with the severity of histopathology and HPV viral load, providing evidence of an active immunosuppressive mechanism employed by HPV that targets Langerhans cells in vivo. (wikipedia.org)
  • This finding may mean that LC In the LN are fully developed cells and do not divide In the LN. Langerhans cells may migrate from the skin lesions to the paracortical areas in the LN, which then may become enlarged. (fujita-hu.ac.jp)
  • CD1a is a non-polymorphic type 1 integral glycoprotein with a similar structure to MHC class I molecules. (hcdm.org)
  • We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. (medscape.com)
  • Cite this: Langerhans Cell Granulomatosis Manifested as Pigmented Villonodular Synovitis - Medscape - Dec 01, 2001. (medscape.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown (\"X\") because its cellular basis has now been clarified. (mayabouchenaki.com)
  • One of the key cellular components with functional roles in both innate and adaptive arms of the immune response are Langerhans cells (LCs) (2). (mayabouchenaki.com)
  • Research in fields studying cellular response to surface tension and mechanical forces necessitates cell culture tools with tunability of substrate stiffness. (mdpi.com)
  • I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. (cardiff.ac.uk)
  • 2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
  • 107] demonstrated that IL-1 production and signaling from the IL-1 receptor are necessary components of Raf-induced transformation of NIH 3 T3 cells, which exclude other factors involvement in the vivo model [85]. (mayabouchenaki.com)
  • We found IL-17A receptor expression levels in LCH cells are important for defining LCH subclasses. (mayabouchenaki.com)
  • 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. (biolegend.com)
  • CD1a is a member of the lipid antigen presenting molecules family. (beckman.com)
  • The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. (thermofisher.com)
  • Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
  • JXG is the most common form of non-Langerhans' cell histiocytoses. (eyewiki.org)
  • CD1a may be a novel biomarker for Barrett's metaplasia, and its expression may help to predict the prognosis of this pathology. (micro-shop.pl)
  • 2023. SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses . (cardiff.ac.uk)
  • Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation. (ox.ac.uk)
  • However, HPV does not activate Langerhans cells in vitro, and this may represent a key mechanism by which HPV evades immune detection in vivo. (wikipedia.org)
  • In vitro generated CD1a+, but not CD1a- HPC-derived cells are potent stimulators of the primary mixed leukocyte reaction and, as such, promising candidates for vaccination purposes. (ashpublications.org)
  • Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
  • Furthermore, individuals with psoriasis had significantly higher frequencies of circulating GAS-reactive T cells, enriched for markers of activation, cytolytic potential, and tissue association. (ox.ac.uk)
  • The results indicated that in vulvar papillomavirus infection the intraepithelial Langerhans' cells showed abnormal morphology and a significantly lower density than controls. (medicaljournals.se)
  • CD1a positive Langerhans' cells were also observed in dermis of condylomata, suggesting an abnormal epithelial traffic of dendritic cells. (medicaljournals.se)
  • The abnormal cells in LCH have abnormal proliferation and lower antigen-presenting capability. (capsulehealth.one)
  • Immunohistochemical staining of MMP1 and MMP25 as well as chemokine (C-C motif) ligand (CCL) 5 in the lesional skin from five patients with PCAC showed a substantial number of MMP1-bearing cells and MMP25-bearing cells, as well as CCL5-producing cells, that were distributed in the lesional skin. (iiarjournals.org)
  • Histopathological features in early psoriasis were studied, and CD1a immunoexpression in lesional, perilesional, and distant skin was analysed. (njlm.net)
  • In this study, the average number of CD1a positive Langerhans cells was highest (54.92±5.26) in perilesional skin compared to lesional skin (30±3.96), which was statistically significant (p-value=0.04). (njlm.net)
  • Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule. (hcdm.org)
  • This molecule is also expressed on some circulating and marginal zone B cells, as well as in lymph nodes and germinal centers. (fishersci.com)
  • Together, these findings link GAS infection to the CD1a pathway and show that GAS infection promotes the proliferation and activation of CD1a-autoreactive T cells, with relevance to post-streptococcal disease, including the pathogenesis and treatment of psoriasis. (ox.ac.uk)
  • It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. (biolegend.com)
  • Here, we investigated whether GAS-responsive CD1a-restricted T cells contribute to the pathogenesis of psoriasis. (ox.ac.uk)