• As indicated by immunohistochemical analyses, TRAP significantly increased microglial infiltration in the CA1 hippocampus, but decreased astrogliosis in the dentate gyrus. (nature.com)
  • To gain insight into the comparative organization of the hippocampal formation in catarrhine primates, we quantified neurons stereologically in its major subdivisions-the granular layer of the dentate gyrus, CA4, CA2-3, CA1, and the subiculum-in archival brain tissue from six chimpanzees ranging from 29 to 43 years of age. (mssm.edu)
  • These are 3-repeat tau-immunopositive bodies predominantly located in granular neurons in the hippocampal dentate gyrus, hippocampal CA1 pyramidal neurons, and layer II of frontal and temporal cortices. (medscape.com)
  • layer III projects primarily to hippocampal region CA1 and the subiculum. (wikipedia.org)
  • The highest levels are in neurons of entorhinal cortex layer II, alongside hippocampal neurons at the CA1/subiculum border. (lu.se)
  • In the context of prior investigations of rhesus monkeys and humans, our findings indicate that, in the hippocampal formation as a whole, the proportions of neurons in CA1 and the subiculum progressively increase, and the proportion of dentate granule cells decreases, from rhesus monkeys to chimpanzees to humans. (mssm.edu)
  • Because CA1 and the subiculum engender key hippocampal projection pathways to the neocortex, and because the neocortex varies in volume and anatomical organization among these species, these findings suggest that differences in the proportions of neurons in hippocampal subregions of catarrhine primates may be linked to neocortical evolution. (mssm.edu)
  • Recently, three independent studies, two using parallel neurophysiological recording methods and one using immediate-early gene imaging, have examined the responses of CA3 and CA1 ensembles to alterations of environmental context in rats. (nih.gov)
  • Homosynaptic long-term depression (LTD) was studied in hippocampal slices from 12-18-d-old rats using field EPSP recording in the apical dendritic layer of CA1 pyramidal cells. (jneurosci.org)
  • We show that, in rats, reward-predictive cues result in enhanced hippocampal theta and beta band rhythmic activity during subsequent action, compared with uncued goal-directed navigation. (jneurosci.org)
  • In male rats, TRAP significantly increased hippocampal neurogenesis, while in females, TRAP increased granule cell layer width. (nature.com)
  • The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
  • In addition, hippocampal dystrophin levels were estimated by Western blot analysis in biopsies from TLE patients, post-mortem controls, amygdala kindled (AK)-, and control rats. (frontiersin.org)
  • Hippocampal full-length dystrophin (Dp427) levels are upregulated in human TLE, but not in AK rats, possibly indicating a compensatory mechanism in the chronic epileptic human brain. (frontiersin.org)
  • After behavioral tests were completed, serum, feces, and hippocampal tissue of rats were collected. (medscimonit.com)
  • This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
  • RESULTS: In healthy Wistar rats, we find intracellular Aβ42 (iAβ42) in neurons throughout the brain at all ages, but levels vary greatly between brain regions. (lu.se)
  • In the hippocampal CA1 region, long‐term potentiation requires stronger stimulation for induction in aged rats and mice and long‐term depression becomes more prevalent. (dericbownds.net)
  • Material/Methods: Adult male rats were bilaterally cannulated into the CA1 region of their hippocampus. (medscimonit.com)
  • To address this issue, we evaluated behavioral responses, assessed neuronal function and integrity, and conducted a comprehensive analysis of mitochondria-related parameters in selected brain regions of aged (24 months old) male rats supplemented with testosterone propionate (TP). (aging-us.com)
  • 1997. Congener-specific effects of maternal PCB exposure on functional plasticity in cortical and hippocampal slices of rats. (cdc.gov)
  • The temporoammonic (TA) pathway is the direct, monosynaptic projection from layer III of entorhinal cortex to the distal dendritic region of area CA1 of the hippo- campus. (caltech.edu)
  • In the CA3 region, there was no difference in dendritic arborization between hydrocephalic and control mice. (bvsalud.org)
  • In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippocampal slices and the pathway through which lead induced these effects were studied with conventional whole-cell recording. (nih.gov)
  • For this purpose the extent of chemically and electrically induced LTP of hippocampal slices each was compared between Cav1.2HCKO- and control mice. (tum.de)
  • For this purpose the extent of chemically and electrically induced LTP of hippocampal slices. (tum.de)
  • Ripple oscillations persist in the absence of chemical synaptic transmission and inhibitors of gap junctions were shown to block high-frequency oscillations in hippocampal slices. (medscimonit.com)
  • Frequency-Dependent Synaptic Dynamics Differentially Tune CA1 and CA2 Pyramidal Neuron Responses to Cortical Input. (rush.edu)
  • CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. (yale.edu)
  • A number of electrophysiological techniques have been employed to study synaptic function in the rat hippocampal slice preparation. (soton.ac.uk)
  • The TA pathway provides a strongly excitatory input to stratum radiatum giant cells of CA1. (caltech.edu)
  • The Dendrites of CA2 and CA1 Pyramidal Neurons Differentially Regulate Information Flow in the Cortico-Hippocampal Circuit. (rush.edu)
  • this spike-blocking effect shows that the TA pathway can act to regulate information flow through the hippocampal trisynaptic pathway. (caltech.edu)
  • Ventral striatal neuronal firing phase-locked not only to hippocampal theta, but also to beta band activity. (jneurosci.org)
  • In this model, autaptic hippocampal neurons express CB1 receptors, the cellular machinery to synthesize and metabolize the endocannabinoid 2-AG, and several other forms of CB1-mediated neuronal plasticity (Kellogg et al. (fabbs.org)
  • Consequences of transient ischemia on the neuronal activity of hippocampal CA1 region were investigated in Mongolian gerbil. (en-journal.org)
  • Marked neuronal loss and cortical atrophy, especially in right ventral and dorsal frontal and anterior temporal regions. (medscape.com)
  • Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons. (rush.edu)
  • The use of information from the hippocampal memory system in motivated behavior depends on its communication with the ventral striatum. (jneurosci.org)
  • It is unknown, however, how this process affects hippocampal dynamics and their influence on target structures, such as ventral striatum. (jneurosci.org)
  • These results suggest that cue-triggered reward expectancy intensifies hippocampal output to target structures, such as the ventral striatum, by which the hippocampus may gain prioritized access to systems modulating motivated behaviors. (jneurosci.org)
  • Morphological analysis was carried out on hematoxylin and eosin stained coronal sections of the hippocampus: the pyramidal neurons (normal and pyknotic) in the CA1 and CA3 subregions were counted and the pyknotic index (PI) was calculated. (bvsalud.org)
  • Dystrophin was expressed in all hippocampal pyramidal subfields and in the molecular-, Purkinje-, and granular cell layer of the cerebellum. (frontiersin.org)
  • Neuron loss in the cerebellum and changes found in volume of regions in cerebellum and brain stem (MeHg) most likely account for motor impairment. (cdc.gov)
  • Relating the motor activity results with the neuropathology findings it was concluded that the hyperactivity on PN 21 (MAM) suggested a loss of spatial memory due to observed neuron loss in the hippocampal CA1 region, rather than motor impairment. (cdc.gov)
  • The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to abilities thought to be uniquely human, yet little is known about how the human hippocampal formation compares to that of our closest living relatives, the chimpanzees. (mssm.edu)
  • Although this pathway has been implicated in various functions, such as memory encoding and retrieval, spatial navigation, generation of oscillatory activity, and control of hippocampal excitability, the details of its physiology are not well understood. (caltech.edu)
  • The second project was an extracellular electrophysiological study of CA1 pyramidal cell region in the slice. (soton.ac.uk)
  • I show that the TA pathway is subject to forms of short-term activity-dependent regulation, including paired-pulse and frequency- dependent plasticity, similar to other hippocampal pathways such as the Schaffer collateral (SC) input from CA3 to CA1. (caltech.edu)
  • CA1 Region, Hippocampal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • The beta band component, also labeled theta's harmonic, involves selective hippocampal CA1 cell groups showing frequency doubling of firing periodicity relative to theta rhythmicity and it partitions the theta cycle into segments showing clear versus poor spike timing organization. (jneurosci.org)
  • Alterations in the neural activity across the brain region results in an observed "traveling wave" phenomena across the MEC long-axis, similar to that of the hippocampus, due to asymmetric theta oscillations. (wikipedia.org)
  • Histological analysis indicated that in both hemispheres CA1 cell death was observed in Group 2 but it was noticed only at small region in Group 1. (en-journal.org)
  • Representative sections and quantification of the histological assessment of the hippocampal CA1 region at 72 hours post-cardiac arrest. (himafund.org)
  • The temporal lobe is the most epileptogenic region of the brain. (medscape.com)
  • Electrical coupling is also known to be important in the development of hippocampal and neocortical principal cell networks. (degruyter.com)
  • Its presence in the latter regions is illustrated by the cognitive problems seen in Duchenne Muscular Dystrophy (DMD). (frontiersin.org)
  • SyG37 mice showed an age‐dependent decline in cognitive abilities in behavioural tasks that require hippocampal processing including the Barnes maze, T‐maze and object location but not recognition tests. (dericbownds.net)
  • The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. (colorado.edu)
  • In this thesis, I examine the contribution of the TA pathway to hippocampal processing. (caltech.edu)
  • This protein serves as a kind of molecular glue that likely imparts specific functional properties to this region. (nih.gov)
  • The results of this study suggest that functional loss of CA1 activity and morphological death following ischemia in chronically implanted Mongolian gerbil could not occur in parallel. (en-journal.org)
  • In the high-frequency region, the phase shift was close to zero, indicating simultaneous fluctuations of RR and systolic pressure. (researchgate.net)
  • This NEURON code implements a small network model (100 pyramidal cells and 4 types of inhibitory interneuron) of storage and recall of patterns in the CA1 region of the mammalian hippocampus. (yale.edu)
  • Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. (yale.edu)
  • Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative memory network, capable of performing the competing functions of pattern completion and pattern separation. (nih.gov)
  • It is usually divided into medial and lateral regions with three bands with distinct properties and connectivity running perpendicular across the whole area. (wikipedia.org)
  • The large, crescent-shaped area in green is hippocampal zone CA1. (nih.gov)
  • Brain morphology showed considerable effects of MAM in the forebrain including also a loss of hippocampal CA1 neurons. (cdc.gov)
  • These effects were consistent with improved mitochondrial function, reflected by testosterone-induced increases in mitochondrial membrane potential (MMP), antioxidant enzyme (GSH-PX, catalase, and Mn-SOD) expression/activity, and mitochondrial respiratory complex activities in both brain regions. (aging-us.com)
  • EC neurons process general information such as directional activity in the environment, which contrasts to that of the hippocampal neurons, which usually encode information about specific places. (wikipedia.org)
  • Thereafter, CA1 activity was gradually de-creased to below the pre-ischemia level (-29.17% at day 3 in Group 1 and -44.95% at day 4 in Group 2). (en-journal.org)
  • Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons. (rush.edu)
  • In these regions it colocalized with GFAP, suggesting expression in astrocytes such as Bergmann glia (BG) and velate protoplasmic astrocytes. (frontiersin.org)
  • If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)
  • Hence the aim of this work was to analyze the role of the Cav1.2 L-type VDCC for LTP in the hippocampal CA1 region by means of a mouse line with a forebrain-specific inactivation of the Cav1.2 gene (Cav1.2HCKO). (tum.de)
  • An important basis for representing the spatiotemporal components of memory traces is the location-selective discharge of hippocampal neurons ("place cells") as rodents navigate through an environment ( O'Keefe and Dostrovsky, 1971 ). (jneurosci.org)
  • MicrocircuitDB: Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. (yale.edu)
  • 1 . Cutsuridis V, Cobb S, Graham BP (2010) Encoding and retrieval in a model of the hippocampal CA1 microcircuit. (yale.edu)
  • Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. (rochester.edu)
  • This graph shows the total number of publications written about "CA1 Region, Hippocampal" by people in this website by year, and whether "CA1 Region, Hippocampal" was a major or minor topic of these publications. (rush.edu)