• In cases of lung metastasis, large tumor masses underwent necrosis, with some of them hemorrhaging and even fewer exhibiting acute inflammation. (wikipedia.org)
  • The Lewis lung carcinoma tumor model's role in cancer has been its use for research into tumor metastasis and angiogenesis properties. (wikipedia.org)
  • The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. (nih.gov)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
  • We tested the role of systemic fetuin in tumor cell growth and metastasis by injecting Lewis lung carcinoma (LLC) cells into fetuin-A null and their wild-type (WT) littermate control C57BL/6 mice via the tail vein, s.c., and intrasplenic routes. (ac.ke)
  • In the experimental metastasis assay, the lungs of the WT mice were filled with metastatic nodules, whereas the lungs of the fetuin-A null mutant mice were virtually free of colonies at the end of 2 weeks. (ac.ke)
  • Similarly, intrasplenic injection of LLC cells resulted in rapid colonization of the liver with metastasis to the lungs within 2 weeks in the WT but not fetuin-A null mice. (ac.ke)
  • Early metastasis is still the most recalcitrant factor in the treatment of lung cancer patients. (scienceopen.com)
  • In vivo 0.4, 2.0, and 8.9 µmol/kg of BHIMHA dose dependently inhibited the metastasis of LLC (Lewis Lung Carcinoma) toward lung. (scienceopen.com)
  • Therefore, BHIMHA simultaneously blocked tumor metastasis toward lung, slowed the primary tumor growth, and limited the inflammation. (scienceopen.com)
  • Main methods: Anticancer activity of the I. obliquus extract was examined in mouse models of Lewis lung carcinoma growth and spontaneous metastasis after 3 weeks of continuous extract intake at the dose of 6 mg/kg/day, which corresponded to that ingested daily with Chaga infusion in Japan. (researchgate.net)
  • Furthermore, the frequency of predicted pathogenic mtDNA mutations was significantly correlated with distant metastasis in patients with non-small cell lung carcinoma (NSCLC) and colon cancers [ 2 ]. (biomedcentral.com)
  • Navelbine and carboplatin, two chemotherapeutics currently on the market, were tested in C57BL mice with Lewis lung carcinoma tumors in their hind flank. (wikipedia.org)
  • Current evidence finds that circulating exosomal lncRNA focally amplified lncRNA on chromosome 1 (FAL1) promotes the progression of hepatocellular carcinoma (HCC). (bvsalud.org)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors. (wikipedia.org)
  • Orthotopic models focus upon correctly modeling the tumor microenvironment by injecting or implanting tumors into the corresponding organ that they originated from (i.e. implanting a Lewis lung carcinoma into the lung of another C57BL mouse). (wikipedia.org)
  • The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
  • In spite of these differences, rodent lung tumors recapitulate many fundamental areas of human being lung tumor biology Dinaciclib kinase inhibitor in the morphologic Dinaciclib kinase inhibitor and molecular level specifically in lung malignancies resulting from contact with environmental carcinogens. (bioshockinfinitereleasedate.com)
  • Any risk of strain variations in the occurrence of spontaneous lung tumors in the rat aren't as striking as with the mouse. (bioshockinfinitereleasedate.com)
  • The purchase of reducing incidences of spontaneous lung tumors in a variety of rat strains can be F344 (1.9%), Lewis (1.8%) Osborne Mendel (0.7%), Brown Norway (0.6%) Sprague Dawley (0.5%), Wistar (0.5%), Compact disc (0.4%) ACI/N (0%) (Manenti and Dragani, 2005). (bioshockinfinitereleasedate.com)
  • Lung cancer of rodents and humans shares several important morphologic and molecular similarities (Nikitin mutations in humans are primarily targeted within codon 12 followed by codons 61 and 13 and the same trend is seen in mouse tumors. (bioshockinfinitereleasedate.com)
  • Meta-analysis of transcriptomic alterations in human COG7 and mouse lung tumors revealed significant similarities in lung cancer pathways in both species (Stearman em et al. (bioshockinfinitereleasedate.com)
  • These data indicate that mouse lung tumors are similar to human adenocarcinomas at the morphologic and molecular levels and that mouse lung tumors are relevant in evaluating carcinogenic hazards associated with environmental exposures. (bioshockinfinitereleasedate.com)
  • In a recent workshop organized by the US EPA on mouse lung tumors, Dr. Dan Krewski from the University of Ottawa presented information on the human and rodent cancer site concordance of IARC group I agents (109) (Krewski, 2014). (bioshockinfinitereleasedate.com)
  • Tumors in the lung had greater site concordance than any other organ in the body, indicating that rodents are indeed most suitable to study environmental pulmonary carcinogens. (bioshockinfinitereleasedate.com)
  • Generally, Lewis lung carcinoma is highly metastatic in immunocompetent mice. (wikipedia.org)
  • Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
  • When MitoTracker Deep Red-labeled high-metastatic Lewis lung carcinoma A11 cells carrying the ND6 G13997A mtDNA mutation were cocultured with CellLight mitochondria-GFP-labeled low-metastatic P29 cells harboring wild-type mtDNA, bidirectional transfer of red- and green-colored vesicles, probably mitochondria-related EVs, was observed in a time-dependent manner. (biomedcentral.com)
  • T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. (wakeup-world.com)
  • They have been shown in laboratory tests to kill pre-cancer cells, Lewis Lung carcinoma, and prevent DNA damage. (bns53.com)
  • CAPE inhibited the growth and neovascularization of primary tumor cells in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. (northwestern.edu)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
  • In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. (wikipedia.org)
  • They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. (wakeup-world.com)
  • According to the World Health Organization, lung cancer has the highest mortality rate of all cancers. (frontiersin.org)
  • [1] However, the five-year lung cancer survival rate is only around 20% and is considerably lower than other cancers. (labcorp.com)
  • If lung cancer is detected early, the five-year survival climbs to ~56%, but only ~16% of lung cancers are detected that early. (labcorp.com)
  • On the host side, antibiotic-induced dysbiosis caused elongated small intestines and ceca, and B16-F10 melanoma and Lewis lung carcinoma progressed more quickly than in control mice. (aacrjournals.org)
  • In 2019, the American Cancer Society estimates that 228,150 new cases of lung cancer (116,440 in men and 111,710 in women) will be diagnosed, and 142,670 deaths from lung cancer (76,650 in men and 66,020 in women) will occur. (labcorp.com)
  • Some people use Panax ginseng to treat breast cancer and prevent ovarian cancer , liver cancer , lung cancer , and skin cancer . (emedicinehealth.com)
  • I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. (wakeup-world.com)
  • 8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. (wakeup-world.com)
  • Lung tissues of patients with RIPF and idiopathic pulmonary fibrosis, and lung tissues from various fibrotic mouse models, as well as appropriated cell line systems were used. (biomedcentral.com)
  • Inverse correlation between pHSP27 and Smurf2 was observed in the lung tissues of PF animals, an irradiated orthotropic lung cancer models, and PF tissues from patients. (biomedcentral.com)
  • Moreover, in vivo assays with Lewis lung carcinoma (LLC) C57BL/6J male mice showed that the C60+Cis complex increases tumor growth inhibition, when compared to Cis or C60 fullerenes alone. (hereon.de)
  • In vivo, 2 µmol/kg of BHIMHA showed additional actions of slowing the growth of the primary tumor of C57BL/6 mice and S180 mice as well as inhibiting xylene-induced ear edema of the mice. (scienceopen.com)
  • The Country wide Toxicology Applications mouse model (B6C3F1) gets the C57BL/6J-type haplotype since both mother or father C57BL6 and C3H strains possess the C57BL/6J-type haplotype (Manenti and Dragani, 2005). (bioshockinfinitereleasedate.com)
  • Targeting of CD169+ macrophages in order to inhibit tumor Lewis lung carcinoma growth also caused depletion of bone and bone marrow in mice. (wikipedia.org)
  • Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
  • A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases. (wakeup-world.com)
  • Pulmonary fibrosis (PF) is a chronic and fatal interstitial lung disease involving deposition of collagen and extracellular matrix (ECM) around the fibrotic foci, as well as honeycomb changes of the subpleural and basement membranes. (biomedcentral.com)
  • One of these models is the LL/2 (Lewis Lung) lung carcinoma model that has been characterized by Labcorp to support development of novel agents. (labcorp.com)
  • Ferritin-based protein C nanoparticles (PCNs), known as TFG and TFMG, were generated and tested in Lewis lung carcinoma (LLC) allograft and MMTV-PyMT spontaneous breast cancer models. (biomedcentral.com)
  • HSP25 (murine form of HSP27) transgenic (TG) and LLC1-derived orthotropic lung tumor models were also used. (biomedcentral.com)
  • Interestingly, the pulmonary adenocarcinomas in smokers and chemically induced bronchioloalveolar carcinomas in mice usually harbor G to T transversions (Husgafvel-Pursiainen and Kannio, 1996, Hong em et al. (bioshockinfinitereleasedate.com)
  • The pleura is a thin membrane that covers the outer surface of the lungs as well as the mediastinum, diaphragm, and inner surface of the chest wall. (medscimonit.com)
  • The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. (wakeup-world.com)
  • Taking Panax ginseng by mouth seems to improve lung function and some symptoms of COPD . (emedicinehealth.com)
  • There are many treatment options for lung cancer, depending on which type of lung cancer one is diagnosed with and what stage of disease is present. (labcorp.com)
  • The inhibition of circIGF2BP3/PKP3 enhanced the treatment efficacy of anti-PD-1 therapy in a Lewis lung carcinoma mouse model. (biomedcentral.com)
  • Panax ginseng is also used for depression , anxiety , general fatigue and chronic fatigue syndrome (CFS), multiple sclerosis , for boosting the immune system, and for fighting particular infections in a lung disease called cystic fibrosis. (emedicinehealth.com)
  • These mice were selected for their genetic background proximity to C57BL/6J mice. (wikipedia.org)
  • Examples of clear human carcinogens that were difficult to model in rodents There is overwhelming epidemiologic data demonstrating the lung cancer hazard associated with exposures to arsenic and tobacco smoke. (bioshockinfinitereleasedate.com)
  • Lung colonization responded to the levels of serum fetuin-A in a dose-dependent manner, as observed by the formation of half as many colonies in mice heterozygous for the fetuin-A locus compared with homozygous WT mice and restoration of lung colonization by the administration of purified fetuin-A to fetuin-A-null mice. (ac.ke)
  • An Italian study published in the journal Reproductive Biology and Endocrinology, titled " Levothyroxine and lung cancer in females: the importance of oxidative stress ," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). (wakeup-world.com)
  • An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5′-monodeiodination (DI). (wakeup-world.com)
  • The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. (wakeup-world.com)
  • In the United States, statistics from 2013 to 2018 show that men account for approximately 46.9% of lung cancer and women account for 32.0% ( 1 ). (frontiersin.org)
  • Lung cancer is the second most common cancer diagnosed in both men and women in the United States and is, by far, the most common cause of cancer-related deaths in men and women. (labcorp.com)
  • This randomized double-blind placebo-controlled clinical trial was conducted on 30 women with breast carcinoma aged 28-65 years. (betaglucan.com)
  • Lung cancer remains the most common malignancy and is the leading cause of cancer-related death globally [ 1 ]. (biomedcentral.com)