Butyrate response factor 1. Medical search. Frequent questions

Propionate concentrations in feces were consistently elevated in treated mice, while the concentrations of acetate and butyrate reflected a dependence on study site. (biomedcentral.com)
Cox proportional hazards regression showed that the fecal concentrations of acetate, butyrate, and propionate were, together, predictive of mouse longevity even while controlling for sex, site, and acarbose. (biomedcentral.com)
acetate, butyrate, proprionate) by the microflora of the large bowel. (biomedcentral.com)
In a four-week study comparing a standard low-fiber Western diet to a high-fiber diet with high levels of resistant starch from potato and wheat bran concentrated in the hemicellulose fiber arabinoxylan, levels of butyrate, acetate and other SCFAs significantly increased, as did epithelial mucin 2 (MUC2) and the tight junction protein occludin. (pureprescriptions.com)
These metabolic responses were associated with changes in appetite and energy intake, and plasma acetate and succinate were subsequently identified as potential novel mediators of exercise-induced appetite and energy intake responses. (imperial.ac.uk)
In particular, soluble fiber may be important in and 48 mo from 3358 children from the United States and Germany this respect, because it is converted to the short-chain fatty acids prospectively followed in the TEDDY (The Environmental Deter- acetate, propionate, and butyrate by bacterial fermentation in the minants of Diabetes in the Young) study. (lu.se)

These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. (nih.gov)
The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. (nih.gov)

This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. (nih.gov)
Figure 1: The barplots show the top 50 bacteria within the network based on their centrality measures (Betweenness, Degree, Eigenvalue centrality, PageRank). (ecco-ibd.eu)
When you don't eat enough foods consisting of resistant starch, the bacteria in your gut don't produce enough butyrate, and your gut lining suffers. (bodybio.co.uk)
For example, alterations in the relative abundances of Gammaproteobacteria and Verrucomicrobia phyla as well as in the ratios of Firmicutes to Bacteroidetes are associated to overweight, and alterations in butyrate-producing bacteria, such as Faecalibacterium prausnitzii, are often related to diabetes mellitus [11, 12]. (deepdyve.com)
The chemical and physical properties of fibre define how well gut bacteria will respond to supplementation and depend on the composition of an individual's baseline gut ecosystem, which is affected by factors such as diet and genetics, the scientists explain. (foodnavigator.com)
The overall gut microbiota composition establishes the competitive environment of the target bacteria for nutrient acquisition and utilization and was shown to be an important driving force to interindividual variability regarding fibre responses. (foodnavigator.com)
Analyses determined individual shifts in target bacteria which confirm divergent fibre responses occur when utilising both low-specificity dietary fibres. (foodnavigator.com)
Fibres of intermediate and high specificity elicited similar responses across subjects in support of targeted bacteria and high-specificity dietary fibres. (foodnavigator.com)
These were associated with increases in ratios of related metabolites (butyrate and propionate, respectively) in every microbial community in which these bacteria were present, which help support many of the body's essential functions, they explained. (foodnavigator.com)
This is because bacteria that live in the GI tract break down fiber through fermentation, increasing production of short chain fatty acids (SCFAs), like butyrate. (wholisticmatters.com)
Accepted August 23, 2012 ABSTRACT The catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria. (studyres.com)

The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of the microbiota in these diseases. (frontiersin.org)
Gut microbiota composition is influenced by internal and external factors. (springer.com)
As for external factors, faecal transplantations and antibiotics have dramatic but temporary effects on the host microbiota [ 9 ]. (springer.com)
However, to date, there is no conclusive evidence to support this thesis, likely due to the lack of studies focusing primarily on the relationship between the composition of the gut microbiota and metabolic response. (springer.com)
human gut microbiome, data repositories, large-scale and integrative computational tools, modelling, immunomodulation, drug screening Background The human gastrointestinal tract is a complex ecosystem in which eukaryotic cells continuously interact with nutrients and with the complex microbial population of the gut microbiota [1]. (deepdyve.com)
The immune system is trained to ensure a fine balance between the response given to commensal gut microbiota (i.e. homeostatic and healthy situations) and pathogens (i.e. gastrointestinal disorders) [8]. (deepdyve.com)
For example, some dietary factors may alter gut microbiota interactions and affect cancer development and response to cancer treatment [22]. (deepdyve.com)
Dietary (prebiotic) fibres are carbohydrate polymers and oligomers made up of one or more types of sugar units (such as xylose, fructose, glucose, galactose, arabinose, rhamnose) and promote colonic and systemic health, however they provoke different and unpredictable responses to gut microbiota. (foodnavigator.com)
To test their theory, fibres were classified as low (fructooligosaccharides), low-to-intermediate (type 2 resistant starch), intermediate (pectin), and high (insoluble β-1,3-glucan) specificity, and microbiota fermentation evaluated using faecal inoculum from 10 healthy subjects presenting different ratios of gut microbiota. (foodnavigator.com)
microbiota intestinal, en especial con el uso de Lactobacilli y Bifidobacterium spp. (bvsalud.org)

Sodium butyrate induces mitophagy and apoptosis of bovine skeletal muscle satellite cells through the mammalian target of rapamycin signaling pathway. (usda.gov)
Butyrate induces modifications of the CTCF-binding landscape in cattle cells. (usda.gov)
Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages from turbot (Scophthalmus maximus L. (researchgate.net)

Proteins containing CCCH Znf domains include Znf proteins from eukaryotes involved in cell cycle or growth phase-related regulation, e.g. human TIS11B (butyrate response factor 1), a probable regulatory protein involved in regulating the response to growth factors, and the mouse TTP growth factor-inducible nuclear protein, which has the same function. (embl.de)
Tristetraprolin (TTP), the prototype of a class of CCCH zinc finger proteins, is a phosphoprotein that is rapidly and transiently induced by growth factors and serum in fibroblasts. (embl.de)
Based on 49% overall amino acid identity and 84% amino acid identity within the double zinc finger domain, one of the Xenopus proteins (XC3H-1) appears to be the homologue of TTP. (embl.de)
The S. 6803 mutant, deficient in flavodiiron (FLV) proteins 1 and 3, showed the same phenotype as S. 6803(WT). (bvsalud.org)
High-mobility group box 1 (HMGB1), adenosine-triphosphate (ATP), uric acid, heparan-sulphate proteoglycans (HSPG) as a part of extracellular matrix (ECM), and heat-shock proteins are the most significant DAMPs [ 13 , 14 ]. (hindawi.com)
The obvious next step is to integrate this information and learn how genes, proteins, and/or epigenetic factors influence the phenotype of a disease in context of the system. (rsc.org)
In addition to the host regulatory mechanisms response to disease, the microbiome can make changes to the expression of the host features such as their genes, proteins, and/or PTMs. (rsc.org)
Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)

The short chain fatty acid butyrate has been shown to partially ameliorate such phenotypes in other studies, and indeed the same occurs here - exogenous or bacterially produced butyrate suppressed both polyQ aggregation and resultant phenotypes. (plos.org)
The benefits of butyrate, a postbiotic short-chain fatty acid produced in the colon, begin in the gut and extend to a host of other important body systems. (bodybio.co.uk)

The colon utilizes butyrate from the contents of the intestine as an energy source. (wikidoc.org)
Butyrate is one of the three most abundant short-chain fatty acids (SCFAs) produced by anaerobic bacterial fermentation of polysaccharides/fiber in the colon, where it serves as an energy source for epithelial cells. (pureprescriptions.com)
As butyrate is typically produced in the colon, oral butyrate salts have poor palatability and are easily degraded by stomach acid, preventing delivery to the colon. (pureprescriptions.com)

Reviewer #1: The human microbiome is suspected of influencing morbidity and mortality due to protein conformational diseases such as Alzheimer's, Parkinson's and Lou Gehrig's diseases. (plos.org)
Treatment modulated the taxonomic composition and fermentation products of the gut microbiome, while the site-dependence of the responses illustrate the challenges facing reproducibility and interpretation in microbiome studies. (biomedcentral.com)
A key component of the gut microbiome, butyrate has been found to support gut function, hormone regulation, control centers of the brain, and more. (bodybio.co.uk)
Features such as the transcriptome, methylome, proteome, histone post-translational modifications and the microbiome all influence the host response to various diseases and cancers. (rsc.org)
16 Many factors may affect the content and diversity of the human microbiome: antibiotic use, prolonged prescription drug use, dietary changes, gastrointestinal illness, development of chronic conditions, moving to a new country, short term travel, and even the stressful holiday season. (wholisticmatters.com)

This RNA binding protein most likely functions in regulating the response to growth factors. (wikipedia.org)

SCFA concentration in the periphery, however, is very low and therefore difficult to measure accurately so any increase in production of SCFA in response to RS consumption may not be detectable in the peripheral circulation. (biomedcentral.com)
Animal studies suggest that SCFA supplementation may moderate corticosterone response and promote the secretion of peptide YY, to inhibit gastric emptying and intestinal transit time. (pureprescriptions.com)

Recent evidence suggests that a physiological function of TTP is to inhibit tumor necrosis factor alpha secretion from macrophages by binding to and destabilizing its mRNA (Carballo, E., Lai, W.S., Blackshear, P.J., 1998. (embl.de)
The current understanding of aGVHD pathogenesis can be summarized as (1) initial tissue damage induced by the conditioning regimen followed by the denudation of auto- and alloantigens accompanied by massive inflammatory cytokine secretion ("cytokine storm") activating APCs, (2) auto- and alloantigen presentation mediated by APCs together with the costimulatory signaling prime donor's cytotoxic T lymphocytes and their proliferation, and (3) the migration of activated cellular effectors toward GVHD target tissues. (hindawi.com)

At all three study sites, the bloom of a single bacterial taxon was the most obvious response to acarbose treatment. (biomedcentral.com)
An integration host factor that was originally identified as a bacterial protein required for the integration of bacteriophage Q beta ( ALLOLEVIVIRUS ). (nih.gov)
It mediates cellular responses to bacterial pathogens by distinguishing between self and bacterial DNA. (bvsalud.org)

Resistant starch (RS) is any starch that is not digested in the small intestine but passes to the large bowel for fermentation [ 1 ]. (biomedcentral.com)

Indeed, it may influence multiple physiological mechanisms related to human health, i.e. synthesis of micronutrients, defence against pathogens, regulation of glucose and lipid metabolism, and immune function [ 1 ]. (springer.com)
It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE. (rush.edu)

Fluid shifts from the lower into the upper part of the body and might alongside other factors, cause changes in gastrointestinal function. (frontiersin.org)
In other words, one of the most exciting prospects of butyrate is its ability to manage and support healthy gut functions for those who already struggle with gastrointestinal issues. (bodybio.co.uk)

The amount of butyrate available decreases toward the rectum. (wikidoc.org)

Within this context, the prebiotic effect of dietary fibres might be a feasible strategy to prevent T2D, through the modulation of metabolic response. (springer.com)
Metabolic responses to acute exercise are, however, dependent on pre-exercise nutritional practices, including carbohydrate intake. (imperial.ac.uk)

Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
Pathogenic strains then produce two toxins (TcdA and TcdB), which are considered as the major virulence factors, that lead to the disruption of the actin cytoskeleton of intestinal epithelium cells (6,7), therefore, conferring the CDI symptoms (diarrhoea, epithelial apoptosis and ulceration). (studyres.com)

In the present study, we have thoroughly investigated butyrate-induced production and function of IL-22 in fish macrophages. (researchgate.net)

and the transcription factor NF-kB. (pureprescriptions.com)

Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
G-Box Binding Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Factor For Inversion Stimulation Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)

We therefore aimed to determine the interactive effects of dietary carbohydrate and exercise on plasma hormonal and metabolite responses and explore mediators of exercise-induced changes in appetite regulation across nutritional states. (imperial.ac.uk)

The known Arabidopsis PGR5 deficient mutant, pgr5-1, is incapable of P700 oxidation regulation and has been used in numerous photosynthetic studies. (bvsalud.org)
The introduction of PGR5 into pgr5-1 restored P700 oxidation regulation, but remained a pale-green phenotype, indicating that pgr5-1 had additional mutations. (bvsalud.org)

1 However, when patients are treated with therapies that inhibit BRAF, they often develop resistance. (rsc.org)

ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)

When your gut lining lacks the butyrate "fuel" it needs to maintain healthy gut permeability , toxins and pathogens can slip through. (bodybio.co.uk)

Although obesity has been mainly related with perturbations of the balance between food intake and energy expenditure, other factors must nevertheless be considered. (frontiersin.org)
Background: Deficient soluble fiber intake has been suggested to are not well understood, although early diet is suspected to be an dysregulate the immune response either directly or through alter- important factor. (lu.se)
fatty acids may regulate inflammatory responses is based on Results: There were no statistically significantly protective associ- their interaction with GPR43 receptors, which are mainly ex- ations observed between a high intake of soluble fiber and islet pressed on cells of the innate immune system (9). (lu.se)

Genome-wide acetylation modification of H3K27ac in bovine rumen cell following butyrate exposure. (usda.gov)

However, data from indirect calorimetry and oxidation of [1- 14 C]-triolein to 14 CO 2 showed that addition of 5.4% RS to the diet significantly increased fat oxidation. (biomedcentral.com)

The spectrum of diseases caused by C. difﬁcile is highly variable and depends not only on host factors but also, for the severe forms, on the level of toxin production (4). (studyres.com)

Some parasites are able to reduce the immune response of the intestine, an adaptation that helps the parasite colonize the intestine. (wikidoc.org)
CD), wheat allergy (WA), and non-celiac tion and the immune response it presents gluten sensitivity (NCGS)2. (bvsalud.org)

We discuss butyrate and diet more in-depth here. (bodybio.co.uk)
It is important to note that the fat content of the diet has a significant impact on the glycemic response to a meal and some meal tests contained no fat or the fat content of the meal varied among the different RS diets making results from these studies difficult to interpret [ 2 - 4 ]. (biomedcentral.com)
3 For example, phytonutrients from plant-based foods and omega-3 fatty acids in the diet are linked to healthy inflammatory response in the GI tract. (wholisticmatters.com)

The degree of HLA disparity between donor and recipient is a well-known and widely accepted independent risk factor for GVHD development [ 2 ]. (hindawi.com)
Here are the top ten reasons why butyrate is widely considered by functional and holistic health professionals to be a foundation of total body health. (bodybio.co.uk)

Many modern-day humans, though, experience chronic activation of the "fight or flight" response as a result of boosted cortisol levels from everyday stress. (wholisticmatters.com)

Butyrate plays a major role in intestinal physiology, supporting both physical and biochemical protective barrier function, bowel motility, nutrient absorption, and immune activity of intestinal cells. (pureprescriptions.com)

Single-cell transcriptomic and chromatin accessibility analyses of dairy cattle peripheral blood mononuclear cells and their responses to lipopolysaccharide. (usda.gov)
Derived from the peripheral blood of a 1 year old male with acute monocytic leukaemia. (sigmaaldrich.com)

Inadequate butyrate levels in the lower intestine have been suggested as a contributing factor for the disease. (wikidoc.org)
This is because the "fight or flight" response to stress, quantified by changing cortisol levels, prioritizes blood flow to the heart and brain, temporarily sacrificing less vital organs like those in the digestive system. (wholisticmatters.com)

The three most abundant scent chemicals were 1-hexen-3-one, 3-hexanone, and ethyl butyrate. (fountainmagazine.com)
1986. Oncogenic response of strain A/J mice to inhaled chemicals. (cdc.gov)

Clinical trials indicate that butyrate supplementation supports intestinal function and promotes healthy cytokine balance in the GI tract. (pureprescriptions.com)
Dosage can be titrated to 50 mg if the clinical response is not adequate. (medscape.com)

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene. (wikipedia.org)
Thus, these same humans constantly experience the detrimental digestive effects of "fight or flight," even when there is no emergency driving the response. (wholisticmatters.com)

Another protein containing this domain is the human splicing factor U2AF 35kDa subunit, which plays a critical role in both constitutive and enhancer-dependent splicing by mediating essential protein-protein interactions and protein-RNA interactions required for 3' splice site selection. (embl.de)
Acute human studies describe variable postprandial glycemic and/or insulinemic responses to RS ingestion. (biomedcentral.com)

We cannot make any decision about publication until we have seen the revised manuscript and your response to the reviewers' comments. (plos.org)

Introducing AT2G17240, a candidate gene for the second mutation into pgr5-1 restored the pale-green phenotype and partially restored PSI activity. (bvsalud.org)

So, the source of RS can influence the glycemic/insulinemic response to RS ingestion. (biomedcentral.com)
What are the Risk Factors for Digital Dermatitis and How Big is their Influence? (ualberta.ca)
How Do Lifestyle Factors Influence GI Health? (wholisticmatters.com)

Conclusions Our findings inform the utility of family history data as a risk assessment and screening tool for the prevention of ODHBs and to provide additional insights into shared risk factors and pathogenic mechanisms. (cdc.gov)

Novel triglyceride-form SunButyrate™ offers a light and pleasant-tasting, unique triglyceride-form sunflower-based oil designed to protect butyrate from degradation in the stomach and upper GI tract. (pureprescriptions.com)

The dynamics of chromatin accessibility prompted by butyrate-induced chromatin modification in bovine cells. (usda.gov)
THP-1 cells have Fc and C3b receptors and lack surface and cytoplasmic immunoglobulins. (sigmaaldrich.com)
These cells also stain positive for α-napthhyl butyrate esterase, produce lysozymes and are phagocytic (both latex beads and sensitised erythrocytes). (sigmaaldrich.com)
THP-1 cells can also restore the response of purified T lymphocytes to Concanavlin A, show increased CO 2 production on phagocytosis and can be differentiated into macrophage-like cells using for example DMSO. (sigmaaldrich.com)
Special cells in the gut called colonocytes use butyrate as their primary fuel source. (bodybio.co.uk)

Anatomy1

Diseases5

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Acetate6

Propionate and butyrate2

Bacteria11

Microbiota10

Induces3

Proteins12

Short chai2

Colon3

Microbiome5

Binding protein1

SCFA2

Secretion2

Bacterial3

Resistant starch1

Metabolism2

Gastrointestinal2

Decreases1

Metabolic2

Apoptosis2

Macrophages1

Transcription factor1

MeSH3

Dietary1

Regulation2

Inhibit1

Epithelial1

Pathogens1

Intake3

Exposure1

Significantly increased1

HOST FACTORS1

Immune response2

Diet3

Widely2

Chronic1

Physiology1

Peripheral blood2

Levels2

Chemicals2

Clinical2

Humans2

Human2

Publication1

Partially1

Influence3

Mechanisms1

Tract1

Cells5