• Some chemical mutagens, such as 5-bromouracil (5BU), are base analogs. (biologyideas.com)
  • Bromouracil and aminopurine are two common base analogs that are similar to the bases of DNA purine and pyrimidine which are altered during the time of replication and cause mutation. (thesciencenotes.com)
  • Base analog - A base analog is a chemical that can substitute for a normal nucleobase in nucleic acids.A common example would be 5 bromouracil (5BU), the abnormal base found in the mutagenic nucleotide analog BrdU. (academic.ru)
  • 5-Bromouracil (5-BrU, 5BrUra, or br5Ura) is a brominated derivative of uracil that acts as an antimetabolite or base analog, substituting for thymine in DNA, and can induce DNA mutation in the same way as 2-aminopurine. (wikipedia.org)
  • We have synthesized and studied by proton NMR a duplex heptaoligonucleotide containing a 5-bromouracil (brU) o adenine base pair. (utmb.edu)
  • Crick here discussed continued efforts to decipher the genetic code, in particular the use of base-equivalents such as bromouracil (chemically very similar to the base uracil in RNA) to induce mutations, specifically the substitution of one base by another. (nih.gov)