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Spirochete Borrelia burgdorferiAntibodiesBacteriaCauses Lyme diseaseBacteriumInfectionErythemaEvaluated for Lyme NeuroborreliosisStrainsAntigensLyme DiseaseGenospeciesBorreliosisAcute Lyme neuroborreliosisGariniiAfzeliiPrevalence of BorreliaSpeciesPathogenInfectionsProteinsManifestationsAnaplasmaCerebrospinalIxodesEndemic AreaPathogensAntibody indexELISANeurologicSymptomsPatientsNervous SystemFlagellinClinicalBiteAffinity
Spirochete Borrelia burgdorferi5
Antibodies22
  • We investigated a case of B. miyamotoi in- were negative for B. burgdorferi -specific antibodies by fection that was initially diagnosed as seronegative early the chemiluminescent immunoassay LIASON (DiaSorin, Lyme neuroborreliosis (LNB) that could be attributed to B. Vercelli, Italy). (cdc.gov)
  • Because of intrathecal production of specific antibodies, diagnosis of asymptomatic neuroborreliosis was established. (medscape.com)
  • These findings on cardiovascular MRI in combination with positive Borrelia IgM antibodies were strongly suggestive of Lyme carditis. (cmaj.ca)
  • The Borrelia assay is a 2 hour, 96-well indirect ELISA for the qualitative or quantitative determination of Borrelia IgM antibodies in human serum, plasma and CSF samples. (bmgrp.com)
  • In a next step, the conjugate (HRP-conjugated rabbit anti-human IgM antibody) is pipetted into the wells and reacts with the anti-Borrelia IgM antibodies present in the sample. (bmgrp.com)
  • According to European guidelines, diagnosis of Lyme disease is based on the presence of characteristic symptoms and the detection of anti-Borrelia antibodies in patient's serum. (euroimmunblog.com)
  • The ELISA plates are coated with different antigens from Borrelia extracts which bind the corresponding anti-Borrelia antibodies in the sample. (euroimmunblog.com)
  • IgM antibodies against the Borrelia outer surface protein C (OspC) and IgG antibodies targeting the variable major protein-like sequence expressed (VlsE) belong to the first detectable anti-Borrelia antibodies in patients' sera. (euroimmunblog.com)
  • What, however, if there is a negative test result with no detectable anti-Borrelia antibodies, although an infection with Borrelia is strongly suspected? (euroimmunblog.com)
  • In fact, specific anti-Borrelia antibodies cannot be detected in up to 20% of acute Lyme neuroborreliosis patients, especially in the early stages of infection. (euroimmunblog.com)
  • After differentiation, the B-cells produce the specific anti-Borrelia antibodies. (euroimmunblog.com)
  • Anti-Borrelia antibodies may persist especially in CSF for years despite a successful therapy, thereby hindering differentiation between acute and past Lyme neuroborreliosis. (euroimmunblog.com)
  • Immunoenzymatic kits for the semiquantitative / quantitative detection of specific IgG and IgM antibodies against major human pathogenic borrelia strains (B. afzelii, B. garinii and B. burgdorferi sensu stricto) in human serum, plasma, cerebrospinal fluid and synovial fluid and for the determination of intrathecal antibody synthesis. (vidia.cz)
  • Enzymatic immuno-blot LIA kits for the qualitative detection of specific IgG and IgM antibodies against major human pathogenic borrelia strains (B. afzelii, B. garinii and B. burgdorferi sensu stricto) in human serum, plasma, cerebrospinal fluid and synovial fluid. (vidia.cz)
  • The determination of antibodies specific against antigens of human pathogenic strains of Borrelia is one of the tools used in the diagnosis of Lyme borreliosis (LB). The detection of this multisystem disease is based on the detection of early IgM and late IgG antibodies by ELISA and LIA. (vidia.cz)
  • We provide from own research and production our immunoenzymatic kits ELISA-VIDITEST and MONO-VIDITEST and enzymatic immuno-blot kits LIA-VIDITEST for testing of the detection of specific antibodies IgG and IgM isotypes against borrelia antigens (B. afzelii, B. garinii and B. burgdorferi sensu stricto, and also B.spielmanii) in serum / plasma / cerebrospinal fluid / synovial fluid. (vidia.cz)
  • The ELISA-VIDITEST and MONO-VIDITEST anti-Borrelia kits can be achieved to calculate the intrathecal synthesis of specific antibodies in cerebrospinal fluid. (vidia.cz)
  • LIA-VIDITEST anti-Borrelia kits are designed for qualitative detection of specific antibodies against Borrelia antigens. (vidia.cz)
  • The patterns of anti-Borrelia antibodies, in infected people, show a high degree of variability, which makes their assessment difficult. (altmeyers.org)
  • however, high plasma fibrinogen concentration and relative lymphopenia were identified and the horse was seropositive for antibodies against Borrelia burgdorferi . (avma.org)
  • This study concluded that measuring these antibodies is a sensitive and reliable way to detect Lyme neuroborreliosis. (livediseasefree.com)
  • Having antibodies against Borrelia is a common finding in horses in areas where Lyme disease is prevalent. (vetster.com)
Bacteria23
  • Caused by infection with the spirochetal (helical) bacteria Borrelia burgdorferi, Lyme disease is primarily transmitted to humans , as well as dogs , horses and other domesticated animals, by the bite of infected ticks . (newworldencyclopedia.org)
  • Lyme disease is caused by spirochetal bacteria from the genus Borrelia , which has well over 300 known genomic strains. (newworldencyclopedia.org)
  • Borrelia is a genus of gram-negative, microaerophilic bacteria of the class Spirochaetes. (vidia.cz)
  • Furthermore, Borrelia bacteria prefer to adhere to different lymphatic fluids. (altmeyers.org)
  • The BmpA protein (Borrelia membran protein A) seems to play an important role in the adherence of Borrelia bacteria (Verma et al. (altmeyers.org)
  • A number of conserved Borrelia proteins, such as heat shock proteins and parts of flagellin have epitopes that are also found on other bacteria. (altmeyers.org)
  • The main component of Lyme disease, infection is what happens when the borrelia bacteria invade the host's system. (lyme-time.com)
  • Approximately eight to ten weeks later, the State of Connecticut mailed out the letter stating that my tick was a "Lone Star Tick" and it had tested positive for Borrelia burgdorferi, the bacteria which causes Lyme disease. (laedwardswriter.com)
  • Lyme disease is an infectious disease caused by Borrelia burgdorferi bacteria. (medlineplus.gov)
  • Borrelia burgdorferi and it is a highly motile spirochete that belongs to a genus of bacteria that are notorious for giving rise to variant strains. (medicpdf.com)
  • Borrelia are bacteria that are associated with dozens of tick and louse-borne Relapsing Fevers that are found throughout the world. (medicpdf.com)
  • The hallmark attribute that most Borrelia bacteria have in common is their ability to adapt, change and infect host animals that in turn infect many species of ticks and lice. (medicpdf.com)
  • The Lyme bacteria Borrelia burgdorferi likes to preferentially express certain genes and suppress others. (medicpdf.com)
  • Dr. Andrew Pachner infected mice with Borrelia burgdorferi and later extracted the bacteria from the blood and from the brains of the infected mice. (medicpdf.com)
  • This is more bad news as this suggests that the CNS of primates is an isolated and protective incubator for Borrelia bacteria. (medicpdf.com)
  • Digitally colorized scanning electron microscope image depicting a grouping of numerous, Gram-negative anaerobic Borrelia burgdorferi bacteria derived from a pure culture. (health.mil)
  • Lyme borreliosis is (presumably) caused by bacteria of the species Borrelia burgdorferi. (lyme-borreliose-arzt.de)
  • The Borrelia bacteria enter the bloodstream through bites or stings (ticks, insects, fleas, mosquitoes, wasps, etc.) and spread in the tissues and organs of the human body causing numerous non-specific symptoms. (lyme-borreliose-arzt.de)
  • If the Lyme disease bacteria have penetrated the nervous system - CNS (central nervous system) and brain - it is called a neuroborreliosis. (lyme-borreliose-arzt.de)
  • Lyme disease is caused by the tick-borne bacteria Borrelia burgdorferi . (vetster.com)
  • The most well-established form of Lyme disease in horses is neuroborreliosis, a condition where the bacteria affects the brain. (vetster.com)
  • Lyme disease or Lyme borreliosis is an infectious disease caused by borrelia bacteria. (lu.se)
  • The reason is probably differences in the ability of the immune systems of women and men to combat the borrelia bacteria. (lu.se)
Causes Lyme disease1
Bacterium5
Infection19
  • We investigated a A lumbar puncture was performed to assess the patient case of B. miyamotoi infection of the central nervous system resembling B. burgdorferi -induced Lyme neuroborreliosis for viral or lymphomatous meningitis. (cdc.gov)
  • [ 1 , 2 ] This unusual progressive fibrosing skin process is caused by an ongoing active infection with Borrelia afzelii . (medscape.com)
  • Infection of Borrelia burgdorferi was diagnosed with enzyme-linked immunosorbent assay, and acrodermatitis chronica atrophicans was confirmed histologically. (medscape.com)
  • Borrelia burgdorferi infection was diagnosed with enzyme-linked immunosorbent assay, indirect immunofluorescence assay (titer: 1:1,024), and Western blot. (medscape.com)
  • Additional diagnostics revealed signs indicative of a recent infection with Borrelia burgdorferi. (canlyme.com)
  • Before 1975, elements of Borrelia infection were also known as Tickborne meningopolyneuritis, Garin-Bujadoux syndrome, Bannwarth syndrome, or sheep tick fever. (newworldencyclopedia.org)
  • During the infection Borrelia burgdorferi migrate into different tissues of the host organism to reach so-called "immune privileged niches" where they are protected from the attack of the immune system. (altmeyers.org)
  • Note: A distinction between a clinically manifest and a survived Borrelia infection is not possible due to a positive IgG detection. (altmeyers.org)
  • The current notification criteria include a combination of clinical and laboratory results for borrelia infection (excluding Erythema migrans) but there are indications that these criteria are not followed consistently by clinicians and by laboratories. (biomedcentral.com)
  • The infection may disseminate weeks to months following exposure and can result in a range of manifestations, including multiple erythema migrans skin lesions, Lyme neuroborreliosis, Lyme arthritis, borrelial lymphocytoma, acrodermatitis chronica atrophicans (ACA) and Lyme carditis [ 3 ]. (biomedcentral.com)
  • Neuroborreliosis, infection of the nervous system by B. burgdorferi, may occur during early disseminated or late persistent disease. (mssm.edu)
  • The term given to an infection or disease caused by a spirochete of the Borrelia genus. (lyme-time.com)
  • Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick-borne disease complex. (personalconsult.com)
  • Patients with a history of neuroborreliosis who have incomplete resolution of symptoms should be evaluated for B henselae infection. (personalconsult.com)
  • Lyme disease, known commonly outside the U.S. as Lyme borreliosis, is caused by infection with tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex. (health.mil)
  • The migrating redness indicates a Lyme infection, but it does not occur in everyone infected with Borrelia. (lyme-borreliose-arzt.de)
  • However, the absence of erythema migrans does not mean that there is no infection with Borrelia or any other pathogen. (lyme-borreliose-arzt.de)
  • Erythema migrans = response of the body's immune system to the Borrelia infection. (lyme-borreliose-arzt.de)
  • Case Presentation: Lyme disease (LD) is caused by the Ixodes tick-borne infection with spirochetes Borrelia burgdorferi [1]. (shmabstracts.org)
Erythema2
  • Restricting reportable Lyme borreliosis to neuroborreliosis may increase validity, while a more sensitive case definition (potentially including erythema migrans) may better reflect the true burden of disease. (biomedcentral.com)
  • Symptoms in the early stages can start with erythema migraines, followed several weeks later by neuro-borreliosis (meningo-radiculitis, meningitis, or meningo-encephalitis), Lyme arthritis and/or Borrelia lymphocytoma. (orthocureclinic.com)
Evaluated for Lyme Neuroborreliosis1
Strains2
  • Arthralgias and neuroborreliosis are common manifestations when infected with the European strains of Borrelia hence the different symptom patterns to those seen in North American patients. (lymediseaseaction.org.uk)
  • The causative agents are strains of the genus Borrelia. (vidia.cz)
Antigens1
  • The antigens of Borrelia burgdorferi can be separated according to their molecular weight by means of SDS-Page (laboratory method for the separation of proteins) and determined by a size marker. (altmeyers.org)
Lyme Disease6
Genospecies3
  • Apart from this group of closely related genospecies, additional Borrelia species of interest include B. lonestari, a spirochete recently detected in the Amblyomma americanum tick (Lone Star tick) in the U.S. [7] B. lonestari is suspected of causing STARI (Southern Tick-Associated Rash Illness), also known as Masters disease in honor of its discoverer. (newworldencyclopedia.org)
  • Ixodes ricinus ticks and genospecies of Borrelia burgdorferi sensu lato complex. (szu.cz)
  • The present study investigated the prevalence of Borrelia burgdorferi sensu lato (s.l.) genospecies in Ixodes ricinus ticks collected in Hanover, Northern Germany, in 2010. (biomedcentral.com)
Borreliosis3
  • Kriz B, Maly M, Daniel M. Neuroborreliosis in patients hospitalised for Lyme borreliosis in the Czech Republic in 2003 - 2013. (szu.cz)
  • There can be a number of different types of borreliosis, including neuroborreliosis and cardiac borreliosis. (lyme-time.com)
  • Lyme borreliosis is transmitted by the bite of Ixodes ticks infected with Borrelia burgdorferi sensu lato (the term "sensu lato" refers to all of the species of Lyme borrelia) [1] . (cdc.gov)
Acute Lyme neuroborreliosis4
Garinii1
  • Like B. garinii, B. burgdorferi is a trigger of neuroborreliosis. (altmeyers.org)
Afzelii1
  • Flisiak I, Schwartz RA, Chodynicka B. Clinical features and specific immunological response to Borrelia afzelii in patients with acrodermatitis chronica atrophicans. (medscape.com)
Prevalence of Borrelia1
Species6
Pathogen3
  • Borrelia miyamotoi is a newly recognized human pathogen in notable findings. (cdc.gov)
  • OBJECTIVES: To investigate Bartonella henselae as a potential human tick-borne pathogen and to evaluate its role as a coinfecting agent of the central nervous system in the presence of neuroborreliosis. (personalconsult.com)
  • But what does it take for Borrelia burgdorferi to express one of the suppressed genes of an ancient pathogen cousin? (medicpdf.com)
Infections4
  • It is not the deer tick which carries Borrelia and its co-infections in Britain but the sheep tick ( Ixodes ricinus) which feeds on sheep, deer, cattle and many smaller animals. (lymediseaseaction.org.uk)
  • Elevated antibody levels may be a major indicator of neuroborreliosis infections in the central nervous system (CNS). (vidia.cz)
  • Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. (sdsu.edu)
  • PCR analysis of Ixodes scapularis ticks collected in New Jersey identified infections with Borrelia burgdorferi (33.6%), Babesia microti (8.4%), Anaplasma phagocytophila (1.9%), and Bartonella spp. (personalconsult.com)
Proteins3
  • In order to survive in the body of ticks and borrelia hosts, they have gained the ability to adapt to a changing environment by expressing and constantly altering external surface proteins (Osp) and utilizing tick proteins for transmission. (vidia.cz)
  • This panel should contain proteins such as Osp C, BmpA (Borrelia membrane antigen = p39 antigen), p41 antigen and p100 antigen. (altmeyers.org)
  • A number of immunodominant Borrelia proteins could be assigned to the clinical stages of the disease. (altmeyers.org)
Manifestations4
  • Lyme neuroborreliosis (LNB) in children is a challenging diagnosis based on clinical manifestations and laboratory findings. (scirp.org)
  • The trend (average yearly increase or decrease in reported cases) of neuroborreliosis in MSIS was not significantly different from the trend for all other clinical manifestations recorded in MSIS in negative binomial regression ( p = 0.3). (biomedcentral.com)
  • Comparative in vitro and in heated manifestations of the Lyme buy psychiatric rehabilitation second edition amount Borrelia burgdorferi to affinity and 2-slice civil discounts. (vonroda.com)
  • the most common non-cutaneous manifestations are Lyme neuroborreliosis (LNB) and Lyme arthritis. (cdc.gov)
Anaplasma1
  • A key aspect of their research was the consideration of patients suffering from multiple tick-borne diseases simultaneously, such as Borrelia, Babesia, Bartonella, and Anaplasma. (invisible.international)
Cerebrospinal1
Ixodes1
  • The European tick Ixodes ricinus is the vector of several potential human pathogens, of which Borrelia burgdorferi sensu lato (s.l.) and tick-borne encephalitis virus (TBEV) are the most important and well-known in human medicine. (frontiersin.org)
Endemic Area2
  • Oymar, K. and Tveitnes, D. (2009) Clinical Characteristics of Childhood Lyme Neuroborreliosis in an Endemic Area of Northern Europe. (scirp.org)
  • Stinco G, Ruscio M, Bergamo S, Trotter D, Patrone P. Clinical features of 705 Borrelia burgdorferi seropositive patients in an endemic area of northern Italy. (medscape.com)
Pathogens1
  • We know for example that if you rank all the known Borrelia pathogens in a phylogenetic tree based on related genetics, you will find many disease causing pathogens that cause similar symptoms will often end up close together in related groups on the phylogenetic family-tree. (medicpdf.com)
Antibody index2
  • They had been diagnosed as "Possible LNB" or "Not determined" due to negative Borrelia antibody index in CSF. (scirp.org)
  • This is determined by calculation of the Borrelia - specific antibody index (serum/CSF). (euroimmunblog.com)
ELISA2
  • All reagents of the Borrelia IgM ELISA kit as supplied are stable at 4°C until the expiry date stated on the label of each reagent. (bmgrp.com)
  • 2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
Neurologic1
Symptoms3
  • Tveitnes, D., Oymar, K. and Natas, O. (2009) Laboratory Data in Children with Lyme Neuroborreliosis, Relation to Clinical Presentation and Duration of Symptoms. (scirp.org)
  • Therefore, the complete clinical findings in CSF and symptoms have to be considered for diagnosis of Lyme neuroborreliosis. (euroimmunblog.com)
  • Taken together, these findings indicate that the neurotoxic surroundings generated by microglial cell responses to B. burgdorferi in the CNS, may be creating a bystander effect which potentiates the neuronal cell damage responsible for symptoms observed in neuroborreliosis While the cultivation of primary microglia and astrocyte cells is reasonable to attain, there are inherent difficulties in the generation of primary neuronal cultures. (tulane.edu)
Patients2
Nervous System1
  • Inflammation in the central nervous system (CNS) is thought to either cause or contribute to the pathogenesis of many neurodegenerative disorders including Lyme neuroborreliosis. (tulane.edu)
Flagellin1
  • Preparation and immunogenicity of a polyclonal antibody against outer membrane protein OspC and flagellin FlaB of Borrelia burgdorferi [J]. Chines Journal of Vector Biology and Control, 2020, 31(5): 531-535. (bmsw.net.cn)
Clinical1
Bite1
  • Only if the patient remembers or if the physician explicitly asks, may the cause be rapidly found: a tick bite - an indication that the person may be infected with Borrelia and is suffering from Lyme neuroborreliosis. (euroimmunblog.com)
Affinity1
  • All types of Borrelia differ in their antigenic composition and different affinity for individual organs. (vidia.cz)