• Bordetella bronchiseptica", stain RB50, is a small (0.4 by 8.0 um), gram negative, rod shaped beta-proteobacteria belonging to the Bordetellae family. (kenyon.edu)
  • B. bronchiseptica" is closely related to "Bordetella pertussis" and "Bordetella parapertussis", causing pertussis or whooping cough in humans [2]. (kenyon.edu)
  • Bordetella bronchiseptica" can infect a wide range of hosts causing different diseases and is most commonly found in canines, pigs, and laboratory animals [2]. (kenyon.edu)
  • 1 year with and without pertussoid cough were investigated for the presence of B. pertussis/parapertussis using culture and real-time polymerase chain reaction (PCR). (pasteur.fr)
  • Pertussis, or whooping cough, is a very contagious disease caused by the Bordetella pertussis bacteria, which attach to the cilia that line part of the upper respiratory tract, causing inflammation through the release of toxins, which cause airways to swell. (rapidmicromethods.com)
  • Although whooping cough cases can be sporadic, outbreaks are often highly contagious, and we believe that this test can provide healthcare workers with the ability to quickly diagnose whooping cough and B. parapertussis. (rapidmicromethods.com)
  • Bordetella parapertussis also has been associated with whooping cough in humans. (medscape.com)
  • The most common single agent was B. pertussis, representing 56%(64/115), with a median cough period of 51 d, followed by M. pneumoniae 26%(30/115), 23 d, C. pneumoniae 17% (19/115), 26 d, and B. parapertussis 2% (2/115). (babydr.us)
  • Spasmodic cough for 21 d or more (clinical WHO criteria for pertussis) was present in 82% (41/50) of infections with B. pertussis as single agent, 38% (17/45) with B. parapertussis, 38% (5/13) with C. pneumoniae, 26% (5/19) with M. pneumoniae and 30%(17/56) in cases where no aetiology was found. (babydr.us)
  • Whooping cough, also known as pertussis, is a respiratory disease that is predominantly caused by the gram-negative bacterium Bordetella pertussis , which is found only in humans [ 1 ]. (biomedcentral.com)
  • That is not a surprise, but what is surprising is that Germany and France are discovering that the predominant organism causing whooping cough is B. parapertussis. (whoopingcough.net)
  • Clearly they will be negative for whooping cough if parapertussis is the cause as it does not produce this toxin, leading to a negative diagnosis when it is really positive. (whoopingcough.net)
  • Pertussis or whooping cough, mainly caused by Bordetella pertussis , is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. (frontiersin.org)
  • The main causative agent of whooping cough is Bordetella pertussis ( 2 ), a gram negative coccobacillus which is able to colonize the human upper respiratory tract by attaching to the ciliated cells. (frontiersin.org)
  • Antigens of Bordetella pertussis that not only are completely ineffective at preventing infection with Bordetella parapertussis , a whooping cough bacterium similar to B. pertussis , but actually promote it by interfering with the body's natural infection clearance protocols. (naturalnews.com)
  • W]e show that aP [whooping cough] vaccination impedes host immunity against B. parapertussis -measured as reduced lung inflammatory and neutrophil responses," wrote the authors. (naturalnews.com)
  • In other words, children who are vaccinated for whooping cough actually suffer from decreased immunity and are more susceptible to B. parapertussis infection than their unvaccinated peers. (naturalnews.com)
  • The pathogenic bacteria Bordetella pertussis and Bordetella parapertussis cause pertussis (whooping cough) and pertussis-like disease, respectively, both of which are characterized by paroxysmal coughing. (bvsalud.org)
  • In contrast, the mechanism of cough induced by B. parapertussis, which produces Vag8 and lipopolysaccharide (LPS) containing lipid A, but not PTx, remained to be elucidated. (bvsalud.org)
  • Here, we show that a toxin we named deacylating autotransporter toxin (DAT) of B. parapertussis inactivates heterotrimeric Gi GTPases through demyristoylation of their α subunits and contributes to cough production along with Vag8 and LPS. (bvsalud.org)
  • This antigen protects B. parapertussis against antibodies specific to B. pertussis, so the bacteria are free to colonize the host's lungs without being subject to attack by previous antibodies. (wikipedia.org)
  • According to the CDC, B. parapertussis causes a pertussis-like illness that is generally milder than pertussis, likely because the bacteria do not produce pertussis toxin. (rapidmicromethods.com)
  • Material collected during a prospective pertussis vaccine trial in 1992-95 was examined for Bordetella pertussis (culture and serology), Bordetella parapertussis (culture), Mycoplasma pneumoniae and Chlamydia pneumoniae (PCR). (babydr.us)
  • Immunity derived from B. pertussis does not protect against infection by B. parapertussis, however, because the O-antigen is found only on B. parapertussis. (wikipedia.org)
  • Co-infection of B. pertussis and B. parapertussis can occur but is uncommon. (rapidmicromethods.com)
  • 6] B. parapertussis is not easily distinguished from B. pertussis infection by symptoms, and unlike B. pertussis, usually it is not laboratory confirmed. (rapidmicromethods.com)
  • Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis. (greatergoodmovie.org)
  • Our data raise the possibility that widespread aP vaccination can create hosts more susceptible to B. parapertussis infection. (naturalnews.com)
  • These results indicate that DAT plays a role in B. parapertussis infection in place of PTx. (bvsalud.org)
  • Pertussis is a respiratory tract infection caused by the gram-negative coccobacillus Bordetella pertussis . (medscape.com)
  • All except 1 NPAs were negative by conventional culture, whereas PCR gave positive signals for 126 specimens (21%): B. pertussis, B. parapertussis, and Bordetella spp. (pasteur.fr)
  • Hassan, F., Hays, L., Bell, J., Selvarangan, R. Evaluation of 3 analyte-specific reagents for detection of Bordetella pertussis and Bordetella parapertussis in clinical specimens Diagnostic Microbiology and Infectious Disease 80, 181-184 (2014). (childrensmercy.org)
  • Specific diagnostic tools were applied for the first time in a Tunisian prospective study in order to get a first estimation of the prevalence of Bordetella pertussis/parapertussis infections and to evaluate their use to determine the epidemiologic characteristics of these infections in Tunisian infants. (pasteur.fr)
  • Vaccines of this type, prepared from suspensions of inactivated Bordetella pertussis bacterial cells, have been licensed for routine vaccination of infants since the mid-1940s. (cdc.gov)
  • The most common causative organism is Bordetella pertussis (see the image below), though Bordetella parapertussis also has been associated with this condition in humans. (medscape.com)
  • W]e conclude that aP vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. (naturalnews.com)
  • These findings suggest B. parapertussis evolved in a host population that had already developed immunity to B. pertussis, where being able to evade B. pertussis immunity was an advantage. (wikipedia.org)
  • This increase has been attributed to increased circulation of Bordetella pertussis , waning vaccine-induced immunity among adults and adolescents, heightened awareness of pertussis among health-care providers, increased public health reporting, and increased use of polymerase chain reaction (PCR) testing for diagnosis ( 1 ). (cdc.gov)
  • Genetic heterogeneity of ribosomal internal transcribed spacer in clinical samples of Leishmania donovani spotted on We report a pseudo-outbreak of Bordetella par- filter paper as revealed by single-strand conformation apertussis in the Department of Pediatrics in polymorphisms and sequencing. (cdc.gov)
  • B parapertussis is less common than B pertussis and produces a clinical illness that is similar to, but milder than, that produced by B pertussis . (medscape.com)
  • When possible, patients' household contacts provided nasopharyngeal aspirates (NPAs) for RT-PCR detection of B. pertussis/parapertussis or single-serum samples for anti-PT IgG quantification. (pasteur.fr)
  • Evaluation of 3 analyte-specific reagents for detection of Bordetella " by Ferdaus Hassan, Lindsay Hays et al. (childrensmercy.org)
  • CDC is actively researching new laboratory methods to better identify and characterize other Bordetella and Corynebacterium species. (cdc.gov)
  • Concerns about the safety of whole-cell pertussis vaccines prompted development of acellular vaccines that are less likely to provoke adverse events because they contain purified antigenic components of Bordetella pertussis. (cdc.gov)
  • For these reasons, the epidemiology of illness caused by B. parapertussis is poorly recognized. (rapidmicromethods.com)
  • Humans are the sole reservoir for B pertussis and B parapertussis . (medscape.com)
  • Immunisation against B.pertussis, which is standard is thought to be ineffective or poorly effective against B. parapertussis. (whoopingcough.net)
  • Pertussis caused by B. parapertussis manifests with similar symptoms to B. pertussis-derived disease, but in general tends to be less severe. (wikipedia.org)
  • Simptome foarte asemănătoare tusei convulsive pot fi prezente și în cazul infecțiilor cauzate de specii înrudite de bacterii, precum Bordetella parapertussis, acestea fiind de obicei mai puțin severe 37 . (synevo.ro)
  • Molecular evolution and host adaptation of Bordetella spp. (wikipedia.org)
  • The Solana Bordetella Complete Assay leverages the Helicase-Dependent Amplification (HDA) technology that is resident in Quidel's AmpliVue® molecular product line to generate a fast and accurate test result on the Solana molecular diagnostic instrument. (rapidmicromethods.com)
  • We are pleased to receive 510(k) clearance for our Solana Bordetella Complete Assay, as this test rounds out our Solana molecular test offering in the respiratory category," said Douglas Bryant, president and chief executive officer of Quidel Corporation. (rapidmicromethods.com)
  • An increase in positive Bordetella parapertussis tests repeat proteins by Leishmania amastigotes. (cdc.gov)
  • PCR-positive case-patients had pertussis-like of Fisheries and Livestock, Department of Veterinary Services, complaints, and we confirmed B. parapertussis in the Central Veterinary Research Institute, PO Box 33980, Lusaka, patients or their siblings. (cdc.gov)
  • When paired with Quidel's Virena ecosystem, clinicians will be able to see real-time positive cases at the local level, giving them further insights into disease prevalence for both parapertussis and pertussis. (rapidmicromethods.com)
  • The simultaneous presence of B. pertussis and B. parapertussis was noted in 8% of the cases. (pasteur.fr)
  • It parapertussis really gets hold we will quickly learn an awful lot more. (whoopingcough.net)