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  • limbs
  • The growth plate (GP) of developing limbs contain a plethora of growth factors and matrix cues which contribute to long bone growth, suggesting that biomaterials derived from its extracellular matrix (ECM) may be uniquely suited to promoting bone regeneration. (rcsi.ie)
  • tissues
  • In hard tissues another mechanism of control exists, where locally produced growth factors, or those in the circulation, are incorporated into mineralised matrix and are released during matrix dissolution by osteoclasts or chondroclasts. (unu.edu)
  • Covering a diverse and current range of topics, including the genetic and epigenetic aspects of bone development, cell signaling in growth plate and bone development, evolution of bone proteins and the interrelationship between bone and other tissues, this volume provides a thorough look at bone development biology. (springer.com)
  • Therefore, the tissues in the bone are not getting enough blood and they begin to go through necrosis, and they begin to die. (wikipedia.org)
  • The death of the tissues eventually leads to deterioration of the bone's growth plate. (wikipedia.org)
  • The preferential addition of heparan sulfate or chondroitin sulfate chains to domains I and V could have an effect on the differentiation of mesenchymal tissues into cartilage, bone or any number of tissues, but the regulatory mechanism of changing from heparan sulfate to chondroitin sulfate addition are not well understood. (wikipedia.org)
  • fibrous
  • A child's bones heal faster than an adult's because a thicker, stronger, and more active dense fibrous membrane (periosteum) covers the surface of their bones. (wikipedia.org)
  • Cartilaginous joints allow more movement between bones than a fibrous joint but less than the highly mobile synovial joint. (wikipedia.org)
  • histological
  • The authors are experienced practitioners of Cañadell's technique, but the book also explores, thanks to the focused contributions of experts from other fields of medicine, a range of topics from the molecular biology and histological aspects of bone tumors, to the use of imaging techniques and surgical options for epiphyseal preservation. (exlibris.ch)
  • Growth Plate Involvement in Malignant Bone Tumours: Relationship Between Imaging Methods and Histological Findings. (exlibris.ch)
  • Histological analysis showed no effects of MH on tibial growth plate thickness in either fetal or postnatal offspring, although there was increased VEGF mRNA expression in the growth plate of postnatal offspring. (hindawi.com)
  • mesodermal
  • Body composition and musculoskeletal development begin in embryonic life, when bone and muscle develop from the mesodermal layer. (hindawi.com)
  • calcium
  • PTHrP can simulate most of the actions of PTH including increases in bone resorption and distal tubular calcium reabsorption, and inhibition of proximal tubular phosphate transport. (wikipedia.org)
  • limb growth
  • In the forelimb initiation and limb growth in mice, axial (lengthwise) cues from the intermediate mesoderm produces Tbx5, which subsequently signals to the same mesoderm to produce Fgf10. (wikipedia.org)
  • Postnatal
  • There was increased mRNA expression of adipogenesis-related gene (FABP4) in bone from the MH postnatal offspring. (hindawi.com)
  • However, MH reduced expression of bone formation marker (collagen-1) and increased expression of fat formation marker (FABP4) in postnatal offspring bone. (hindawi.com)
  • periosteum
  • The stronger and thicker periosteum in children causes a better supply of oxygen and nutrients to the bones, and this helps in the remodeling of the fractured bones by supplying. (wikipedia.org)
  • The periosteum in children causes a more rapid union of fractured bones and an increased potential for remodeling. (wikipedia.org)
  • The bones of a child are more likely to bend than to break completely because they are softer and the periosteum is stronger and thicker. (wikipedia.org)
  • development
  • Those cytokines and growth factors considered to be of particular importance during bone development and growth include the IGFs, TGF a and b , bone morphogenetic proteins (BMPs), FGF, PDGF and epidermal growth factor (EGF). (unu.edu)
  • Limitations associated with demineralised bone matrix and other grafting materials have motivated the development of alternative strategies to enhance the repair of large bone defects. (rcsi.ie)
  • Insights stemming from molecular and cellular events are applied to the clinical setting, providing a deeper understanding of bone development complications for the practicing clinician, whilst informing bone scientists of the advancements in their field and the wider applications of their research. (springer.com)
  • His research involves investigating the growth and development of the human skeleton through the use of non-invasive imaging methods. (schweitzer-online.de)
  • Panner Disease is part of a family of bone development diseases known as osteochondrosis. (wikipedia.org)
  • This bone growth abnormality may be a predisposing factor in the development of elbow dysplasia seen in the breed, which leads to arthritis of the elbow joint. (wikipedia.org)
  • This indicates that although GPER and ERβ play a modulatory role in breast development, ERα is the main receptor responsible for estrogen-mediated breast tissue growth. (wikipedia.org)
  • It regulates endochondral bone development by maintaining the endochondral growth plate at a constant width. (wikipedia.org)
  • necrosis
  • ESWT is also used to promote bone healing and treat bone necrosis. (wikipedia.org)
  • The bone tissue does regrow, but the necrosis can cause temporary problems in the affected area until the strenuous arm and elbow activity is significantly decreased or stopped for a period of time. (wikipedia.org)
  • thickness
  • This evolutionary innovation involved many morphological changes such as webbed digits, elongation of the forelimb, and reduction in bone thickness. (wikipedia.org)
  • cells
  • In fact, several lines of evidence point to there being a close relationship between bone cells and cells of the immune system (Skjodt & Russell, 1993). (unu.edu)
  • It is a selective estrogen-receptor modulator (SERM) that works both by decreasing factors that increase the growth of breast cells and increasing factors that decrease the growth of breast cells. (wikipedia.org)
  • HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones. (wikipedia.org)
  • joints
  • Women have smaller feet than men due to the fact that, in general, women have smaller joints and bones than their male counterparts. (reference.com)
  • vascular
  • These include glycolysis enzymes, which allow ATP synthesis in an oxygen-independent manner, and vascular endothelial growth factor (VEGF), which promotes angiogenesis. (wikipedia.org)
  • gene
  • Another good candidate for bat bone reduction is Hox-d13, a gene belonging to the Hox gene family. (wikipedia.org)
  • showed that disruption of the PTHrP gene in mice caused a lethal phenotype and distinct bone abnormalities, suggesting that PTHrP has a physiological function. (wikipedia.org)
  • osteoporosis
  • Weight-bearing exercise also helps to prevent osteoporosis and to improve bone strength in those with osteoporosis. (wikipedia.org)
  • When tamoxifen was launched as a drug, it was thought that tamoxifen would act as an ER antagonist in all tissue, including bone, and therefore it was feared that it would contribute to osteoporosis. (wikipedia.org)