Bone tissue array analysis. Medical search. Frequent questions

In medical imaging, these segments often correspond to different tissue classes, organs, pathologies, or other biologically relevant structures. (wikipedia.org)
ECMs range from pericellular matrices, such as basement membranes, to the grander structures of connective tissue that give organs their shape, and the tendons, cartilage and bones that bestow humans and animals with their form. (biologists.com)
Even if hair analysis was a highly reproducible and valid test, done properly, there are virtually no data for correlation of findings with levels of elemental minerals found in other tissues or organs. (cdc.gov)
Cells Tissues Organs. (cancercentrum.se)

DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
The molecular mechanism of TSP-2 on prostate cancer (PCa) metastasis was investigated through pharmaceutical inhibitors, siRNAs, and miRNAs analyses. (tmu.edu.tw)
MicroRNAs (miRNAs), which are rapidly released from damaged tissues into the host fluids, constitute a promising biomarker for the prognosis of SM. (cdc.gov)

in osteosarcoma per the Gene Appearance Omnibus (GEO) and immunohistochemistry analyses. (nanoker-society.org)
The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)
Methods The expression of TSP-2 on prostate cancer progression was determined in the tissue array by the immunohistochemistry. (tmu.edu.tw)

At the same time, many researchers are attempting to use IR imaging to analyze human tissue, especially in an effort to distinguish diseased and healthy tissues based upon differences in their biomolecular structure or the content of biologically active molecular components and compounds. (spectroscopyonline.com)
T cells transduced with these CAR constructs mediate efficient and effective cytotoxicity against ALPL-positive cells in in vitro settings and in state-of-the-art in vivo orthotopic models of primary and metastatic OS, without unexpected toxicities against hematopoietic stem cells or healthy tissues. (bvsalud.org)

Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. (degruyter.com)
ROC analysis demonstrated Bcl3 is specific to metastasis. (degruyter.com)
In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
Metastasis to bone typically results in a poor prognosis, reducing life expectancy to 2-3 years post-diagnosis. (degruyter.com)
During the advanced stages of disease, many breast cancer patients suffer from bone metastasis. (biomedcentral.com)
Bone is one of the most common sites for metastasis in human breast cancer. (biomedcentral.com)
However, there is no single animal model that ideally replicates the entire metastatic process from primary breast tumor to bone metastasis. (biomedcentral.com)
Nevertheless, several models that represent various aspects of bone metastasis have been used successfully to study specific features of the disease. (biomedcentral.com)
On the other hand, the animal studies revealed that the bone metastasis was abolished when TSP-2 was stably knocked down in PCa cells. (tmu.edu.tw)

Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging to the spectrum of LFS tumors. (oncotarget.com)
Analysis of tumors from this model revealed that they exhibited strong bone resorption, induction of osteoclasts and intracranial penetration at the tumor bone (TB)-interface. (biomedcentral.com)
Current projects involve the construction of tissue arrays of plasma cell tumors for immunohistochemical and in-situ hybridization assays. (ucsf.edu)
Cutaneous tumors encompass a vast array of malignancies, from neuroendocrine to lymphoid. (medscape.com)

The microenvironment is fundamental in attracting tumor cells to the bone as well as promoting tumor progression. (degruyter.com)
These metastases are predominantly osteolytic and develop when tumor cells interact with bone. (biomedcentral.com)
Furthermore, these treatment methods have limited efficacy due in part to the fact that they do not effectively target the interaction between tumor cells and bone [ 5 ]. (biomedcentral.com)
Within the osteolytic lesions of bone metastases, tumor cells interact with osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells), thereby inhibiting normal bone development and ultimately leading to bone destruction [ 1 - 4 ]. (biomedcentral.com)

Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity. (kb.se)
Pathway evaluation of kinome data The kinome data was put through pathway analysis to determine which cellular pathways/processes are activated beneath the different treatment conditions. (fabretp.org)

Images of (a) trabecular and (b) cortical bone. (spectroscopyonline.com)

Squamate reptiles represent ideal model systems for understanding phenotypic diversity and developmental disorders, as they exhibit an extraordinary array of life-styles, ecologies and craniofacial features representing patterns found across mammalian and non-mammalian taxa. (helsinki.fi)
The vertical nanowires are laterally arrayed in various patterns on the surface. (lu.se)

Our analysis will unequivocally determine the in vitro and in vivo fates of hES cell-derived cells with the neural crest cell markers present in our cultures. (ca.gov)
In vivo models that mimic the breast cancer-specific osteolytic bone microenvironment are limited. (biomedcentral.com)
Then, we comprehensively assessed the functional and histological parameters of skeletal muscle injury in mice and the phenotype shifting in macrophages through molecular biological methods and immunofluorescence analysis both in vivo and in vitro . (ijbs.com)
The comprehensive functional tests and histological analysis in vivo indirectly and directly proved the effectiveness of LIPUS for muscle recovery. (ijbs.com)
Through biological methods and immunofluorescence analysis both in vivo and in vitro , we found that this improvement was attributable in part to the clearance of M1 macrophages populations and the increase in M2 subtypes with the change of macrophage-mediated factors. (ijbs.com)

A second ongoing project is a flow cytometric analysis of bone marrow derived B-lymphocytes from patients with the X-linked Hyper IgM Syndrome. (ucsf.edu)
The expression of TLR4 on both bone marrow-derived and radioresistant cells is necessary for carcinogenesis. (unimi.it)

In the model organism NC cells generate an amazing array of tissues, including peripheral and enteric nervous systems, cranial bones and cartilage, some cardiac muscle and virtually all pigmented cells in the body. (ca.gov)
If our hypothesis is correct, hES cell-derived neural precursors will be a rich source for NC cells, and subsequently for an array of human NC derivatives such as bones, cartilage, muscles, peripheral and enteric neurons and melanocytes. (ca.gov)
In this syndrome, specific point mutations in the receptor lead to shortened bones, particularly in the thighs and upper arms, because over-activity of FGFR3 causes premature differentiation of cartilage tissue in the growth zones. (forextrading-madeeasy.com)

Diffuse Raman spectroscopy (DIRS) extends the high chemical specificity of Raman scattering to in-depth investigation of thick biological tissues. (lu.se)
An additional drawback with reagent staining is that if research findings later suggest that an additional chemical or biological component is of interest, additional biopsied tissue will need to be obtained and new stains applied, which is often difficult and time-consuming. (spectroscopyonline.com)
Reviews linear and nonlinear systems analysis and control system design and biological and medical applications. (washington.edu)
Despite the widespread use of Ti6Al4V in orthopaedics, the bioinert nature of this alloy limits its biological fixation with the bone tissue. (metu.edu.tr)
Such a future grand plan will require initial efforts in order to develop an infrastructure (research coordinator, biological cores, interacting investigators) for clinically characterizing the patients, as well as an array of fundamental studies of mechanisms. (bu.edu)
Langer and Vacanti 19 defined tissue engineering as an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. (bvsalud.org)
The purpose of this article is to review the biological principles of tissue engineering and the hurdles that must be overcome to develop regenerative endodontic procedures. (bvsalud.org)

PreAnalytiX, a joint venture between BD and QIAGEN, develops, manufactures and sells integrated and standardized systems for sample collection, stabilization and purification of high-quality RNA, microRNA and DNA from human blood, bone marrow, or tissue specimens. (preanalytix.com)
PAXgene products integrate and standardize the collection, stabilization and purification of nucleic acids from human specimens to optimize the analysis of clinically relevant biomarkers. (preanalytix.com)

In this field, nanoparticles have notable importance due to their unique properties and characteristics, which are useful in different applications, including tissue engineering, biomarkers, and drug delivery systems. (mdpi.com)

A majority of diseases leading to premature death originate in tissue and cell dysfunction, primarily due to genetic deficiency, either existing at birth or acquired after birth. (spectroscopyonline.com)
All tissues originate from stem cells. (bvsalud.org)

[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)

Furthermore, genomic complexity was the best predictor of disease progression in multivariate analysis. (biomedcentral.com)

In this study, we identified and used a TB microenvironment-specific gene expression signature from this model to extend our understanding of the metastatic bone microenvironment in human disease and to predict potential therapeutic targets. (biomedcentral.com)
By comparing the TB signature with gene expression profiles from human breast metastases and an in vitro osteoclast model, we demonstrate that our model mimics both the human breast cancer bone microenvironment and osteoclastogenesis. (biomedcentral.com)
Our mouse breast cancer model morphologically and genetically resembles the osteoclastic bone microenvironment observed in human disease. (biomedcentral.com)

S.D. In every statistical analyses, a worth ?0.05 was considered significant in the Remogliflozin two-sided check statistically. (nanoker-society.org)
Statistical analyses Test size was approximated using. (informationalwebs.com)

Here, we estimate the bite force of Zygophyseter varolai, a macroraptorial physeteroid from lower upper Miocene strata of the Pietra leccese formation (Apulia, Italy) using the finite element analysis (FEA). (researchgate.net)
We compared equivalent stress and strain energy density (SED) to bone mineral density (BMD) in the femur after total hip arthroplasty (THA) using subject-specific finite element analysis (FEA). (intechopen.com)

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. (kb.se)

Electrospinning of fibrous scaffolds containing nano-hydroxyapatite (nHAp) embedded in a matrix of functional biomacromolecules offers an attractive route to mimicking the natural bone tissue architecture. (ad-astra.ro)
Functional fibrous substrates will support cell attachment, proliferation and differentiation, while the role of HAp is to induce cells to secrete extracellular matrix (ECM) for mineralization to form bone. (ad-astra.ro)
The structure and properties of the nanocomposite fibrous membranes were investigated by means of Scanning Electron Microscopy in combination with Energy Dispersive X-Ray Analysis (SEM/EDX), Fourier Transformed Infrared Spectroscopy (FT-IR), uniaxial tensile and compressive mechanical testing, degradation tests and in vitro bioactivity tests. (ad-astra.ro)

Dr Kasuya Motomura amplification bias, we assessed genome secondary events reflecting progressive wide chromosomal imbalance by array genomic instability, a hallmark of CGH (Agilant 105K) in DNA from 2-5 glioblastomas. (who.int)

ECM receptors thus convert both chemical and physical extracellular inputs to determine cell survival, proliferation, migration and tissue-specific gene expression. (biologists.com)

We validated the system using a bilayer tissue-bone mimicking phantom composed of a 1 cm thick slab of silicone overlaying a calcium carbonate specimen and demonstrated a high differentiation of the two Raman signals. (lu.se)
To pursue Aim1 we will use in situ hybridization, immunostaining, prospective isolation of candidate NC cells by FACS and in vitro differentiation analysis to determine the vitro fates of candidate human NC cells. (ca.gov)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
While this analysis highlights the obvious useful flexibility of PrPC being a signaling molecule and could offer understanding into cellular systems of TSE pathology in addition, it emphasizes the dangers connected with attributing activation of particular intracellular occasions to particular receptors through artificial types of receptor activation. (fabretp.org)
Granulocytic and monocytic myeloid-derived suppressor cellular material employed from the bone fragments marrow in order to cells along with phagocytosis of apoptotic neutrophils may attenuate macrophage microbicidal action. (mirnamimic.com)
Moreover, navicular bone marrow granulocytes reduced the actual phagocytic task of macrophages in addition to their capacity to wipe out intra-cellular Escherichia coli. (mirnamimic.com)

Docking analysis showed that these genes possessed strong binding with the drugs. (degruyter.com)
Initial studies of bariatric surgery patients by the Ruderman laboratory established (1) that they could be subdivided into insulin resistant (75%) and insulin sensitive (25%) subgroups and (2) that these subgroups were distinguished by differences in AMPK activity, oxidative stress and the expression of inflammatory, mitochondrial and other genes in their adipose tissue. (bu.edu)

Breast cancer metastases are most commonly found in bone, an indication of poor prognosis. (degruyter.com)
Bone cancer metastases usually occur in the axial skeleton, in areas with active hematopoiesis and high red marrow content. (degruyter.com)
In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
While a number of strategies exist to treat breast cancer bone metastases (e.g., surgery, radiation and/or chemotherapy), none are curative. (biomedcentral.com)

Craniofacial tissues such as skull bones, teeth, and the brain are finely tuned to meet functional and ecological demands with tremendous precision, and their evolution has been a major driving force in the expansion of vertebrate lineages. (helsinki.fi)
The condition involves the gradual loss of gum tissue around the teeth, leading to exposure of the tooth roots and potential tooth loss if left untreated. (receding-gums.org)
It is characterized by the progressive loss of gum tissue surrounding teeth, leading to exposure of tooth roots and consequent sensitivity. (receding-gums.org)
Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)

Using a bilayer phantom made of porcine muscle and calcium carbonate, we proved that our system can retrieve Raman peaks even in the presence of autofluorescence typical of biomedical tissues. (lu.se)
IR imaging spectrometers now are being used by researchers in many areas of biomedical research to provide a greater understanding of the chemical constituents in diseased tissues with the end goal of delivering improved therapies. (spectroscopyonline.com)

In comparison to regular bone tissues, the PD-L1, PD-L2, Remogliflozin and PD-1 mRNA expressions had been considerably higher in osteosarcoma (Extra?file?3). (nanoker-society.org)

and unstructured meshes, such as hexahedral and tetrahedral forms, which are used in advanced biomechanical analysis (e.g., tissue deformation, vascular transport, bone implants). (wikipedia.org)
Although the shark's cartilaginous jaws undergo considerably greater deformation than would jaws constructed of bone, effective bite force is not greatly diminished. (researchgate.net)
Moreover, CMR tissue tracking (TT) technique, which could measure cardiac muscle motion and both LV and RV deformation, has emerged as more sensitive indicators than the ejection fraction (EF) [ 8 - 12 ]. (hindawi.com)

and bone morphogenetic proteins, BMPs) that stimulate tumor growth and bone destruction [ 1 ]. (biomedcentral.com)
Allografts contain bone morphogenic proteins (BMPs), which help stimulate bone growth. (allenpress.com)

But according to a recently published article, new techniques pioneered by New York City's Chief Medical Examiner Barbara Sampson and the Department of Forensic Biology, have finally tied a bone fragment to Johnson's genetic profile by using new digestion chemicals to isolate the DNA from the fragment. (berkshire.com)
It is our goal to establish an ARC focused on understanding the relationship between metabolic disorders and Adipose Tissue Biology by studying adipose tissues from insulin sensitive and insulin resistant patients obtained during and after Bariatric Surgery. (bu.edu)
With collective efforts of faculty representing different expertise and disciplines, we are posed to begin the development at BUMC of a unique center of knowledge in the field of adipose tissue biology pre- and -post bariatric surgery. (bu.edu)

STRING database and Enrichr were used for GO-term analysis, miRNA and TF analysis associated with DEGs. (degruyter.com)

Low-intensity pulsed ultrasound (LIPUS, a form of mechanical stimulation) can promote skeletal muscle functional repair, but a lack of mechanistic understanding of its relationship and tissue regeneration limits progress in this field. (ijbs.com)

A diagnosis of light chain amyloidosis was made based on a biopsy of subcutaneous fat or an involved organ with the demonstration of typical Congo red birefringence, the detection of a monoclonal protein in the serum or urine and/or a monoclonal population of plasma cells in the bone marrow [ 13 ]. (hindawi.com)
Reports claim that sufferers with SLE possess modifications in steroid hormone fat burning capacity.11 It's been demonstrated Nifuroxazide that oestrogen results are mediated through oestrogen receptors and probably , that are expressed in an array of immune system cells and so are involved with adaptive and innate immune system responses. (informationalwebs.com)
12 Unlike autogenous bone, allografts do not contain live bone cells, but they do provide type I collagen, which is composed mostly of the organic component of bone. (allenpress.com)
[17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
[18] Whereas, with CLL, diseased cells propagate from within the bone marrow, in SLL they propagate from within the lymphatic tissue. (wikipedia.org)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)

This study presents a valuable finding on the causal relationship between second primary cancers and the initial diagnosis of a primary cancer via rigorous analysis of large-scale data. (elifesciences.org)
Neither CT nor MRI is tissue specific, and tissue diagnosis may be required. (medscape.com)

Focal plane arrays are grids of a large number of small detectors, typically 4096 in a 64 X 64 element configuration. (spectroscopyonline.com)
The technology for using focal plane array detectors to sense IR radiation has developed and matured over the past 15 years. (spectroscopyonline.com)

A book on such a profoundly important topic requires a clear vision of the breadth of the ECM and its roles in development, cell and tissue function and disease. (biologists.com)
2. Mode of carcinogenic action cell and tissue changes over time. (cdc.gov)

Thus, anodized nanotubular Ti6Al4V foams could potentially induce enhanced integration of Ti6Al4V-based porous implants with the bone tissue. (metu.edu.tr)
This article reports the results of implants placed into maxillary sinuses grafted with particulate mineralized cancellous bone allograft alone or in combination with resorbable hydroxyapatite over a 3-year period. (allenpress.com)
Implant placement can be performed at the time of sinus grafting, if there is enough existing bone height for primary stability of the implants (usually 4 to 5 mm) or delayed for several months (4 to 9 months) to allow for adequate graft maturation. (allenpress.com)

Every forensic anthropologic case is different, and many do not lend themselves to the collection of all of the lines of evidence listed above, because most of the human remains are traumatically incomplete, missing many of the 206 adult bones found in an intact adult skeleton. (medscape.com)
The analysis complied using the Declaration of Helsinki and was accepted by the Moral Committee of Divide University Medical College for clinical research on human topics. (informationalwebs.com)
And they are universally applicable - whether the analysis stretches as far back in time as examining the links between Neanderthal genetics and those of modern man, the screening of human DNA in sediments where even bones are absent, or more contemporary uses such as identifying bone fragments from the Twin Towers. (berkshire.com)
solid course="kwd-title" Keywords: kinome, PrP, cell signaling, peptide array, transmissible spongiform encephalopathy Launch Transmissible spongiform encephalopathies (TSEs) consist of Creutzfeldt-Jakob disease in human beings, bovine spongiform encephalopathy in cattle, scrapie in chronic and sheep squandering disease in deer and elk. (fabretp.org)
Consistently, a human tissue microarray analysis showed that melanoma and colon cancer display an over-expression of TLR4 and its downstream adaptor protein MyD88 within tumours. (unimi.it)

A comparative analysis between NK-based non-engineered, engineered, and combination therapies is presented, examining the choices made by product developers regarding the NK cell source and the targeted tumor indications, for both solid and hematological cancers. (bvsalud.org)

The following, all of us indicated that bone fragments marrow neutrophils, however, not thioglycollate-recruited neutrophils, straight reduce the answers of macrophages that have been previously committed to the -inflammatory phenotype. (mirnamimic.com)

2 Of the various bone augmentation materials available, allografts provide easily procured graft materials. (allenpress.com)

In multivariate analysis, FOXO1 mutation was an independent prognostic factor for Operating system (P 0.05) that was connected with a rise in the chance ratio by one factor of just one 1.35. (p38-mapk-inhibitors.com)

13 , 14 Osteoinductive materials encourage new bone formation by acting as a signaling agent in initiating and regulating specific tissue formation. (allenpress.com)

We combined our data with publicly available information from a genome-wide association study (GWAS) of bone mineral density (BMD). (nih.gov)

We reconstructed the Raman spectra of the two layers, offering the potential for improved and quantitative material analysis. (lu.se)
In addition, an independent cohort of 55 clinical samples was analyzed by quantitative real-time PCR analysis. (cancerindex.org)
When hair analyses have been done rigorously in quantitative laboratory settings, it has been pointed out that great care must be taken to avoid possible sources of contamination. (cdc.gov)

It should also include a disclaimer that credits any analyses, interpretations, or conclusions reached to the author (user of the tape) and not to the Center, which is responsible only for the initial data. (cdc.gov)

Includes methods of measurement, analysis, and design. (washington.edu)

This overcomes the intrinsic complexity and high cost of detection arrays with ps-resolving time capability. (lu.se)
IR imaging provides a new tool for disease detection, revealing compositional and structural information in tissue previously not available with contrast staining. (spectroscopyonline.com)
For over 160 years, disease detection in biopsied tissue has relied upon the painstaking preparation of thin sections followed by contrast staining to visibly signal the presence or absence of diseases with an optical microscope. (spectroscopyonline.com)

Manual segmentation, using tools such as a paint brush to explicitly define the tissue class of each pixel, remains the gold standard for many imaging applications. (wikipedia.org)
We explore potential relationships between craniofacial morphology and ecological/behavioral parameters, using high-definition 3D reconstructions of craniofacial tissues based on 3D imaging techniques such as X-ray microcomputed tomography, soft tissue contrast enhancement, 3D image analysis, and segmentation. (helsinki.fi)

More recent studies suggest that inflammation in adipose tissue could be a key factor leading to these illnesses. (bu.edu)

Sensitivity and specificity of DEGs was assessed using receiver operating characteristic (ROC) analyses. (degruyter.com)
Tissue imaging with infrared (IR) imaging provides a new window into disease processes, revealing compositional and structural information previously not available or at higher sensitivity or specificity than with contrast staining. (spectroscopyonline.com)
More recently, focal plane arrays have been developed specifically for tissue imaging applications that offer larger array sizes and higher sensitivity than earlier military technology. (spectroscopyonline.com)

When located at the focal point of an optical system, the arrays act like the film in a conventional camera, enabling the multichannel collection of a large number of spatially resolved areas in a single measurement. (spectroscopyonline.com)

Years of analysis have learned to fruition during the past 18 months along with magazines on clinical studies for several gene therapy processes for Duchenne buff dystrophy. (others-signal.com)
The Company serves healthcare institutions, academic researchers, clinical laboratories and the pharmaceutical industry with a broad array of manual and automated products. (preanalytix.com)

Anatomy39

Organisms10

Diseases29

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes54

Disciplines and Occupations4

Technology, Industry, Agriculture19

Information Science4

Health Care4

Geographicals1

Organs4

MiRNAs3

Immunohistochemistry3

Healthy tissues2

Metastasis10

Tumors4

Tumor cells4

Pathway2

Cortical bone1

Patterns2

Vivo5

Marrow derived2

Cartilage3

Biological7

Specimens2

Biomarkers1

Originate2

Lymph nodes1

Progression1

Microenvironment3

Statistical2

Finite element2

Identifies1

Fibrous3

Chromosomal1

Proliferation1

Differentiation2

Cellular4

Genes2

Metastases4

Teeth5

Biomedical2

Osteosarcoma1

Deformation3

BMPs2

Biology3

MiRNA1

Functional1

Cells8

Regeneration1

Diagnosis2

Detectors2

Cell and tissue2

Implants3

Human5

Therapies1

Fragments1

Augmentation1

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Conclusions1

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Detection3

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Inflammation1

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Optical1

Clinical2