MolecularDevelopmental Biology2023GeneticsFibroblastEpidermalPluripotent stemStimulates hair growthHormoneSignal transductionCellsProteinFetalTumorChemistryCellularCharacterizationEmbryologyDevelopmentBiologicalReplicationBone growth2022Systems biologyBroadlyMetabolismCellAntibodyFactorAirwayTissueStudyAlternativelyEcologicalInhibitDistinctResearchContentFollicleSuccessfullyRoleGrewEcosystemsIntermediateFundamentalsMethods
Molecular3
- To find a publication from the Department of cell and molecular biology search the university publication database DiVA. (uu.se)
- Current advances in molecular biology are allowing new insights into the pathogenesis of skin cancer. (medscape.com)
- Molecular anatomy (often called molecular biology) is the study of the smallest components of cells at the biochemical level. (msdmanuals.com)
Genetics1
- The span at which the hair remains in this stage of growth is determined by genetics. (wikipedia.org)
Fibroblast7
- Mode of fibroblast growth enhancement by human interleukin-1. (rupress.org)
- Previous studies have demonstrated that interleukin-1 (IL-1) stimulates fibroblast growth (Schmidt, J. A., S. B. Mizel, D. Cohn, and I. Green. (rupress.org)
- We have investigated the mechanism of fibroblast growth stimulation by IL-1. (rupress.org)
- Addition of fibroblast growth factor derived from platelets (PDGF) to a quiescent culture of BALB/c3T3 cells produced 8-10-fold increase in DNA synthesis during 24-h incubation. (rupress.org)
- The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (nih.gov)
- Fibroblast Growth Factor 2 Levels in Patients with Major Depressive Disorder: A Meta-analysis. (nih.gov)
- The dogs have an extra copy of the gene that codes for a growth-promoting protein called fibroblast growth factor 4 (FGF4). (nih.gov)
Epidermal6
- We have recently shown that human epidermal melanocytes, pigment cells derived from the neural crest, express the NGF receptor (p75 NGF-R) in vitro (Peacocke, M., M. Yaar, C. P. Mansur, M. V. Chao, and B. A. Gilchrest. (silverchair.com)
- In this study, we report that human serum selectively promotes epidermal cell migration and halts dermal cell migration. (rupress.org)
- In contrast, human plasma promotes dermal but not epidermal cell migration. (rupress.org)
- The on-and-off switch is operated by transforming growth factor (TGF) β3 levels, which are undetectable in plasma and high in serum, and by TGFβ receptor (TβR) type II levels, which are low in epidermal cells and high in dermal cells. (rupress.org)
- Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
- The Utility of Oncotype DX for Adjuvant Chemotherapy Treatment Decisions in Estrogen Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative, Node-negative Breast Cancer. (cdc.gov)
Pluripotent stem4
- Since the introduction of the mouse small intestinal organoid model in 2009, 1 there has been an avalanche of developments in this field, including development of culture conditions for human organoids derived from primary colonic tissue, 2 as well as from human pluripotent stem cells (hPSCs). (stemcell.com)
- This strategy provides a useful tool for visualization and identification of neural progeny derived from human pluripotent stem cells. (lu.se)
- Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)
- However, current protocols for deriving neurons from human pluripotent stem cells give rise to heterogeneous cell populations both in regard to the temporal aspects and the cellular composition. (lu.se)
Stimulates hair growth1
- The protein called keratin makes up hair and stimulates hair growth. (wikipedia.org)
Hormone7
- Mouse anti Human Growth Hormone antibody, clone GhB9 recognizes human growth hormone (hGH), a 22 kDa polypeptide synthesised by acidophilic or somatotropic cells of the anterior pituitary gland. (bio-rad-antibodies.com)
- Growth hormone plays an important role in growth and cell production. (bio-rad-antibodies.com)
- Growth hormone can be used to treat conditions that result in short stature or decreased muscle mass. (bio-rad-antibodies.com)
- A Transgenic Mouse Model with Human Growth Hormone" by Benan DİNÇTÜRK, Abdullah TÜRKMENLER et al. (tubitak.gov.tr)
- The objective of this research was the optimization of transgenic manipulation in the laboratory, by the production of model mice harbouring human growth hormone, and thwe identification of the transgenic mice. (tubitak.gov.tr)
- Human growth hormone fragment 176-191 - aka frag 176-191 - is a synthetic peptide that is identical to the final 16 amino acids of human growth hormone (hGH). (outlookindia.com)
- Human growth hormone fragment 176-191 (frag 176-191) was discovered to be responsible for the fat-burning effects of the full human growth hormone (hGH) protein by Dr. Frank Ng in the 1990s at Monash University [1, 2]. (outlookindia.com)
Signal transduction1
- Human GH binds to two GH receptors and induces signal transduction through receptor dimerisation. (bio-rad-antibodies.com)
Cells29
- Perfusion cultures of human bone marrow mononuclear cells (BMMNC) provide a unique in vitro model of hematopoiesis, supporting growth of both accessory and hematopoietic elements. (ucsd.edu)
- In this study, bioreactors were used to analyze the consumption and production of growth factors (GFs) in relation to each other and to the cells produced. (ucsd.edu)
- Researchers have created an implantable bio patch that regrows bone in a living body, using existing cells. (sciencedaily.com)
- The plasmids are absorbed by bone cells already in the body, spurring new growth. (sciencedaily.com)
- Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells. (sciencedaily.com)
- It also stimulated new growth in human bone marrow stromal cells in lab experiments. (sciencedaily.com)
- The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells in vivo, allowing those cells to produce the proteins that led to more bone production. (sciencedaily.com)
- Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
- A strain of Vesicular Stomatitis virus, serotype Indiana (VSV), was compared after a single in vitro passage and after 16 in vitro passages in human white blood cells from patients suffering mostly from acute myeloid leukemia. (karger.com)
- The in vitro growth characteristics of these two virus lines in white blood cells (predominantly myeloblasts) from a patient with acute myeloid leukemia were measured, starting with low multiplicities of infection. (karger.com)
- No differences were seen in the following parameters: Length of latency phase, growth rate, final titer, thermal inactivation rate, plaque size, titer difference in chick embryo vs. human diploid cells, and extent of neutralization by a standard rabbit antiserum. (karger.com)
- Infectivity titrations in chick embryo cells gave consistently about ten times higher values than the same titrations done in human diploid cells, strain Wi38. (karger.com)
- Atypical patterns of human cytomegalovirus infection and spread in U373 glioblastoma cells. (uc.edu)
- Rescue of Pentamer-Null Strains of Human Cytomegalovirus in Epithelial Cells by Use of Histone Deacetylase Inhibitors Reveals an Additional Postentry Function for the Pentamer Complex. (uc.edu)
- Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers. (uc.edu)
- Arrows show dermal condensate (in red), a subpopulation of cells essential for embryonic hair follicle growth. (scitechdaily.com)
- The human cranium develops from mesoderm and neural crest cells. (medscape.com)
- Cancer cells have a greater need for energy compared with normal cells, and mitochondrial dysfunction plays an important role in cancer biology. (who.int)
- Now, a research group at Lund University has succeeded in finding a drug candidate that binds to the protein, something that has been shown to affect the growth capability of leukemia cells. (lu.se)
- It seems that cancer cells may increase the number of aquaporins to enhance their own survival and increase their spreading ability, says Karin Lindkvist, professor of cell biology at Lund University and structural biology researcher. (lu.se)
- They have also shown that the drug affects the growth capability of leukemia cells by inactivating aquaporins. (lu.se)
- 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
- Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
- We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)
- Although possible, these strategies are often complicated to transfer to human cells due to technical issues (9 ), and only a few successful cases have been described ( 10, 11 ). (lu.se)
- Here we describe how this system can be used for human embry- onic stem cells. (lu.se)
- The human body is a complex, highly organized structure made up of unique cells that work together to accomplish the specific functions necessary for sustaining life. (msdmanuals.com)
- Human cells vary in size, but all are quite small. (msdmanuals.com)
- The cancer stem cell theory holds that tumors also contain stem-like cells that drive tumor growth and metastasis formation. (medscape.com)
Protein7
- The intestinal niche has been well-characterized, and shown to consist of spatial gradients of high WNT and Epithelial Growth Factor (EGF), while Bone Morphogenetic Protein (BMP) signals are inhibited. (stemcell.com)
- This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. (nih.gov)
- This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
- The progenitor protein of frag 176-191, hGH, is a 191 amino acid protein that controls a complex interplay of diverse physiological processes, from cellular and tissue growth to fat loss and glucose metabolism [3]. (outlookindia.com)
- This results in overproduction of the FGF4 protein, which the researchers hypothesize may turn on key growth receptors at the wrong times during fetal development. (nih.gov)
- Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
- The TP53 gene codes for a protein product that is a strong negative regulator of normal human cell growth and is thought to act as a tumor suppressor. (medscape.com)
Tumor1
- Tumors, like the tissues from which they originate, contain a unique SC population that is capable of self-renewal and of sustaining tumor growth indefinitely. (medscape.com)
Cellular1
- Examination of these early cellular changes showed that IL-1 did not produce similar induction of cellular proteins and the morphological changes associated with growth stimulation. (rupress.org)
Characterization1
- Ubiquitous sequencing will allow for the near real-time characterization of pathogen biology, including determinations of virulence, transmissibility, sensitivity or resistance to medicines or vaccines. (slideshare.net)
Embryology1
Development17
- To assess the life history consequences of cow milk consumption at different stages in early life (prenatal to adolescence), especially with regard to linear growth and age at menarche and the role of insulin-like growth factor I (IGF-I) in mediating a relationship among milk, growth and development, and long-term biological outcomes. (nih.gov)
- IGF-I is a candidate bioactive molecule linking milk consumption to more rapid growth and development, although the mechanism by which it may exert such effects is unknown. (nih.gov)
- Each strand of hair on the human body is at its own stage of development. (wikipedia.org)
- Exceptions to this rule can be observed in individuals with hair development abnormalities, which may cause an unusual length of hair growth. (wikipedia.org)
- Nerve growth factor (NGF) is critical to the development and maintenance of the peripheral nervous system, but its possible roles in other organ systems are less well characterized. (silverchair.com)
- This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
- The purpose of this research was to study the growth of the nasopharynx and adenoid development. (scielo.br)
- A detailed consideration of the basic properties of bone growth, development, and function in the human body. (kent.ac.uk)
- It's caused by calcification of growth plates, which curtails long bone development and results in short legs with a curved appearance. (nih.gov)
- Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium. (uc.edu)
- Shape changes to the human ilium during individual growth and development reflect biomechanical adaptations. (vassar.edu)
- We established the human growth trajectory using 40 individuals in various stages of development from infancy to adulthood. (vassar.edu)
- To test our hypothesis, we also simulated development of immature human ilia and compared the simulated versus actual adult shape. (vassar.edu)
- Given the tremendous business benefits that these experiences can bring, it is time for organizations to double down on their commitments to professional growth and development. (deloitte.com)
- Broadly speaking, growth in the workplace refers to work aligning with personal goals and development of the worker, 1 and the ability of organizations to meet the needs of their workers' personal and professional aspirations. (deloitte.com)
- Career development and potential for growth are quickly becoming the foundation of effective workforce strategy. (deloitte.com)
- For increasing numbers of workers, professional growth and development opportunities are what inspire them to choose (and remain at) certain jobs and certain organizations over others. (deloitte.com)
Biological6
- Routine milk consumption is an evolutionarily novel dietary behavior that has the potential to alter human life history parameters, especially vis-à-vis linear growth, which in turn may have negative long-term biological consequences. (nih.gov)
- The study of the human skeletal system is basic to the disciplines of biological anthropology and human biology. (kent.ac.uk)
- Students will learn to identify and analyse human bone and evaluate and interpret major research in biological anthropology and human biology hat has as its basis the analysis of bone. (kent.ac.uk)
- Major techniques used in biological anthropology to analyse human bone, such as estimation of age at death, estimation of biological sex and stature. (kent.ac.uk)
- An understanding of the human skeletal system, including the nature and function of bone, the identification of bone and bony fragments in an anthropological context, and the interpretation of morphological features of bone for research in biological anthropology and human biology. (kent.ac.uk)
- The work also underscores the value of canine studies for uncovering new biological mechanisms that are likely relevant to human disease. (nih.gov)
Replication1
- WHA50.37, which states "the use of cloning for the replication of human individuals is ethically unacceptable and contrary to human integrity and morality. (who.int)
Bone growth3
- Aerial and cross-sectional scans showed the plasmid-encoded scaffolds had spurred enough new bone growth to nearly close the wound area, the researchers report. (sciencedaily.com)
- Elangovan and Salem next hope to create a bio platform that promotes new blood vessel growth- needed for extended and sustained bone growth. (sciencedaily.com)
- Craniosynostosis refers to a specific aberration of the growth process in which bone growth at a particular suture site (or sites) is arrested prematurely, resulting in a specific skull shape deformity. (medscape.com)
20223
- Hermanussen M, Erofeev S & Scheffler C (2022) The socio-endocrine regulation of human growth. (uni-potsdam.de)
- Hermanussen M, Groth D, Scheffler C (2022) Human Growth data analyses and statistics. (uni-potsdam.de)
- Wilke L, Böker S , Mumm R , Groth D (2022) Social status influences human growth- a summary and analysis of historical data from Gemany school girls in 1914 with comparision to modern references. (uni-potsdam.de)
Systems biology1
- SYSTEMCERV, Systems biology approaches to cervical pre-cancer and cancer, is a SME targeted collaborative research project funded through the European Union Seventh Framework Programme Health programme [Grant number 306037]. (europa.eu)
Broadly1
Metabolism1
Cell4
- Growth factor consumption and production in perfusion cultures of human bone marrow correlate with specific cell production. (ucsd.edu)
- 17 This property of rapid regeneration at intestinal stasis makes the intestine a uniquely convenient model system for epithelial cell biology and adult stem cell biology studies both inside and outside the specific context of intestinal function. (stemcell.com)
- Loss of this inhibition results in increased expression of the GLI family of transcription factors, promoting cell growth. (medscape.com)
- Constitutive activation of this pathway in human keratinocytes has been shown to produce a neoplasm identical to basal cell carcinoma. (medscape.com)
Antibody1
- Commercially available test antibodies included CD71 clone 1a, 2, CD20 (Sigma), clone 3-5 (Abcam), CD3, CD45 (Biolegend), human IgG isotype control (Absolute Antibody), mouse IgG1 isotype control (R&D Systems). (news-medical.net)
Factor2
- Maternal education is an important factor influencing children linear growth even in a patriarchy. (human-biology-and-public-health.org)
- Evidence for nerve growth factor-mediated paracrine effects in human epidermis. (silverchair.com)
Airway1
Tissue3
- The plasmid-seeded bio patch grew 44-times more bone and soft tissue in the affected area than with the scaffold alone, and was 14-fold higher than the affected area with no manipulation. (sciencedaily.com)
- Although the nasopharynx follows a growth pattern similar to that of the rest of the body, adenoid tissue does not. (scielo.br)
- Furthermore, pathways controlling the self-renewal capacity of normal tissue SCs are frequently deregulated in human cancer. (medscape.com)
Study4
- An understanding of the ethical treatment of human remains in light of major moral and legal dilemmas facing the scientific study of humans today. (kent.ac.uk)
- Exposure to an anthropological approach to the study of the skeletal structure of humans. (kent.ac.uk)
- This study points to a new gene that should be investigated for its possible role in human hypochondroplasia," Ostrander says. (nih.gov)
- This program will offer an opportunity to study evidence-based scientific approach to analysis the impacts of foods and nutrition on the human mind and body. (eiyo.ac.jp)
Alternatively1
Ecological1
Inhibit2
- Consequently, the chemotherapy drugs usually inhibit hair growth. (wikipedia.org)
- CDC) estimates that annually, at least two million illnesses and 23,000 deaths are caused by antibiotic-resistant bacteria in the United States alone.1 If the effectiveness of antibiotics (drugs that kill or inhibit the growth of bacteria) is lost, we will no longer be able to reliably and rapidly treat bacterial infections, including bacterial pneumonias, foodborne illnesses, and healthcare- associated infections. (cdc.gov)
Distinct2
- Hair follows a specific growth cycle with three distinct and concurrent phases: anagen, catagen, and telogen. (wikipedia.org)
- To understand what causes chondrodysplasia, a team of researchers led by Dr. Elaine Ostrander of NIH's National Human Genome Research Institute (NHGRI) examined DNA samples from 835 dogs from 76 distinct breeds, including 95 dogs from 8 breeds with short legs. (nih.gov)
Research4
- However, more recent research has shown that the growth rate of hair in men and women does not significantly differ and that the hair of Chinese people grew more quickly than the hair of French Caucasians and West and Central Africans. (wikipedia.org)
- Evaluation of major research studies involving analysis of human bone. (kent.ac.uk)
- Experience with the identification, and analysis of human bone, and understanding of how these data are utilized to answer significant anthropological research questions. (kent.ac.uk)
- Evaluation of new research in the field of human skeletal biology. (kent.ac.uk)
Follicle1
- In most people, scalp hair growth will halt due to follicle devitalization after reaching a length of generally two or three feet. (wikipedia.org)
Successfully1
- In experiments, the gene-encoding bio patch successfully regrew bone fully enough to cover skull wounds in test animals. (sciencedaily.com)
Role4
- The literature tends to support milk's role in enhancing growth early in life (prior to age 5 years), but there is less support for this relationship during middle childhood. (nih.gov)
- These combined data suggest a paracrine role for NGF in human epidermis. (silverchair.com)
- The human pelvis is uniquely adapted for bipedal walking, and the shape of the ilium plays an important role in locomotion. (vassar.edu)
- Although scientists know that microbial ecology plays an important role in maintaining human health, there are remaining scientific questions. (cdc.gov)
Grew2
- It was previously thought that Caucasian hair grew more quickly than Asian hair and that the growth rate of women's hair was faster than that of men. (wikipedia.org)
- Using this human growth projection, we "grew" two immature A. africanus ilium fossils into simulated adults, which we then compared to an actual adult A. africanus fossil. (vassar.edu)
Ecosystems2
- They used to cleanse ecosystems and spur healthy growth. (motherjones.com)
- The continuing growth of the human population has an impact on virtually all ecosystems on Earth. (ucd.ie)
Intermediate1
Fundamentals1
- This module will examine the fundamentals of human osteology. (kent.ac.uk)
Methods1
- We revisited the issue of ilium growth using advanced geometric morphometric methods, to test the hypothesis that A. africanus ilia follow the same shape growth pattern as humans. (vassar.edu)