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2021Genetics2022ProteinsSenescenceGeneticMechanisms2023InflammationGenomicsOnsetAssaysMetabolismRegenerationDiseasesAccumulationBiochemistryHematopoietic stemStemHumansMitochondrialResearchApoptosisSenescent cellsHomeostasisBone marrowSystems BiologyMechanismGeneDisordersMammalian cellsBioinformaticsGenesVitroTelomereOrganismsDifferentiationViabilityDiseaseMoleculeAdultIntracellularBiologicalMacular degenerationDeclinesResearcherProliferationOccursPharmacologyResearchersLaboratoryDiabetesFindings
20213
Genetics1
  • Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)
20224
  • Dec. 28, 2022 Researchers are bridging mouse and human data to reveal the biology of senescent cells. (sciencedaily.com)
  • June 30, 2022 Senescent cells -- those that have lost the ability to divide -- accumulate with age and are key drivers of age-related diseases, such as cancer, dementia and cardiovascular disease. (sciencedaily.com)
  • American journal of respiratory cell and molecular biology 2022 0 0. (cdc.gov)
  • Teplizumab, a humanized monoclonal antibody to CD3 on T cells, was approved by the US Food and Drug Administration in November 2022 to delay the onset of clinical type 1 diabetes in patients aged 8 years or older with preclinical (stage 2) disease. (medscape.com)
Proteins8
  • The Salk scientists are the first to discover an essential intracellular machine whose components include proteins of this age. (sciencedaily.com)
  • Damage to the ELLPs weakens the ability of the three-dimensional transport channels that are composed of these proteins to safeguard the cell's nucleus from toxins, says Martin Hetzer, a professor in Salk's Molecular and Cell Biology Laboratory, who headed the research. (sciencedaily.com)
  • Most cells, but not neurons, combat functional deterioration of their protein components through the process of protein turnover, in which the potentially impaired parts of the proteins are replaced with new functional copies," says Hetzer. (sciencedaily.com)
  • These age-related immunological changes resemble those seen during treated HIV-1 infection and include high levels of soluble inflammatory proteins, high levels of monocyte and T cell activation, T cell exhaustion and senescence, and low levels of naïve T cells ( 14 - 25 ). (frontiersin.org)
  • During the first stage called G1, cells monitor their environment and, when the requisite signals are received, the cells synthesize RNA and proteins to induce growth. (bdbiosciences.com)
  • Several cell cycle-associated proteins, such as Ki-67, are also used as indicators of cell proliferation. (bdbiosciences.com)
  • Our recent studies as well as others indicate that senescent cells change their secretory patterns of cytokines, chemokines, growth factors, extracellular matrix proteins and proteases. (umassmed.edu)
  • We are interested how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense normal and pathologically altered extracellular matrix. (mcgill.ca)
Senescence12
  • The Stanford article that you read is correct, in the sense that telomeres do not need to be completely removed by cell division before deleterious effects occur and cells start undergoing senescence. (stackexchange.com)
  • Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)
  • Raw RNA-seq data for RAS-induced senescence and control conditions in IMR90 cells were downloaded from GEO (under accession code GSE74324 ) 41 . (nature.com)
  • Failure to execute these regulatory responses causes cell damage and inflammation or senescence, compromising cell survival and the ability to adapt to energetically demanding conditions. (nature.com)
  • We observed that age advancement in all three groups combined was associated with a monocyte immune phenotypic profile related to inflammation and a T cell immune phenotypic associated with immune senescence and chronic antigen exposure. (frontiersin.org)
  • The T cell immune phenotypic profile in blood donors was related to loss of T cell function, whereas the same set of markers were related to chronic antigen stimulation and immune senescence in HIV-negative individuals. (frontiersin.org)
  • The identified monocyte and T cell immune phenotypic profiles that were associated with age advancement, were strongly related to inflammation, chronic antigen exposure and immune senescence. (frontiersin.org)
  • Senescence limits proliferative capacity of cells and thus impedes the accumulation of multiple mutations necessary for tumorigenesis. (umassmed.edu)
  • Furthermore, aberrant oncogenic activation, DNA damage or oxidative stress activates senescence, providing a failsafe mechanism that prevents the proliferation of cells at risk of neoplastic transformation. (umassmed.edu)
  • Consistent with this notion, we have found that Smurf2-deficient mouse embryonic fibroblasts exhibit delayed senescence entry and enhanced potential to become immortalized in culture, while Smurf2-deficient mice show increased susceptibility to various types of cancer, including B-cell lymphoma, hepatocellular carcinoma, adenocarcinoma in small intestine and soft tissue sarcoma. (umassmed.edu)
  • Mayo Clinic researchers, working in collaboration with the University Medical Center Groningen and The Scripps Research Institute, induced senescence in human cell cultures by radiating human primary preadipocytes, Human Umbilical Vein Endothelial Cell cultures and IMR90 cell cultures. (sciencedaily.com)
  • Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. (cdc.gov)
Genetic12
  • Your genetic destiny rest in every cell in your body, all 37 trillion of them, coded into a tiny strands of DNA. (naturalbiology.com)
  • Every time your cells divide, your genetic information is duplicated and your telomeres get a little bit shorter. (naturalbiology.com)
  • Other tolls that are available from HAGR include GenAge (a database of genes correlated to age and longevity in both humans and model organisms), AnAge (a database collecting records from over 4,000 species aging, longevity and life-history), GenDR (a database of genes connected to the life extending effects of caloric restriction), and LongevityMap (a database of more than 2000 longevity-associated human genes and genetic variations). (labroots.com)
  • To investigate the background in more detail, the Max Planck researchers used heart muscle cells in which miR-1/133a could be temporarily inactivated by genetic engineering. (mpg.de)
  • My laboratory works on the genetic and molecular mechanisms that regulate aging and aging-related disease. (berkeley.edu)
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. (todayinsci.com)
  • Cells are also programmed for death at the genetic level as a response to DNA damages through the process of apoptosis. (bdbiosciences.com)
  • Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
  • According to a recent study by researchers from the Lund Stem Cell Center at Lund University, published in Nature Aging, the genetic changes previously observed in aging blood stem cells could be linked to cell extraction stress rather than the aging process itself. (lu.se)
  • All specimens were tested using the Synthetic Peptide Enzyme Immunoassay (EIA) (Genetic Systems HIV-1/HIV-2 Peptide EIA) for the detection of antibody to human immunodeficiency virus type 1 or type 2 (HIV-1 or HIV-2) or both (Bio-Rad Laboratories, Redmond, WA). (cdc.gov)
  • These genetic changes appear to be most frequent in men with hair loss that begins at an early age. (medlineplus.gov)
Mechanisms7
  • There has been some evidence to suggest that free radicals and some reactive nitrogen species trigger and increase cell death mechanisms within the body such as apoptosis and in extreme cases necrosis. (wikipedia.org)
  • These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)
  • [ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
  • Pack LR, Daigh LH, Meyer T. Putting the brakes on the cell cycle: mechanisms of cellular growth arrest. (bdbiosciences.com)
  • To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. (upenn.edu)
  • the FCG track provides advanced training in computational and systems biology, and the MBoA track provides training in the molecular mechanisms of aging. (brown.edu)
  • The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)
20233
  • For 2023, the IDF Research Grant Program is awarding more than $190,000 in support of five projects that advance the diagnosis, knowledge of underlying biology, and potential treatments for primary immunodeficiencies (PI). (primaryimmune.org)
  • Cell;186(19): 4038-4058, 2023 09 14. (bvsalud.org)
  • Cite this: Teplizumab Preserves Beta Cells in New-Onset Type 1 Diabetes - Medscape - Oct 18, 2023. (medscape.com)
Inflammation10
  • Containing natural, soothing compounds, Aloe Vera may help reduce inflammation, nourish skin cells and protect skin from harmful UV rays. (naturalchoicecompany.com)
  • The ability of the blood stem cells to regenerate was suppressed for at least one year after challenge with inflammation, suggesting that infection and inflammation may act as a prominent driver of age-associated functional decline in tissues. (eurekalert.org)
  • However, the question that we wanted to answer was whether inflammation and infections in early life can permanently damage blood stem cells and thus promote aging of the blood system," says Mick Milsom of the German Cancer Research Center and the Stem Cell Institute HI-STEM. (eurekalert.org)
  • We have therefore carried out time-consuming experiments to determine for how we observe an inhibitory effect on stem cell function following infection and inflammation, and came to the surprising conclusion that we never see any evidence of stem cell recovery, suggesting that this process is long-lasting or perhaps even irreversible. (eurekalert.org)
  • The lack of stem cell recovery between each round of challenge meant that these treatments resulted in an additive inhibitory effect, supporting a model that explains age-associated tissue dysfunction and disease: where separate instances of infection or inflammation can have a cumulative inhibitory effect on stem cell function, even if separated by months or years. (eurekalert.org)
  • Importantly, the inflammation in young mice led to persistent changes in the hematopoietic system resembling age-related changes often found in elderly people. (eurekalert.org)
  • Inflammation and infection at a young age appear to accelerate the aging of the hematopoietic system,' Milsom said, summarizing the findings. (eurekalert.org)
  • HIV-associated immune dysfunction and inflammation have been suggested to contribute to this age advancement and increased risk of comorbidities. (frontiersin.org)
  • In the general population aging is associated with immunological changes resulting in low grade inflammation and deterioration of the innate and adaptive immune system in the elderly ( 10 - 13 ). (frontiersin.org)
  • Recent research in the lab indicates that inflammation promotes cellular iron overload in a vicious cycle leading to cell death. (upenn.edu)
Genomics2
  • There is still very much left to learn,' explained Joao Pedro de Magalhaes, PhD, a Trustee of the Biogerontology Research Foundation (BGRF) and a Principal Investigator at the University of Liverpool's Integrative Genomics of Aging Group (IGAG). (labroots.com)
  • For the Applied Mathematics track, in the first semester training in statistical analysis of complex datasets will begin with "Statistical Inference" (APMA 1650) and will continue in the second semester with "Inference in Genomics and Molecular Biology" (APMA 1080). (brown.edu)
Onset8
  • When Hetzer decided three years ago to investigate whether the NPC plays a role in initiating or contributing to the onset of aging and certain neurodegenerative diseases, some members of the scientific community warned him that such a study was too bold and would be difficult and expensive to conduct. (sciencedaily.com)
  • We used International Classification of Diseases, 9th Revision codes to identify AMD diagnoses and L-DOPA prescriptions to determine the relative risk of developing AMD and age of onset with or without an L-DOPA prescription. (nih.gov)
  • In the retrospective analysis of patients without an L-DOPA prescription, AMD age of onset was 71.2, 71.3, and 71.3 in 3 independent retrospective cohorts. (nih.gov)
  • In a pilot study, 30 rural Iowan males ages 44-73 at the study onset, about half farmers, were evaluated. (cdc.gov)
  • Researchers have uncovered three new agents to add to the emerging repertoire of drugs that aim to delay the onset of aging by targeting senescent cells - cells that contribute to frailty and other age-related conditions. (sciencedaily.com)
  • While additional studies are needed to determine the safety and efficacy, we hope that they will be able to extend health span and delay the onset of multiple age-related diseases and disabilities. (sciencedaily.com)
  • Teplizumab (Tzield) infusions in children and adolescents with new-onset type 1 diabetes met the primary endpoint of preserved beta-cell function and trended toward improved secondary glycemic endpoints. (medscape.com)
  • The study was a phase 3, randomized, placebo-controlled trial of teplizumab (n = 217) vs placebo (n = 111) in children and adolescents aged 8-17 years within 6 weeks of clinical type 1 diabetes (stage 3) onset. (medscape.com)
Assays1
  • Methodologically, the lab employs a wide spectrum of techniques ranging from in vitro biochemical and biophysical assays, to cell biology methods with primary cells and transformed cell lines, to light and electron microscopic techniques, to in vivo studies with genetically modified mouse models. (mcgill.ca)
Metabolism1
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Regeneration4
Diseases9
  • In later years, the free radical theory was expanded to include not only aging per se, but also age-related diseases. (wikipedia.org)
  • Thus, mitochondrial adaptive cellular processes are important for physiological responses, including to nutrient availability, temperature and physical activity, and their failure leads to diseases associated with mitochondrial dysfunction such as metabolic and age-associated diseases and cancer. (nature.com)
  • New Research on Cell Aging and Death reviews previous literature to describe the main behavioral and biochemical characteristics of the SAMP8 mouse model, discussing its main advantages as well as potential weaknesses to model age-related diseases. (novapublishers.com)
  • Such diseases are thought to be caused by an age-associated decline in stem cell self-renewal. (eurekalert.org)
  • However, mouse models housed under highly controlled, pathogen-free conditions, rarely spontaneously develop such age-related diseases. (eurekalert.org)
  • Our next challenge is to explore whether prophylactic anti-inflammatory treatment could delay the development of age-related diseases of the blood system, while still preserving the immune response against pathogens. (eurekalert.org)
  • Senescent cells accumulate with age and at sites of multiple chronic conditions, such as in fat tissue in diabetes, the lungs in chronic pulmonary diseases, the aorta in vascular disease, or the joints in osteoarthritis," says James Kirkland, M.D., Ph.D., director of the Robert and Arlene Kogod Center on Aging. (sciencedaily.com)
  • Telomere Shortening and Its Association with Cell Dysfunction in Lung Diseases. (cdc.gov)
  • Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Lung Diseases: Current Status and Perspectives. (cdc.gov)
Accumulation3
  • This damage then causes mutations which lead to an increase of ROS production and greatly enhance the accumulation of free radicals within cells. (wikipedia.org)
  • Sustaining an appropriate level of genes encoding DNA repair factors is thought to be necessary for cell survival by preventing the accumulation of DNA mismatches and epigenetic alterations. (novapublishers.com)
  • We are interested in whether age-dependent accumulation of senescent cells leads to alterations in tissue microenvironment that is favorable for oncogenesis. (umassmed.edu)
Biochemistry2
Hematopoietic stem1
  • Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. (eurekalert.org)
Stem19
  • Leveraging the advances in Plant Stem Cell technology and advanced Peptides, this multi-purpose anti-aging serum does wonders for face, eyes and neck reducing the appearance of wrinkles, helping to boost collagen and restore elasticity. (naturalchoicecompany.com)
  • „MARRUBIUM MERISTEM CELLS END HYALORUBIONIC COMPLEX™" este un complex bioactiv de ultima generatie e laborat din celule stem, incorporate intr-un purtator de glycozaminoglycan i hidrolizati, reprezentand „varful de lance"al cercetarii fitocosmetice moderne , cu efecte multiple si simultane. (biopur.ro)
  • Accordingly, in contrast to organs with a high regenerative capacity, no divisible, regenerative stem cells are found in the heart. (mpg.de)
  • In one study, the authors focus on the effects of aging on adult neurogenesis, a process of producing new neurons from neural stem cells and neural progenitor cells in the neocortex, comparing the dentate gyrus and subventricular zone. (novapublishers.com)
  • Blood stem cells in the bone marrow provide a lifelong replenishment of the different cell types making up the blood system. (eurekalert.org)
  • According to experts, the cause of this age-related loss of function of the hematopoietic system is a chronic low-grade inflammatory condition called inflammaging, that only develops in later life and impairs the function blood stem cells. (eurekalert.org)
  • The researchers subsequently identified the cause of the dysfunctional hematopoiesis: Blood stem cells failed to self-renew as they were forced to divide in response to the inflammatory stimuli. (eurekalert.org)
  • This observation in mice contradicts common doctrine: we had previously believed that, after inflammatory challenge, blood stem cells revert into a so-called dormant state that preserves their capacity for self-renewal,' says Milsom, explaining this surprising aspect of his work. (eurekalert.org)
  • Lund University researchers find that individual blood stem cells (depicted as snowflakes in this image) express stress-related transcripts when subjected to experimental procedures involving cell incubation at elevated temperatures. (lu.se)
  • Blood stem cells, in particular, lose some of their functionality over time, contributing to various blood disorders and disease-related conditions. (lu.se)
  • Hematopoietic stem cells, known as blood stem cells, are crucial for producing all types of blood cells throughout a person's life. (lu.se)
  • As individuals age, the ability of these stem cells to renew themselves and produce new blood cells declines, which can lead to health issues. (lu.se)
  • Researchers at Lund Stem Cell Center are particularly interested in studying hematopoietic stem cells, their changes with age, and the factors contributing to this decline. (lu.se)
  • Anna Konturek-Ciesla, a researcher at Lund Stem Cell Center and the lead author of the study explains, "In our research, which focuses on hematopoiesis, or blood cell formation, many studies have attempted to analyze the changes associated with aging in blood stem cells using gene expression profiling. (lu.se)
  • Today, performing gene expression analysis on young and aged hematopoietic stem cells is a common practice, used to understand the changes associated with aging. (lu.se)
  • Despite this wealth of knowledge, Anna Konturek-Ciesla noted that there is still no consensus about the molecular profile of aged hematopoietic stem cells. (lu.se)
  • When we looked at our data, we noticed a pattern of stress-induced changes in gene activity, especially in cells exposed to higher temperatures during isolation," explains David Bryder, Professor of Molecular Hematology at Lund University, and research group leader at Lund Stem Cell Center. (lu.se)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
Humans2
  • In line with this, mice exposed to such challenges in early life developed clinically relevant features of aging that are often observed in elderly humans. (eurekalert.org)
  • Humans accumulate with age the dark-brown pigment neuromelanin inside specific neuronal groups. (biorxiv.org)
Mitochondrial7
  • Denham Harman first proposed the free radical theory of aging in the 1950s, and in the 1970s extended the idea to implicate mitochondrial production of ROS. (wikipedia.org)
  • This mitochondrial theory has been more widely accepted that it could play a major role in contributing to the aging process. (wikipedia.org)
  • Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. (nature.com)
  • These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
  • Using a high-throughput mitochondrial phenotyping platform to quantify multiple mitochondrial features among molecularly defined immune cell subtypes, we quantify the natural variation in mitochondrial DNA copy number (mtDNAcn), citrate synthase, and respiratory chain enzymatic activities in human neutrophils, monocytes, B cells, and naïve and memory T lymphocyte subtypes. (nih.gov)
  • In mixed peripheral blood mononuclear cells (PBMCs) from the same individuals, we show to what extent mitochondrial measures are confounded by both cell type distributions and contaminating platelets. (nih.gov)
  • Finally, a proof-of-concept, repeated-measures study in a single individual validates cell type differences and also reveals week-to-week changes in mitochondrial activities. (nih.gov)
Research9
  • Research says you can affect the age of your cells at any age, and we should all be blessed to have healthier cells and feel as good as possible. (naturalbiology.com)
  • Interestingly, the scientists, from the Biogerontology Research Foundation (BGRF) and University of Liverpool have found that drugs have not yet targeted the majority of cellular chemical cascades that relate to aging. (labroots.com)
  • Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that the two micro RNA molecules miR-1 and miR-133 in the adult heart inactivate two genes that normally force cell division. (mpg.de)
  • In turn, as a result of research into the abnormal cancer cell, the basic understanding of the cell has greatly improved. (medscape.com)
  • Funded by the Ellison Medical Foundation and the Glenn Foundation for Medical Research, Hetzer's research group is the only lab in the world that is investigating the role of these transport channels, called the nuclear pore complex (NPC), in the aging process. (sciencedaily.com)
  • Recent research in several laboratories has linked breakdown of protein homeostasis to declining cell function. (sciencedaily.com)
  • The Lefeber Hughes Winter Series on Aging, now in its 28th year, features nationally recognized gerontology research educators, basic scientists, clinicians, and social scientists. (utmb.edu)
  • Each speaker will present a lecture on an important aspect of aging research and consult with students, faculty, and staff on research topics, grant applications, and articles being written for publication while they are at UTMB. (utmb.edu)
  • The purpose of our research is to understand how each islet cell type and each enteroendocrine cell type in the gut is affected in type 2 diabetes. (lu.se)
Apoptosis8
Senescent cells4
  • A recent study of human cell cultures shows that the drugs, fisetin and two BCL-XL inhibitors -- A1331852 and A1155463 -- cleared senescent cells in vitro. (sciencedaily.com)
  • At Mayo Clinic, we discovered the first senolytic drugs -- agents that selectively eliminate senescent cells while leaving normal cells unaffected. (sciencedaily.com)
  • Then, using an ATPLite and a crystal violet assay, researchers measured cell viability and demonstrated that fisetin and BCL-XL inhibitors A1331852 and A1155463 cleared senescent cells in vitro. (sciencedaily.com)
  • We predict many more senolytic drugs will appear at an accelerating pace over the next few years and that these drugs will be improved to more effectively target senescent cells," says Dr. Kirkland. (sciencedaily.com)
Homeostasis1
Bone marrow2
  • These include anemia and decreased number of cells in the bone marrow. (eurekalert.org)
  • Unfortunately there are other negative changes in body fat distribution with age, including increased fat storage in the heart, liver, bone marrow, and skeletal muscle, all of which are associated with increased metabolic risk, as well as increased risk of fractures in the case of bone marrow. (scienceblogs.com)
Systems Biology1
  • Systems Biology - In the first semester, training in the mathematical modeling of biological systems will begin with "Methods of Applied Mathematics I" (APMA 0330 or APMA 0350). (brown.edu)
Mechanism2
  • The subsequent chapter discusses the effect of the mechanism of cell death of neutrophil granulocytes on the realization of the inflammatory process. (novapublishers.com)
  • Our results also suggest that nuclear pore deterioration might be a general aging mechanism leading to age-related defects in nuclear function, such as the loss of youthful gene expression programs," he adds. (sciencedaily.com)
Gene7
  • Previous studies have revealed that alterations in gene expression underlie the aging process. (sciencedaily.com)
  • The FCG curriculum is aimed at students with a primary background in biology, but also with appropriate mathematical preparation (college-level calculus) and interest in applying advanced quantitative methodologies towards the understanding of gene function and regulation in development and disease. (brown.edu)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Studying gene expression is essential for understanding how cells function and respond to different stimuli. (lu.se)
  • Suspecting that experimental procedures used during gene expression analysis might be influencing the results, they examined how stress-related genes behaved in cells collected under different conditions. (lu.se)
  • We compared the power of gene expression measurements with that of conventional prognostic markers, i.e., clinical, histo- pathological, and cell biological parameters, for predicting distant metastases in breast cancer patients using both established prognostic indices (e.g., the Nottingham Prognostic Index (NPI)) and novel combinations of conventional markers. (lu.se)
  • Spinal and bulbar muscular atrophy, a disorder of specialized nerve cells that control muscle movement (motor neurons), results from an expansion of the CAG trinucleotide repeat in the AR gene. (medlineplus.gov)
Disorders2
  • Free radical damage within cells has been linked to a range of disorders including cancer, arthritis, atherosclerosis, Alzheimer's disease, and diabetes. (wikipedia.org)
  • The findings may prove relevant to understanding the molecular origins of aging and such neurodegenerative disorders as Alzheimer's disease and Parkinson's disease. (sciencedaily.com)
Mammalian cells1
  • Viable Offspring Derived from Petal and Adult Mammalian Cells', Nature (1997), 385 , 810. (todayinsci.com)
Bioinformatics2
  • MCB students will gain instruction in quantitative approaches to biological processes including statistics and bioinformatics through "Quantitative Approaches in Biology" (BIOL2010, one credit) during the second semester. (brown.edu)
  • Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients. (cdc.gov)
Genes4
  • Indeed, the expression of the genes for the oncostatin M receptor and the FGF receptor 1 increased in these cells, and with it the number of receptor molecules. (mpg.de)
  • In the concluding review the authors evaluated the effects of natural and chemical compounds on promoter activities of several human DNA repair-associated genes in HeLa S3 cells. (novapublishers.com)
  • These toxins may alter the cell's DNA and thereby the activity of genes, resulting in cellular aging. (sciencedaily.com)
  • Tumorigenesis is a multi-step process in which a normal cell acquires changes in a number of critical cancer causing genes. (umassmed.edu)
Vitro2
  • An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
  • Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
Telomere2
  • These Natural Biology supplement are committed to cellular health which improves telomere health. (naturalbiology.com)
  • 2007). Baird suggests that without sufficiently long telomere caps, the cell may perceive the chromosome ends as broken strands of DNA and attempt to piece them together. (stackexchange.com)
Organisms2
  • DNA in (regular) cells (in human and some other organisms) are protected by telomers. (stackexchange.com)
  • The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. (wikipedia.org)
Differentiation2
  • The pheromone signalling pathway of baker's yeast belongs to a class of MAPK (mitogen-activated protein kinase) signalling pathways, which in eukaryotes commonly play a key role in the transmission and translation of extracellular stimuli into intracellular responses such as cell differentiation, proliferation or stress responses. (mpg.de)
  • Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. (todayinsci.com)
Viability1
  • In the experiment, the heart muscle cells from miR-1/133a knockout animals showed higher viability and survival in hypoxia,' Valussi said. (mpg.de)
Disease5
  • Students complete an CER on how Brazilian wasp venom can disrupt the cell membrane of cancer cells which can potentially be used to treat disease. (biologycorner.com)
  • Here, by taking advantage of this newly developed animal model, we assessed whether the intracellular buildup of neuromelanin that occurs with age can be slowed down in vivo to prevent or attenuate Parkinson's disease. (biorxiv.org)
  • These senolytic agents alleviated a range of age- and disease-related problems in mice. (sciencedaily.com)
  • Experience: Martin Brand is an authority on mitochondria, the energy-converting unit of cells and their influence on aging and disease. (cdc.gov)
  • We aim to identify type 2 diabetes-induced, cell type-specific alterations in islet and intestinal cells that explain why the disease develops. (lu.se)
Molecule5
  • The free radicals produced in such reactions often terminate by removing an electron from a molecule which becomes changed or cannot function without it, especially in biology. (wikipedia.org)
  • Such an event causes damage to the molecule, and thus to the cell that contains it (since the molecule often becomes dysfunctional). (wikipedia.org)
  • Hyaluronic acid: A key molecule in skin aging . (naturalchoicecompany.com)
  • In people without PI, each T cell makes one version of TCR, and that version determines what protein or other biological molecule the T cell will recognize. (primaryimmune.org)
  • The first tests whether the thymocyte's TCR is capable of recognizing a foreign molecule, which ensures that released T cells will actually protect against infection. (primaryimmune.org)
Adult4
  • The two molecules, oncostatin M receptor and FGF receptor 1, control the division activity of heart muscle cells in the adult heart,' says Thomas Böttger, one of the lead authors of the study. (mpg.de)
  • English embryologist who in 1996 supervised the team of scientists that produced a lamb named Dolly, the first mammal cloned from a cell from an adult. (todayinsci.com)
  • Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. (todayinsci.com)
  • The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells. (todayinsci.com)
Intracellular2
  • This triggered intracellular processes, at the end of which cell division was initiated in the cardiac muscle cells. (mpg.de)
  • To make the decision of whether to enter the cell cycle or not, cells integrate information from a variety of intracellular and extracellular signals. (bdbiosciences.com)
Biological4
  • The free radical theory of aging was conceived by Denham Harman in the 1950s, when prevailing scientific opinion held that free radicals were too unstable to exist in biological systems. (wikipedia.org)
  • In biological systems, random fluctuations of signals always lead to background noise, which can impede cell communication. (mpg.de)
  • Partial least squares regression (PLSR) was used to explore associations between biological age advancement and immunological changes in the T cell and monocyte compartment in people with HIV (n=40), comparable HIV-negative individuals (n=40) participating in the Comorbidity in Relation to AIDS (COBRA) cohort, and blood donors (n=35). (frontiersin.org)
  • a literature-based class on multidisciplinary experimental approaches to biological questions (BIOL2030 "Foundations for Advanced Study in Experimental Biology," two credits) in the first semester, and a class on scientific communication skills (BIOL2150 "Scientific Communication," one credit) in the third semester. (brown.edu)
Macular degeneration3
  • Age-related macular degeneration (AMD) is a leading cause of visual loss among the elderly. (nih.gov)
  • Age-related macular degeneration occurred significantly later in patients with an L-DOPA prescription, 79.4 in all cohorts. (nih.gov)
  • Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. (upenn.edu)
Declines1
  • Also in previous studies, Hetzer and his team documented age-dependent declines in the functioning of NPCs in the neurons of healthy aging rats, which are laboratory models of human biology. (sciencedaily.com)
Researcher1
Proliferation6
Occurs4
  • Now scientists report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain. (sciencedaily.com)
  • Globally, menopause occurs around the age of 49 years, with geographic and ethnic variation. (bvsalud.org)
  • Although BPDCN occurs more frequently in the elderly, it may occur in patients of any age, including pediatric patients. (medscape.com)
  • Using single cell RNA sequencing, we aim to identify which cellular processes are affected by type 2 diabetes and in which islet and small intestinal cell type this occurs. (lu.se)
Pharmacology1
  • Instead, most work on the manipulation of aging through pharmacology has remained focused on a small group of chemical cascades or pathways that have been known to relate to aging in one way or another. (labroots.com)
Researchers3
  • Biology Stack Exchange is a question and answer site for biology researchers, academics, and students. (stackexchange.com)
  • In their studies on genetically modified mice, the Bad Nauheim researchers also found that in animals in which miR-1/133a was switched off, the heart muscle cells coped much better with hypoxia conditions (oxygen depletion), such as those that exist after a heart attack. (mpg.de)
  • Researchers believe that a fragment of the androgen receptor protein containing the CAG repeats accumulates within these cells and interferes with normal cell functions. (medlineplus.gov)
Laboratory2
  • Russ Hodge z European Molecular Biology Laboratory (EMBL) w Heidelbergu w Niemczech opowiada o pierwszym pełnym przeglądzie "molekularnych maszyn" w komórkach drożdży. (scienceinschool.org)
  • Mina J. Bissell is a Distinguished Senior Scientist, (the highest rank bestowed at Lawrence Berkeley NationalLaboratory (LBNL), serves as Senior Advisor to the Laboratory Director on Biology. (stanford.edu)
Diabetes1
  • Our strategy to understand cell type specific alterations in type 2 diabetes is entirely based on findings in patient material using, for example, single cell- or bulk RNA sequencing and histological techniques. (lu.se)
Findings1