• JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. (wikipedia.org)
  • TGF-β regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and cell death. (wikipedia.org)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
  • Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)
  • The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
  • These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)
  • Deletion of HP1β, but not HP1α, in ESCs provokes a loss of the morphological and proliferative characteristics of embryonic pluripotent cells, reduces expression of pluripotency factors and causes aberrant differentiation. (biomedcentral.com)
  • However, in differentiated cells, loss of HP1β has the opposite effect, perturbing maintenance of the differentiation state and facilitating reprogramming to an induced pluripotent state. (biomedcentral.com)
  • We demonstrate an unexpected duality in the role of HP1β: it is essential in ESCs for maintaining pluripotency, while it is required for proper differentiation in differentiated cells. (biomedcentral.com)
  • This unique duality makes them an attractive system for potential regenerative medicine and cell therapies, but also for differentiation studies in vitro and for modeling diseases. (biomedcentral.com)
  • What makes characterization challenging is that heterogeneity within a given stem cell population can cause variability in the differentiation into important downstream lineages, such as cardiomyocytes and hepatocytes. (genengnews.com)
  • We also show that Col4a1 and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration. (biomedcentral.com)
  • In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum. (biomedcentral.com)
  • The formation of the mammalian respiratory unit is initiated during the transition between the pseudoglandular and canalicular/saccular stages and is characterized by coordinated proliferation and differentiation of epithelial and mesenchymal cells. (biomedcentral.com)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
  • There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. (frontiersin.org)
  • This theory has its origins in the concept of "Wirkungssphäre" or "sphere of influence" proposed by Strassburger (1893) , in which he argued that a nucleus can only support a discrete volume of cytoplasm, thus defining the upper limits to cell size. (frontiersin.org)
  • This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and the cytoplasm. (wikipedia.org)
  • At the level of the cell, Daxx is found in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the nucleus, where it interacts with some subnuclear structures. (wikipedia.org)
  • Fas-receptor stimulation causes Daxx to translocate out of the nucleus and into the cytoplasm. (wikipedia.org)
  • This led to the assumption that a given nucleus controls a defined volume of cytoplasm - so that when a muscle shrinks or 'atrophies' due to disuse or disease, the number of myonuclei decreases. (robert-gorter.info)
  • These include changes in the plasma membrane (such as loss of membrane symmetry and loss of membrane attachment), a condensation of the cytoplasm and nucleus, protein cleavage, and internucleosomal cleavage of DNA. (bdbiosciences.com)
  • One of the most important regulators of p53 is MDM2, a RING domain E3 ligase that ubiquitinates p53, leading to both proteasomal degradation and relocation of p53 from the nucleus to the cytoplasm. (nih.gov)
  • The cells are polyhedral and have abundant granular cytoplasm with well-defined cell borders. (medscape.com)
  • [ 2 ] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)
  • They have a large pleomorphic hyperchromatic nucleus, a prominent nucleolus, and intensely pink, fine, granular cytoplasm with hematoxylin-eosin staining. (medscape.com)
  • Note the blue cytoplasm, eccentric nucleus, and perinuclear pale zone (or halo). (medscape.com)
  • The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)
  • The chemi- appear to interact with the structural elements of the cell, cal analysis was assessed at DATA CHEM Laboratories using plasma- with apparent binding to the cytoskeleton [Porter et al. (cdc.gov)
  • In β-actin knockouts, epigenetic reprogramming and rDNA transcription inactivation lead to growth and proliferation defects. (nyu.edu)
  • 2019. Cell Rep. 28:3011. (biolegend.com)
  • Percipalle P*, Vartiainen, MK (2019) 'Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective. (nyu.edu)
  • J Cell Biol (2016) 215 (3): 297-299. (rupress.org)
  • The peripheral blood mononuclear cells (PBMCs) have a round nucleus ( Delves, 2016 ). (frontiersin.org)
  • It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
  • Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
  • Genes necessary for cell cycle progression, such as E2F-dependent genes, are incorporated into the SAHF and are thereby silenced, contributing to the stability of the growth arrest. (rupress.org)
  • A series of signal transduction events starting from the activation of cyclin-dependent kinase 2 (CDK2) to binding of E2F -target transcription to phosphorylation of Rb helps maintain cell-cycle progression. (bdbiosciences.com)
  • p53 functions to prevent malignant progression, in part by inhibiting proliferation or inducing the death of potential tumour cells. (nih.gov)
  • Sarshad A, Sadeghifar F, Louvet E, Mori R, Böhm S, Vintermist A, Fomproix N, Östlund A-K, Percipalle P* (2013) 'Nuclear myosin 1 facilitates chromatin modifications required to activate rRNA gene transcription and cell cycle progression. (nyu.edu)
  • trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. (nih.gov)
  • Here, we demonstrate that the dNTPase activity of SAMHD1 is regulated by acetylation, which promotes cell cycle progression in cancer cells. (oncotarget.com)
  • The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
  • In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. (wikipedia.org)
  • The nuclear protein Ki-67 was first identified by the monoclonal antibody Ki-67, which was generated by immunizing mice with nuclei of the L428 Hodgkin lymphoma cell line. (biolegend.com)
  • Ki-67 protein plays an essential role in ribosomal RNA transcription and cell proliferation. (biolegend.com)
  • Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
  • The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. (koreamed.org)
  • Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB , Rao A. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. (nih.gov)
  • In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8. (signalchem.com)
  • This protein is present in many types of cells and tissues, where it is primarily found at junctions that connect neighboring cells (adherens junctions). (medlineplus.gov)
  • The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
  • Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
  • This protein is active in cells that make up a part of the hair follicle known as the matrix. (medlineplus.gov)
  • As a result, the protein accumulates within cells. (medlineplus.gov)
  • This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
  • Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
  • LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
  • SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells. (oncotarget.com)
  • Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)
  • Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
  • First described in 1848, MM is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). (medscape.com)
  • Altered responsiveness to co- oup the nucleus accumbens reflect the behavioral approaches that incorporate caine and increased immobility in the forced swim test associated with elevated cAMP response ele- memory of associations between the extinction-like processes may have effi- ment binding protein in nucleus accumbens. (lu.se)
  • In pluripotent and differentiated cells HP1β is differentially localized and differentially associated with chromatin. (biomedcentral.com)
  • The minor fraction of HP1β that is chromatin-bound in ESCs is enriched within exons, unlike the situation in differentiated cells, where it binds heterochromatic satellite repeats and chromocenters. (biomedcentral.com)
  • 2010. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. . (ucsf.edu)
  • Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
  • It consists of a continuous monolayer of intestinal epithelial cells connected by intercellular junctional complexes which shrink the space between adjacent cells. (mdpi.com)
  • SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection (2). (signalchem.com)
  • 2. Nagasko, T. et al: Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. (signalchem.com)
  • During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
  • 1998. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. . (ucsf.edu)
  • 2007. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. . (ucsf.edu)
  • Using mouse models, we discovered that mutations in murine Col4a1 and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. (biomedcentral.com)
  • In the developing lung, the specific temporal-spatial interactions between mesenchymal and epithelial cells are carefully orchestrated to permit the gradual establishment of an effective blood-gas barrier (BGB) [ 1 , 2 ]. (biomedcentral.com)
  • The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
  • Cells are also programmed for death at the genetic level as a response to DNA damages through the process of apoptosis. (bdbiosciences.com)
  • Cell division, proliferation, and apoptosis and death are integral parts of life. (bdbiosciences.com)
  • The balance of cell proliferation and apoptosis is important for both development and normal tissue homeostasis. (bdbiosciences.com)
  • Apoptosis is an organized process that signals cells to self-destruct for cell renewal or to control aberrant cell growth. (bdbiosciences.com)
  • As cells become damaged or are no longer needed, they undergo apoptosis or programmed cell death, a normal physiological process that occurs during embryonic development and tissue homeostasis. (bdbiosciences.com)
  • Apoptosis controls the orderly death of damaged cells, whereas necrosis occurs as a result of tissue damage, causing the loss of both damaged and surrounding cells. (bdbiosciences.com)
  • Methods for detecting apoptosis or dead cells (viability) by cell preparation type. (bdbiosciences.com)
  • However, some cell types do not display characteristic features of apoptosis. (bdbiosciences.com)
  • In those cases, multiple aspects of apoptosis might need to be analyzed to confirm the mechanism of cell death. (bdbiosciences.com)
  • Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
  • In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
  • Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
  • Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (medlineplus.gov)
  • Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
  • Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
  • Collectively, these findings suggest that SAMHD1 acetylation enhances its dNTPase activity and promotes cancer cell proliferation. (oncotarget.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
  • Although senescent cells repress proliferation-promoting genes, they also induce the gene program necessary for the implementation of senescence. (rupress.org)
  • regulators of the rat and human 5-HT1A receptor genes using luciferase reporter fusion constructs transfected in cell lines. (vdocuments.net)
  • The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)
  • This pathway normally regulates stress-induced cell death. (wikipedia.org)
  • When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
  • SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. (signalchem.com)
  • In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (medlineplus.gov)
  • we have found the Hippo pathway effectors TAZ and YAP are responsible for the cell density-dependent ferroptosis (4, 6, 7). (duke.edu)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
  • In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
  • Once activated, R-Smads accumulate in the nucleus where they associate with Smad4, a common partner for all R-Smads, to form transcription complexes. (biomedcentral.com)
  • Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, Visa N, Percipalle P*. (2014) 'Glycogen synthase kinase (GSK) 3 β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells. (nyu.edu)
  • The ppGpp binds to the transcription factor DksA and RNA polymerase to orchestrate extensive transcriptional changes that repress proliferation and promote stress survival (8, 9). (duke.edu)
  • IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration. (nih.gov)
  • In agreement with these observations, expression of dominant-negative Smads in the developing basal ganglia phenocopies the cell migration defects observed in Dlx1/2 -deficient mice. (biomedcentral.com)
  • The ability of cancer proliferation, migration and invasion can be evaluated after co-culture by CCK-8, wound healing and transwell assay. (aging-us.com)
  • Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
  • The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
  • In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)
  • Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
  • Kreienkamp R*, Graziano S*, Coll-Bonfill N*, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ and Gonzalo S (2018) A cell-intrinsic interferon-like response links replication stress to cellular aging caused by progerin . (imb.de)
  • Cellular senescence was first identified as a type of irreversible cell cycle arrest that occurs when cells reach the end of their replicative potential ( Hayflick and Moorhead, 1961 ). (rupress.org)
  • Senescent cells also undergo dramatic changes in their morphology and in the organization and architecture of their cellular compartments. (rupress.org)
  • Pack LR, Daigh LH, Meyer T. Putting the brakes on the cell cycle: mechanisms of cellular growth arrest. (bdbiosciences.com)
  • Chlamydia trachomatis manipulates host cellular pathways to ensure its proliferation and survival. (duke.edu)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. (koreamed.org)
  • The defining characteristic of senescence is a highly stable cell cycle arrest, triggered by the up-regulation of cyclin-dependent kinase inhibitors such as p16 INK4a and p21 CIP1a . (rupress.org)
  • Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
  • and regulation of cell population proliferation. (nih.gov)
  • Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation (By similarity). (proteopedia.org)
  • Binds to dendritic cells (DCs) via C1QR1, resulting in down-regulation of T-lymphocytes proliferation (PubMed:11086025, PubMed:17881511). (proteopedia.org)
  • Das D, Tapryal N, Goswami S.K., Fox P.L, and Mukhopadhyay C.K. Regulation of Ceruloplasmin in human hepatic cells by redox active copper: Identification of a novel AP-1 site in ceruloplasmin gene. (jnu.ac.in)
  • Vidak S, Kubben N, Dechat T # and Foisner R # (2015) Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins . (imb.de)
  • During the first stage called G1, cells monitor their environment and, when the requisite signals are received, the cells synthesize RNA and proteins to induce growth. (bdbiosciences.com)
  • Several cell cycle-associated proteins, such as Ki-67, are also used as indicators of cell proliferation. (bdbiosciences.com)
  • Exosomes are composed of a lipid bilayer like cell membranes, and contain all known molecular constituents of a cell, such as DNA, proteins, and RNA [ 5 ]. (aging-us.com)
  • INTRODUCTION: Proteins that undergo receptor-mediated endocytosis are subject to lysosomal degradation, requiring radioiodination methods that minimize loss of radioactivity from tumor cells after this process occurs. (duke.edu)
  • There is a general agreement that hypertrophy is accompanied by the addition of new nuclei from stem cells to help the muscles meet the enhanced synthetic demands of a larger cell. (frontiersin.org)
  • Other studies showed that lack of Daxx gene caused a higher apoptotic rate in embryonic stem cells. (wikipedia.org)
  • Muscle growth is accompanied by the addition of new nuclei from stem cells to help meet the enhanced synthetic demands of larger muscle cells," explains Schwartz. (robert-gorter.info)
  • During adolescence muscle growth is enhanced by hormones, nutrition and a robust pool of stem cells, making it an ideal period for individuals to "bank" myonuclei that could be drawn upon to remain active in old age. (robert-gorter.info)
  • Exosomes from bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment. (aging-us.com)
  • The tumor microenvironment induced by interactions between hepatocarcinoma cancer cells (HCC) and bone marrow-derived mesenchymal stem cells (BMSCs) is critical for HCC proliferation and metastasis, HCC microenvironment consists of stromal cells, extracellular and HCC components [ 1 ]. (aging-us.com)
  • Some miRNAs contained in stem cell-derived exosomes could be a promising metastasis and proliferation in the context of hypoxic conditions [ 7 , 8 ]. (aging-us.com)
  • Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. (biomedcentral.com)
  • Embryonic stem cells (ESCs), derived from the blastocyst-stage embryo, are capable of generating all cell types of the mammalian body (pluripotency) and of maintaining the capacity for indefinite self-renewal without compromising their genomic integrity. (biomedcentral.com)
  • Advertorial: Pluripotent Stem Cell Verification: Is There an Alternative to Teratoma Assays? (genengnews.com)
  • Pluripotent stem cells have great potential for use in regenerative medicine and are an important tool for understanding developmental and disease mechanisms. (genengnews.com)
  • The defining characteristics of pluripotent stem cells, which include embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, are straightforward: their ability to self-renew and differentiate into ectoderm, mesoderm, and endoderm germ layers. (genengnews.com)
  • To account for this high level of functional variation, verifying the pluripotency of stem cells-from the generation of a new cell line through its expansion for an experiment-is crucial. (genengnews.com)
  • Time and resources spent expanding stem cells are wasted if the resulting population is not functionally pluripotent. (genengnews.com)
  • To address these difficulties, R&D Systems has developed new tools that aid in the verification of stem cell pluripotency during derivation, maintenance, and expansion. (genengnews.com)
  • Manually picking colonies that contain pluripotent stem cells is possible through an analysis of colony morphology. (genengnews.com)
  • The GloLIVE™ Human Pluripotent Stem Cell Live Cell Imaging Kit and individual GloLIVE antibodies available from R&D Systems allow you to verify the pluripotency status of your stem cells by monitoring the expression of both positive and negative markers ( Figure 1 ). (genengnews.com)
  • The kit contains a set of azide-free, fluorochrome-conjugated GloLIVE antibodies that recognize two positive markers and one negative marker of human pluripotent stem cells. (genengnews.com)
  • This kit, used in combination with the analysis of colony morphology, promotes the selection of high-quality, undifferentiated stem cell colonies, thereby reducing wasted time. (genengnews.com)
  • Pluripotency of live human stem cell colonies was verified using a NorthernLights™ (NL) 493-conjugated Mouse Anti-Human SSEA-4 Monoclonal Antibody (green) and a NL557-conjugated Mouse Anti-Human TRA-1-60(R) Monoclonal Antibody (red). (genengnews.com)
  • Despite its broad use as the most common assay for assessing the pluripotency of stem cells, the teratoma assay has limitations. (genengnews.com)
  • Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration? (educell.si)
  • Stem Cell Rev Rep. 2018 Jun;14(3):346-369. (educell.si)
  • Stem Cell Res. (sciendo.com)
  • Stem Cells Transl. (sciendo.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
  • Adipose stem cells in reparative goat mastitis mammary gland. (sciendo.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
  • Helps maintain human pluripotent stem cells in undifferentiated state. (rndsystems.com)
  • Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
  • Li M , Zhai P , Mu X , Song J , Zhang H , Su J , . Hypoxic BMSC-derived exosomal miR-652-3p promotes proliferation and metastasis of hepatocarcinoma cancer cells via targeting TNRC6A. (aging-us.com)
  • In this study, we reveal that miRNA-652-3P from BMSC-derived exosomes promotes proliferation and metastasis in HCC. (aging-us.com)
  • Our data demonstrate that hypoxic BMSCs-derived exosomal miR-652-3p promotes proliferation in HCC cells by inhibiting TNRC6A. (aging-us.com)
  • 1997. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. . (ucsf.edu)
  • Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
  • Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)
  • Epithelioid angiosarcoma (EA) is a rare variant of angiosarcoma, which is characterized by a high-grade malignant neoplasm, which consists of an atypical, multilayered, or solid endothelial proliferation and vasoformative architecture, presenting necrosis and an area of hemorrhage 1-5 . (bvsalud.org)
  • Instead, the experiments suggest that Tao negatively regulates BMP signaling as reduction of Tao leads to an increase in pMad levels in motor neuron nuclei and an increase in BMP target gene expression. (sdbonline.org)
  • Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
  • Canonically, functioning ST6GAL1 resides within the intracellular ER-Golgi secretory complex, where sialylation of nascent cell surface and secreted components occurs cell-autonomously. (nature.com)
  • To make the decision of whether to enter the cell cycle or not, cells integrate information from a variety of intracellular and extracellular signals. (bdbiosciences.com)
  • Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
  • Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
  • Skeletal muscle is fairly unique in that the mature cells are syncytial and can contain hundreds of nuclei. (frontiersin.org)
  • Heart, bone and even placenta are built on these networks of cells," says Lawrence Schwartz, Professor of Biology at the University of Massachusetts. (robert-gorter.info)
  • The study appears online on September 13 in the Journal of Cell Biology ( www.jcb.org ). (eurekalert.org)
  • Founded in 1955, The Journal of Cell Biology (JCB) is published by The Rockefeller University Press. (eurekalert.org)
  • 3. Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine. (jcancer.org)
  • Congratulations to Dr. Weaver on being awarded the American Society for Cell Biology's Women in Cell Biology (WICB) Mid-Career Award for Excellent in Research ! (ucsf.edu)
  • Dr. Mukhopadhyay did his doctoral studies in Biochemistry at the Department of Biochemistry from Calcutta University and received the postdoctoral training in the Department of Cell Biology, Cleveland Clinic Foundation, USA. (jnu.ac.in)
  • We already have many examples ure of a discrete action (lever press) to in the sensitivity of nucleus accumbens of how brain biology can affect behav- produce the expected results (cocaine). (lu.se)
  • Cancer microenvironment plays an important role in the proliferation and metastasis of hepatocarcinoma cancer cells (HCC). (aging-us.com)
  • In addition, a miR-652-3p inhibitor attenuates the proliferation and metastasis of HCC cells after co-culturing with BMSCs. (aging-us.com)
  • Stromal cells that contribute to HCC proliferation and metastasis are mainly BMSCs and others immune cell. (aging-us.com)
  • Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
  • Beta-catenin plays an important role in sticking cells together (cell adhesion) and in communication between cells. (medlineplus.gov)
  • Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (medlineplus.gov)
  • Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)
  • Understanding the intrinsic molecular mechanisms underlying precursor cell diversity is essential to understanding the genesis of the forebrain. (biomedcentral.com)
  • Although SAMHD1 is expressed ubiquitously throughout the human body, the molecular mechanisms regulating its enzymatic activity and function in non-immune cells are relatively unexplored. (oncotarget.com)
  • Correspondence to: Linda M. Sargent, Toxicology and Molecular Biol- have not been investigated fully. (cdc.gov)
  • Thymosin Beta-4 is found in numerous bodily fluids, all tissues, and all cell types except red blood cells. (peptides.org)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
  • Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain infections and cancers. (msdmanuals.com)
  • Therefore, MESH1 knockdown leads to both stress survival and proliferation arrest, two cardinal features highly reminiscent of the bacterial stringent response. (duke.edu)
  • Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
  • Integrins and cell adhesions as modulators of mammary cell survival and transformation. (ucsf.edu)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
  • No expression of Daxx leads to malfunction of S phase and cells with two nuclei are formed. (wikipedia.org)
  • We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
  • Caplan and colleagues blocked Wnt signaling in a metastatic cell line after restoring CD82 expression. (eurekalert.org)
  • Endisha H, Merrill-Schools J, Zhao M, Bristol M, Wang X, Kubben N and Elmore LW (2015) Restoring SIRT6 expression in Hutchinson-Gilford progeria syndrome cells impedes premature senescence and formation of dysmorphic nuclei . (imb.de)
  • Several previous studies have been demonstrated that function of many miRNAs as tumor suppressor in the majority of cancers profiled by far, but function of other miRNAs as oncogenous-miR in the most of cancer malignancies profiled, such as abnormal expression of miR-155 was found in Reed-Sternberg cells of Hodgkin's Lymphoma [ 11 ]. (aging-us.com)
  • The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • Pulsating tandem microbubble for localized and directional single-cell membrane poration. (duke.edu)
  • Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)
  • Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
  • Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
  • 1998. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. . (ucsf.edu)
  • The CTNNB1 gene mutations that cause desmoid tumors are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)
  • The cells can be obtained from lipoaspirates or bone marrow aspirates. (educell.si)
  • Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
  • Affects various cell signaling pathways, host immunity and lipid metabolism (Probable). (proteopedia.org)
  • The impact of this non-canonical extrinsic mechanism of ST6GAL1 on tumor cell pathobiology is not known. (nature.com)
  • Recently, we have found that the genetic removal of MESH1 in tumor cells triggers extensive transcriptional changes and confers protection against oxidative stress-induced ferroptosis (11). (duke.edu)
  • Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
  • Until recently, scientists thought this meant that nuclei - the cell control centers that build and maintain muscle fibers - are also lost to sloth. (robert-gorter.info)
  • Two independent studies - one in rodents and the other in insects - have demonstrated that nuclei are not lost from atrophying muscle fibers, and even remain after muscle death has been initiated. (robert-gorter.info)
  • We are using functional genomic approaches to investigate the nutrient signaling and stress adaptations of cancer cells when exposed to various nutrient deprivations and microenvironmental stress conditions. (duke.edu)
  • [ 4 ] Hürthle cells are large and polygonal in shape, with indistinct cell borders. (medscape.com)
  • Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. (koreamed.org)
  • Fig. 2 Schematic presentation of the role of autophagy in endothelial cells. (koreamed.org)
  • The histologic hallmark of AE is represented by the presence of sheets and groups of atypical endothelial cells with prominent epithelioid morphologies. (bvsalud.org)
  • These mutations are somatic and occur only in kidney cells that give rise to the tumor. (medlineplus.gov)
  • In people without MEN1 , two independent somatic mutations must occur within a single cell for tumor formation. (medscape.com)
  • This assumption long seemed valid, with many researchers reporting the presence of disintegrating nuclei in muscle tissue during atrophy induced by inactivity, injury or paralysis. (robert-gorter.info)
  • But modern cell-type-specific dyes and genetic markers have shown that the dying nuclei other researchers had detected were in fact inflammatory and other cells recruited to atrophic muscle. (robert-gorter.info)
  • This interaction was demonstrated when PML-NB disrupted cells were treated and Daxx relocalized with the PML-NB. (wikipedia.org)
  • The interaction of laser-generated tandem microbubble (maximum diameter of about 50 μm) with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer. (duke.edu)
  • Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. (duke.edu)
  • For instance, H19 is the first lncRNA transcribed by RNA polymerase II and is expressed mainly in human embryonic cells. (jcancer.org)
  • J Mammary Gland Biol Neoplasia. (ucsf.edu)
  • Central role of metabolism in endothelial cell function and vascular disease. (koreamed.org)
  • Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
  • In the final stages of the process, dying cells become fragmented into apoptotic bodies and consequently are eliminated by phagocytic cells without significant inflammatory damage to surrounding cells. (bdbiosciences.com)