2023ScaffoldsBioprintingBioinksScaffoldPolymersCharacterizationRegenerationBioink2020CollagenBiocompatibleGelMAVitroHyaluronicMethacryloyl-basedRange of biomaterialsAlginate-gelatineInjectable hydrogelsRegenerativeConstructs2021Healthcare MaterialsElectrospunCompositeMechanical propertiesInksCellsBiomoleculesEncapsulationNanoparticlesFibersHutmacherTissuesMaterialsProtocolsApproachesStem
20237
- Journal of Functional Biomaterials 14 , 160 (2023). (csic.es)
- Ahmadi Soufivand A, Faber J, Hinrichsen J, Budday S, Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures, Sci Rep 13(1) ( 2023 ) 11253. (trr225biofab.de)
- Andrade Mier MS, Dalton PD, Stahlhut P, Bakirci E, Blum R, Villmann C, Primary Glial Cell and Glioblastoma Morphology in Cocultures Depends on Scaffold Design and Hydrogel Composition, Adv Biol (Weinh) doi:10.1002/adbi.202300029 ( 2023 ) e2300029. (trr225biofab.de)
- Chayanun S, Soufivand AA, Faber J, Budday S, Lohwongwatana B, Boccaccini AR, Reinforcing tissue‐engineered cartilage: Nano fibrillated cellulose enhances mechanical properties of Alginate Dialdehyde‐Gelatin (ADA‐GEL) hydrogel, Advanced Engineering Materials doi:10.1002/adem.202300641 ( 2023 ). (trr225biofab.de)
- Genc H, Cianciosi A, Lohse R, Stahlhut P, Groll J, Alexiou C, Cicha I, Jungst T, Adjusting Degree of Modification and Composition of gelAGE-Based Hydrogels Improves Long-Term Survival and Function of Primary Human Fibroblasts and Endothelial Cells in 3D Cultures, Biomacromolecules doi:10.1021/acs.biomac.2c01536 ( 2023 ). (trr225biofab.de)
- Hazur J, Röder J, Czwalinna J, Schubert DW, Boccaccini AR, Pre‐Crosslinking with Hydrogel Microparticles Enhances the Printability of Alginate‐Based Inks, Macromolecular Materials and Engineering doi:10.1002/mame.202200675 ( 2023 ). (trr225biofab.de)
- Khadem E, Kharaziha M, Salehi S, Colorimetric pH-responsive and hemostatic hydrogel-based bioadhesives containing functionalized silver nanoparticles, Mater Today Bio 20 ( 2023 ) 100650. (trr225biofab.de)
Scaffolds6
- developed a method for printing cellularised scaffolds from thermosensitive hydrogels. (slideshare.net)
- The Ideal candidate will have experience in design, fabrication, and testing of novel biomaterials, particularly biomimetic scaffolds and membranes for tissue engineering/wound healing applications. (nas.edu)
- These hydrogels, together with SaOS-2 cells, were bioprinted to computer-designed scaffolds. (desktopmetal.com)
- To overcome these drawbacks, alginate (Alg)/poly-L-ornithine (PLO) PEC hydrogels are fabricated into microcapsules, fibers, and bulk scaffolds to explore their feasibility as drug and cell carriers. (desktopmetal.com)
- This study shows that carboxymethyl cellulose (CMC) cryogels prompted cells to generate beta-cell clusters in comparison to gelatin-based scaffolds, that did not induce this cell organization. (ibecbarcelona.eu)
- Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
Bioprinting9
- He is an academic entrepreneur who has made contributions in biomaterials and regenerative medicine, particular for developing hydrogels for tissue engineering and bioprinting. (wikipedia.org)
- For example, he has developed and popularized gelatin methacryloyl (GelMA) which has become one of the main materials for 3D bioprinting industry. (wikipedia.org)
- Three-dimensional (3D) bioprinting is an additive manufacturing process in which the combination of biomaterials and living cells, referred to a bioink, are deposited layer-by-layer to form biologically active 3D tissue constructs. (sabanciuniv.edu)
- Recent advancements in the field show that the success of this technology highly depends on the development of novel biomaterials or the improvement of existing bioinks for bioprinting. (sabanciuniv.edu)
- Polyethylene glycol (PEG) is one of the well-known synthetic biomaterials and has been commonly used as a photocrosslinkable bioink for bioprinting. (sabanciuniv.edu)
- In summary, the presented micro-capillary based bioprinting process for a PEG-based hydrogel system can be promising to construct the complex 3D structures with spatiotemporal variations without using any cytotoxic photoinitiator, UV light, or polymer support. (sabanciuniv.edu)
- Jia Min Lee and Wai Yee Yeong, 2016, "Design and Printing Strategies in 3D Bioprinting of Cell-Hydrogels: A Review", Adv. Healthcare Mater. (slideshare.net)
- The aim of this project is to improve the properties of ADA-GEL hydrogels for cell-loaded 3D bioprinting by adding phytotherapeutics loaded mesoporous bioactive glass nano-particles. (fau.eu)
- Depending on the goals of 3D bioprinting experiments, biomaterials can be used alone or in combination with various polymers. (e-asct.org)
Bioinks4
- Biofabrication is a widely used tissue engineering technique which allows pre-defined deposition of cell containing hydrogels (bioinks). (fau.eu)
- Combination of materials like oxidized alginate (ADA) and gelatin could be used for bioinks due to suitable properties for cell growth [1]. (fau.eu)
- The hydrogel-based bioinks offered high cell viability and proliferative capability for rabbit ADMSCs. (desktopmetal.com)
- Gelatin methacryloyl (GelMA) was investigated as a base hydrogel for the respective myocardial and vascular bioinks with collagen, Matrigel and fibrinogen as interpenetrating polymers to support myocardial functionality. (regenhu.com)
Scaffold5
- The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin. (genomicglossaries.com)
- They are composed of a hydrogel scaffold consisting of two negatively charged natural polymers, alginate and a modified chitosan, N,O-carboxymethyl chitosan (N,O-CMC). (desktopmetal.com)
- Into this biologically inert scaffold two biofunctionally active biopolymers are embedded, inorganic polyphosphate (polyP) and silica, as well as gelatin which exposes the cell recognition signal, Arg-Gly-Asp (RGD). (desktopmetal.com)
- She has worked on designs and chemical modification of scaffold/hydrogel and assessment of them by in vitro and in vivo studies, and published in journals such as Nature Communications, Biomaterials, Biofabrication, and Advanced Healthcare Materials. (southampton.ac.uk)
- L. Morelli and Vozzi, G. , " Realization and characterization of bilayer scaffold with molecularly imprinted hydrogel layer, " , in Congresso Nazionale di Bioingegneria 2012 Atti , Roma, Italy, 2012, pp. 65 - 66. (unipi.it)
Polymers1
- For this purpose, we can synthesize, chemically modify or suitably formulate coating materials , e.g. with biobased polymers, hydrogels or functional nano- and microparticles. (fraunhofer.de)
Characterization3
- In this work, the use of methylcellulose to improve the printability of ADA-gelatin bioink will be evaluated to achieve robust 3D robust constructs for biofabrication [2] The scope of the project includes hydrogel characterization as well as cell viability studies of the created 3D structures. (fau.eu)
- This approach has gained a central role in the fields of mechanobiology, biomaterials design and tissue engineering, to obtain a proper mechanical characterization of soft materials with a resolution comparable to the size of single cells (μm). (jove.com)
- 7.1 Pluronic F127 hydrogel characterization and biofabrication in cellularized constructs for tissue engineering applications Emilia Gioffredi et. (slideshare.net)
Regeneration5
- TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
- Her research is focused on developing biomaterials and harnessing their potential for tissue regeneration. (southampton.ac.uk)
- She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
- Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
- Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects. (mpg.de)
Bioink2
- Low molecular weight gelatin fragments (LMWG) were supplemented into the bioink to extrude smooth cylindrical strands of the hydrogel for shape fidelity. (sabanciuniv.edu)
- Professor Hutmacher said the new hydrogel could be used as a 'bioink' to print 3D 'microenvironments' or models of a tumour to test different anti-cancer drugs. (vetscite.org)
20201
Collagen3
- Mechanical stimulation led to a significant increase in chondrogenic gene expression, while histological analysis detected sulphated glycosaminoglycans and collagen II only in loaded specimens, confirming MC hydrogel suitability to support load induced MSCs chondrogenesis. (nature.com)
- The functionality and reactivity of polysaccharides, and in particular hyaluronic acid, in combination with proteins like gelatin, collagen and many others, offer very interesting opportunities for the new trends in regenerative medicine. (csic.es)
- With a printhead temperature range of 4°C to 250°C and a printbed temperature range between 4°C and 65°C, enjoy precise control of temperatures when working with temperature-sensitive materials like collagen and gelatin. (cellink.com)
Biocompatible2
- It is a highly biocompatible hydrogel whose physical properties can potentially be tailored to direct 3D cell growth and differentiation both in vitro and in vivo 10 , 11 , 12 . (nature.com)
- The design of a suitable injectable hydrogel with an adequate gelation time that gathers perfect bioactive, biocompatible, biodegradable and good mechanical properties for clinical repair of damaged cartilage and bone tissue is a challenge of significant medical interest that remain to be achieved. (csic.es)
GelMA2
- He also developed electrically conductive, tunable hydrogels by mixing GelMA with nanomaterials, including gold nanoparticles and carbon-based nanomaterials. (wikipedia.org)
- Photocrosslinkable gelatin has attracted increasing interest in the field of biofabrication, with the most studied and widely used photocrosslinkable gelatin being gelatin methacrylate (GelMa). (researchgate.net)
Vitro4
- Bischel, LL, et al: "Electrospun gelatin biopapers as substrate for in vitro bilayer models of blood-brain barrier tissue. (nas.edu)
- Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
- Recapitulating the Angiogenic Switch in a Hydrogel-Based 3D In Vitro Tumor-Stroma Model. (ilexlife.com)
- In vitro testing of Mg-based orthopedic biomaterials. (dokumen.pub)
Hyaluronic2
- Contribution of bioactive hyaluronic acid and gelatin to regenerative medicine. (csic.es)
- In this review is described the relevance of gelatin (Gel) and hyaluronic acid (HA) biopolymers in the field of tissue engineering due to the excellent response of these biomimetic materials and their bioactive and biodegradable character in the human body. (csic.es)
Methacryloyl-based1
- The study, Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms was published this week. (vetscite.org)
Range of biomaterials1
- While we offer an extensive portfolio of biomaterials, we understand the necessity and importance to make the BIO X compatible with the widest range of biomaterials available. (cellink.com)
Alginate-gelatine2
- 1] T. Zehnder, B. Sarker, A. R. Boccaccini and R. Detsch, Evaluation of an alginate-gelatine crosslinked hydrogel for bioplotting, Biofabrication 7 (2015) 025001 . (fau.eu)
- We investigated the effect of bioglass (bioactive glass) on growth and mineralization of bone-related SaOS-2 cells, encapsulated into a printable and biodegradable alginate/gelatine hydrogel. (desktopmetal.com)
Injectable hydrogels1
- Injectable hydrogels have demonstrated being a promising strategy for cartilage and bone tissue engineering applications, owing to their minimal invasive injection procedure, easy incorporation of cells and bioactive molecules, improved contact with the surrounding tissues and ability to match defects with complex irregular shapes, characteristics of osteoarthritic pathology. (csic.es)
Regenerative3
- He has also developed various high-performance biomaterials for numerous applications in tissue engineering and regenerative medicine. (wikipedia.org)
- She was appointed principal investigator of the group of Biomaterials for Regenerative Therapies at IBEC in September 2012. (ibecbarcelona.eu)
- In addition, it is reported an overview of the most relevant crosslinking processes and agents that are being developed for regenerative medicine, including different hydrogel modifications as well as several interesting and advanced applications. (csic.es)
Constructs1
- The hydrogels with pre-differentiated (into tenogenic, chondrogenic, and osteogenic lineages) or undifferentiated rabbit ADMSCs were 3D-bioprinted into zonal-specific constructs to mimic the structure of the tendon-to-bone interface. (desktopmetal.com)
20211
Healthcare Materials1
- By the number of citations, he is the most cited author of in various journals in the field of biomaterials like Biomaterials, Advanced Healthcare Materials, Biofabrication, Tissue Engineering - Part B: Reviews. (wikipedia.org)
Electrospun6
- Expertise in tuning hydrogel or electrospun biomaterials for specific applications is valued. (nas.edu)
- Electrospun biomaterials for bone tissue engineering. (dokumen.pub)
- Electrospun nanofiber-reinforced hydrogels. (dokumen.pub)
- Electrospun hydrogels with biological electrospray cells. (dokumen.pub)
- Electrospun hydrogels with antimicrobial activity. (dokumen.pub)
- Future applications of electrospun hydrogels. (dokumen.pub)
Composite2
- This work proposes a microfibers-hydrogel assembled composite as delivery vehicle able to combine into a single system both burst and prolonged release of lactate. (ibecbarcelona.eu)
- Structure and composition of the tunic in the sea pineapple Halocynthia roretzi: a complex cellulosic composite biomaterial. (mpg.de)
Mechanical properties3
- Nanoindentation refers to a class of experimental techniques where a micrometric force probe is used to quantify the local mechanical properties of soft biomaterials and cells. (jove.com)
- From whole tissues to single cells, mechanical properties can inform about the pathophysiological state of the biomaterial under investigation 3 , 4 . (jove.com)
- Bioinspired histidine-Zn 2+ coordination for tuning the mechanical properties of self-healing coiled coil cross-linked hydrogels. (mpg.de)
Inks1
- To address these drawbacks, the current study introduces flexible photonic hydrogels with chromatic patterns that are 3D printed using CNC-based inks. (desktopmetal.com)
Cells7
- The protocol presents a complete workflow for soft material nanoindentation experiments, including hydrogels and cells. (jove.com)
- In this protocol, a step-by-step guide detailing the experimental procedure to acquire nanoindentation data on hydrogels and cells using a commercially available ferrule-top optical fiber sensing nanoindenter is presented. (jove.com)
- Artificial organs that are composites of biomaterials and cells. (genomicglossaries.com)
- We will be able to use this hydrogel infused with tumour cells to quickly create a number of models of patient-specific tumours. (vetscite.org)
- Because the hydrogel can be modified to mimic the firmness of cartilage or softness of breast tissue it can be used to create models for all types of cancer and also for research on stem cells and tissue engineering. (vetscite.org)
- She is the Director and PI for Stem Cells and Biomaterials Engineering Laboratory at Stanford University, jointly supported by Departments of Orthopaedic Surgery and Bioengineering. (stanford.edu)
- In addition, the choice of cells and biomaterials is an important factor in fabricating tissue/organ models. (e-asct.org)
Biomolecules1
- Current research in tissue engineering is geared towards elucidating the appropriate compositional elements (biomaterials, biomolecules and cell sources) as well as methods of assembly. (biomedcentral.com)
Encapsulation1
- Traditionally-used hydrogel encapsulation methods do not accomplish all the requisites for pancreatic tissue engineering, as its poor nutrient and oxygen diffusion induces cell death. (ibecbarcelona.eu)
Nanoparticles3
- He combined silica nanoparticles with gelatin to engineer shear-thinning materials for the embolization of blood vessels in the peripheral vasculature. (wikipedia.org)
- In this work, nanoparticles of a luminescent metal-organic framework were embedded in a photopolymerized methacrylated gelatin. (desktopmetal.com)
- Steady-state and time-resolved luminescence spectroscopy was used to explore the drying and the photopolymerization processes, as well as the effect the methacrylated gelatin had on the quantum yield and decay time of the nanoparticles. (desktopmetal.com)
Fibers1
- Also, most current cell-laden PEC hydrogels are limited to fibers and microcapsules with unfavorable dimensions and structures for practical implantations. (desktopmetal.com)
Hutmacher2
- Professor Dietmar W. Hutmacher from QUT's Institute of Health and Biomedical Innovation said the new material was a gelatine-based hydrogel that mimicked human tissue. (vetscite.org)
- The new hydrogel discovery is part of Biofabrication Research led by Professor Hutmacher at IHBI, which launched the world's first Master of Biofabrication, a dual Australian and European master degree. (vetscite.org)
Tissues3
- In addition, his laboratory is utilizing biofabrication to form vascularized tissues with appropriate microarchitectures and regulate stem cell differentiation in microengineered environments. (wikipedia.org)
- We next explored if spatially modulating the stiffness of 3D bioprinted hydrogels could be used to direct MSC fate inside printed tissues. (nature.com)
- Statement of significance This study describes a multiple tool biofabrication strategy which enables the engineering of spatially organized fibrocartilage tissues. (regenhu.com)
Materials4
- Interconnected 3-dimensional (3D) networks, so called hydrogels, are materials which show promising features for the use as biomaterials in TE [2]. (fau.eu)
- Alginate di-aldehyde (ADA) and gelatin (GEL) are two materials, which are already successfully considered in this field of research [3]. (fau.eu)
- We invent biomaterials and engineering tools to elucidate and modulate biology, and also use biology to inform materials and engineering design. (stanford.edu)
- A clear advantage of cell sheet technology for therapeutic applications is the absence of biomaterials, which reduces the risk of immune rejection that could arise from xenobiotic or non-autologous materials, and that no suture is needed to ligate the construct to the injured heart. (encyclopedia.pub)
Protocols1
- The method for producing the gelatine-based hydrogel is published in the journal Nature Protocols. (vetscite.org)
Approaches1
- 3-D Life hydrogels and accessories are used in this CloneSeq protocol which combines clonal expansion inside 3D hydrogel spheres and droplet-based RNA sequencing to resolve the limited sensitivity of single-cell approaches. (ilexlife.com)