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  • markers of lipid
  • Corresponding methods of treatment and pharmaceutical compositions are disclosed that are based on an active ingredient or ingredients that demonstrates the ability to modulate the levels of all of the foregoing markers of lipid oxidation. (freepatentsonline.com)
  • liver
  • S. D. Aust, D. L. Roerig and T. C. Pederson, Evidence for superoxide generation by NADPH-cytochrome c reductase of rat liver microsomes, Biochem. (springer.com)
  • cytotoxic
  • The eventual degradation of lipid hydroperoxides releases a wide variety of aldehydes, which, owing to their stability and ability to react cellular nucleophiles, are both cytotoxic and genotoxic in nature. (wikipedia.org)
  • vivo
  • E. K. Lai, P. B. McCay, T. Noguchi and K-L. Fong, In vivo spin trapping of trichloromethyl radicals formed from CC1 4 , Biochem. (springer.com)
  • Membrane lipid peroxidation has been documented in the brain regions affected in these disorders as well as in cell culture and in vivo models. (jneurosci.org)
  • The isoprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily arachidonic acid) without the direct action of cyclooxygenase (COX) enzymes. (wikipedia.org)
  • human
  • C. Benedetto and T.F. Slater, Electron spin resonance studies on human endometrium and cervix, in "Recent Studies on lipid Peroxidation in Health and Disease", T. F. Slater, ed., in press, (1980). (springer.com)
  • free
  • A. Ingall, K. A. K. Lott, T. F. Slater, S. Finch and A. Stier, Metabolic activation of CC14 to a free-radical product: studies using a spin trap, Biochem. (springer.com)
  • systems
  • K. Hasegawa and L. K. Patterson, Pulse r.adiolysis studies in model lipid systems: formation and behaviour of peroxyradicals in fatty acids, Photochem. (springer.com)
  • further
  • Reactive oxygen species (ROS) are generated in several metabolic pathways, a major source being mitochondrially derived superoxide anion radical, which gives rise to hydrogen peroxide, which is converted further to hydroxyl radical, which induces membrane lipid peroxidation ( Evans, 1993 ). (jneurosci.org)
  • membrane
  • We find that oxygen consumption, ΔΨ generation, adenine nucleotide translocator-dependent ADP/ATP exchange and both mitochondrial Complex I and IV activities are impaired in CF cells, while both mitochondrial ROS production and membrane lipid peroxidation increase. (springer.com)
  • Cardiolipin (IUPAC name "1,3-bis(sn-3'-phosphatidyl)-sn-glycerol") is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. (wikipedia.org)
  • reactions
  • The phenol at position 3 and aminomethyl group at position 4 of its ring endow pyridoxamine with a variety of chemical properties, including the scavenging of free radical species and carbonyl species formed in sugar and lipid degradation and chelation of metal ions that catalyze Amadori reactions. (wikipedia.org)
  • Pyridoxamine also inhibits the formation of advanced lipoxidation endproducts during lipid peroxidation reactions by reaction with dicarbonyl intermediates. (wikipedia.org)
  • The immediate metabolic precursor to 5(S)-HETE, 5(S)-hydroperoxy-6S,8Z,11Z,14Z-eicosatetraenoic acid 5(S)-HpETE, can be converted to 5-oxo-ETE in a non-enzymatic dehydration reaction or chemical lipid peroxidation reactions. (wikipedia.org)
  • significantly
  • One study of elderly people found that 400 mg of vitamin C per day (for a one-year period) reduced serum lipid peroxide levels significantly. (biomatrixone.com)
  • DEX-induced remarkable elevation in the activities of alkaline phosphatase and acid phosphatase, and level of blood urea nitrogen (BUN) with concomitant declined in electrolyte profile (Na, K, and Ca). Lipid peroxidation marker (MDA) was significantly elevated in DEX-induced animals with concomitant declined in glutathione (GSH) content and superoxide dismutase (SOD) activity. (springermedizin.de)
  • role
  • Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. (wikipedia.org)