• Endocrine fibroblast growth factors (FGFs) require Klotho transmembrane proteins as necessary co-receptors to activate FGF receptor (FGFR) signaling. (lifetein.com)
  • Increased ligand binding affinity was accompanied by a gain in calcium mobilization capability, suggesting functional coupling to G proteins. (unm.edu)
  • Peptides are made up of short chains of amino acids that are the building blocks of proteins. (outlookindia.com)
  • Peptide analysis identified products from known matrix protease substrates and secretory proteins, which offered functional relevance to immunoinflammatory responses, extracellular matrix remodeling, and receptor interactions. (cdc.gov)
  • It binds on the DNA, exerting an effect on DNA to regulate the synthesis of proteins regulated by DNA. (cdc.gov)
  • However, most drugs act as haptens, binding covalently to serum or cell-bound proteins, including peptides embedded in major histocompatibility complex (MHC) molecules. (msdmanuals.com)
  • Understanding how proteins interact entails studying the binding affinity (strength) and the lifetime (duration) of the protein-protein interaction to better decompose how an immune response is initiated and how we can explore this knowledge to treat diseases. (lu.se)
  • Some of the genes thought to be associated with the development of antibiotic-refractory Lyme arthritis provide instructions for making proteins called Toll-like receptors. (medlineplus.gov)
  • These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. (reactome.org)
  • The CD ring of the superpotent analogue, 2MD, is tilted within the binding site relative to the other ligands in this study and to (20S)-1alpha,25-dihydroxyvitamin D(3) [Tocchini-Valentini et al. (rcsb.org)
  • The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (ku.dk)
  • In summary, our study presents a rapid and efficient methodology to use peptide sequences from a protein-receptor interaction interface as epitopes for screening nanobodies against potential pathogenic targets. (instem.res.in)
  • Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)
  • the modulation of epitope immunodominance and the processing and presentation of HIV peptides for MHC class I recognition were shown to be dependent on flanking residues that were N terminal to the natural epitopes (see the related article beginning on page 3563). (jci.org)
  • These rare mAbs bind to functionally conserved epitopes such as those in the hemagglutinin (HA) stem, thereby providing strain independent protection. (frontiersin.org)
  • Nanobody derived using a peptide epitope from the spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants. (instem.res.in)
  • Unlike the previous reports, our study used a nine-amino acid peptide from the receptor-binding motif of the spike protein as an epitope. (instem.res.in)
  • To determine from a repertoire whether its host had been exposed to a target, computational tools that predict TCR-epitope binding are required. (frontiersin.org)
  • The affinity of a TCR for a given peptide epitope and the specificity of the binding are governed by the heterodimeric αβ T-cell receptors ( 2 ). (frontiersin.org)
  • The kinetics and products of degradation of HIV-1 Gag favored the production of peptides encompassing the immunodominant epitope and destruction of the subdominant one. (jci.org)
  • We have previously described R1a-B6, an alpaca-derived single domain antibody (nanobody), that is capable of potent cross-subtype neutralization in vitro of H1N1, H5N1, H2N2, and H9N2 influenza viruses, through binding to a highly conserved epitope in the influenza hemagglutinin stem region. (frontiersin.org)
  • The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
  • In both TCRα and TCRβ chains, CDR3 loops have the highest sequence diversity and are the principal determinants of receptor binding specificity. (frontiersin.org)
  • The Xinbo Yang lab is interested in studying the T cell receptor (TCR) specificity in Cancer and autoimmune disease. (mskcc.org)
  • Xinbo Yang's lab applies structural biology and protein engineering to decode T cell receptor specificity in Cancer and autoimmune disease. (mskcc.org)
  • Bacteriocin specificity is not well understood, but specific receptors may play a role in their binding to cells. (usda.gov)
  • The specific characters of peptides (high bioactivity, high specificity, and low toxicity) have made them attractive therapeutic agents. (intechopen.com)
  • To characterize fMLF binding domain, we adopted a "gain-of-function" approach by selective replacement of non-conserved residues in the FPR2 portion of the chimeric receptors with those from the FPR. (unm.edu)
  • These reports led to the hypothesis that Toc159 functions as a selective import receptor for preproteins that are required for chloroplast development. (rupress.org)
  • selective externalization of the receptor. (nature.com)
  • A selective novel KOP receptor agonist emerged as a notable result and is proposed as a new chemotype for the study of the KOP receptor in the etiology of drug addiction, depression, and/or pain. (acs.org)
  • This dual ligand quality characterizes what is now known as a selective estrogen receptor modulator (SERM). (umsystem.edu)
  • and glucagon family peptide binding activity. (nih.gov)
  • Thus, alternative or chimeric natriuretic peptides maintaining the renal but lacking the vasorelaxation properties of BNP provide an alternative approach. (umn.edu)
  • Replacement of N-formyl peptide receptor (FPR) domains with those from a homologous receptor, FPR2, resulted in chimeric receptors displaying low binding affinity to fMet-Leu-Phe (fMLF). (unm.edu)
  • Introduction of 2 positively charged amino acids, Arg84 and Lys85, dramatically improved binding affinity of one chimeric receptor (Kd from 105 nM to 1.6 nM). (unm.edu)
  • Similarly, restoration of either Gly89/His90 or Phe102/Thr103 improved the binding affinity of another chimeric receptor from a Kd of 275 nM to a 2.3 Kd and 3.3 nM, respectively. (unm.edu)
  • To boost immune recognition of non- or low-immunogenic antigens, we developed a vaccine platform based on the conjugation of a target protein to a chimeric designer peptide (CDP) of bacterial origin. (amsterdamumc.org)
  • B-type natriuretic peptide (BNP) decreases cardiac preload and hypertrophy. (umn.edu)
  • Meanwhile, wild-type and L-BNP bound the natriuretic peptide clearance receptor with similar affinities. (umn.edu)
  • These data indicate that Arg13 of BNP is a critical discriminator of binding to guanylyl cyclase-linked but not clearance natriuretic peptide receptors, supporting designer natriuretic peptides as an alternative to wild-type BNP for the treatment of heart failure. (umn.edu)
  • This led to the identification of 3 clusters of residues required for high-affinity fMLF binding. (unm.edu)
  • Transfection of this cDNA into COS cells resulted in expression of receptors with high affinity for salmon CT (Kd = approximately 0.44 nM) and for human CT (Kd = approximately 5.4 nM). (jci.org)
  • The structural differences may account for observed differences in binding affinity between the porcine renal and human ovarian CTRs. (jci.org)
  • HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
  • In the first part of this thesis, the interaction between the rat CD2 (rCD2) adhesion protein and its ligand rat CD48T92A (rCD48T92A), a high-affinity mutant of the wild type rat CD48, was used to establish a new method of obtaining single-cell binding affinities of T cells interacting with SLBs using imidazole titrations. (lu.se)
  • The results showed a relatively small spread in the rCD2-rCD48T92A binding affinity values despite the considerable spread of receptor densities within the cell population. (lu.se)
  • Using both these methods, the single-cell binding affinity and lifetime of the cell population can be investigated and their spread can provide information concealed with population-average techniques. (lu.se)
  • Even though the CD4 co-receptor increases the sensitivity of T cell signalling manyfold, it binds to its ligand, peptide major histocompatibility complex II (pMHCII), with the lowest binding affinity known to this day. (lu.se)
  • These are known as synthetic peptides and are mainly used for scientific experiments or studies. (vanillamist.com)
  • This is a synthetic peptide that also serves as the analog of the natural growth hormone. (vanillamist.com)
  • The use of synthetic peptides approved by the health authorities for vaccine, for cancer, and in drug delivery systems is increasing with these developments. (intechopen.com)
  • The aim of this chapter is to review some applications of synthetic peptides providing a brief knowledge about peptide synthesis. (intechopen.com)
  • Then the synthetic peptide vaccine application of peptides was reviewed. (intechopen.com)
  • The reason for this is because the synthetic RNA has been manipulated in such a way as to create a very unnatural spike protein that result in it not collapsing on itself into the cell once it attaches to the ACE2 receptor, as it normally does. (fromthetrenchesworldreport.com)
  • A set of standard tests are defined for the performance of peptide-TCR binding, including the detection of TCRs binding to a given peptide/antigen, choosing among a set of candidate peptides for a given TCR and determining whether any pair of TCR-peptide bind. (frontiersin.org)
  • The immense diversity of the T-cell receptor (TCR) enables specific antigen recognition ( 3 , 4 ). (frontiersin.org)
  • The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
  • CGRP release was induced by either 60 mM K + (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay. (ku.dk)
  • The cloned cDNA encodes a putative peptide of 490 amino acids with seven potential transmembrane domains. (jci.org)
  • these receptors comprise a distinct family of G protein-coupled seven transmembrane domain receptors. (jci.org)
  • The next step will be to determine each ligand's tissue specific activity and identify the unique peptide fingerprint that predicts its in vivo biological response. (umsystem.edu)
  • ABSTRACT Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. (who.int)
  • Harding, C., Heuser, J. & Stahl, P. Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding. (nature.com)
  • When this decoy receptor is engaged by a ligand to the displayed protein/peptide, the receptor expressing cell is rescued from apoptosis. (lu.se)
  • The observed agonist-bound state contains the ERRgamma LBD, a ligand (GSK4716), and the RIP140 peptide and reveals an unexpected rearrangement of the phenol-binding residues. (rcsb.org)
  • We hypothesized that substitution of highly conserved residues in BNP with highly conserved residues from a GC-B-specific peptide would yield BNP variants with increased and decreased potency for human GC-B and GC-A, respectively. (umn.edu)
  • LifeTein is asked frequently to synthesize relatively large peptides sized 100-200 residues. (pr.com)
  • Binding of TNF to the extracellular domain leads to homotrimerization. (lu.se)
  • Extracellular Domain Of The 55Kda Tumor Necrosis Factor Receptor. (lu.se)
  • X-ray crystal structures of the ligand binding domain (LBD) of the estrogen-related receptor-gamma (ERRgamma) were determined that describe this receptor in three distinct states: unliganded, inverse agonist bound, and agonist bound. (rcsb.org)
  • Two structures were obtained describing the inverse agonist-bound state, the ERRgamma LBD with 4-hydroxytamoxifen (4-OHT), and the ERRgamma LBD with 4-OHT and a peptide representing a portion of the silencing mediator of retinoid and thyroid hormone action protein (SMRT). (rcsb.org)
  • The 4-OHT structure was similar to other reported inverse agonist bound structures, showing reorientation of phenylalanine 435 and a displacement of the AF-2 helix relative to the unliganded structures with little other rearrangement occurring. (rcsb.org)
  • Thermal stability studies show that agonist binding leads to global stabilization of the ligand binding domain. (rcsb.org)
  • The activated receptors stimulate the pancreas to release insulin when blood sugar levels rise. (popsci.com)
  • This is a growth hormone-releasing peptide and has been shown to stimulate growth hormones in all animal test subjects. (vanillamist.com)
  • It can bind the GHRH receptors in the pituitary gland and also stimulate the release and production of the growth hormone greatly. (vanillamist.com)
  • As one of the first lines of defense against infection, Toll-like receptors recognize patterns that are common to many foreign invaders, rather than recognizing a specific invader, and stimulate a quick immune response that triggers inflammation. (medlineplus.gov)
  • Electrostatic and hydrophobic interactions between the peptide and the LBD stabilize the active receptor conformation. (rcsb.org)
  • Peptide profiling, a novel ER ligand screening assay, is a method that can potentially identify SERMS by correlating in vitro ER conformation with in vivo biological response. (umsystem.edu)
  • After screening a ligand against a library of fifteen different peptides, a unique peptide profile will figuratively illustrate the induced ER conformation. (umsystem.edu)
  • Each ligand was found to have a unique peptide profile and, implicitly, a distinct ER conformation. (umsystem.edu)
  • By correlating a ligand's tissue specific estrogenic activity with its unique ER conformation, peptide profiling will not only further elucidate tissue-specific ER activity differences but could also be used as a high-throughput screening tool for other potential environmental xenoestrogens and identify novel therapeutic SERMs. (umsystem.edu)
  • Successful recognition of antigenic peptides bound to Major Histocompatibility Complexes (pMHCs) requires specific binding of the TCR to these complexes ( 5 - 7 ), which in turn modulates the cell's fitness, clonal expansion, and acquisition of effector properties ( 7 ). (frontiersin.org)
  • Peptides represent over decades of innovative peptide synthesis expertise. (anaspec.com)
  • LifeTein was awarded the fastest peptide synthesis service in 2021 by New world Report, thanks to their speedy custom protein, antibody, and chemical services for biotech, pharma, academia, government customers, and diagnostics. (pr.com)
  • LifeTein provides the fastest turnaround time and most reliable quality in the industry, using their proprietary microwave-assisted heating technology for peptide synthesis. (pr.com)
  • Regarded as the fastest peptide synthesis service in 2021 by New World Report, LifeTein also provides custom protein, antibody, and chemical services for biotech, pharma, academia, government customers, and diagnostics. (pr.com)
  • Being recognized as the Fastest Peptide Synthesis Service is a tremendous honor for LifeTein. (pr.com)
  • This demonstrates that the synthesis of peptides sized 100-200 amino acids is not beyond the capabilities of our current PeptideSyn technology. (pr.com)
  • LifeTein's primary focus is peptide synthesis service. (pr.com)
  • The company has developed proprietary PeptideSyn technology, which provides a platform for continuous peptide synthesis using Fmoc and Boc chemistry, microwave technology, and a proprietary solid support resin. (pr.com)
  • The company takes great pride in this acknowledgement of the speed of its peptide synthesis as well. (pr.com)
  • In the first part, information about the peptide synthesis was given in a very simple and readable format under the title of solid-phase peptide synthesis including a brief history, solid supports, linkers, protecting groups, and analysis method sections. (intechopen.com)
  • The synthesis of the peptides may provide sufficient material to enable further studies and to determine the structure-activity relationships or may provide discovery of new analogues with improved properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. (intechopen.com)
  • In metazoans, intracellular receptors recognize these molecules. (nature.com)
  • Peptide hormones are a group of signaling molecules that are secreted by endocrine glands and regulate various metabolic processes in the body. (outlookindia.com)
  • Haptens may also bind directly to class II MHC molecules, directly activating T cells. (msdmanuals.com)
  • It does so by binding it with the GHRP receptors and then activates the GH release. (vanillamist.com)
  • It activates the complement system and binds to Fc receptors. (medscape.com)
  • The analysis of CGRP release data was combined with immunohistochemistry in order to study the cellular localization of CB1, cannabinoid receptor type 2 (CB2), CGRP and receptor activity modifying protein 1 (RAMP1), a subunit of the functional CGRP receptor, in the TG. (ku.dk)
  • Kappa-opioid (KOP) receptor agonists exhibit analgesic effects without activating reward pathways. (acs.org)
  • Therapeutic peptides that are growing in popularity are unsurprisingly those that are associated with assisting people to reduce body weight, including AOD-9604, Tesofensine and GLP-1 agonists are just a few offered for research by Direct Peptides. (outlookindia.com)
  • This especially applies to the use of ß or a adrenergic receptors agonists/antagonists (e.g., ß-blockers). (who.int)
  • In the search for nonaddictive opioid therapeutics and novel chemical tools to study physiological functions regulated by the KOP receptor, we screened in silico its recently released inactive crystal structure. (acs.org)
  • Therapeutic peptides are designed to mimic the function of natural peptides that are involved in regulating various physiological processes in the human body. (outlookindia.com)
  • These hormones function by binding to specific receptor sites on target cells, thereby initiating a cascade of cellular events leading to various physiological effects. (outlookindia.com)
  • Lastly, CD4 binding studies showed that the co-receptor did not noticeably affect the TCR-MHC II binding at physiological levels of hCD4 in the SLB. (lu.se)
  • One specific peptide-displaying cell could be identified and amplified, based on a specific receptor engagement, in a background of 12 500 wild-type cells after four selections. (lu.se)
  • A series of peptides were synthesized by LifeTein and used for the competition binding assay. (lifetein.com)
  • We have demonstrated proof of concept by creating a general plasma membrane bound decoy receptor, by displaying a protein or a peptide genetically fused to a trunctated version of the CD40 molecule. (lu.se)
  • A 70-amino-acid island domain between LRRs 21 and 22 folds back into the interior of the superhelix to create a surface pocket for binding the plant hormone brassinolide. (nature.com)
  • Known loss- and gain-of-function mutations map closely to the hormone-binding site. (nature.com)
  • Our findings provide insight into the activation mechanism of this highly expanded family of plant receptors that have essential roles in hormone, developmental and innate immunity signalling. (nature.com)
  • The steroid hormone binding site maps to the C-terminal inner surface of the superhelix. (nature.com)
  • Semaglutide mimics a hormone called glucagon-like peptide-1 (GLP-1) that binds to GLP-1 receptors. (popsci.com)
  • Besides that, this peptide does not come with any side effects, and it has also been shown that it does not release ACTH [Adrenocorticotropic Hormone]. (vanillamist.com)
  • The peptide can easily replicate the growth hormone-releasing peptide known as "Ghrelin. (vanillamist.com)
  • Besides that, this peptide can also be used as a replacement for GH [ Growth Hormone ] during growth hormone replacement therapy. (vanillamist.com)
  • The hypothalamus secretes a small peptide called Thyroid Releasing Hormone. (cdc.gov)
  • It is metabolized so one iodine atom is removed to produce T3 - about 10 times as active as T4 in binding to a receptor that exerts the action as receptor to the thyroid hormone. (cdc.gov)
  • The iodine hormone exerts its action on receptors on the nucleus in cells. (cdc.gov)
  • 2022) Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. (mskcc.org)
  • Plants, however, perceive steroids at membranes, using the membrane-integral receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1). (nature.com)
  • Li, J. & Chory, J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. (nature.com)
  • This approach can be extended to characterize HLA-bound peptides in various autoimmune settings. (jci.org)
  • In this thesis, total internal fluorescence microscopy (TIRF) and single-molecule imaging were used to observe and characterize protein-functionalized supported lipid bilayers (SLBs) interacting with immune cells to obtain the binding kinetics of various protein-protein pairs. (lu.se)
  • Mutations that alter the structure of the binding site render monoclonal antibodies useless. (forbes.com)
  • 2023) Facile repurposing of peptide-MHC restricted antibodies for cancer immunotherapy. (mskcc.org)
  • Because of this redesign, it can't do that, so it sits there on the ACE receptor, exposed … That allows the immune cells to produce antibodies specific to that place where it should be fusing with the cell, the fusion domain. (fromthetrenchesworldreport.com)
  • 5. The peptide mutation FGF21 and an anti-β-Klotho antibody were biotinylated with EZ-Link Sulfo-NHS-LC-Biotin at the indicated concentrations. (lifetein.com)
  • Peptide presentation is critical for immune recognition of pathogen-infected cells by CD8+ T lymphocytes. (jci.org)
  • The targets in the Spike protein are the primary receptor-binding domain (RBD) and the secondary N-terminal domain (NTD). (forbes.com)
  • The FGF19 peptide was used for alanine scanning mutagenesis. (lifetein.com)
  • In contrast to the conventional mechanism of nuclear receptor ligand activation, activation of ERRgamma by GSK4716 does not appear to involve a major rearrangement or significant stabilization of the C-terminal helix. (rcsb.org)
  • Disruption of any of the steps leading to activity (binding, insertion, and poration) could theoretically generate resistant cells, but binding is the most well understood mechanism of resistance. (usda.gov)
  • In the last part, information about cell-penetrating peptides that can be used as molecular carries is mentioned with providing classification and cellular uptake mechanism of them. (intechopen.com)
  • As a result, the RBD peptide was used for monoclonal antibody production and the antibody was successfully made and licensed to a reputable pharmaceutical company. (pr.com)
  • The binding makes the protein-drug complex immunogenic, stimulating antidrug antibody production, T-cell responses against the drug, or both. (msdmanuals.com)
  • Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene. (wikipedia.org)
  • Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)
  • The receptors are ligand inducible transcription factors that exhibit unique biological actions. (umsystem.edu)
  • The aim of this book chapter is to review the recent developments in the use of peptides in the diagnosis of drug and vaccine systems and to present them to the reader with commercially available illustrations. (intechopen.com)
  • 3. The β-Klotho ECD 6 × His, varying amounts of FGF19 and 21 peptides, and biotinylated human FGF19 or FGF21 protein were prepared. (lifetein.com)
  • Orthologous to human GIPR (gastric inhibitory polypeptide receptor). (nih.gov)
  • Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (jci.org)
  • A human ovarian small cell carcinoma line (BIN-67) expresses abundant calcitonin (CT) receptors (CTR) (143,000 per cell) that are coupled, to adenylate cyclase. (jci.org)
  • All these peptides are used by researchers and are not created for human consumption. (vanillamist.com)
  • So, the spike protein binds to the ACE2 receptor once it's produced by the human cell … but it's a modified version of the spike protein. (fromthetrenchesworldreport.com)
  • Crystal structure of the soluble human 55 kd TNF receptor-human TNF complex: implications for TNF receptor activation. (lu.se)
  • For this reason, the influence of an adhesion molecule, rat CD2, on the obtained binding kinetics of the human CD4 co-receptor was initially examined showing that the accumulation of CD4 was influenced when having a high concentration of bound CD2 inside the cell-SLB contacts. (lu.se)
  • Differences in µ-opioid receptors in the human brain [Time Frame: The 11C-carfentanil binding potential (BP) will be analyzed 45 minutes after the consumption of the two meals (high or low-hedonic reward). (who.int)
  • Interestingly, the hCTR sequence is remotely related to the cAMP receptor of Dictyostelium discoideum (21% identical), but is not significantly related to other G protein-coupled receptor sequences now in the data bases. (jci.org)
  • Furthermore, we demonstrate that the cytoplasmic and recombinant forms of soluble Toc159 bind directly and selectively to the transit peptides of these representative photosynthetic preproteins, but not representative constitutively expressed plastid preproteins. (rupress.org)
  • recently, it has synthesized the Receptor Binding Domain (RBD) of the spike protein of the COVID-19 virus. (pr.com)
  • The effective substrates displayed heparin-binding peptides, which can interact with cell-surface glycosaminoglycans and could be used with a defined medium to culture hES cells for more than 3 months. (nih.gov)
  • T3 binds to the nuclear receptor (TR) and combines with another receptor (RXR) then combines with a receptor element on DNA. (cdc.gov)
  • We used an array of self-assembled monolayers to identify peptide surfaces that sustain pluripotent stem cell self-renewal. (nih.gov)
  • The peptides supported growth of eight pluripotent cell lines on a variety of scaffolds. (nih.gov)
  • Current sequencing methods allow for detailed samples of T cell receptors (TCR) repertoires. (frontiersin.org)
  • Following specific binding of T cell receptors to viral and bacterial-derived peptides bound to MHC ( 5 ), or from neo-antigens ( 8 - 10 ), the appropriate T cells expand, resulting in the increased frequency of T cells carrying such receptors. (frontiersin.org)
  • Tuning T cell receptor sensitivity through catch bond engineering. (mskcc.org)
  • CD3ε is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T cell receptor (α/β or γ/δ) heterodimer. (biolegend.com)
  • To design a high-throughput system with a highly parallel capacity, we utilized the B cell line WEHI-231, as carrier of the decoy receptor. (lu.se)
  • In this study, we have characterized a novel approach for identification and selection of protein-protein interactions, denoted SPIRE (selection of protein interactions by receptor engagement), which is based on a mammalian expression system. (lu.se)
  • Catalog peptides are 95% purity by HPLC unless otherwise specified. (eurogentec.com)
  • Subsequently, peptides were separated by reversed-phase HPLC and analyzed by liquid chromatography-mass spectrometry. (jci.org)