Production continued throughout the 1960s, but by 1970, meprobamate was listed as a controlled substance after it was discovered to cause physical and psychological dependence. (wikipedia.org)
Clinical4
Berger, clinical director of Wallace Laboratories, described it as a relaxant of the central nervous system, whereas other tranquilizers suppressed it. (wikipedia.org)
its therapeutic effect in psychoses and especially in schizophrenia was demonstrated in a series of clinical studies by Delay and Denikerat Ste. Anne's Hospital in Paris. (inhn.org)
1984). Lieberman was also principal investigator of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), which conclusively demonstrated that "atypical neuroleptics" offered a different side effect profile from typical neuroleptics but no advantages in terms of efficacy and therapeutic profile in the treatment of schizophrenia (Lieberman, Stroup, McEvoy et al. (inhn.org)
Uhlenhuth was first, in the late 1950s, to conduct a placebo- and standard-controlled clinical trial with meprobamate in patients with anxiety symptoms (Uhlenhuth, Canter, Neustadt and Payson 1959). (inhn.org)
19571
By 1957, over 36 million prescriptions had been filled for meprobamate in the US alone, a billion pills had been manufactured, and it accounted for fully a third of all prescriptions written. (wikipedia.org)
Symptoms1
A December 1955 study of 101 patients at the Mississippi State Hospital in Whitfield, Rankin County, Mississippi, found meprobamate useful in the alleviation of "mental symptoms": 3% of patients made a complete recovery, 29% were greatly improved, 50% were somewhat better, while 18% realized little change. (wikipedia.org)
Patients2
Though patients reported being able to relax more easily, meprobamate did not completely alleviate their tense feelings. (wikipedia.org)
The Effect of Diazepam on Patients' Memory. (benzo.org.uk)
Brain1
However, three major drawbacks existed to the use of mephenesin as a tranquilizer: a very short duration of action, greater effect on the spinal cord than on the brain (resulting in a very low therapeutic index), and a weak activity. (wikipedia.org)
Side1
On January 19, 2012, the European Medicines Agency withdrew marketing authorization in the European Union for all medicines containing meprobamate, "due to serious side effects seen with the medicine. (wikipedia.org)
Drug4
Meprobamate-marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others-is a carbamate derivative used as an anxiolytic drug. (wikipedia.org)
Frank Berger was working in a laboratory of a British drug company, looking for a preservative for penicillin, when he noticed that a compound called mephenesin calmed laboratory rodents without actually sedating them. (wikipedia.org)
In April 1965, meprobamate was removed from the list of tranquilizers when experts ruled that the drug was a sedative, instead. (wikipedia.org)
In December 1967, meprobamate was placed under abuse control amendments to the Food, Drug and Cosmetic Act. (wikipedia.org)
Miltown2
Carisoprodol has a qualitatively different set of effects to that of meprobamate (Miltown). (wikipedia.org)
Study of effect of miltown (2-methyl-2-n-propyl-1,3-propanediol dicarbamate) on psychiatric states. (nih.gov)
Include2
Serious side effect may include addiction, allergic reactions, and seizures. (wikipedia.org)
They include patients whose personality is only in part affected, who can distinguish between their subjective experiences and reality and who do not construct a false environment (Hamilton 1976). (inhn.org)