• Exposure to polycyclic aromatic hydrocarbons (PAHs) in foundry workers has been evaluated by determination of benzo(a)pyrene-serum albumin adducts and urinary 1-hydroxypyrene. (bmj.com)
  • Dose-response relations between total PAH, pyrene, carcinogenic PAHs, and 1-hydroxypyrene for smokers, and polycyclic aromatic hydrocarbons adsorbed to dust for non-smokers are suggested. (bmj.com)
  • This Public Health Statement is the summary chapter from the Toxicological Profile for polycyclic aromatic hydrocarbons (PAHs) . (cdc.gov)
  • This statement was prepared to give you information about polycyclic aromatic hydrocarbons (PAHs) and to emphasize the human health effects that may result from exposure to them. (cdc.gov)
  • Benzo[c]fluorene and PAHs in general are mostly absorbed via ingestion, inhalation, and dermal contact. (wikipedia.org)
  • The distribution of PAHs depends on their lipophilicity and probably benzo[c]fluorene can easily cross the cell membrane, because of this lipophilicity. (wikipedia.org)
  • Polycyclic Aromatic Hydrocarbons (PAHs): What Health Effects Are Associated With PAH Exposure? (cdc.gov)
  • Information on benzo(a)pyrene (BaP), an indicator species for polycyclic aromatic hydrocarbons (PAHs), for use in responding to chemical incidents. (www.gov.uk)
  • Polycyclic aromatic hydrocarbons ( PAHs ) are a group of several hundred chemically-related environmentally persistent organic compounds. (www.gov.uk)
  • For the second study looking at Hispanics in El Paso County, AORs and 95% confidence intervals (CI) for increases of 5 ng/m3 for the sum of carcinogenic PAHs (S c-PAHs), 1 ng/m3 of benzo[a]pyrene, and 100 ng/m3 in naphthalene during the third trimester of pregnancy were 1.02 (0.97 - 1.07), 1.03 (0.96 - 1.11), and 1.01 (0.97 - 1.06), respectively. (cdc.gov)
  • Benzo[a]pyrene ( B[a]P ) is a surrogate for all polyaromatic hydrocarbons ( PAHs ). (ontario.ca)
  • Benzo(a)pyrene (BaP) is a compound in a group of chemicals called polycyclic aromatic hydrocarbons (PAHs). (chej.org)
  • Polycyclic aromatic hydrocarbons, PAHs make up a group of chemicals that are formed during incomplete combustion of organic materials. (swedishmatch.com)
  • Benzo(a)pyrene (B(a)P) is one of many identified PAHs. (swedishmatch.com)
  • In this dissertation, I present electronic spectra of a few polycyclic aromatic hydrocarbons (PAHs): tetracene, pentacene, pyrene, benzo[g,h,i]perylene and benzo[a]pyrene using resonantly enhanced multiphoton ionization (REMPI) and zero kinetic energy (ZEKE) photoelectron spectroscopy. (oregonstate.edu)
  • In low symmetry PAHs such as benzo[a]pyrene, the Franck-Condon allowed total symmetric modes are already IR active. (oregonstate.edu)
  • Highly oxygenated organic molecules with high unsaturation (HU-HOMs) are formed by the multigenerational photo-oxidation of large polycyclic aromatic hydrocarbons (PAHs) on soot. (mpic.de)
  • Air pollution with increased concentrations of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs, represented by benzo[a]pyrene, B[a]P) affect fetal development, reduce birth weights (LBW) of newborns, and increases intrauterine growth retardation (IUGR). (nel.edu)
  • Polycyclic Aromatic Hydrocarbons (PAHs), from combustion of carbon (coal, diesel, tobacco, etc.), comprise three of the top ten chemicals of concern (Agency for Toxic Substances and Disease Registry) at priority pollutant sites and are main drivers of remediation. (nih.gov)
  • Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. (dtu.dk)
  • Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. (biomedcentral.com)
  • Klozur® SP is the oxidant of choice for in situ chemical oxidation (ISCO), because of its ability to treat a wide range of contaminants including chlorinated solvents, petroleum hydrocarbons and PAHs. (fmc.com)
  • Benzo[b]fluoranthene and Benzo[k]fluoranthene are also among the 16 PAHs included by the U.S. EPA in the list of priority pollutants ( EPA list ). (umweltprobenbank.de)
  • Food can be contaminated by PAHs because of the contamination of air, water or soil, and during industrial process, as heating, drying and Polycyclic aromatic hydrocarbons (PAHs) are a group of over 200 smoking process. (bvsalud.org)
  • PAHs were found in different foodstuffs, including different organic compounds with two or more fused aromatic rings vegetables, fruit, cereals, oils and fats, smoked fish and meat, coffee and ( Domingo & Nadal, 2015 ). (bvsalud.org)
  • Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure. (bmj.com)
  • Benzo(a)pyrene binding to albumin and 1-hydroxypyrene were quantitatively measured by enzyme linked immunosorbent assay (ELISA) and reverse phase high performance liquid chromatography (HPLC), respectively. (bmj.com)
  • Median benzo(a)pyrene-albumin adduct concentrations (10-90% percentiles) were similar in foundry workers (smokers 0.55 (0.27-1.00) and non-smokers 0.58 (0.17-1.15)) pmol/mg albumin and age matched controls (smokers 0.57 (0.16-1.45) and non-smokers 0.70 (0.19-1.55) pmol/mg albumin). (bmj.com)
  • There was no correlation between the concentrations of 1-hydroxypyrene and benzo(a)pyrene-albumin adducts. (bmj.com)
  • Smoking did not affect the concentrations of 1-hydroxypyrene or benzo(a)pyrene-albumin adducts. (bmj.com)
  • Benzo[a]pyrene ( BaP ) acts as an indicator species for PAH contamination. (www.gov.uk)
  • 2018. Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. . (oregonstate.edu)
  • Researchers at Columbia University measured the amount of a car exhaust chemical known as benzo[a]pyrene in 233 African-American and Dominican women in New York City. (chem-tox.com)
  • It was possible to demonstrate, for example, that even low quantities of benzo[a]pyrene can have effects on the protein pattern and hence the metabolism and signal pathways in cells, even though the concentration is a hundred times below what is required to drive cells into apoptosis. (analytica-world.com)
  • The scientists undertook a detailed study of the effects of benzo[a]pyrene as a genotoxic model substance in cell cultures. (analytica-world.com)
  • Benzo[a]pyrene is long been known and one of the best studied carcinogenic substances. (analytica-world.com)
  • Benzo[a]pyrene is a polycyclic aromatic hydrocarbon which is generated during incomplete combustion of organic materials. (analytica-world.com)
  • Liver cells of mice were subjected for 24 hours to both a toxic and a benzo[a]pyrene concentration which was clearly below a threshold at which changes in the cell culture are typically observed. (analytica-world.com)
  • In this way, 190 proteins were identified - for a concentration that is toxic to the cell - which as a result of the treatment with benzo[a]pyrene underwent changes in their cellular quantity. (analytica-world.com)
  • Benzo[a]pyrene is one of 105 substances which are classified as carcinogen by the International Agency for Research on Cancer (IARC). (analytica-world.com)
  • Whereas there remains much to learn about the potential biological relevance of UGTs, deficient glucuronidation can result in either elevated tissue concentrations and direct toxicity of substrates, as with the endobiotic bilirubin, or, alternatively, enhanced bioactivation of substrates to toxic reactive intermediates, as in the case of acetaminophen and benzo[ a ]pyrene. (aspetjournals.org)
  • The ability of prostaglandin synthetase (PGS) to cooxidize benzo( a )pyrene, benzo( a )anthracene, chrysene, and several of their dihydrodiol derivatives to mutagenic products was tested with Salmonella typhimurium strains TA98 and TA100. (aacrjournals.org)
  • The microsomal fraction of ram seminal vesicles, a known source of PGS, in the presence of the PGS substrate arachidonic acid, metabolized benzo( a )pyrene-7,8-dihydrodiol, benzo( a )anthracene-3,4-dihydrodiol, and chrysene-1,2-dihydrodiol to mutagenic products. (aacrjournals.org)
  • Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. (invivobiosystems.com)
  • Benzo(a)pyrene is a polycyclic aromatic hydrocarbon (PAH) with cancer-causing properties. (leanweb.org)
  • Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord blood. (cdc.gov)
  • Important peak concentrations were identified and their average marker substance benzo[a]pyrene (BaP)) and bladder cancer devel- duration ranged between 12.5 and 22.1% of the work shift. (cdc.gov)
  • Furthermore, a known carcinogen (Benzo(a)pyrene) was detected in field-generated roofing fumes. (cdc.gov)
  • Benzo(a)anthracene (PubChem CID: 5954) vegetable oils and examined the identity through the fatty acids profiles. (bvsalud.org)
  • Benzo[b]fluoranthene and benzo[j]fluoranthene are also mutagenic and carcinogenic in animal studies and are classified as possibly carcinogenic to humans. (umweltprobenbank.de)
  • These effects of generally non-cell-toxic concentrations were clearly detectable in the case of benzo[a]pryrene and could not be predicted by effects of directly toxic concentrations. (analytica-world.com)
  • These applications demonstrate the ability of Klozur activated persulfate to treat diverse organic contaminants of concern including: chlorinated ethenes, chlorinated ethanes, chlorinated methanes, BTEX, MTBE, polyaromatic hydrocarbons, petroleum hydrocarbons, 1,4-dioxane and pesticides. (fmc.com)
  • The burned charcoal releases chemicals such as carbon monoxide (CO), polyaromatic hydrocarbons (PAH) and other combustion-related toxins that the smoker inhales. (who.int)
  • Exposure to benzo[c]fluorene in vivo leads to the induction of mainly lung tumors where it acts as a DNA adductor. (wikipedia.org)
  • Together, these studies implicate UGT1A10 as an important detoxifier of polycyclic aromatic hydrocarbons in humans and that the UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers. (aspetjournals.org)
  • Benzo[c]fluorene is a polycyclic aromatic hydrocarbon (PAH) with mutagenic activity. (wikipedia.org)
  • The mutagenicity of benzo[c]fluorene is mainly attributed to formation of metabolites that are reactive and capable of forming DNA adducts. (wikipedia.org)
  • Other names for benzo[c]fluorene are 7H-benzo[c]fluorene, 3,4-benzofluorene, and NSC 89264. (wikipedia.org)
  • The structure of benzo[c]fluorene is depicted in the infobox on the right. (wikipedia.org)
  • Benzo[c]fluorene occurs naturally in tar, but can also be manually synthesized in a four step process, which is depicted in the picture below. (wikipedia.org)
  • The final step is reduction of this compound with hydrazine hydrate, generating benzo[c]fluorene (5). (wikipedia.org)
  • While benzo[c]fluorene does not have a bay or fjord region it does undergo a similar transformation with a pseudo-bay region that reacts instead. (wikipedia.org)
  • First benzo[c]fluorene (1) is transformed into trans-3,4-dihydrodiol (2). (wikipedia.org)
  • Ingestion of benzo[c]fluorene makes it a very potent lung tumorigen In particular, benzo[c]fluorene is better absorbed in the lungs. (wikipedia.org)
  • Once it is absorbed, benzo[c]fluorene enters the lymph, circulates in the blood and is metabolized. (wikipedia.org)
  • This has been proven for similar substances like fluorene and fluoranthene, but has yet to be investigated for benzo[c]fluorene. (wikipedia.org)
  • Benzo[c]fluorene is mainly metabolized by the CYP enzymes in the liver. (wikipedia.org)
  • There is also evidence that a larger number of metabolites are formed in the lungs, which might explain why benzo[c]fluorene is such a potent lung tumorigen. (wikipedia.org)
  • It is possible that benzo[c]fluorene may have a unique (and still unknown) mechanism of activation or transportation, which explains why the lungs are targeted. (wikipedia.org)
  • More research on this topic is necessary for benzo[c]fluorene. (wikipedia.org)
  • The carcinogenic metabolites of benzo[c]fluorene bind to DNA which involves the opening of the epoxide ring in benzo[c]fluorene anti- and syn-diolepoxide. (wikipedia.org)
  • The benzo[c]fluorene metabolites bind in a yet unknown fashion to the DNA. (wikipedia.org)
  • When these are burned in the engine combustion process, they form new highly toxic chemicals including dioxin and a group of chemicals called polycyclic aromatic hydrocarbons (PAH for short). (chem-tox.com)
  • Car exhaust is a major source of the carcinogenic and neurotoxic chemicals polycyclic aromatic hydrocarbons (PAH). (chem-tox.com)
  • However, the Ah receptor agonists containing four or five aromatic rings (i.e. (dtu.dk)
  • Aryl hydrocarbon receptor (AHR) is a transcription factor [ 41 ], Gargaro, Manni et al. (biomedcentral.com)
  • The rail yard site in Nijmegen, Netherlands has been subject to contamination via leaks, spills, and filling losses of hydrocarbon fuels over the years. (fmc.com)
  • Compounds belonging to the class of 1H-benzo[d]imidazole hydroxamic acids have been identified as novel HDAC6 inhibitors, with the benzimidazole group serving as a specific linker for these inhibitors. (bvsalud.org)
  • Harnessing In Silico, In Vitro, and In Vivo Data to Understand the Toxicity Landscape of Polycyclic Aromatic Compounds (PACs). (nih.gov)
  • To better assess the potential role of UGT1A10 in risk for tobacco-related cancers, the glucuronidation activity of UGT1A10 was compared with that of other known UGT enzymes against selected polycyclic aromatic hydrocarbons, and the effects of the codon 139 polymorphism on UGT1A10 function were examined in vitro. (aspetjournals.org)
  • Benzo[k]fluoranthene is classified as a substance of very high concern under REACH . (umweltprobenbank.de)
  • It is mostly flat, because it consists of 3 aromatic rings. (wikipedia.org)
  • At a concentration of only 50 nanomolar (nanomoles per litre) of benzo[a]pryrene, as many as 150 proteins were still found to be altered in their cellular levels. (analytica-world.com)
  • The mutagenic activities toward Salmonella typhimurium TA 100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF), 2-methylBkF, 8-methylBkF, 9-methylBkF and 7,12-dimethylBkF were compared. (psu.edu)
  • A chlorinated hydrocarbon that is not easily soluble in water, but miscible with most organic solvents. (fmc.com)
  • Coconut, safflower, evening primrose, Benzo(b)fluoranthene (PubChem CID: 9153) and linseed oils marketed in São Paulo (Brazil) were investigated totaling 69 samples. (bvsalud.org)
  • We show that particle-phase photochemical oxidation of polycyclic aromatic hydrocarbons on soot can produce a substantial amount of highly oxygenated OA, which changes soot from being hydrophobic to being hydrophilic and increases the ability of soot particles to serve as cloud condensation nuclei. (mpic.de)
  • This has been proven for similar substances like fluorene and fluoranthene, but has yet to be investigated for benzo[c]fluorene. (wikipedia.org)
  • Coconut, safflower, evening primrose, Benzo(b)fluoranthene (PubChem CID: 9153) and linseed oils marketed in São Paulo (Brazil) were investigated totaling 69 samples. (bvsalud.org)
  • L. R Bordajandi, M. Dabrio, F. Ulberth and H. Emons, "Optimization of the GC-MS Conditions for the Determination of the 16 EU Foodstuff Priority Polycyclic Aromatic Hydrocarbons," Journal of Separation Science, Vol. 31, No. 10, 2008, pp. 1769-1778. (scirp.org)
  • This would be done by extending Annex I or establishing new limit values in Annex III for the following priority substances or groups of substances: welding fumes, polycyclic aromatic hydrocarbons (using benzo(a)pyrene as a marker), isoprene, 1,4-dioxane and cobalt and inorganic cobalt compounds. (etuc.org)
  • It is a polycyclic aromatic hydrocarbon generated by the incomplete combustion of organic compounds. (endocrine-abstracts.org)
  • Benzo[c]fluorene is a polycyclic aromatic hydrocarbon (PAH) with mutagenic activity. (wikipedia.org)
  • 2. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. (nih.gov)
  • M. Samdudin, H. Azahar, A. Abas and Z. Zakaria, "Determination of Heavy Metals and Polycyclic Aromatic Hydrocarbons (PAH) Contents Using the Lichen Dirinaria picta in Universiti Kebangsaan Malaysia," Journal of Environmental Protection , Vol. 4 No. 8, 2013, pp. 760-765. (scirp.org)
  • This study examines the use of various types of mineral sorbents (Tripoli, Brown coal, Diatomite) and mineral sorbents (Biochar, Granular activated coal) to reduce the toxic effects of pollutants on the sources of anthropogenic emissions of heavy metals and polycyclic aromatic hydrocarbons adjacent to the sources. (omu.edu.tr)
  • Importantly, both exposomal factors unleash their carcinogenic potential, at least to some extent, by activating the aryl hydrocarbon receptor (AHR). (frontiersin.org)
  • A biomonitoring study on lichens was conducted to assess the levels of atmospheric heavy metal and polycyclic aromatic hydrocarbon (PAH) at ten sites at the Universiti Kebangsaan Malaysia Campus, Bangi, Selangor, Malaysia. (scirp.org)
  • By being insensitive to these compounds, FID becomes ideally suited for the analysis application for hydrocarbons in atmospheric and aqueous samples. (ukessays.com)
  • 12. Determination of polycyclic aromatic hydrocarbons in infant formula using solid state urea clathrate formation with gas chromatography - tandem mass spectrometry. (nih.gov)
  • 16. Validation of analytical conditions for determination of polycyclic aromatic hydrocarbons in roasted coffee by gas chromatography-mass spectrometry. (nih.gov)
  • The Monitoring Program for the Quality of Toxic Waters, Mollusks and Phytoplankton in the Seafood Production Areas of the Catalan Coast (PSQAM) executes the analysis for the determination of chemical contaminants (metals, dioxins, furans and polychlorinated biphenyls) and aromatic hydrocarbons polycyclic through the different collaborations and agreements with laboratories accredited by ENAC to comply with the requirements of analytical quality and current legislation. (marinemonitoring.org)
  • 17. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. (nih.gov)
  • 7. Polycyclic aromatic hydrocarbons in the Chinese diet: contamination characteristics, indicator screening, and health risk assessment. (nih.gov)
  • 14. Contamination of Scots pine forests with polycyclic aromatic hydrocarbons on the territory of industrial city of Siberia, Russia. (nih.gov)
  • Health assessment document for polycyclic organic matter. (epa.gov)
  • The EWG Health Guideline of 0.007 ppb for benzo[a]pyrene was defined by the California Office of Environmental Health Hazard Assessment as a public health goal, the level of a drinking water contaminant that does not pose a significant health risk. (ewg.org)
  • Up- regulation of GPR35 has been found in human mast cells upon stimulation with IgE antibodies, human macrophages treated with the environmental contaminant polycyclic aromatic hydrocarbon benzo[a]pyrene, failing heart cells, and gastric cancer cells. (multispaninc.com)
  • Benzo[a]pyrene (BaP), a key polycyclic aromatic hydrocarbon (PAH) often associated with soot particles coated by organic compounds, is a known carcinogen and mutagen. (escholarship.org)
  • The capacity of isolated strains to mineralize 5 hydrocarbons is presented in this study wherein ISO2 showed a consistent degradation and higher metabolic versatility in comparison to other strains in all the experiments. (scialert.net)
  • Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. (cdc.gov)
  • Introduction: Benzo[a]Pyrene (BaP) is an endocrine-disrupting chemical, which may impact reproduction. (endocrine-abstracts.org)
  • Benzo(a)pyrene should be handled with care, as it is toxic. (gc.ca)
  • Among the 34 oil-degrading microbial isolates collected from petrochemical contaminated workshop sediments of Puducherry in India five isolates are screened and selected based on their efficiency to mineralize Polycyclic Aromatic Hydrocarbons. (scialert.net)
  • The legal limit for benzo[a]pyrene, established in 1992, was based on analytical detection limits at the time that the standard was set. (ewg.org)
  • 10. Polycyclic aromatic hydrocarbon profile analysis of high-protein foods, oils, and fats by gas chromatography. (nih.gov)
  • Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources. (cri.or.th)
  • 11. Polycyclic aromatic hydrocarbons in spanish olive oils: relationship between benzo(a)pyrene and total polycyclic aromatic hydrocarbon content. (nih.gov)