Benzo(a)pyreneMicrosomes, LiverMicrosomesBenzopyrenesCytochrome P-450 Enzyme SystemBiotransformationDihydroxydihydrobenzopyrenesAryl Hydrocarbon HydroxylasesHydroxylationDNA AdductsCarcinogensMixed Function OxygenasesGlucuronosyltransferaseMethylcholanthreneGlucuronidesBenzoflavonesCytochrome P-450 CYP3APolycyclic CompoundsMutagensChromatography, High Pressure LiquidDealkylationNADPH-Ferrihemoprotein ReductaseKineticsCytochrome P-450 CYP1A1Polycyclic Hydrocarbons, AromaticPhenobarbitalChrysenesStereoisomerismOxidoreductases, N-DemethylatingEpoxy CompoundsLiverBenz(a)AnthracenesSteroid 16-alpha-HydroxylaseProadifenMutagenicity TestsRats, Inbred StrainsCytochrome P-450 CYP1A2NADPPyrenesEnzyme InductionUridine Diphosphate Glucuronic AcidKetoconazoleIsoenzymesbeta-NaphthoflavoneTroleandomycinPhenanthrenesSteroid HydroxylasesCarcinogens, EnvironmentalMetabolic Detoxication, DrugAnisolesOxidation-ReductionCytochrome P-450 CYP2D6Glucose-6-PhosphataseCoumarinsCoal TarCytochrome ReductasesGlycolsCytochrome P-450 CYP2E1Substrate SpecificityNitrosaminesOxygenasesSulfaphenazole7-Alkoxycoumarin O-DealkylaseFluorenesDNATrichloroepoxypropaneCytochromes b5Enzyme InhibitorsMolecular StructureSafrolePhenacetinRabbitsBenzopyrene HydroxylaseReceptors, Aryl HydrocarbonMetabolic Detoxication, Phase IIntracellular MembranesGlucuronatesMass SpectrometrySpecies SpecificityRats, Sprague-DawleyEndoplasmic ReticulumAflatoxin B1Gas Chromatography-Mass SpectrometryStructure-Activity Relationship2-AcetylaminofluoreneDose-Response Relationship, DrugCell FractionationDrug InteractionsTetrachlorodibenzodioxinCytosolAcronineAroclorsQuinidineDolicholButylated HydroxyanisoleDogsChlorzoxazoneSpectrophotometry, UltravioletRecombinant ProteinsSubcellular Fractions