• When Ca2+ channels are activated in response to a variety stimuli, a drastic increase in the [Ca2+]c is induced and the entered free Ca2+ binds to the sets of Ca2+-regulated proteins such as calmodulin and calcium dependent protein kinases to modify the activities or affinities of these proteins in binding to specific targets. (globalsciencebooks.info)
  • The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. (antibodypedia.com)
  • S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. (scytek.com)
  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. (genetex.com)
  • PIM-1 is a serine/ threonine kinase belonging to the group of calcium/calmodulin-regulated kinases (CAMK). (proteinkinase.biz)
  • CAMK2β belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca(2+)/calmodulin-dependent protein kinase subfamily. (signalchem.com)
  • Kinase D (PKD) enzymes are serine/threonine protein kinases that belong to the calmodulin-dependent protein kinases (CAMK) superfamily and modulate numerous biological processes. (opioid-receptors.com)
  • CDPKs combine an amino-terminal serine/threonine kinase domain and a carboxy-terminal calmodulin-like domain, composed of four EF hands, in the same molecule. (pberghei.eu)
  • Protein phosphatase 1 regulatory subunit 3F (PPP1R3F) is a member of the glycogen targeting subunits (GTSs), which belong to the large group of regulatory subunits of protein phosphatase 1 (PP1), a major eukaryotic serine/threonine protein phosphatase that regulates diverse cellular processes. (bvsalud.org)
  • Pim-1, 2 and 3 (EC 2.7.11.1) make up a distinct and highly homologous family of serine/threonine kinases belonging to the Ca2+/ calmodulin -dependent protein kinase-related (CAMK) family. (axonmedchem.com)
  • Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). (bvsalud.org)
  • This arrangement allows the EF-hand motif of one molecule to interact with that of an adjacent molecule to form a two EF-hand domain similar to that seen in the N-terminal domain of the NMR structure of CaBP1, calmodulin and troponin C. The oligomeric state of EhCaBP1 results in reduced flexibility between domains and may be responsible for the more limited set of targets recognized by EhCaBP1. (rcsb.org)
  • "It was expected answers would describe in detail the role of troponin, tropomyosin and calmodulin in mediating muscle contraction" , the examiners rejoined. (derangedphysiology.com)
  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. (icr.ac.uk)
  • CDPK4 belongs to an expanded family of Ca 2+ dependent protein kinases (CDPKs). (pberghei.eu)
  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. (string-db.org)
  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. (string-db.org)
  • Calmodulin Mutations in Human Disease. (nih.gov)
  • Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)
  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. (creativebiomart.net)
  • Phylogenetic analysis of fragments of the calmodulin ( cmdA ), translation elongation factor ( tef1 ), RNA polymerase second largest subunit ( rpb2 ), and β-tubulin ( tub ) loci revealed that strain CBS 143874 was closely related to isolate NRRL 25615, a known but undescribed phylogenetic species belonging to the African clade of the Fusarium fujikuroi species complex. (knaw.nl)
  • A polyphasic taxonomic approach comprising extrolite profiles, phenotypic characters and molecular data (beta-tubulin, calmodulin and ribosomal polymerase II second largest subunit gene sequences) was applied to determine their novel taxonomic status. (knaw.nl)
  • This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. (wikipedia.org)
  • This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
  • Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. (creativebiomart.net)
  • This gene belongs to the IQ motif-containing family of proteins. (antibodypedia.com)
  • EF-hand Ca2+-binding proteins (CBPs), such as calmodulin (CaM) or those belonging to the S100 protein family (S100s) undergo conformational changes upon increasing intracellular Ca2+, facilitating interactions with protein targets and inducing important biological responses. (umaryland.edu)
  • These plasma membraneClocalized receptors belong to a bigger family members that can end up being categorized into ionotropic G2A receptor and metabotropic G2Y receptors (Burnstock and Ralevic, 1998). (abt-888.net)
  • NCS (neuronal Ca 2+ sensor) proteins belong to a family of calmodulin-related EF-hand Ca 2+-binding proteins which, in spite of a high degree of structural similarity, are able to selectively recognize and regulate individual effector enzymes in a Ca 2+-dependent manner. (univr.it)
  • Proteins in the eluates from four different affinity chromatography experiments were identified by 1-DE and in-gel digestion followed by LC-MS/MS. Parallel experiments were performed using two related control-proteins belonging to the EF-hand family. (lu.se)
  • TRPM3 belongs to the melastatin sub-family of TRP channels and has been shown to function as a spontaneous calcium channel, with permeability to other cations influenced by alternative splicing and/or non-canonical channel activity. (wustl.edu)
  • The CACNA1D gene belongs to a family of genes that provide instructions for making calcium channels. (medlineplus.gov)
  • Belongs to the tubulin family. (string-db.org)
  • Here, the tools are specifically used to study the Ca 2+ -dependent state ensembles of the regulatory protein calmodulin. (kth.se)
  • A total of 140 putative Ca2+-calmodulin-binding proteins were identified of which 87 proteins contained calmodulin-binding motifs. (lu.se)
  • Among the 87 proteins that contained calmodulin-binding motifs, 48 proteins have not previously been shown to interact with calmodulin and 39 proteins were known calmodulin-binding proteins. (lu.se)
  • Two novel Aspergillus species, one belonging to the section Terrei and the other to section Flavipedes, were isolated from hypersaline soils of The National Park of Lake Urmia (Iran) and are here described as Aspergillus iranicus and Aspergillus urmiensis. (knaw.nl)
  • Aspergillus tubingensis is a black Aspergillus belonging to the Aspergillus section Nigri, which includes species that morphologically resemble Aspergillus niger . (biomedcentral.com)
  • The species belonging to the Aspergillus section Nigri are phylogenetically closely related. (biomedcentral.com)
  • however, most of the species belonging to the Aspergillus section Nigri are morphologically indistinguishable. (biomedcentral.com)
  • The systematic name of this enzyme class is S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase. (wikipedia.org)
  • A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. (ciliate.org)
  • The C terminus of the KCNQ1 channel protein has two calmodulin-binding sites that are involved in regulating I Ks channels. (molcells.org)
  • Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions. (nih.gov)
  • Calmodulin is an essential Ca2+-binding protein that binds to a variety of targets that carry out critical signaling functions. (lu.se)
  • We describe the proteomic characterization of mouse brain Ca2+-calmodulin-binding proteins that were purified using calmodulin affinity chromatography. (lu.se)
  • Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca(2+)-ligated calmodulin. (nih.gov)
  • 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. (lu.se)
  • Calmodulin Interactions with Voltage-Gated Sodium Channels. (nih.gov)
  • Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation. (nih.gov)
  • The CV-system is also assumed to be involved in Ca 2+ -transport since it contains a PMCA-type Ca 2+ -ATPase (PAT1), calmodulin [ 3 ] and a vacuolar proton pump that establishes a proton gradient for Ca 2+ -transport [ 4 ]. (biomedcentral.com)
  • This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. (affbiotech.com)
  • Other names in common use include S-adenosylmethionine:calmodulin (lysine) N-methyltransferase, and S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase. (wikipedia.org)
  • This short three-sentence comment has informed the content and structure of what follows, but a lot of that material belongs in the section on excitation-contraction coupling. (derangedphysiology.com)
  • A .gov website belongs to an official government organization in the United States. (medlineplus.gov)
  • The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)