Significant association for germline variations only in the COX pathway (specifically in the antioxidant microsomal glutathione S-transferase 1 [MGST1] gene), with risk for Barrett's esophagus and the combined outcome of Barrett's esophagus and esophageal adenocarcinoma was found. (cusabio.com)
As an addition to the high-density SNP (single-nucleotide polymorphism) maps of 12 glutathione S-transferase and related genes reported earlier, a SNP map of the microsomal glutathione S-transferase 1 (MGST1) gene is provided. (cusabio.com)
This study examined the association between overall survival and Glutathione S-transferase Pi (GST Pi) expression and genetic polymorphism in stage C colon cancer patients after resection alone versus resection plus 5-fluourouracil-based adjuvant chemotherapy. (biomedcentral.com)
In colorectal biopsies and peripheral blood lymphocytes of patients with IBD, polyps and CRC, we evaluated 1) genomic instability using the γH2AX assay as marker of DSB and micronuclei in mononuclear lymphocytes kept under cytodieresis inhibition, and 2) cellular stress through expression and cellular localization of glutathione-S-transferase omega 1 (GSTO1). (oncotarget.com)
Expression1
Tart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage. (exeter.ac.uk)
Pathway2
In addition, increases in GPX, SOD3, G6PD, HK, and PFK at proteomic and transcriptomic levels suggested elevation of glycolysis and pentose phosphate pathway, synthesis of glutathione and nucleotides, and antioxidative pathway activity, whereas oxidative phosphorylation, TCA and mitochondrial energy metabolism were reduced. (frontiersin.org)
On the other hand, oral administration of MSNs disturbed inflammatory factors and metabolites of ribose-5-phosphate, 6-phosphogluconate, GSSG, and NADP+ associated with the pentose phosphate pathway, glutathione synthesis and oxidative stress albeit to a lesser extent than intravenous injection despite the administration of a ten-fold greater dose. (frontiersin.org)
Enzymes1
Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). (cancerindex.org)
Administration of paclitaxel and propolis effectively suppressed breast cancer, which is revealed by the decrease in the extent of lipid peroxidation (LPO) with concomitant increase in the activities of enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)) and non-enzymic antioxidants (reduced glutathione (GSH), Vitamin C and Vitamin E) levels when compared to breast cancer-bearing animals treated with either paclitaxel or propolis alone. (propoleo.cl)
Antioxidant enzymes2
To adapt to the hostile micromilieu and to ensure its long-term survival, the parasite continuously produces a diverse repertoire of antioxidant enzymes including several species of glutathione transferases (GSTs). (biomedcentral.com)
Glutathione is the most abundant thiol antioxidant in mammalian cells that is directly involved in defense of reactive oxygen species and that functions as a cofactor of antioxidant enzymes such as the glutathione peroxidase (GPx) [ 12 ]. (biomedcentral.com)
Barrett's2
2. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. (nih.gov)
Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade. (cusabio.com)
Depletion1
This study investigated the effect of glutathione depletion on lipid concentrations in plasma and liver, on expression of genes and activities of enzymes involved in lipid synthesis. (biomedcentral.com)
Concentrations2
Glutathione-deficient rats had lower triglyceride concentrations in their livers than the control rats (-23%), whereas the circulating triglycerides and the cholesterol concentrations in plasma and liver were not different between the two groups of rats. (biomedcentral.com)
This study shows that glutathione deficiency lowers hepatic triglyceride concentrations via influencing lipogenesis. (biomedcentral.com)
Although pro-oxidants and many pathological conditions such as inflammatory liver diseases, diabetes and hyperglycemia are accompanied by reduced intracellular levels of glutathione [ 13 - 15 ], the effect of inhibited glutathione synthesis as a model for endogenously produced oxidative stress on lipogenesis is not yet well understood. (biomedcentral.com)
Levels1
Glutathione levels were reduced by administration of BSO. (biomedcentral.com)
Activity2
Livers of glutathione-deficient rats had lower mRNA abundance of sterol regulatory element-binding protein (SREBP)-1c (-47%), Spot (S)14 (-29%) and diacylglycerol acyltransferase 2 (DGAT-2, -27%) and a lower enzyme activity of fatty acid synthase (FAS, -26%) than livers of the control rats. (biomedcentral.com)
Glutathione-deficient rats had also a lower hepatic activity of the redox-sensitive protein-tyrosine phosphatase (PTP)1B, and a higher concentration of irreversible oxidized PTP1B than control rats. (biomedcentral.com)