• The SERPINA6 gene provides instructions for making a protein called corticosteroid-binding globulin (CBG), which is primarily produced in the liver. (medlineplus.gov)
  • The CBG protein attaches (binds) to a hormone called cortisol . (medlineplus.gov)
  • It is unclear how a decrease in CBG protein and total cortisol leads to the signs and symptoms of corticosteroid-binding globulin deficiency. (medlineplus.gov)
  • A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (nih.gov)
  • The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis. (nih.gov)
  • Positive Expression of Retinol-Binding Protein 4 Is Related to the Malignant Clinical Features Leading to Poor Prognosis of Glioblastoma. (nih.gov)
  • Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). (nih.gov)
  • In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. (lu.se)
  • Additionally, we compared how MD and grand-canonical Monte Carlo (GCMC) can be used to assess dynamics and thermodynamics of protein-ligand binding for both buried and solvent-exposed binding sites. (lu.se)
  • Title : Accounting for the influence of inflammation on retinol-binding protein in a population survey of Liberian preschool-age children Personal Author(s) : Larson, Leila Margaret;Addo, O. Yaw;Sandalinas, Fanny;Faigao, Katherine;Kupka, Roland;Flores-Ayala, Rafael;Suchdev, Parminder S. (cdc.gov)
  • Thyroid-binding globulin (TBG) is produced in the liver and is a circulating protein that reversibly binds thyroid hormones3,5,3'-triiodothyronine (T3) and thyroxine (T4) and carries them in the bloodstream. (medscape.com)
  • Understanding how proteins interact entails studying the binding affinity (strength) and the lifetime (duration) of the protein-protein interaction to better decompose how an immune response is initiated and how we can explore this knowledge to treat diseases. (lu.se)
  • In this thesis, total internal fluorescence microscopy (TIRF) and single-molecule imaging were used to observe and characterize protein-functionalized supported lipid bilayers (SLBs) interacting with immune cells to obtain the binding kinetics of various protein-protein pairs. (lu.se)
  • In the first part of this thesis, the interaction between the rat CD2 (rCD2) adhesion protein and its ligand rat CD48T92A (rCD48T92A), a high-affinity mutant of the wild type rat CD48, was used to establish a new method of obtaining single-cell binding affinities of T cells interacting with SLBs using imidazole titrations. (lu.se)
  • In one of two complementary studies, IARC scientists analysed data from almost 230 000 women using Mendelian randomization to examine genetic variants known to be associated with circulating concentrations of IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3), which may modulate the availability of IGF-1. (who.int)
  • We would like to understand the 'driving forces' of protein-ligand binding, which amounts to understanding the statistical thermodynamics of the binding process at atomic resolution. (lu.se)
  • For these reasons, we are interested in the role of the conformational entropy of the target protein in ligand-binding processes. (lu.se)
  • By comparing NMR-derived order parameters between the free and ligand-bound protein, we estimate the contributions from conformational entropy to the free energy of ligand binding. (lu.se)
  • We combine NMR relaxation experiments with molecular dynamics (MD) simulations to derive a highly detailed picture of how the conformational entropy changes when the protein binds different ligands. (lu.se)
  • Thyroxine-binding globulin (TBG) deficiency is a benign condition that is either acquired or inherited. (medscape.com)
  • 95%) of THs are thyroxine-binding globulin (TBG), transthyretin (TTR, or prealbumin), and albumin. (medscape.com)
  • Thyroxine-binding globulin (TBG) is a 395-amino acid, 54kd polypeptide that is synthesized in the liver and encoded by a single gene copy. (medscape.com)
  • ARUP's Laboratory Test Directory: Thyroxine Binding Globulin. (medscape.com)
  • The thyroid hormones (THs)-thyroxine (T4) and 3,5,3'-triiodothyronine (T3)-circulate in blood by reversibly binding to carrier proteins. (medscape.com)
  • Furthermore, it is important and challenging to accurately model the large entropic contribution to ligand-binding free energies. (lu.se)
  • Even though the CD4 co-receptor increases the sensitivity of T cell signalling manyfold, it binds to its ligand, peptide major histocompatibility complex II (pMHCII), with the lowest binding affinity known to this day. (lu.se)
  • In addition to NMR relaxation methods, we use isothermal titration calorimetry to obtain the thermodynamic fingerprint of ligand binding, including the total (standard) free energy, enthalpy, and entropy of the process. (lu.se)
  • Corticosteroid-binding globulin deficiency is a condition with subtle signs and symptoms, the most frequent being extreme tiredness (fatigue), especially after physical exertion. (medlineplus.gov)
  • Some people with corticosteroid-binding globulin deficiency also have a condition called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (medlineplus.gov)
  • The prevalence of corticosteroid-binding globulin deficiency is unknown, but it is thought to be a rare disorder. (medlineplus.gov)
  • However, because some people with the disorder have mild or no symptoms, it is likely that corticosteroid-binding globulin deficiency is underdiagnosed. (medlineplus.gov)
  • Mutations in the SERPINA6 gene cause corticosteroid-binding globulin deficiency. (medlineplus.gov)
  • With less functional CBG to bind cortisol, people with corticosteroid-binding globulin deficiency usually have increased unbound cortisol levels. (medlineplus.gov)
  • Determining the optimal binding energies for heterogeneous chemical reactions -- usually meaning that the reactant is in the gas or liquid phase while the catalyst is a solid -- is critical for many aspects of modern society, as we rely on such reactions for processes as diverse as the production of fertilizers and plastics. (sciencedaily.com)
  • The team performed a new set of calculations, based on reaction kinetic modeling, that take this discrepancy into account, and calculated new optimal binding energies for hydrogen oxidation, which uses heterogeneous catalysis, finding that the calculations gave different values at high reaction rates. (sciencedaily.com)
  • ATR- FTIR , molecular docking , and dynamic simulation between SARS-CoV-2 S and either lectins indicated molecular interactions with predicted binding energies of -85.4 and -72.0 Kcal/Mol, respectively. (bvsalud.org)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • The amount of total cortisol in the body consists of both bound (inactive) and unbound (active) cortisol. (medlineplus.gov)
  • TIBC was calculated indirectly using the unsaturated iron binding capacity (UIBC) method. (cdc.gov)
  • The unsaturated iron-binding capacity (UIBC) is measured using radioactive iron or spectrophotometric approaches. (medscape.com)
  • The sum of the UIBC and the plasma iron is the total iron-binding capacity (TIBC). (medscape.com)
  • TIBC must not be confused with unsaturated binding capacity (UIBC), which represents the residual after subtraction of serum iron from TIBC. (medscape.com)
  • Binding of hemagglutinin proteins is indicated in relative fluorescence units (RFU). (cdc.gov)
  • Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity. (cdc.gov)
  • The relationship of TIBC and transferrin is disrupted in individuals with conditions that affect transferrin-binding capacity or other iron-binding proteins. (medscape.com)
  • Figure 4: Identification of enriched motifs within the estrogen receptor binding sites and validation of transcription factor binding. (nature.com)
  • The results showed a relatively small spread in the rCD2-rCD48T92A binding affinity values despite the considerable spread of receptor densities within the cell population. (lu.se)
  • Using both these methods, the single-cell binding affinity and lifetime of the cell population can be investigated and their spread can provide information concealed with population-average techniques. (lu.se)
  • Total iron-binding capacity (TIBC) is an indirect method assessment of transferrin levels. (medscape.com)
  • [ 1 ] Direct measurement of total iron-binding capacity may also be performed. (medscape.com)
  • This specification defines SVG's XML Binding Language (or XBL for short) and some supporting DOM interfaces. (w3.org)
  • Continued input from users has helped further mature the BIND data specification, which now includes the ability to store detailed information about genetic interactions. (nih.gov)
  • The BIND data specification is available as ASN.1 and XML DTD. (nih.gov)
  • We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. (lu.se)
  • Very rarely, and in the context of anti-TH antibodies in autoimmune thyroid disease, immunoglobulins also may bind TH. (medscape.com)
  • In cases of high TBG, more thyroid hormone will be bound, decreasing free hormone in the blood. (medscape.com)
  • The data binding core plug-in does not depend on SWT but needs to talk about "being on the UI thread" in the abstract. (eclipse.org)
  • In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)
  • Initially, foot binding was common only in the wealthiest parts of China, particularly in northern China. (newworldencyclopedia.org)
  • For this reason, the influence of an adhesion molecule, rat CD2, on the obtained binding kinetics of the human CD4 co-receptor was initially examined showing that the accumulation of CD4 was influenced when having a high concentration of bound CD2 inside the cell-SLB contacts. (lu.se)
  • Where can I find examples of how to use data binding? (eclipse.org)
  • If you are writing an application that only uses SWT, data binding, and optionally JFace, you will have to provide the realm explicitly, or set up a default realm in your main method. (eclipse.org)
  • Does Data Binding depend on Eclipse and the OSGi runtime? (eclipse.org)
  • The core Data Binding plug-in only depends on org.eclipse.equinox.common, ICU4J but no other parts of Eclipse. (eclipse.org)
  • See also JFace Data Binding/Runtime Dependencies . (eclipse.org)
  • Does Data Binding depend on SWT? (eclipse.org)
  • No. Data Binding is meant to be UI toolkit agnostic and more specifically UI agnostic. (eclipse.org)
  • There is default support for SWT and JFace but this is in the org.eclipse.jface.databinding project which is separate from the core Data Binding APIs that live in org.eclipse.core.databinding. (eclipse.org)
  • This project contributes the "JFace-Data Binding Test Suite" to the IDE. (eclipse.org)
  • Can JFace Data Binding run against older versions of Eclipse? (eclipse.org)
  • Yes, we try to keep the data binding bundles compatible with the previous release of Eclipse - for example, data binding released with Eclipse 3.3 will work against Eclipse 3.2. (eclipse.org)
  • Since this is the case, there cannot be any binding to a PL/SQL array because at least one field in the table must be either a VARRAY, NESTED TABLE or ASSOCIATIVE ARRAY data type. (php.net)
  • Data binding is classically done between a user interface element and a data object. (oreilly.com)
  • BIND continues to grow with the addition of individual submissions as well as interaction data from the PDB and a number of large-scale interaction and complex mapping experiments using yeast two hybrid, mass spectrometry, genetic interactions and phage display. (nih.gov)
  • and (4) how dynamic modeling of DNA-binding and gene expression data can be used to infer regulatory logic of TF circuitry. (lu.se)
  • A known ferrous iron standard of 105 μmol/L (586 μg/dL) was incubated with serum at a pH of 7.9, which saturates the available binding sites on serum transferrin. (cdc.gov)
  • The index of transferrin present in circulating blood is the iron-binding capacity. (medscape.com)
  • The measurement of the blood's capacity to bind iron with transferrin is the iron-binding capacity. (medscape.com)
  • Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)
  • Figure 3: Estrogen receptor and RNA PolII binding relative to specific gene targets. (nature.com)
  • These instrument types differ across a number of important criteria, including the process by which they come into being, their scope, and their legally binding nature on Member States. (who.int)
  • In the ideal scenario, we would be able to attribute the contributions from individual molecular groups to the enthalpy and entropy of binding. (lu.se)
  • In addition, when the node with binding SIDs fails, the procedure on each of the related node is illustrated in different cases for two different time periods. (ietf.org)
  • Release candidates for upcoming maintenance releases in the 9.9, 9.10, and 9.11 branches of BIND are now available. (mail-archive.com)
  • Therefore, carbohydrate binding agents may represent potential candidates to abrogate virus infection . (bvsalud.org)
  • A minor proportion of the THs is bound on serum lipoproteins. (medscape.com)
  • Here's the good news: One study found that women who delivered by C-section and practiced belly binding during their postpartum recovery experienced less pain, bleeding, and discomfort as compared to those who had a c-section and didn't use belly binding. (healthline.com)
  • Our recent efforts have focused on aromatic side chains, which often are found in binding sites. (lu.se)
  • Look up binding in Wiktionary, the free dictionary. (wikipedia.org)
  • If your document is larger than 275 sheets we can bind in two or more volumes (each volume is costed as one book). (uwe.ac.uk)
  • If your document is larger than 270 sheets we can offer binding in two or more volumes per document in the regular and usual 24-hour turnaround time. (uwe.ac.uk)
  • Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)
  • When cortisol is bound to CBG, the hormone is turned off (inactive). (medlineplus.gov)
  • Objective It is recognized that total testosterone (TT) does not sufficiently describe androgen status when sex hormone-binding globulin (SHBG) is altered. (medscape.com)
  • Recently, advances in computational chemistry have provided a framework with which to calculate the optimal binding energy, based on equilibrium thermodynamics and assuming that the process will proceed smoothly if all steps in the process are thermodynamically favorable. (sciencedaily.com)
  • In a discovery that could lead to the development of novel catalysts that do not rely on expensive rare metals, scientists have shown that the optimal binding energy can deviate from traditional calculations, which are based on equilibrium thermodynamics, at high reaction rates. (sciencedaily.com)
  • There is an optimal binding energy -- meaning the degree of interaction between the reactants and the catalyst -- where the process is most efficient (if it is too low, the reactants will not react with the catalyst, and if it is too high they will remain bound to it), and catalysts are designed based on this. (sciencedaily.com)
  • High quality carpet binding service. (yell.com)
  • We provide a high quality binding service tailored to individual customers requirements. (yell.com)
  • A high Binding score means more power imbalance between the two individuals - effectively, getting a higher Binding score means the demon is more real because it's Bound to you instead of to that guy. (indie-rpgs.com)
  • Preference is given to Upward Bound Program graduates attending NMC within two years of high school graduation. (fastweb.com)
  • the converse is true, ie, high capacity but low avidity, for TH binding to TTR and albumin. (medscape.com)
  • In your script, you need to bind process variables to attach your script variables to the orchestration process' variables. (ibm.com)
  • You should place the Bind Process Variables command before any changes to the script variables you want to bind to the orchestration process' variables. (ibm.com)
  • By default, using the database specified by the DB compiler directive option, the DB2 ECM preprocessor automatically binds your program during the compilation process, creating and storing in your DB2 database a DB2 package required for successful execution. (microfocus.com)
  • Once you're ready to get back on your feet (slowly, please), you might consider belly binding, a process that's designed to make postpartum recovery a little easier and might help your body heal faster, too. (healthline.com)
  • With a single screw to fully adjust the vertical and lateral release as well as a trimmed-down shape, the Zed definitely walks close to the line of a minimalist binding, yet has everything we need for a confidence-inspiring descent and optimal efficiency on the ascent. (backcountry.com)
  • Optimal Monetary Policy under Commitment with a Zero Bound on Nominal Interest Rates ," Journal of Money, Credit and Banking , Blackwell Publishing, vol. 38(7), pages 1877-1905, October. (repec.org)
  • Optimal Monetary Policy Under Commitment with a Zero Bound on Nominal Interest Rates ," CEPR Discussion Papers 4111, C.E.P.R. Discussion Papers. (repec.org)
  • Optimal Monetary Policy under Commitment with a Zero Bound on Nominal Interest Rates ," Computing in Economics and Finance 2004 67, Society for Computational Economics. (repec.org)
  • Optimal monetary policy under commitment with a zero bound on nominal interest rates ," Working Paper Series 377, European Central Bank. (repec.org)
  • Optimal monetary policy under commitment with a zero bound on nominal interest rates ," CFS Working Paper Series 2004/13, Center for Financial Studies (CFS). (repec.org)
  • Optimal monetary policy under commitment with a zero bound on nominal interest rates ," Research Working Paper RWP 05-07, Federal Reserve Bank of Kansas City. (repec.org)
  • Optimal Monetary Policy When Interest Rates are Bound at Zero ," Working Papers 01-12, Ohio State University, Department of Economics. (repec.org)
  • The Biomolecular Interaction Network Database (BIND: http://bind.ca) archives biomolecular interaction, complex and pathway information. (nih.gov)
  • Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)
  • US-bound refugees at participating sites are offered 1-3 doses in each vaccine series, depending on age, availability of appropriate vaccines, time to departure, and logistics. (cdc.gov)
  • Bindings can be attached to elements by declaring, in XBL, that a particular element in a particular namespace is implemented by a particular binding. (w3.org)
  • commands are confined to the target elements within the bound instance associated with the SDC file. (intel.com)
  • The following bindings can be converted to custom elements by prepending/appending elements when CE connects. (mozilla.org)
  • The Zed 12 Binding is G3's lightest binding, borrowing all the best elements from the well-loved Ion to create a set of clamps that take us further and still offer up the reliability we require when we're far back in the mountains. (backcountry.com)
  • United States standard that codes elements of a binding record to enable library and bindery automated systems to communicate. (ala.org)
  • pinyin: chánzú, literally "bound feet") was a custom practiced on young females for approximately one thousand years in China , from the tenth century until the early twentieth century. (newworldencyclopedia.org)
  • When a girl was between the ages of three and eight years old, the four small toes on each foot were folded over and bound tightly with long bandages, which were re-wrapped every one or two days. (newworldencyclopedia.org)
  • This working draft describes SVG's XML Binding Language (s XBL ). (w3.org)
  • This document describes a architecture of fast re-route protection for binding SIDs on SR paths including SRv6 paths and SR-MPLS paths. (ietf.org)
  • He bound 2 rugs for me and what an amazing piece of work. (yell.com)
  • Details of our binding options and prices, and how to place your order. (uwe.ac.uk)
  • The Neo-Confucian scholar Zhu Xi (1130-1200 C.E. ), advocated foot binding and introduced the practice into southern Fuijan in order to spread Chinese culture and teach proper relations between men and women. (newworldencyclopedia.org)
  • I-D.hu-spring-segment-routing-proxy-forwarding ] proposes a mechanism that provides FRR protection for a binding SID of a transit node on a SR path within a single domain. (ietf.org)
  • It is used to explain the mechanism of SR path binding protection in single domain. (ietf.org)
  • In 1911, the French chemist Paul Sabatier proposed, based on experiments, that there is an optimum binding energy which allows the catalytic activity to be maximized. (sciencedaily.com)
  • When compiling with NOACCESS, no binding takes place. (microfocus.com)
  • arguments together disable scoping, treating an entity-bound SDC as a global SDC file. (intel.com)
  • In addition to instructing the DB2 ECM to create a DBRM file, you can also use BIND to specify an alternative filename for the DBRM file. (microfocus.com)
  • BIND also enables you to redirect the created DBRM file to an alternative directory. (microfocus.com)
  • When compiling a program with the ACCESS compiler directive option (default), the DBRM is bound into the connected database, where it creates the SQL package required for execution. (microfocus.com)
  • command to bind those variables. (ibm.com)
  • For instance, you might want to create DBRMs ( .bnd files) during compilation, and bind the DBRMs later using the DB2 LUW BIND command against your DB2 LUW databases. (microfocus.com)
  • Optional) Interface VLAN ID or S-VLAN ID interface on which to show binding state information. (juniper.net)
  • Optional) Set of interfaces on which to show binding state information. (juniper.net)
  • We identify anticipation effects that make the ZLB more likely to bind and we show that allowing negative nominal interest rates shortens average durations, but only by about one quarter. (repec.org)
  • Display the DHCPv6 address bindings in the Dynamic Host Configuration Protocol (DHCP) client table. (juniper.net)
  • A mitered binding corner is simply a clever way to make a neat flat corner. (asg.org)
  • While belly binding does have therapeutic benefits that can help to speed up postpartum recovery - or at least make that transitional period more comfortable - it's not a magic pill. (healthline.com)
  • The iron-binding capacity reference range is 255-450 μg/dL. (medscape.com)
  • If you want to use BIND or BINDDIR when compiling from your Visual COBOL , set one or both of these directives in your project properties on the SQL Preprocessor page. (microfocus.com)
  • Note that it looks like you can't bind a multi-dimensional array with this method. (php.net)
  • The British Library, Binding Index, lists [C. L. H.] L. Hay-Cooper, who worked with the binder S. Bernard. (antiqbook.com)
  • Often, people assume that postpartum belly binding is the same as waist training , or an effective part of a weight loss routine. (healthline.com)