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DoxorubicinCyclophosphamideAntineoplastic Combined Chemotherapy ProtocolsEtoposideLomustineVinca AlkaloidsAntineoplastic Agents, PhytogenicBleomycinVinblastineMethotrexateP-GlycoproteinDrug ResistanceAntibodies, Monoclonal, Murine-DerivedLeukemia P388Lymphoma, Non-HodgkinAsparaginaseAntineoplastic AgentsCombined Modality TherapyDaunorubicinDrug Resistance, MultiplePrednisoloneLymphoma, Large B-Cell, DiffuseRhabdomyosarcomaDrug Administration ScheduleRemission InductionCytarabinePrecursor Cell Lymphoblastic Leukemia-LymphomaHodgkin DiseaseDactinomycinMelphalanIfosfamideOligodendrogliomaTreatment OutcomeDexamethasoneVerapamilDisease-Free SurvivalCarcinoma, Small CellDacarbazineDrug Resistance, NeoplasmCatharanthusSurvival AnalysisVindesineLeukemia, LymphoidCisplatinTeniposideSurvival RateColchicineSemustinePodophyllotoxinChlorambucilMitoxantroneLeukemia L1210Sarcoma, EwingMultiple MyelomaWilms TumorKB CellsTumor Cells, CulturedAntibiotics, AntineoplasticMultidrug Resistance-Associated ProteinsNimustineCarmustineLymphoma, FollicularDrug Screening Assays, AntitumorDose-Response Relationship, DrugNeoplasm StagingDrug SynergismBrain NeoplasmsPrognosisPeripheral Nervous System DiseasesLymphoma, B-CellLymphomaLiposomesCell SurvivalMedulloblastomaAntimitotic AgentsPaclitaxelTime Factors6-MercaptopurineMesnaAstrocytomaLung NeoplasmsMicrotubulesNeuroblastomaTubulinLeukotriene C4MitolactolCerebellar NeoplasmsLeukemia, ExperimentalDrug CarriersTopotecanPeptichemioCentral Nervous System NeoplasmsFollow-Up StudiesNeoplasm Recurrence, LocalCarboplatinRecurrenceActuarial AnalysisAbdominal NeoplasmsSupratentorial NeoplasmsHematologic Diseases
DoxorubicinChemotherapyMarqiboCyclophosphamideEffects of vincristineOncovinLiposomeSulfateVinblastineIsolated in 1961IntravenousVincaChemotherapeuticPeripheral neuropathyPatientsPaclitaxelNeurotoxicityInteractionsLymphomaToxicityCarboplatinIntrathecallyTubulinSevereRitonavirDrugMultidrugIntravenouslyMildVeinNumbnessInhibitorsAntibioticsMedicinesTreatmentTherapiesTreatsSyntheticInfusionCancerNeuropathyAlcoholPotentiallyTherapyBlood
Doxorubicin5
  • One dog died after the third dose of vincristine, and in one case the tumor was vincristine resistant, and the doxorubicin treatment was required. (vin.com)
  • If you are having vincristine in combination with another chemotherapy drug called doxorubicin , the infusion may be given over a few days using a pump that you take home. (macmillan.org.uk)
  • Medical editor's note: CHOP stands for cyclophosphamide , doxorubicin/hydroxydoxorubicin, vincristine/Oncovin and prednisone . (everydayhealth.com)
  • Doses were polatuzumab vedotin at 1.8 mg/kg, vincristine at 1.4 mg/m 2 , rituximab at 375 mg/m 2 , cyclophosphamide at 750 mg/m 2 , doxorubicin at 50 mg/m 2 (on day 1), and oral prednisone at 100 mg once daily (on days 1-5). (ascopost.com)
  • Twelve out of 36 samples submitted were positive for vincristine (10,000 ng/sample), methotrexate (5.3 to 480 ng/sample), cyclophosphamide (5.8 to 1,400 ng/sample), and doxorubicin (19,000 ng/sample) while simultaneously being ND for epirubicin. (cdc.gov)
Chemotherapy12
  • Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. (wikipedia.org)
  • Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. (wikipedia.org)
  • The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. (wikipedia.org)
  • Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. (wikipedia.org)
  • Avoiding chemotherapy spares patients from treatment side effects and long-term health risks, such as cardiovascular disease and development of a second cancer. (news-medical.net)
  • We describe three families with autosomal dominant CMT1, among whom a family member with a neoplastic disease suffered rapid onset, severe neuropathy after receiving initial doses of vincristine as a part of a routine chemotherapy protocol. (nih.gov)
  • Vincristine is a chemotherapy drug used to treat many types of cancer. (macmillan.org.uk)
  • You will be given vincristine in the chemotherapy day unit or during a stay in hospital. (macmillan.org.uk)
  • Toxicity of vincristine another chemotherapy agent, may be more likely if vincristine and L-asparaginase are given at the same time. (marvistavet.com)
  • Drugs used as chemotherapy, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (vicc.org)
  • 18.Whittle AM, Ali S. Primary prophylaxis with voriconazole in patients receiving induction chemotherapy on the MRC adult acute lymphoblastic leukaemia trial (UK-ALL XII) to avoid itraconazole-enhanced vinca neurotoxicity. (webmd.com)
  • For cancer chemotherapy, avoiding the side effects of chemotherapeutic agents is difficult. (elsevierpure.com)
Marqibo2
  • The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL). (news-medical.net)
  • 1.Marqibo (vincristine sulfate) US prescribing information. (webmd.com)
Cyclophosphamide1
  • while no randomized trials have compared regimens, the multidrug regimen of etoposide , MTX, Act-D, cyclophosphamide , and vincristine (EMA-CO) is the one most commonly used (see Table 2, below) and is considered to be the standard of care. (medscape.com)
Effects of vincristine2
  • The purpose of this work was to document the efficacy and side effects of vincristine sulphate treatment on TVTc. (vin.com)
  • Nervous system effects may be more likely to occur in the elderly, who are usually more sensitive to the effects of vincristine. (drugs.com)
Oncovin1
  • The vincristine (Oncovin) drug in CHOP can also cause numbness and tingling in the fingers and toes which can rarely persist for a year or more. (everydayhealth.com)
Liposome1
  • The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the neurotoxicity associated with it. (wikipedia.org)
Sulfate1
Vinblastine2
  • Vincristine and vinblastine are most commonly used, and new drugs such as etoposide, teniposide, and vinorelbine are being used in human medicine but have not yet received widespread use in veterinary oncology. (vin.com)
  • Vinblastine is more myelosuppressive than is vincristine in general. (vin.com)
Isolated in 19611
Intravenous1
  • It is extremely important that the intravenous needle delivering vincristine be properly positioned in the vein. (medicap.com)
Vinca3
  • Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. (wikipedia.org)
  • Vincristine sulphate belongs to a group of medications known as vinca alkaloids and is obtained from the plant Vinca rosea Linn. (vin.com)
  • Vincristine belongs to a group of drugs called vinca alkaloids. (medicap.com)
Chemotherapeutic2
  • Vincristine was an effective chemotherapeutic agent for genital TVTc, showing tumours totally regression in 13 dogs, among them the therapy was also efficient for one case of diffuse cutaneous TVTc. (vin.com)
  • The National Comprehensive Cancer Network (NCCN) has launched the "Just Bag It" campaign for the safe handling of vincristine, a chemotherapeutic agent used primarily in the treatment of patients with leukemia and lymphoma. (oncologynurseadvisor.com)
Peripheral neuropathy3
  • One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid vincristine. (wikipedia.org)
  • With repeated doses of vincristine, you may feel symptoms of peripheral neuropathy (tingling sensation and numbness in the fingers and toes). (medicap.com)
  • Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X. (webmd.com)
Patients9
  • Vincristine is safe for most patients, but potential side effects can occur, as gastrointestinal alterations, myelosuppression and extravasation injury. (vin.com)
  • In a retrospective case series, we investigated the possible association between the DNA rearrangement found in patients with Charcot-Marie-Tooth Disease Type 1A (CMT1A) and susceptibility to the neurotoxicity of vincristine. (nih.gov)
  • These cases show that 17p11.2-12 duplication predisposes patients to severe neurotoxicity from vincristine and that this drug should be avoided with patients with CMT1A. (nih.gov)
  • In patients with unexplained or preexisting familial neuropathy, testing for 17p11.2-12 duplication should be carried out prior to initiating vincristine therapy. (nih.gov)
  • It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine. (vicc.org)
  • 7.Pana ZD, Roilides E. Risk of azole-enhanced vincristine neurotoxicity in pediatric patients with hematological malignancies: old problem - new dilemma. (webmd.com)
  • 10.Harnicar S, Adel N, Jurcic J. Modification of vincristine dosing during concomitant azole therapy in adult acute lymphoblastic leukemia patients. (webmd.com)
  • Paired rectal biopsy specimens from seven patients with severe disease were established in organ culture with or without calcipotriol (1 x 10(-6) M). After 15 hours, vincristine (0.6 microgram/ml) was added to induce metaphase arrest, and CCPR was determined by linear regression analysis of accumulated metaphases. (uea.ac.uk)
  • Vincristine has been proven hazardous and should be avoided by all CMT patients, including those with no symptoms. (asociatiacmt.ro)
Paclitaxel1
Neurotoxicity4
  • 8.Jain S, Kapoor G. Severe life threatening neurotoxicity in a child with acute lymphoblastic leukemia receiving posaconazole and vincristine. (webmd.com)
  • 12.Ariffin H, Omar KZ, Ang EL, Shekhar K. Severe vincristine neurotoxicity with concomitant use of itraconazole. (webmd.com)
  • 13.Sathiapalan RK, El-Solh H. Enhanced vincristine neurotoxicity from drug interactions: case report and review of literature. (webmd.com)
  • 14.Jeng MR, Feusner J. Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia. (webmd.com)
Interactions2
Lymphoma2
  • Vincristine is used alone or in combination with other antineoplastic medications to treat many different types of cancer , including leukemia (cancer of white blood cells), lymphoma (cancer of the lymph cells), breast cancer, lung cancer, malignant melanoma, cancer of the cervix, colorectal cancer, and Wilms' tumor. (medbroadcast.com)
  • Vincristine has been use in combination with other medicines to treat the following cancers: non-Hodgkin's lymphoma, Hodgkin's lymphoma, acute lymphoblastic leukemia (ALL), Wilms' tumor (a form of pediatric kidney cancer), rhabdomyosarcoma, and neuroblastoma. (medicap.com)
Toxicity2
  • 15.Gillies J, Hung KA, Fitzsimons E, Soutar R. Severe vincristine toxicity in combination with itraconazole. (webmd.com)
  • Vincristine toxicity in five children with acute lymphoblastic leukaemia. (webmd.com)
Carboplatin1
  • This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). (vicc.org)
Intrathecally2
  • A significant series of inadvertent intrathecal vincristine administration occurred in China in 2007 when batches of cytarabine and methotrexate (both often used intrathecally) manufactured by the company Shanghai Hualian were found to be contaminated with vincristine. (wikipedia.org)
  • To prevent fatal instances when vincristine is administered intrathecally, the NCCN developed the "Just Bag It" campaign to ensure the proper administration of vincristine and to render it impossible to accidentally administer the medication into the spinal fluid. (oncologynurseadvisor.com)
Tubulin1
  • Vincristine works partly by binding to the tubulin protein, stopping the tubulin dimers from polymerizing to form microtubules, causing the cell to be unable to separate its chromosomes during the metaphase. (wikipedia.org)
Severe1
  • Ifosfamide must be given with the bladder-sparing agent Mesna, to avoid severe urothelial injury). (vin.com)
Ritonavir1
  • Paralytic ileus possibly associated with interaction between ritonavir/lopinavir and vincristine. (webmd.com)
Drug3
Multidrug1
  • We examined the effect of MRK-16, a monoclonal antibody against P-gp, modified liposomes (MRK-Lip) on the human myelogenous leukemia K-562 cells and its adriamycin resistance cell line K-562/ADM cells to avoid the side effects and to reverse the multidrug resistance. (elsevierpure.com)
Intravenously1
Mild1
  • Toxicities associated with vincristine are mild, but perivascular reaction can be a problem. (vin.com)
Vein2
  • Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. (medbroadcast.com)
  • [3] If vincristine is used alone, it is given once a week strictly into a vein. (mdwiki.org)
Numbness1
  • Vincristine can cause tingling sensation and numbness in the fingers and toes. (medicap.com)
Inhibitors1
  • Blood levels and effects may be altered by concurrent use of potent P-gp inhibitors or inducers should be avoided. (unboundmedicine.com)
Antibiotics1
  • In great need construction 4-6 months after therapy, Extractions should be avoided, only in great need, under antibiotics (7-15 [2], Imatinib therapy can produce cutaneous and mucosal depigmentation or hyperpigmentation[72] which proved to be dose related and reversible when administration ceases. (jonnevandermeijden.nl)
Medicines2
Treatment9
  • Most people experience some side effects from vincristine treatment. (wikipedia.org)
  • Vincristine is also being studied in the treatment of other types of cancer. (news-medical.net)
  • Vincristine sulphate, at the dose of 0.5 mg/m 2 of body surface (IV), on 7-14 days intervals, reveal high efficiency (86.6%) for TVTc treatment. (vin.com)
  • One tumor (6.6%) was refractory to vincristine, while at the treatment beginning we observed a mass reduction. (vin.com)
  • The extravasation injury was totally avoid by performing the treatment according to all manufacturers' warnings recommendations. (vin.com)
  • Before you begin treatment with vincristine, you and your doctor should talk about the good this medicine will do as well as the risks of using it. (drugs.com)
  • Vincristine is usually given once a week, but your nurse or doctor will discuss your treatment plan with you. (macmillan.org.uk)
  • It usually starts in the first week of treatment and good oral hygiene is mandatory to avoid secondary infections. (elitepainmanagement.com)
  • [ 3 ] Therefore, it is important to understand the cutaneous side effects of EGFRIs and their management in order to improve quality of life, increase compliance and avoid unnecessary interruption or cessation of treatment. (medscape.com)
Therapies1
  • However, surgery often doesn't completely remove the tumor effectively, so there is a need to use other therapies following the surgery to avoid reoccurrence. (healthline.com)
Treats2
  • VINCRISTINE (vin KRIS teen) treats some types of cancer. (chemocare.com)
  • Vincristine treats certain types of cancer. (medicap.com)
Synthetic2
  • For this reason, alternate methods to produce synthetic vincristine are being used. (wikipedia.org)
  • This study investigated the effect of calcipotriol, a synthetic vitamin D3 analogue that avoids hypercalcaemia, on human rectal CCPR in ulcerative proctocolitis. (uea.ac.uk)
Infusion2
  • Your nurse will give you vincristine as a drip (infusion) over 5 to 10 minutes. (macmillan.org.uk)
  • If extravasation occurs, infusion must be stopped and restarted elsewhere to avoid damage to subcut tissue. (unboundmedicine.com)
Cancer6
  • A downside, however, to Vincristine is that it does not only affect the division of cancer cells. (wikipedia.org)
  • Vincristine belongs to the group of cancer-fighting medications known as antineoplastics . (medbroadcast.com)
  • The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. (medbroadcast.com)
  • As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. (medbroadcast.com)
  • Vincristine interferes with the growth of cancer cells, which are eventually destroyed. (drugs.com)
  • Vincristine can be given in combination with other cancer drugs. (macmillan.org.uk)
Neuropathy2
  • Vincristine-induced neuropathy is the main dose-limiting side effect. (wikipedia.org)
  • A general predisposition for vincristine-related neuropathy has been observed in persons with a family history of hereditary neuropathies. (nih.gov)
Alcohol1
Potentially1
  • The campaign encourages health care providers to implement a policy to always dilute and administer vincristine in a mini IV-drip bag, rather than a syringe, in order to avoid potentially deadly medication errors. (oncologynurseadvisor.com)
Therapy1
  • Before the therapy sections it is necessary to execute the clinical evaluation, the cytological exam and the complete blood count for monitoring the side effects related to vincristine. (vin.com)
Blood3
  • 63], Special care should be used not to alter the blood clots to avoid bleeding. (jonnevandermeijden.nl)
  • Blood levels and effectiveness may be ↓ by concurrent use of strong CYP3A inducers including carbamazepine , dexamethasone , phenytoin , rifabutin , rifampin , rifapentine , and phenobarbital , and should be avoided. (unboundmedicine.com)
  • Blood levels and effectiveness may be ↓ by St. John's wort , concurrent use should be avoided. (unboundmedicine.com)